Issues

The cover shows a section from a human pancreatic ductal adenocarcinoma stained for cytokeratin 7 (green) and CCL2 (red) with a nuclear (Topro) counterstain (blue). Immunofluorescence confocal image (×63) reveals that the malignant ductal epithelium as well as cells within the tumor stroma produce CCL2. This chemokine plays a key role in the recruitment of inflammatory monocytes (CCR2⁺) from the bone marrow to both the primary tumor and premetastatic liver, where these cells promote growth and metastasis in pancreatic cancer. For details, see the article by Sanford and colleagues on page 3404 of this issue.