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Issues

Volume 20, Issue 13
1 July 2014
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    Cover Image

    issue cover
    Loss of S6 phosphorylation as a biomarker of response to PI3K/mTOR pathway inhibition. The representative image shows immunohistochemical staining for phosphorylated S6 protein (ser235-236) in SUM190 breast cancer cell line xenografts treated with the pan-PI3K inhibitor BKM120. For details, see the article by O'Brien and colleagues on page 3507 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

MET as a Target in Papillary Renal Cell Carcinoma
André P. Fay; Sabina Signoretti; Toni K. Choueiri
View articletitled, MET as a Target in Papillary Renal Cell Carcinoma
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CCR Perspectives in Drug Approval

U.S. Food and Drug Administration Inspections of Clinical Investigators: Overview of Results from 1977 to 2009
Sonia K. Morgan-Linnell; David J. Stewart; Razelle Kurzrock
View articletitled, U.S. Food and Drug Administration Inspections of Clinical Investigators: Overview of Results from 1977 to 2009
Supplementary data
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Statistics in Clinical Cancer Research

Blocking and Randomization to Improve Molecular Biomarker Discovery
Li-Xuan Qin; Qin Zhou; Faina Bogomolniy; Liliana Villafania; Narciso Olvera; Magali Cavatore; Jaya M. Satagopan; Colin B. Begg; Douglas A. Levine
View articletitled, Blocking and Randomization to Improve Molecular Biomarker Discovery
Supplementary data
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Molecular Pathways

Molecular Pathways: CDK4 Inhibitors for Cancer Therapy
Mark A. Dickson
View articletitled, Molecular Pathways: CDK4 Inhibitors for Cancer Therapy
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Molecular Pathways: Niches in Metastatic Dormancy
Kenji Yumoto; Matthew R. Eber; Janice E. Berry; Russell S. Taichman; Yusuke Shiozawa
View articletitled, Molecular Pathways: Niches in Metastatic Dormancy
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Review

Infusions of Allogeneic Natural Killer Cells as Cancer Therapy
Wing Leung
View articletitled, Infusions of Allogeneic Natural Killer Cells as Cancer Therapy
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Human Cancer Biology

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
Yong-Chen Lu; Xin Yao; Jessica S. Crystal; Yong F. Li; Mona El-Gamil; Colin Gross; Lindy Davis; Mark E. Dudley; James C. Yang; Yardena Samuels; Steven A. Rosenberg; Paul F. Robbins
View articletitled, Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
Supplementary data
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MET Is a Potential Target across All Papillary Renal Cell Carcinomas: Result from a Large Molecular Study of pRCC with CGH Array and Matching Gene Expression Array
Laurence Albiges; Justine Guegan; Audrey Le Formal; Virginie Verkarre; Nathalie Rioux-Leclercq; Mathilde Sibony; Jean-Christophe Bernhard; Philippe Camparo; Zahira Merabet; Vincent Molinie; Yves Allory; Cedric Orear; Sophie Couvé; Sophie Gad; Jean-Jacques Patard; Bernard Escudier
View articletitled, MET Is a Potential Target across All Papillary Renal Cell Carcinomas: Result from a Large Molecular Study of pRCC with CGH Array and Matching Gene Expression Array
Supplementary data
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Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer
Natalie Hartmann; Nathalia A. Giese; Thomas Giese; Isabel Poschke; Rienk Offringa; Jens Werner; Eduard Ryschich
View articletitled, Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer
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Overexpression of Sirt7 Exhibits Oncogenic Property and Serves as a Prognostic Factor in Colorectal Cancer
Hongyan Yu; Wen Ye; Jiangxue Wu; Xiangqi Meng; Ran-yi Liu; Xiaofang Ying; Yi Zhou; Hui Wang; Changchuan Pan; Wenlin Huang
View articletitled, Overexpression of Sirt7 Exhibits Oncogenic Property and Serves as a Prognostic Factor in Colorectal Cancer
Supplementary data
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Cancer Therapy: Preclinical

Effects of MAPK and PI3K Pathways on PD-L1 Expression in Melanoma
Mohammad Atefi; Earl Avramis; Amanda Lassen; Deborah J.L. Wong; Lidia Robert; David Foulad; Michael Cerniglia; Bjoern Titz; Thinle Chodon; Thomas G. Graeber; Begonya Comin-Anduix; Antoni Ribas
View articletitled, Effects of MAPK and PI3K Pathways on PD-L1 Expression in Melanoma
Supplementary data
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Disruption of Follicular Dendritic Cells–Follicular Lymphoma Cross-talk by the Pan-PI3K Inhibitor BKM120 (Buparlisib)
Alba Matas-Céspedes; Vanina Rodriguez; Susana G. Kalko; Anna Vidal-Crespo; Laia Rosich; Teresa Casserras; Patricia Balsas; Neus Villamor; Eva Giné; Elías Campo; Gaël Roué; Armando López-Guillermo; Dolors Colomer; Patricia Pérez-Galán
View articletitled, Disruption of Follicular Dendritic Cells–Follicular Lymphoma Cross-talk by the Pan-PI3K Inhibitor BKM120 (Buparlisib)
Supplementary data
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Regorafenib Inhibits Colorectal Tumor Growth through PUMA-Mediated Apoptosis
Dongshi Chen; Liang Wei; Jian Yu; Lin Zhang
View articletitled, Regorafenib Inhibits Colorectal Tumor Growth through PUMA-Mediated Apoptosis
Supplementary data
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Synergistic Anticancer Effects of Pam3CSK4 and Ara-C on B-Cell Lymphoma Cells
Sae-Kyung Lee; Jyh Y. Chwee; Cheryl A.P. Ma; Nina Le Bert; Caleb W. Huang; Stephan Gasser
View articletitled, Synergistic Anticancer Effects of Pam<sub>3</sub>CSK<sub>4</sub> and Ara-C on B-Cell Lymphoma Cells
Supplementary data
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Author Choice
Importance of EGFR/ERCC1 Interaction Following Radiation-Induced DNA Damage
Gianmaria Liccardi; John A. Hartley; Daniel Hochhauser
View articletitled, Importance of EGFR/ERCC1 Interaction Following Radiation-Induced DNA Damage
Supplementary data
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Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT
Neil A. O'Brien; Karen McDonald; Luo Tong; Erika von Euw; Ondrej Kalous; Dylan Conklin; Sara A. Hurvitz; Emmanuelle di Tomaso; Christian Schnell; Ronald Linnartz; Richard S. Finn; Samit Hirawat; Dennis J. Slamon
View articletitled, Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT
Supplementary data
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Old Drug New Use—Amoxapine and Its Metabolites as Potent Bacterial β-Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity
Ren Kong; Timothy Liu; Xiaoping Zhu; Syed Ahmad; Alfred L. Williams; Alexandria T. Phan; Hong Zhao; John E. Scott; Li-An Yeh; Stephen T.C. Wong
View articletitled, Old Drug New Use—Amoxapine and Its Metabolites as Potent Bacterial β-Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity
Supplementary data
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Imaging, Diagnosis, Prognosis

In Vivo Fluorescence Lifetime Imaging for Monitoring the Efficacy of the Cancer Treatment
Yasaman Ardeshirpour; Victor Chernomordik; Moinuddin Hassan; Rafal Zielinski; Jacek Capala; Amir Gandjbakhche
View articletitled, <em>In Vivo</em> Fluorescence Lifetime Imaging for Monitoring the Efficacy of the Cancer Treatment
Supplementary data
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Improved Differentiation of Benign and Malignant Breast Tumors with Multiparametric 18Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Feasibility Study
Katja Pinker; Wolfgang Bogner; Pascal Baltzer; Georgios Karanikas; Heinrich Magometschnigg; Peter Brader; Stephan Gruber; Hubert Bickel; Peter Dubsky; Zsuzsanna Bago-Horvath; Rupert Bartsch; Michael Weber; Siegfried Trattnig; Thomas H. Helbich
View articletitled, Improved Differentiation of Benign and Malignant Breast Tumors with Multiparametric <sup>18</sup>Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Feasibility Study
Supplementary data
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Treatment Response Evaluation Using 18F-FDOPA PET in Patients with Recurrent Malignant Glioma on Bevacizumab Therapy
Johannes Schwarzenberg; Johannes Czernin; Timothy F. Cloughesy; Benjamin M. Ellingson; Whitney B. Pope; Tristan Grogan; David Elashoff; Cheri Geist; Daniel H.S. Silverman; Michael E. Phelps; Wei Chen
View articletitled, Treatment Response Evaluation Using <sup>18</sup>F-FDOPA PET in Patients with Recurrent Malignant Glioma on Bevacizumab Therapy
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Variability in Assessing Treatment Response: Metastatic Colorectal Cancer as a Paradigm
Binsheng Zhao; Shing M. Lee; Hyun-Ju Lee; Yongqiang Tan; Jing Qi; Thorsten Persigehl; David P. Mozley; Lawrence H. Schwartz
View articletitled, Variability in Assessing Treatment Response: Metastatic Colorectal Cancer as a Paradigm
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Author Choice
TP53 Mutation Spectrum in Breast Cancer Is Subtype Specific and Has Distinct Prognostic Relevance
Laxmi Silwal-Pandit; Hans Kristian Moen Vollan; Suet-Feung Chin; Oscar M. Rueda; Steven McKinney; Tomo Osako; David A. Quigley; Vessela N. Kristensen; Samuel Aparicio; Anne-Lise Børresen-Dale; Carlos Caldas; Anita Langerød
View articletitled, <em>TP53</em> Mutation Spectrum in Breast Cancer Is Subtype Specific and Has Distinct Prognostic Relevance
Supplementary data
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Cancer Therapy: Clinical

Author Choice
A Phase I Trial of LY2510924, a CXCR4 Peptide Antagonist, in Patients with Advanced Cancer
Matthew D. Galsky; Nicholas J. Vogelzang; Paul Conkling; Eyas Raddad; John Polzer; Stephanie Roberson; John R. Stille; Mansoor Saleh; Donald Thornton
View articletitled, A Phase I Trial of LY2510924, a CXCR4 Peptide Antagonist, in Patients with Advanced Cancer
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Identification of Campath-1 (CD52) as Novel Drug Target in Neoplastic Stem Cells in 5q-Patients with MDS and AML
Katharina Blatt; Harald Herrmann; Gregor Hoermann; Michael Willmann; Sabine Cerny-Reiterer; Irina Sadovnik; Susanne Herndlhofer; Berthold Streubel; Werner Rabitsch; Wolfgang R. Sperr; Matthias Mayerhofer; Thomas Rülicke; Peter Valent
View articletitled, Identification of Campath-1 (CD52) as Novel Drug Target in Neoplastic Stem Cells in 5q-Patients with MDS and AML
Supplementary data
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Phase II Study of Cediranib in Patients with Advanced Gastrointestinal Stromal Tumors or Soft-Tissue Sarcoma
Ian Judson; Michelle Scurr; Kate Gardner; Elizabeth Barquin; Marcelo Marotti; Barbara Collins; Helen Young; Juliane M. Jürgensmeier; Michael Leahy
View articletitled, Phase II Study of Cediranib in Patients with Advanced Gastrointestinal Stromal Tumors or Soft-Tissue Sarcoma
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Predictive Biomarkers and Personalized Medicine

Prognostic and Therapeutic Implications of Aromatase Expression in Lung Adenocarcinomas with EGFR Mutations
Mikihiro Kohno; Tatsuro Okamoto; Kenichi Suda; Mototsugu Shimokawa; Hirokazu Kitahara; Shinichiro Shimamatsu; Hideyuki Konishi; Tsukihisa Yoshida; Mitsuhiro Takenoyama; Tokujiro Yano; Yoshihiko Maehara
View articletitled, Prognostic and Therapeutic Implications of Aromatase Expression in Lung Adenocarcinomas with <em>EGFR</em> Mutations
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Letters to the Editor

SNPs in PI3K-PTEN-mTOR and Brain Metastases in NSCLC—Letter
Abolfazl Avan; Mina Maftouh; Amir Avan; Carmelo Tibaldi; Paolo A. Zucali; Elisa Giovannetti
View articletitled, SNPs in PI3K-PTEN-mTOR and Brain Metastases in NSCLC—Letter
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SNPs in PI3K-PTEN-mTOR and Brain Metastases in NSCLC—Response
Qianxia Li; Huihua Xiong; Xianglin Yuan
View articletitled, SNPs in PI3K-PTEN-mTOR and Brain Metastases in NSCLC—Response
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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