Issues

Confocal immunofluorescent image showing the effects of the polycomb repressor complex 2 inhibitor 3-deazaneplanocin A on tumor cellularity and apoptosis in a xenotransplant model of human head and neck cancer. Immunodeficient mice were injected with a head and neck cancer cell line which was allowed to establish prior to daily treatment with 5 mg/kg DZNep. Tumor tissue has been stained with DAPI to highlight cell nuclei. Green immunofluorescence highlights the human epithelial tumor cells (AEI/III positive) and red fluorescence highlights caspase III positive dying cells. For details, see the article by Gannon and colleagues on page 428 of this issue.