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Issues

Volume 20, Issue 10
15 May 2014
Issue Cover
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  • Cover Image

    Cover Image

    issue cover
    The cover shows a brain section from a mouse injected with a brain seeking variant of the human breast cancer cell line MDA-MB-231. Immunohistochemical staining indicates a lack of MGMT expression in the tumor cells. Tissue was stained with anti-MGMT antibody and counterstained with hematoxylin and eosin. For details, see the article by Palmieri and colleagues on page 2727 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

Minimal Residual Disease in Breast Cancer: In Blood Veritas
Giulia Siravegna; Alberto Bardelli
View articletitled, Minimal Residual Disease in Breast Cancer: In Blood Veritas
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Molecular Pathways

Molecular Pathways: Preclinical Models and Clinical Trials with Metformin in Breast Cancer
Alastair M. Thompson
View articletitled, Molecular Pathways: Preclinical Models and Clinical Trials with Metformin in Breast Cancer
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Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF–MEK–ERK Pathway in Cancer
Gary L. Johnson; Timothy J. Stuhlmiller; Steven P. Angus; Jon S. Zawistowski; Lee M. Graves
View articletitled, Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF–MEK–ERK Pathway in Cancer
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CCR Focus

The Language of Pharmacodynamics
Susan E. Bates
View articletitled, The Language of Pharmacodynamics
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Pharmacologic Biomarkers in the Development of Stratified Cancer Medicine
William Douglas Figg; David R. Newell
View articletitled, Pharmacologic Biomarkers in the Development of Stratified Cancer Medicine
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Using Pharmacogene Polymorphism Panels to Detect Germline Pharmacodynamic Markers in Oncology
Daniel L. Hertz; Howard L. McLeod
View articletitled, Using Pharmacogene Polymorphism Panels to Detect Germline Pharmacodynamic Markers in Oncology
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Genome-Wide Association Study: A Useful Tool to Identify Common Genetic Variants Associated with Drug Toxicity and Efficacy in Cancer Pharmacogenomics
Siew-Kee Low; Atsushi Takahashi; Taisei Mushiroda; Michiaki Kubo
View articletitled, Genome-Wide Association Study: A Useful Tool to Identify Common Genetic Variants Associated with Drug Toxicity and Efficacy in Cancer Pharmacogenomics
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Circulating Tumor Cells: A Multifunctional Biomarker
Timothy A. Yap; David Lorente; Aurelius Omlin; David Olmos; Johann S. de Bono
View articletitled, Circulating Tumor Cells: A Multifunctional Biomarker
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In Vivo Imaging as a Pharmacodynamic Marker
Astrid A.M. van der Veldt; Adriaan A. Lammertsma
View articletitled, <em>In Vivo</em> Imaging as a Pharmacodynamic Marker
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Implementation of Validated Pharmacodynamic Assays in Multiple Laboratories: Challenges, Successes, and Limitations
Robert Kinders; Kate Ferry-Galow; Lihua Wang; Apurva K. Srivastava; Jiuping (Jay) Ji; Ralph E. Parchment
View articletitled, Implementation of Validated Pharmacodynamic Assays in Multiple Laboratories: Challenges, Successes, and Limitations
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Pharmacodynamic Biomarkers: Falling Short of the Mark?
Justin F. Gainor; Dan L. Longo; Bruce A. Chabner
View articletitled, Pharmacodynamic Biomarkers: Falling Short of the Mark?
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Human Cancer Biology

FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression
Jiujie Cui; Min Shi; Dacheng Xie; Daoyan Wei; Zhiliang Jia; Shaojiang Zheng; Yong Gao; Suyun Huang; Keping Xie
View articletitled, FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression
Supplementary data
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Human Melanoma Metastases Demonstrate Nonstochastic Site-Specific Antigen Heterogeneity That Correlates with T-cell Infiltration
Edmund K. Bartlett; Patricia A. Fetsch; Armando C. Filie; Andrea Abati; Seth M. Steinberg; John R. Wunderlich; Donald E. White; Daniel J. Stephens; Francesco M. Marincola; Steven A. Rosenberg; Udai S. Kammula
View articletitled, Human Melanoma Metastases Demonstrate Nonstochastic Site-Specific Antigen Heterogeneity That Correlates with T-cell Infiltration
Supplementary data
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miR-141 Is a Key Regulator of Renal Cell Carcinoma Proliferation and Metastasis by Controlling EphA2 Expression
Xuanyu Chen; Xuegang Wang; Anming Ruan; Weiwei Han; Yan Zhao; Xing Lu; Pei Xiao; Hangchuan Shi; Rong Wang; Li Chen; Shaoyong Chen; Quansheng Du; Hongmei Yang; Xiaoping Zhang
View articletitled, miR-141 Is a Key Regulator of Renal Cell Carcinoma Proliferation and Metastasis by Controlling EphA2 Expression
Supplementary data
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Author Choice
Regulation of Colorectal Carcinoma Stemness, Growth, and Metastasis by an miR-200c-Sox2–Negative Feedback Loop Mechanism
Yan-Xia Lu; Li Yuan; Xiao-Lei Xue; Min Zhou; Yan Liu; Chao Zhang; Jing-Ping Li; Lin Zheng; Min Hong; Xue-Nong Li
View articletitled, Regulation of Colorectal Carcinoma Stemness, Growth, and Metastasis by an <em>miR-200c</em>-Sox2–Negative Feedback Loop Mechanism
Supplementary data
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Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer
Julia A. Beaver; Danijela Jelovac; Sasidharan Balukrishna; Rory L. Cochran; Sarah Croessmann; Daniel J. Zabransky; Hong Yuen Wong; Patricia Valda Toro; Justin Cidado; Brian G. Blair; David Chu; Timothy Burns; Michaela J. Higgins; Vered Stearns; Lisa Jacobs; Mehran Habibi; Julie Lange; Paula J. Hurley; Josh Lauring; Dustin A. VanDenBerg; Jill Kessler; Stacie Jeter; Michael L. Samuels; Dianna Maar; Leslie Cope; Ashley Cimino-Mathews; Pedram Argani; Antonio C. Wolff; Ben Ho Park
View articletitled, Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer
Supplementary data
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Cancer Therapy: Preclinical

Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance—Implications for IGF-II and IGF-IR–Targeted Therapy
Bin Li; Sai Wah Tsao; Kwok Wah Chan; Dale L. Ludwig; Ruslan Novosyadlyy; Yuk Yin Li; Qing Yu He; Annie L.M. Cheung
View articletitled, Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance—Implications for IGF-II and IGF-IR–Targeted Therapy
Supplementary data
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COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis
Anne-Sophie Gallouet; Marion Travert; Laurence Bresson-Bepoldin; Fabien Guilloton; Céline Pangault; Sylvie Caulet-Maugendre; Thierry Lamy; Karin Tarte; Thierry Guillaudeux
View articletitled, COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis
Supplementary data
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Author Choice
Selective JAK2 Inhibition Specifically Decreases Hodgkin Lymphoma and Mediastinal Large B-cell Lymphoma Growth In Vitro and In Vivo
Yansheng Hao; Bjoern Chapuy; Stefano Monti; Heather H. Sun; Scott J. Rodig; Margaret A. Shipp
View articletitled, Selective JAK2 Inhibition Specifically Decreases Hodgkin Lymphoma and Mediastinal Large B-cell Lymphoma Growth <em>In Vitro</em> and <em>In Vivo</em>
Supplementary data
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Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells
Smita K. Nair; Gabriel De Leon; David Boczkowski; Robert Schmittling; Weihua Xie; Janet Staats; Rebecca Liu; Laura A. Johnson; Kent Weinhold; Gary E. Archer; John H. Sampson; Duane A. Mitchell
View articletitled, Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells
Supplementary data
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Anti-VEGF Antibodies Mitigate the Development of Radiation Necrosis in Mouse Brain
Xiaoyu Jiang; John A. Engelbach; Liya Yuan; Jeremy Cates; Feng Gao; Robert E. Drzymala; Dennis E. Hallahan; Keith M. Rich; Robert E. Schmidt; Joseph J.H. Ackerman; Joel R. Garbow
View articletitled, Anti-VEGF Antibodies Mitigate the Development of Radiation Necrosis in Mouse Brain
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ABCB1, ABCG2, and PTEN Determine the Response of Glioblastoma to Temozolomide and ABT-888 Therapy
Fan Lin; Mark C. de Gooijer; Eloy Moreno Roig; Levi C.M. Buil; Susan M. Christner; Jan H. Beumer; Thomas Würdinger; Jos H. Beijnen; Olaf van Tellingen
View articletitled, ABCB1, ABCG2, and PTEN Determine the Response of Glioblastoma to Temozolomide and ABT-888 Therapy
Supplementary data
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Metformin Sensitizes EGFR-TKI–Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal
Li Li; Rui Han; Hualiang Xiao; Caiyu Lin; Yubo Wang; Hao Liu; Kunlin Li; Hengyi Chen; Fenfen Sun; Zhenzhou Yang; Jianxin Jiang; Yong He
View articletitled, Metformin Sensitizes EGFR-TKI–Resistant Human Lung Cancer Cells <em>In Vitro</em> and <em>In Vivo</em> through Inhibition of IL-6 Signaling and EMT Reversal
Supplementary data
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Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner
Diane Palmieri; Renata Duchnowska; Stephan Woditschka; Emily Hua; Yongzhen Qian; Wojciech Biernat; Katarzyna Sosińska-Mielcarek; Brunilde Gril; Andreas M. Stark; Stephen M. Hewitt; David J. Liewehr; Seth M. Steinberg; Jacek Jassem; Patricia S. Steeg
View articletitled, Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner
Supplementary data
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Biologic Effects of Platelet-Derived Growth Factor Receptor α Blockade in Uterine Cancer
Ju-Won Roh; Jie Huang; Wei Hu; XiaoYun Yang; Nicholas B. Jennings; Vasudha Sehgal; Bo Hwa Sohn; Hee Dong Han; Sun Joo Lee; Duangmani Thanapprapasr; Justin Bottsford-Miller; Behrouz Zand; Heather J. Dalton; Rebecca A. Previs; Ashley N. Davis; Koji Matsuo; Ju-Seog Lee; Prahlad Ram; Robert L. Coleman; Anil K. Sood
View articletitled, Biologic Effects of Platelet-Derived Growth Factor Receptor α Blockade in Uterine Cancer
Supplementary data
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Imaging, Diagnosis, Prognosis

Repeatability of Quantitative FDG-PET/CT and Contrast-Enhanced CT in Recurrent Ovarian Carcinoma: Test–Retest Measurements for Tumor FDG Uptake, Diameter, and Volume
Andrea G. Rockall; Norbert Avril; Raymond Lam; Robert Iannone; P. David Mozley; Christine Parkinson; Donald Bergstrom; Evis Sala; Shah-Jalal Sarker; Iain A. McNeish; James D. Brenton
View articletitled, Repeatability of Quantitative FDG-PET/CT and Contrast-Enhanced CT in Recurrent Ovarian Carcinoma: Test–Retest Measurements for Tumor FDG Uptake, Diameter, and Volume
Supplementary data
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A Signature Predicting Poor Prognosis in Gastric and Ovarian Cancer Represents a Coordinated Macrophage and Stromal Response
Rita A. Busuttil; Joshy George; Richard W. Tothill; Kylie Ioculano; Adam Kowalczyk; Catherine Mitchell; Stephen Lade; Patrick Tan; Izhak Haviv; Alex Boussioutas
View articletitled, A Signature Predicting Poor Prognosis in Gastric and Ovarian Cancer Represents a Coordinated Macrophage and Stromal Response
Supplementary data
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In Situ Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas
Kurt A. Schalper; Vamsidhar Velcheti; Daniel Carvajal; Hallie Wimberly; Jason Brown; Lajos Pusztai; David L. Rimm
View articletitled, <em>In Situ</em> Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas
Supplementary data
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Cancer Therapy: Clinical

Population Pharmacokinetics of Bevacizumab in Children with Osteosarcoma: Implications for Dosing
David C. Turner; Fariba Navid; Najat C. Daw; Shenghua Mao; Jianrong Wu; Victor M. Santana; Michael Neel; Bhaskar Rao; Jennifer Reikes Willert; David M. Loeb; K. Elaine Harstead; Stacy L. Throm; Burgess B. Freeman, III; Clinton F. Stewart
View articletitled, Population Pharmacokinetics of Bevacizumab in Children with Osteosarcoma: Implications for Dosing
Supplementary data
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A Pharmacodynamic/Pharmacokinetic Study of Ficlatuzumab in Patients with Advanced Solid Tumors and Liver Metastases
Josep Tabernero; Maria Elena Elez; Maria Herranz; Isabel Rico; Ludmila Prudkin; Jordi Andreu; Jose Mateos; Maria Josep Carreras; May Han; James Gifford; Marc Credi; Wei Yin; Shefali Agarwal; Philip Komarnitsky; Jose Baselga
View articletitled, A Pharmacodynamic/Pharmacokinetic Study of Ficlatuzumab in Patients with Advanced Solid Tumors and Liver Metastases
Supplementary data
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Predictive Biomarkers and Personalized Medicine

Author Choice
Quantitative Measurements of Tumoral p95HER2 Protein Expression in Metastatic Breast Cancer Patients Treated with Trastuzumab: Independent Validation of the p95HER2 Clinical Cutoff
Renata Duchnowska; Jeff Sperinde; Ahmed Chenna; Mojgan Haddad; Agnes Paquet; Yolanda Lie; Jodi M. Weidler; Weidong Huang; John Winslow; Tomasz Jankowski; Bogumiła Czartoryska-Arłukowicz; Piotr J. Wysocki; Małgorzata Foszczyńska-Kłoda; Barbara Radecka; Maria M. Litwiniuk; Jolanta Żok; Michał Wiśniewski; Dorota Zuziak; Wojciech Biernat; Jacek Jassem
View articletitled, Quantitative Measurements of Tumoral p95HER2 Protein Expression in Metastatic Breast Cancer Patients Treated with Trastuzumab: Independent Validation of the p95HER2 Clinical Cutoff
Supplementary data
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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