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1 August 2013
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Cover Image
Cover Image
Primary human glioblastoma cells reveal neuronal (green) and glial (red) differentiation potential. The image was obtained during multipotency and self-renewal analysis investigating antitumor effects of niclosamide. For details, see the article by Wieland and colleagues on page 4124 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
CCR Perspectives in Drug Approval
Molecular Pathways
Reviews
Human Cancer Biology
microRNA 223 Is Upregulated in the Multistep Progression of Barrett's Esophagus and Modulates Sensitivity to Chemotherapy by Targeting PARP1
Mirte Mayke Streppel; Shweta Pai; Nathaniel R. Campbell; Chaoxin Hu; Shinichi Yabuuchi; Marcia Irene Canto; Jean S. Wang; Elizabeth A. Montgomery; Anirban Maitra
Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin
Romain Remark; Marco Alifano; Isabelle Cremer; Audrey Lupo; Marie-Caroline Dieu-Nosjean; Marc Riquet; Lucile Crozet; Hanane Ouakrim; Jeremy Goc; Aurélie Cazes; Jean-François Fléjou; Laure Gibault; Virginie Verkarre; Jean-François Régnard; Olivier-Nicolas Pagès; Stéphane Oudard; Bernhard Mlecnik; Catherine Sautès-Fridman; Wolf-Herman Fridman; Diane Damotte
Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab
Christopher G. Smith; David Fisher; Bart Claes; Timothy S. Maughan; Shelley Idziaszczyk; Gilian Peuteman; Rebecca Harris; Michelle D. James; Angela Meade; Bharat Jasani; Richard A. Adams; Sarah Kenny; Richard Kaplan; Diether Lambrechts; Jeremy P. Cheadle
miRNA Landscape in Stage I Epithelial Ovarian Cancer Defines the Histotype Specificities
Enrica Calura; Robert Fruscio; Lara Paracchini; Eliana Bignotti; Antonella Ravaggi; Paolo Martini; Gabriele Sales; Luca Beltrame; Luca Clivio; Lorenzo Ceppi; Mariacristina Di Marino; Ilaria Fuso Nerini; Laura Zanotti; Duccio Cavalieri; Giorgio Cattoretti; Patrizia Perego; Rodolfo Milani; Dionyssios Katsaros; Germana Tognon; Enrico Sartori; Sergio Pecorelli; Costantino Mangioni; Maurizio D'Incalci; Chiara Romualdi; Sergio Marchini
Cancer Therapy: Preclinical
Author Choice
Anticancer Effects of Niclosamide in Human Glioblastoma
Anja Wieland; Daniel Trageser; Sabine Gogolok; Roman Reinartz; Heike Höfer; Mihaela Keller; Anke Leinhaas; Ramona Schelle; Sabine Normann; Lil Klaas; Andreas Waha; Philipp Koch; Rolf Fimmers; Torsten Pietsch; Anthony T. Yachnis; David W. Pincus; Dennis A. Steindler; Oliver Brüstle; Matthias Simon; Martin Glas; Björn Scheffler
Combined Alloreactive CTL Cellular Therapy with Prodrug Activator Gene Therapy in a Model of Breast Cancer Metastatic to the Brain
Michelle J. Hickey; Colin C. Malone; Kate L. Erickson; Amy Lin; Horacio Soto; Edward T. Ha; Shuichi Kamijima; Akihito Inagaki; Masamichi Takahashi; Yuki Kato; Noriyuki Kasahara; Barbara M. Mueller; Carol A. Kruse
Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer
Anna Spreafico; John J. Tentler; Todd M. Pitts; Aik Choon Tan; Mark A. Gregory; John J. Arcaroli; Peter J. Klauck; Martine C. McManus; Ryan J. Hansen; Jihye Kim; Lindsey N. Micel; Heather M. Selby; Timothy P. Newton; Kelly L. McPhillips; Daniel L. Gustafson; James V. DeGregori; Wells A. Messersmith; Robert A. Winn; S. Gail Eckhardt
Imaging, Diagnosis, Prognosis
Toward Prediction of Efficacy of Chemotherapy: A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography
Astrid A.M. van der Veldt; Mark Lubberink; Ron H.J. Mathijssen; Walter J. Loos; Gerarda J.M. Herder; Henri N. Greuter; Emile F.I. Comans; Hugo B. Rutten; Jonas Eriksson; Albert D. Windhorst; N. Harry Hendrikse; Pieter E. Postmus; Egbert F. Smit; Adriaan A. Lammertsma
A Functional Variant at 19q13.3, rs967591G>A, Is Associated with Shorter Survival of Early-Stage Lung Cancer
Hyo-Sung Jeon; Guang Jin; Hyo-Gyoung Kang; Yi Young Choi; Won Kee Lee; Jin Eun Choi; Eun Young Bae; Seung Soo Yoo; Shin Yup Lee; Eung Bae Lee; Young Tae Kim; Jaehee Lee; Seung-Ick Cha; Chang Ho Kim; Sanghoon Jheon; In San Kim; Jae Yong Park
Breast Cancer Index Identifies Early-Stage Estrogen Receptor–Positive Breast Cancer Patients at Risk for Early- and Late-Distant Recurrence
Yi Zhang; Catherine A. Schnabel; Brock E. Schroeder; Piiha-Lotta Jerevall; Rachel C. Jankowitz; Tommy Fornander; Olle Stål; Adam M. Brufsky; Dennis Sgroi; Mark G. Erlander
Serum Insulin-like Growth Factor-I Level Is an Independent Predictor of Recurrence and Survival in Early Hepatocellular Carcinoma: A Prospective Cohort Study
Eun Ju Cho; Jeong-Hoon Lee; Jeong-Ju Yoo; Won-Mook Choi; Min Jong Lee; Yuri Cho; Dong Hyeon Lee; Yun Bin Lee; Jung Hee Kwon; Su Jong Yu; Jeong Min Lee; Kyung-Suk Suh; Kion Kim; Yoon Jun Kim; Jung-Hwan Yoon; Chung Yong Kim; Hyo-Suk Lee
Cancer Therapy: Clinical
A Randomized Phase II Trial of Multiepitope Vaccination with Melanoma Peptides for Cytotoxic T Cells and Helper T Cells for Patients with Metastatic Melanoma (E1602)
Craig L. Slingluff, Jr; Sandra Lee; Fengmin Zhao; Kimberly A. Chianese-Bullock; Walter C. Olson; Lisa H. Butterfield; Theresa L. Whiteside; Philip D. Leming; John M. Kirkwood
Vandetanib in Children and Adolescents with Multiple Endocrine Neoplasia Type 2B Associated Medullary Thyroid Carcinoma
Elizabeth Fox; Brigitte C. Widemann; Meredith K. Chuk; Leigh Marcus; Alberta Aikin; Patricia O. Whitcomb; Maria J. Merino; Maya Lodish; Eva Dombi; Seth M. Steinberg; Samuel A. Wells; Frank M. Balis
Cyclophosphamide Induces a Type I Interferon–Associated Sterile Inflammatory Response Signature in Cancer Patients' Blood Cells: Implications for Cancer Chemoimmunotherapy
Federica Moschella; Giovanni Fernando Torelli; Mara Valentini; Francesca Urbani; Carla Buccione; Maria Teresa Petrucci; Fiammetta Natalino; Filippo Belardelli; Robin Foà; Enrico Proietti
A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors
Balaji Venugopal; Richard Baird; Rebecca S. Kristeleit; Ruth Plummer; Richard Cowan; Adam Stewart; Nele Fourneau; Peter Hellemans; Yusri Elsayed; Steve Mcclue; Johan W. Smit; Ann Forslund; Charles Phelps; John Camm; T.R. Jeffry Evans; Johann S. de Bono; Udai Banerji
Predictive Biomarkers and Personalized Medicine
ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer
Justin F. Gainor; Anna M. Varghese; Sai-Hong Ignatius Ou; Sheheryar Kabraji; Mark M. Awad; Ryohei Katayama; Amanda Pawlak; Mari Mino-Kenudson; Beow Y. Yeap; Gregory J. Riely; A. John Iafrate; Maria E. Arcila; Marc Ladanyi; Jeffrey A. Engelman; Dora Dias-Santagata; Alice T. Shaw
Putative Predictive Biomarkers of Survival in Patients with Metastatic Pancreatic Adenocarcinoma Treated with Gemcitabine and Ganitumab, an IGF1R Inhibitor
Ian McCaffery; Yanyan Tudor; Hongjie Deng; Rui Tang; Samuel Suzuki; Sunita Badola; Hedy L. Kindler; Charles S. Fuchs; Elwyn Loh; Scott D. Patterson; Li Chen; Jennifer L. Gansert
Letters to the Editor
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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