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15 September 2013
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Cover Image
Cover Image
This image shows a section of a colon from a patient with colon cancer. Immunohistochemical staining shows membranous KIT expression in some of the tumor cells. For details, see the article by Park and colleagues on page 4961 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Drug Approval
First FDA Approval of Dual Anti-HER2 Regimen: Pertuzumab in Combination with Trastuzumab and Docetaxel for HER2-Positive Metastatic Breast Cancer
Gideon M. Blumenthal; Nancy S. Scher; Patricia Cortazar; Somesh Chattopadhyay; Shenghui Tang; Pengfei Song; Qi Liu; Kimberly Ringgold; Anne M. Pilaro; Amy Tilley; Kathryn E. King; Laurie Graham; Barbara L. Rellahan; Wendy C. Weinberg; Bo Chi; Colleen Thomas; Patricia Hughes; Amna Ibrahim; Robert Justice; Richard Pazdur
Molecular Pathways
Review
Human Cancer Biology
Tumor-Infiltrating Lymphocytes in Glioblastoma Are Associated with Specific Genomic Alterations and Related to Transcriptional Class
W. Caleb Rutledge; Jun Kong; Jingjing Gao; David A. Gutman; Lee A.D. Cooper; Christina Appin; Yuna Park; Lisa Scarpace; Tom Mikkelsen; Mark L. Cohen; Kenneth D. Aldape; Roger E. McLendon; Norman L. Lehman; C. Ryan Miller; Matthew J. Schniederjan; Cameron W. Brennan; Joel H. Saltz; Carlos S. Moreno; Daniel J. Brat
Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Xuezheng Sun; Gretchen L. Gierach; Rupninder Sandhu; Tyisha Williams; Bentley R. Midkiff; Jolanta Lissowska; Ewa Wesolowska; Norman F. Boyd; Nicole B. Johnson; Jonine D. Figueroa; Mark E. Sherman; Melissa A. Troester
Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer
Geng Zhang; Peijun He; Hanson Tan; Anuradha Budhu; Jochen Gaedcke; B. Michael Ghadimi; Thomas Ried; Harris G. Yfantis; Dong H. Lee; Anirban Maitra; Nader Hanna; H. Richard Alexander; S. Perwez Hussain
Cancer Therapy: Preclinical
Ligand-Dependent Activation of EGFR in Follicular Dendritic Cells Sarcoma is Sustained by Local Production of Cognate Ligands
William Vermi; Emanuele Giurisato; Silvia Lonardi; Piera Balzarini; Elisa Rossi; Daniela Medicina; Daniela Bosisio; Silvano Sozzani; Wilma Pellegrini; Claudio Doglioni; Antonio Marchetti; Giulio Rossi; Stefano Pileri; Fabio Facchetti
Onartuzumab (MetMAb): Using Nonclinical Pharmacokinetic and Concentration–Effect Data to Support Clinical Development
Hong Xiang; Brendan C. Bender; Arthur E. Reyes, II; Mark Merchant; Nelson L. ‘Shasha’ Jumbe; Mally Romero; Teresa Davancaze; Ihsan Nijem; Elaine Mai; Judy Young; Amy Peterson; Lisa A. Damico-Beyer
Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells
Lee-Hwa Tai; Jiqing Zhang; Karen J. Scott; Christiano Tanese de Souza; Almohanad A. Alkayyal; Anu Abhirami Ananth; Shalini Sahi; Robert A. Adair; Ahmad B. Mahmoud; Subash Sad; John C. Bell; Andrew P. Makrigiannis; Alan A. Melcher; Rebecca C. Auer
Imaging, Diagnosis, Prognosis
Author Choice
Isocitrate Dehydrogenase 1 Is a Novel Plasma Biomarker for the Diagnosis of Non–Small Cell Lung Cancer
Nan Sun; Zhaoli Chen; Fengwei Tan; Baihua Zhang; Ran Yao; Chengcheng Zhou; Jiagen Li; Yibo Gao; Ziyuan Liu; Xiaogang Tan; Fang Zhou; Max Y.F He; Kang Shao; Ning Li; Bin Qiu; Jian Sun; Yue Yu; Suya Wang; Yuda Zhao; Xuejiao Shi; Jie He
Long-Term Survival in Primary Glioblastoma With Versus Without Isocitrate Dehydrogenase Mutations
Christian Hartmann; Bettina Hentschel; Matthias Simon; Manfred Westphal; Gabriele Schackert; Jörg C. Tonn; Markus Loeffler; Guido Reifenberger; Torsten Pietsch; Andreas von Deimling; Michael Weller; for the German Glioma Network
DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome
Pascale Fisel; Stephan Kruck; Stefan Winter; Jens Bedke; Jörg Hennenlotter; Anne T. Nies; Marcus Scharpf; Falko Fend; Arnulf Stenzl; Matthias Schwab; Elke Schaeffeler
Cancer Therapy: Clinical
Phase II Study of Lutetium-177–Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer
Scott T. Tagawa; Matthew I. Milowsky; Michael Morris; Shankar Vallabhajosula; Paul Christos; Naveed H. Akhtar; Joseph Osborne; Stanley J. Goldsmith; Steve Larson; Neeta Pandit Taskar; Howard I. Scher; Neil H. Bander; David M. Nanus
Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics
S. Stacchiotti; M. Tortoreto; F. Bozzi; E. Tamborini; C. Morosi; A. Messina; M. Libertini; E. Palassini; D. Cominetti; T. Negri; A. Gronchi; S. Pilotti; N. Zaffaroni; P.G. Casali
Predictive Biomarkers and Personalized Medicine
TMPRSS2-ERG Status Is Not Prognostic Following Prostate Cancer Radiotherapy: Implications for Fusion Status and DSB Repair
Alan Dal Pra; Emilie Lalonde; Jenna Sykes; Fiona Warde; Adrian Ishkanian; Alice Meng; Chad Maloff; John Srigley; Anthony M. Joshua; Gyorgy Petrovics; Theodorus van der Kwast; Andrew Evans; Michael Milosevic; Fred Saad; Colin Collins; Jeremy Squire; Wan Lam; Tarek A. Bismar; Paul C. Boutros; Robert G. Bristow
A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform
Anne-Joy M. de Graan; Laure Elens; Marcel Smid; John W. Martens; Alex Sparreboom; Annemieke J.M. Nieuweboer; Lena E. Friberg; Samira Elbouazzaoui; Erik A.C. Wiemer; Bronno van der Holt; Jaap Verweij; Ron H.N. van Schaik; Ron H.J. Mathijssen
The Role of Aberrant VHL/HIF Pathway Elements in Predicting Clinical Outcome to Pazopanib Therapy in Patients with Metastatic Clear-Cell Renal Cell Carcinoma
Toni K. Choueiri; André P. Fay; Robert Gagnon; Ying Lin; Brittany Bahamon; Victoria Brown; Jonathan E. Rosenberg; Thomas E. Hutson; Katherine L. Baker-Neblett; Christopher Carpenter; Yuan Liu; Lini Pandite; Sabina Signoretti
Author Choice
Predicting Response to Bevacizumab in Ovarian Cancer: A Panel of Potential Biomarkers Informing Treatment Selection
Fiona Collinson; Michelle Hutchinson; Rachel A. Craven; David A. Cairns; Alexandre Zougman; Tobias C. Wind; Narinder Gahir; Michael P. Messenger; Sharon Jackson; Douglas Thompson; Cybil Adusei; Jonathan A. Ledermann; Geoffrey Hall; Gordon C. Jayson; Peter J. Selby; Rosamonde E. Banks
Bim Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia
Vincent Gagné; Julie Rousseau; Malgorzata Labuda; Bahram Sharif-Askari; Ivan Brukner; Caroline Laverdière; Francesco Ceppi; Stephen E. Sallan; Lewis B. Silverman; Donna Neuberg; Jeffery L. Kutok; Daniel Sinnett; Maja Krajinovic
Letters to the Editor
Retraction
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