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1 June 2013
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Cover Image
Cover Image
The cover shows a noncancerous fallopian tube, H&E stain, magnification × 100. For details, see the article by Chene and colleagues on page 2873 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
CCR Perspectives in Drug Approval
Molecular Pathways
Perspective
Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials
Angela DeMichele; Donald A. Berry; JoAnne Zujewski; Sally Hunsberger; Larry Rubinstein; Joseph E. Tomaszewski; Gary Kelloff; Jane Perlmutter; Meredith Buxton; Julia Lyandres; Kathy S. Albain; Chris Benz; A. Jo Chien; Paul Haluska; Brian Leyland-Jones; Minetta C. Liu; Pamela Munster; Olufunmilayo Olopade; John W. Park; Barbara A. Parker; Lajos Pusztai; Debu Tripathy; Hope Rugo; Douglas Yee; Laura Esserman
Reviews
Molecular Pathogenesis of Neuroendocrine Tumors: Implications for Current and Future Therapeutic Approaches
Kjell Oberg; Oriol Casanovas; Justo P. Castaño; Daniel Chung; Gianfranco Delle Fave; Patrice Denèfle; Philip Harris; Mohid S. Khan; Matthew H. Kulke; Aldo Scarpa; Laura H. Tang; Bertram Wiedenmann
Human Cancer Biology
ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
Hsuan-Ying Huang; Wen-Ren Wu; Yu-Hui Wang; Jun-Wen Wang; Fu-Min Fang; Jen-Wei Tsai; Shau-Hsuan Li; Hsiao-Chin Hung; Shih-Chen Yu; Jui Lan; Yow-Ling Shiue; Chung-His Hsing; Li-Tzong Chen; Chien-Feng Li
Cancer Therapy: Preclinical
Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation
Eric S. Martin; Peter J. Belmont; Mark J. Sinnamon; Larissa Georgeon Richard; Jing Yuan; Erin M. Coffee; Jatin Roper; Lydia Lee; Pedram Heidari; Sophia Y. Lunt; Gautam Goel; Xiadong Ji; Zhi Xie; Tao Xie; John Lamb; Scott L. Weinrich; Todd VanArsdale; Roderick T. Bronson; Ramnik J. Xavier; Matthew G. Vander Heiden; Julie L. C. Kan; Umar Mahmood; Kenneth E. Hung
EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
Friedhelm Bladt; Bettina Faden; Manja Friese-Hamim; Christine Knuehl; Claudia Wilm; Claus Fittschen; Ulrich Grädler; Michael Meyring; Dieter Dorsch; Frank Jaehrling; Ulrich Pehl; Frank Stieber; Oliver Schadt; Andree Blaukat
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Alberto Broniscer; Sharyn D. Baker; Cynthia Wetmore; Atmaram S. Pai Panandiker; Jie Huang; Andrew M. Davidoff; Arzu Onar-Thomas; John C. Panetta; Thomas K. Chin; Thomas E. Merchant; Justin N. Baker; Sue C. Kaste; Amar Gajjar; Clinton F. Stewart
Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients
Manish R. Sharma; Theodore G. Karrison; Bethany Kell; Kehua Wu; Michelle Turcich; David Geary; Soonmo P. Kang; Naoko Takebe; Richard A. Graham; Michael L. Maitland; Richard L. Schilsky; Mark J. Ratain; Ezra E.W. Cohen
A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non–Small Cell Lung Cancer
Mark A. Socinski; Jonathan Goldman; Iman El-Hariry; Marianna Koczywas; Vojo Vukovic; Leora Horn; Eugene Paschold; Ravi Salgia; Howard West; Lecia V. Sequist; Philip Bonomi; Julie Brahmer; Lin-Chi Chen; Alan Sandler; Chandra P. Belani; Timothy Webb; Harry Harper; Mark Huberman; Suresh Ramalingam; Kwok-Kin Wong; Florentina Teofilovici; Wei Guo; Geoffrey I. Shapiro
Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors
Patricia LoRusso; Pasi A. Jänne; Moacyr Oliveira; Naiyer Rizvi; Lisa Malburg; Vicki Keedy; Lorrin Yee; Catherine Copigneaux; Thore Hettmann; Chi-Yuan Wu; Agnes Ang; Abdel-Baset Halim; Robert A. Beckman; Darrin Beaupre; Jordan Berlin
A Dose-Ranging Study of Cabozantinib in Men with Castration-Resistant Prostate Cancer and Bone Metastases
Richard J. Lee; Philip J. Saylor; M. Dror Michaelson; S. Michael Rothenberg; Malgorzata E. Smas; David T. Miyamoto; Carol A. Gurski; Wanling Xie; Shyamala Maheswaran; Daniel A. Haber; Jonathan G. Goldin; Matthew R. Smith
Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel
Anne M. Noonan; Robin A. Eisch; David J. Liewehr; Tristan M. Sissung; David J. Venzon; Thomas P. Flagg; Mark C. Haigney; Seth M. Steinberg; William D. Figg; Richard L. Piekarz; Susan E. Bates
Letters to the Editor
Correction
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