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15 December 2013
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Cover Image
Cover Image
The cover shows drug distribution in a solid tumor derived from breast cancer cells in a mouse xenograft. Immunohistochemical staining shows enhanced doxorubucin distribution around functional blood vessels in mice pretreated with pantoprazole. For details, see the article by Patel and colleagues on page 6766 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Drug Approval
Abiraterone Acetate in Combination with Prednisone for the Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer: U.S. Food and Drug Administration Drug Approval Summary
Paul G. Kluetz; Yang-Min Ning; V. Ellen Maher; Lijun Zhang; Shenghui Tang; Debasis Ghosh; Robeena Aziz; Todd Palmby; Elimika Pfuma; Jeanne Fourie Zirkelbach; Nitin Mehrotra; Amy Tilley; Rajeshwari Sridhara; Amna Ibrahim; Robert Justice; Richard Pazdur
CCR Drug Updates
Molecular Pathways
Perspectives
Review
Human Cancer Biology
Poor Concordance among Nine Immunohistochemistry Classifiers of Cell-of-Origin for Diffuse Large B-Cell Lymphoma: Implications for Therapeutic Strategies
Rita Coutinho; Andrew James Clear; Andrew Owen; Andrew Wilson; Janet Matthews; Abigail Lee; Rute Alvarez; Maria Gomes da Silva; José Cabeçadas; Maria Calaminici; John G. Gribben
Author Choice
BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition
Katherine E. Hutchinson; Doron Lipson; Philip J. Stephens; Geoff Otto; Brian D. Lehmann; Pamela L. Lyle; Cindy L. Vnencak-Jones; Jeffrey S. Ross; Jennifer A. Pietenpol; Jeffrey A. Sosman; Igor Puzanov; Vincent A. Miller; William Pao
Cancer Therapy: Preclinical
Development, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma
Hemant K. Bid; Aaron Kibler; Doris A. Phelps; Sagymbek Manap; Linlin Xiao; Jiayuh Lin; David Capper; Duane Oswald; Brian Geier; Mariko DeWire; Paul D. Smith; Raushan T. Kurmasheva; Xiaokui Mo; Soledad Fernandez; Peter J. Houghton
Author Choice
Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy
Yvonne Kienast; Christian Klein; Werner Scheuer; Romi Raemsch; Erica Lorenzon; Dirk Bernicke; Frank Herting; Sidney Yu; Huynh Hung The; Laurent Martarello; Christian Gassner; Kay-Gunnar Stubenrauch; Kate Munro; Hellmut G. Augustin; Markus Thomas
Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Vanessa E. Zannella; Alan Dal Pra; Hala Muaddi; Trevor D. McKee; Shawn Stapleton; Jenna Sykes; Rachel Glicksman; Selim Chaib; Paul Zamiara; Michael Milosevic; Bradly G. Wouters; Robert G. Bristow; Marianne Koritzinsky
Increased TGF-α as a Mechanism of Acquired Resistance to the Anti-EGFR Inhibitor Cetuximab through EGFR–MET Interaction and Activation of MET Signaling in Colon Cancer Cells
Teresa Troiani; Erika Martinelli; Stefania Napolitano; Donata Vitagliano; Loreta Pia Ciuffreda; Sara Costantino; Floriana Morgillo; Anna Capasso; Vincenzo Sforza; Anna Nappi; Raffaele De Palma; Elena D'Aiuto; Liberato Berrino; Roberto Bianco; Fortunato Ciardiello
A Personalized Preclinical Model to Evaluate the Metastatic Potential of Patient-Derived Colon Cancer Initiating Cells
Isabel Puig; Irene Chicote; Stephan P. Tenbaum; Oriol Arqués; José Raúl Herance; Juan D. Gispert; José Jimenez; Stefania Landolfi; Karina Caci; Helena Allende; Leire Mendizabal; Debora Moreno; Ramón Charco; Eloy Espín; Aleix Prat; Maria Elena Elez; Guillem Argilés; Ana Vivancos; Josep Tabernero; Santiago Rojas; Héctor G. Palmer
Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Ren Liu; Xiuqing Li; Wenming Gao; Yue Zhou; Shiuan Wey; Satyajit K. Mitra; Valery Krasnoperov; Dezheng Dong; Shuanglong Liu; Dan Li; Genyuan Zhu; Stan Louie; Peter S. Conti; Zibo Li; Amy S. Lee; Parkash S. Gill
Imaging, Diagnosis, Prognosis
Loss of PTEN Expression Is Associated with Poor Prognosis in Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas
Dario Garcia-Carracedo; Andrew T. Turk; Stuart A. Fine; Nathan Akhavan; Benjamin C. Tweel; Ramon Parsons; John A. Chabot; John D. Allendorf; Jeanine M. Genkinger; Helen E. Remotti; Gloria H. Su
Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Ernest Nadal; Guoan Chen; Marc Gallegos; Lin Lin; Daysha Ferrer-Torres; Anna Truini; Zhuwen Wang; Jules Lin; Rishindra M. Reddy; Roger Llatjos; Ignacio Escobar; Juan Moya; Andrew C. Chang; Felipe Cardenal; Gabriel Capellà; David G. Beer
Cancer Therapy: Clinical
Phase I Study of Panobinostat plus Everolimus in Patients with Relapsed or Refractory Lymphoma
Yasuhiro Oki; Daniela Buglio; Michelle Fanale; Luis Fayad; Amanda Copeland; Jorge Romaguera; Larry W. Kwak; Barbara Pro; Silvana de Castro Faria; Sattva Neelapu; Nathan Fowler; Fredrick Hagemeister; Jiexin Zhang; Shouhao Zhou; Lei Feng; Anas Younes
Long-term Survival and Biomarker Correlates of Tasquinimod Efficacy in a Multicenter Randomized Study of Men with Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer
A.J. Armstrong; M. Häggman; W.M. Stadler; J.R. Gingrich; V. Assikis; J. Polikoff; J.E. Damber; L. Belkoff; Ö. Nordle; G. Forsberg; M.A. Carducci; R. Pili
Phase I Trial of Preoperative Chemoradiation plus Sorafenib for High-Risk Extremity Soft Tissue Sarcomas with Dynamic Contrast-Enhanced MRI Correlates
Janelle M. Meyer; Kelly S. Perlewitz; James B. Hayden; Yee-Cheen Doung; Arthur Y. Hung; John T. Vetto; Rodney F. Pommier; Atiya Mansoor; Brooke R. Beckett; Alina Tudorica; Motomi Mori; Megan L. Holtorf; Aneela Afzal; William J. Woodward; Eve T. Rodler; Robin L. Jones; Wei Huang; Christopher W. Ryan
Predictive Biomarkers and Personalized Medicine
Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors
David S. Shames; Kristi Elkins; Kimberly Walter; Thomas Holcomb; Pan Du; Dane Mohl; Yang Xiao; Thinh Pham; Peter M. Haverty; Bianca Liederer; Xiaorong Liang; Robert L. Yauch; Thomas O'Brien; Richard Bourgon; Hartmut Koeppen; Lisa D. Belmont
The Effect of VEGF-Targeted Therapy on Biomarker Expression in Sequential Tissue from Patients with Metastatic Clear Cell Renal Cancer
Kevin Sharpe; Grant D. Stewart; Alan Mackay; Christophe Van Neste; Charlotte Rofe; Dan Berney; Irfan Kayani; Axel Bex; Elaine Wan; Fiach C. O'Mahony; Marie O'Donnell; Simon Chowdhury; Rukma Doshi; Colan Ho-Yen; Marco Gerlinger; Dawn Baker; Neil Smith; Barry Davies; Anju Sahdev; Ekaterini Boleti; Tim De Meyer; Wim Van Criekinge; Luis Beltran; Yong-Jie Lu; David J. Harrison; Andrew R. Reynolds; Tom Powles
Prognostic and Predictive Blood-Based Biomarkers in Patients with Advanced Pancreatic Cancer: Results from CALGB80303 (Alliance)
Andrew B. Nixon; Herbert Pang; Mark D. Starr; Paula N. Friedman; Monica M. Bertagnolli; Hedy L. Kindler; Richard M. Goldberg; Alan P. Venook; Herbert I. Hurwitz; for the Alliance for Clinical Trials In Oncology
Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial
George R. Blumenschein, Jr; Pierre Saintigny; Suyu Liu; Edward S. Kim; Anne S. Tsao; Roy S. Herbst; Christine Alden; J. Jack Lee; Ximing Tang; David J. Stewart; Merrill S. Kies; Frank V. Fossella; Hai T. Tran; L. Mao; Marshall E. Hicks; Jeremy Erasmus, Jr; Sanjay Gupta; Luc Girard; Michael Peyton; Lixia Diao; Jing Wang; Suzanne E. Davis; John D. Minna; Ignacio Wistuba; Waun K. Hong; John V. Heymach; Scott M. Lippman
Author Choice
Evaluation and Clinical Analyses of Downstream Targets of the Akt Inhibitor GDC-0068
Yibing Yan; Violeta Serra; Ludmila Prudkin; Maurizio Scaltriti; Sumati Murli; Olga Rodríguez; Marta Guzman; Deepak Sampath; Michelle Nannini; Yuanyuan Xiao; Marie-Claire Wagle; Jenny Q. Wu; Matthew Wongchenko; Garret Hampton; Vanitha Ramakrishnan; Mark R. Lackner; Cristina Saura; Desamparados Roda; Andrés Cervantes; Josep Tabernero; Premal Patel; José Baselga
Reviewers
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