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Issues

Volume 19, Issue 11
1 June 2013
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  • Cover Image

    Cover Image

    issue cover
    The cover shows a noncancerous fallopian tube, H&E stain, magnification × 100. For details, see the article by Chene and colleagues on page 2873 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

Microenvironmental Induced Essentiality of Autophagy
Dean C. Singleton; Adrian L. Harris
View articletitled, Microenvironmental Induced Essentiality of Autophagy
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Mouse Models of Kras-Mutant Colorectal Cancer: Valuable GEMMs for Drug Testing?
Federica Di Nicolantonio; Alberto Bardelli
View articletitled, Mouse Models of <em>Kras</em>-Mutant Colorectal Cancer: Valuable GEMMs for Drug Testing?
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CCR New Strategies

New Strategies in Hodgkin Lymphoma: Better Risk Profiling and Novel Treatments
Catherine Diefenbach; Christian Steidl
View articletitled, New Strategies in Hodgkin Lymphoma: Better Risk Profiling and Novel Treatments
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CCR Perspectives in Drug Approval

Reevaluating the Accelerated Approval Process for Oncology Drugs
Wyndham H. Wilson; David P. Schenkein; Cheryl L. Jernigan; Janet Woodcock; Richard L. Schilsky
View articletitled, Reevaluating the Accelerated Approval Process for Oncology Drugs
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Molecular Pathways

Molecular Pathways: The Complex Roles of Inflammation Pathways in the Development and Treatment of Liver Cancer
Kostas Nikolaou; Michalis Sarris; Iannis Talianidis
View articletitled, Molecular Pathways: The Complex Roles of Inflammation Pathways in the Development and Treatment of Liver Cancer
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Perspective

Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials
Angela DeMichele; Donald A. Berry; JoAnne Zujewski; Sally Hunsberger; Larry Rubinstein; Joseph E. Tomaszewski; Gary Kelloff; Jane Perlmutter; Meredith Buxton; Julia Lyandres; Kathy S. Albain; Chris Benz; A. Jo Chien; Paul Haluska; Brian Leyland-Jones; Minetta C. Liu; Pamela Munster; Olufunmilayo Olopade; John W. Park; Barbara A. Parker; Lajos Pusztai; Debu Tripathy; Hope Rugo; Douglas Yee; Laura Esserman
View articletitled, Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials
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Predictive Biomarkers for Bevacizumab: Are We There Yet?
Dipen Maru; Alan P. Venook; Lee M. Ellis
View articletitled, Predictive Biomarkers for Bevacizumab: Are We There Yet?
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A Proposal Regarding Reporting of In Vitro Testing Results
Malcolm A. Smith; Peter Houghton
View articletitled, A Proposal Regarding Reporting of <em>In Vitro</em> Testing Results
Supplementary data
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Reviews

Infection and Cancer: Revaluation of the Hygiene Hypothesis
Katerina Oikonomopoulou; Davor Brinc; Kyriacos Kyriacou; Eleftherios P. Diamandis
View articletitled, Infection and Cancer: Revaluation of the Hygiene Hypothesis
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Molecular Pathogenesis of Neuroendocrine Tumors: Implications for Current and Future Therapeutic Approaches
Kjell Oberg; Oriol Casanovas; Justo P. Castaño; Daniel Chung; Gianfranco Delle Fave; Patrice Denèfle; Philip Harris; Mohid S. Khan; Matthew H. Kulke; Aldo Scarpa; Laura H. Tang; Bertram Wiedenmann
View articletitled, Molecular Pathogenesis of Neuroendocrine Tumors: Implications for Current and Future Therapeutic Approaches
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Human Cancer Biology

Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization
Hong Wang; Yuanbin Ru; Marta Sanchez-Carbayo; Xuejiao Wang; Jeffrey S. Kieft; Dan Theodorescu
View articletitled, Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization
Supplementary data
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ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
Hsuan-Ying Huang; Wen-Ren Wu; Yu-Hui Wang; Jun-Wen Wang; Fu-Min Fang; Jen-Wei Tsai; Shau-Hsuan Li; Hsiao-Chin Hung; Shih-Chen Yu; Jui Lan; Yow-Ling Shiue; Chung-His Hsing; Li-Tzong Chen; Chien-Feng Li
View articletitled, <em>ASS1</em> as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
Supplementary data
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Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
Gautier Chene; Andrei Tchirkov; Eleonore Pierre-Eymard; Jacques Dauplat; Ines Raoelfils; Anne Cayre; Emmanuel Watkin; Philippe Vago; Frederique Penault-Llorca
View articletitled, Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
Supplementary data
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The Tumor-Suppressive Function of UNC5D and Its Repressed Expression in Renal Cell Carcinoma
Dan Lu; Dong Dong; Yu Zhou; Min Lu; Xue-Wen Pang; Yan Li; Xiao-Jun Tian; Yu Zhang; Jun Zhang
View articletitled, The Tumor-Suppressive Function of <em>UNC5D</em> and Its Repressed Expression in Renal Cell Carcinoma
Supplementary data
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Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia
Peter Ouillette; Kamlai Saiya-Cork; Erlene Seymour; Cheng Li; Kerby Shedden; Sami N. Malek
View articletitled, Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia
Supplementary data
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Author Choice
Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma
Beibei Liang; Rui Chen; Tao Wang; Lei Cao; Yingying Liu; Fan Yin; Minhui Zhu; Xiaoyu Fan; Yingchao Liang; Lu Zhang; Yajun Guo; Jian Zhao
View articletitled, Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma
Supplementary data
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Cancer Therapy: Preclinical

Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB
Xiaoguang Li; Xinying Yang; Yanling Liu; Nuoxi Gong; Wenbo Yao; Peizhan Chen; Jiangjiang Qin; Huizi Jin; Jingquan Li; Ruiai Chu; Lei Shan; Ruiwen Zhang; Weidong Zhang; Hui Wang
View articletitled, Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB
Supplementary data
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Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation
Eric S. Martin; Peter J. Belmont; Mark J. Sinnamon; Larissa Georgeon Richard; Jing Yuan; Erin M. Coffee; Jatin Roper; Lydia Lee; Pedram Heidari; Sophia Y. Lunt; Gautam Goel; Xiadong Ji; Zhi Xie; Tao Xie; John Lamb; Scott L. Weinrich; Todd VanArsdale; Roderick T. Bronson; Ramnik J. Xavier; Matthew G. Vander Heiden; Julie L. C. Kan; Umar Mahmood; Kenneth E. Hung
View articletitled, Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation
Supplementary data
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EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
Friedhelm Bladt; Bettina Faden; Manja Friese-Hamim; Christine Knuehl; Claudia Wilm; Claus Fittschen; Ulrich Grädler; Michael Meyring; Dieter Dorsch; Frank Jaehrling; Ulrich Pehl; Frank Stieber; Oliver Schadt; Andree Blaukat
View articletitled, EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
Supplementary data
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Colon Cancer–Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins
Sandra Travica; Klaus Pors; Paul M. Loadman; Steven D. Shnyder; Inger Johansson; Mohammed N. Alandas; Helen M. Sheldrake; Souren Mkrtchian; Laurence H. Patterson; Magnus Ingelman-Sundberg
View articletitled, Colon Cancer–Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins
Supplementary data
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Sequential Inhibitor Therapy in CML: In Vitro Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment
Robert C. Bauer; Jana Sänger; Christian Peschel; Justus Duyster; Nikolas von Bubnoff
View articletitled, Sequential Inhibitor Therapy in CML: <em>In Vitro</em> Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line Treatment
Supplementary data
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Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Patricia Vrignaud; Dorothée Sémiond; Pascale Lejeune; Hervé Bouchard; Loreley Calvet; Cecile Combeau; Jean-François Riou; Alain Commerçon; François Lavelle; Marie-Christine Bissery
View articletitled, Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Supplementary data
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Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and Its Ligands as an Effective Antiangiogenic Strategy
Hemant K. Bid; Cheryl A. London; Jin Gao; Haihong Zhong; Robert E. Hollingsworth; Soledad Fernandez; Xiaokui Mo; Peter J. Houghton
View articletitled, Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and Its Ligands as an Effective Antiangiogenic Strategy
Supplementary data
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Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy
Muthu Selvakumaran; Ravi K. Amaravadi; Irina A. Vasilevskaya; Peter J. O'Dwyer
View articletitled, Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy
Supplementary data
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Effects of Early Chemotherapeutic Treatment on Learning in Adolescent Mice: Implications for Cognitive Impairment and Remediation in Childhood Cancer Survivors
Emily B. Bisen-Hersh; Philip N. Hineline; Ellen A. Walker
View articletitled, Effects of Early Chemotherapeutic Treatment on Learning in Adolescent Mice: Implications for Cognitive Impairment and Remediation in Childhood Cancer Survivors
Supplementary data
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Author Choice
In Vitro and In Vivo Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells
Dharminder Chauhan; Arghya Ray; Kristina Viktorsson; Jack Spira; Claudia Paba-Prada; Nikhil Munshi; Paul Richardson; Rolf Lewensohn; Kenneth C. Anderson
View articletitled, <em>In Vitro</em> and <em>In Vivo</em> Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells
Supplementary data
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Imaging, Diagnosis, Prognosis

Discovery and Prevalidation of Salivary Extracellular microRNA Biomarkers Panel for the Noninvasive Detection of Benign and Malignant Parotid Gland Tumors
Johannes H. Matse; Janice Yoshizawa; Xiaoyan Wang; David Elashoff; Jan G.M. Bolscher; Enno C.I. Veerman; Elisabeth Bloemena; David T.W. Wong
View articletitled, Discovery and Prevalidation of Salivary Extracellular microRNA Biomarkers Panel for the Noninvasive Detection of Benign and Malignant Parotid Gland Tumors
Supplementary data
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Identification and Validation of a Blood-Based 18-Gene Expression Signature in Colorectal Cancer
Ye Xu; Qinghua Xu; Li Yang; Xun Ye; Fang Liu; Fei Wu; Shujuan Ni; Cong Tan; Guoxiang Cai; Xia Meng; Sanjun Cai; Xiang Du
View articletitled, Identification and Validation of a Blood-Based 18-Gene Expression Signature in Colorectal Cancer
Supplementary data
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Cancer Therapy: Clinical

Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Alberto Broniscer; Sharyn D. Baker; Cynthia Wetmore; Atmaram S. Pai Panandiker; Jie Huang; Andrew M. Davidoff; Arzu Onar-Thomas; John C. Panetta; Thomas K. Chin; Thomas E. Merchant; Justin N. Baker; Sue C. Kaste; Amar Gajjar; Clinton F. Stewart
View articletitled, Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Supplementary data
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Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients
Manish R. Sharma; Theodore G. Karrison; Bethany Kell; Kehua Wu; Michelle Turcich; David Geary; Soonmo P. Kang; Naoko Takebe; Richard A. Graham; Michael L. Maitland; Richard L. Schilsky; Mark J. Ratain; Ezra E.W. Cohen
View articletitled, Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients
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A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non–Small Cell Lung Cancer
Mark A. Socinski; Jonathan Goldman; Iman El-Hariry; Marianna Koczywas; Vojo Vukovic; Leora Horn; Eugene Paschold; Ravi Salgia; Howard West; Lecia V. Sequist; Philip Bonomi; Julie Brahmer; Lin-Chi Chen; Alan Sandler; Chandra P. Belani; Timothy Webb; Harry Harper; Mark Huberman; Suresh Ramalingam; Kwok-Kin Wong; Florentina Teofilovici; Wei Guo; Geoffrey I. Shapiro
View articletitled, A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non–Small Cell Lung Cancer
Supplementary data
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Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors
Patricia LoRusso; Pasi A. Jänne; Moacyr Oliveira; Naiyer Rizvi; Lisa Malburg; Vicki Keedy; Lorrin Yee; Catherine Copigneaux; Thore Hettmann; Chi-Yuan Wu; Agnes Ang; Abdel-Baset Halim; Robert A. Beckman; Darrin Beaupre; Jordan Berlin
View articletitled, Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors
Supplementary data
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A Dose-Ranging Study of Cabozantinib in Men with Castration-Resistant Prostate Cancer and Bone Metastases
Richard J. Lee; Philip J. Saylor; M. Dror Michaelson; S. Michael Rothenberg; Malgorzata E. Smas; David T. Miyamoto; Carol A. Gurski; Wanling Xie; Shyamala Maheswaran; Daniel A. Haber; Jonathan G. Goldin; Matthew R. Smith
View articletitled, A Dose-Ranging Study of Cabozantinib in Men with Castration-Resistant Prostate Cancer and Bone Metastases
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Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel
Anne M. Noonan; Robin A. Eisch; David J. Liewehr; Tristan M. Sissung; David J. Venzon; Thomas P. Flagg; Mark C. Haigney; Seth M. Steinberg; William D. Figg; Richard L. Piekarz; Susan E. Bates
View articletitled, Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for K<sub>ATP</sub> Channel
Supplementary data
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Letters to the Editor

Gender, Cytidine Deaminase, and 5-Aza/Decitabine—Letter
Joseph Ciccolini; Godefridus J. Peters; Elisa Giovannetti
View articletitled, Gender, Cytidine Deaminase, and 5-Aza/Decitabine—Letter
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Gender, Cytidine Deaminase, and 5-Aza/Decitabine—Response
Reda Z. Mahfouz; Lip Seng Koh; Marissa Teo; Chit Lai Chee; Han Chong Toh; Yogen Saunthararajah
View articletitled, Gender, Cytidine Deaminase, and 5-Aza/Decitabine—Response
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Correction

Correction: The Anti-CD19 Antibody–Drug Conjugate SAR3419 Prevents Hematolymphoid Relapse Postinduction Therapy in Preclinical Models of Pediatric Acute Lymphoblastic Leukemia
View articletitled, Correction: The Anti-CD19 Antibody–Drug Conjugate SAR3419 Prevents Hematolymphoid Relapse Postinduction Therapy in Preclinical Models of Pediatric Acute Lymphoblastic Leukemia
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