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15 February 2012
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Cover Image
Cover Image
Pleural fluid cytology specimen from a 45-year-old female never smoker with a lung mass showing malignant cells forming three dimensional flower-like arrangements, consistent with adenocarcinoma. The patient also had a biopsy of a spinal metastasis that showed squamous cell carcinoma. Both the pleural fluid and spine metastasis specimens harbored the same EGFR mutation, supporting their derivation from a single adenosquamous carcinoma of the lung. This patient illustrates how the discovery of an EGFR mutation in a small biopsy diagnosed as squamous carcinoma should raise suspicion for an underlying adenosquamous carcinoma. For details, see the article by Rekhtman and colleagues on page 1167 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
Review
Human Cancer Biology
Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis
Karmele Valencia; Cristina Ormazábal; Carolina Zandueta; Diego Luis-Ravelo; Iker Antón; María J. Pajares; Jackeline Agorreta; Luis M. Montuenga; Susana Martínez-Canarias; Birgit Leitinger; Fernando Lecanda
Characterization and Clinical Evaluation of CD10+ Stroma Cells in the Breast Cancer Microenvironment
Christine Desmedt; Samira Majjaj; Naima Kheddoumi; Sandeep K. Singhal; Benjamin Haibe-Kains; Frank El Ouriaghli; Carole Chaboteaux; Stefan Michiels; Françoise Lallemand; Fabrice Journe; Hughes Duvillier; Sherene Loi; John Quackenbush; Sophie Dekoninck; Cédric Blanpain; Laurence Lagneaux; Nawal Houhou; Mauro Delorenzi; Denis Larsimont; Martine Piccart; Christos Sotiriou
Cancer Therapy: Preclinical
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy
Michael Fraser; Helen Zhao; Kaisa R. Luoto; Cecilia Lundin; Carla Coackley; Norman Chan; Anthony M. Joshua; Tarek A. Bismar; Andrew Evans; Thomas Helleday; Robert G. Bristow
New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting
Ariane Groth; Alexei V. Salnikov; Sabine Ottinger; Jury Gladkich; Li Liu; Georgios Kallifatidis; Olga Salnikova; Eduard Ryschich; Nathalia Giese; Thomas Giese; Frank Momburg; Markus W. Büchler; Gerhard Moldenhauer; Ingrid Herr
Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-Mutant Colorectal Cancer Models
M. Pia Morelli; John J. Tentler; Gillian N. Kulikowski; Aik-Choon Tan; Erica L. Bradshaw-Pierce; Todd M. Pitts; Amy M. Brown; Sujatha Nallapareddy; John J. Arcaroli; Natalie J. Serkova; Manuel Hidalgo; Fortunato Ciardiello; S. Gail Eckhardt
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Phase I Study of Bosutinib, a Src/Abl Tyrosine Kinase Inhibitor, Administered to Patients with Advanced Solid Tumors
Adil I. Daud; Smitha S. Krishnamurthi; Mansoor N. Saleh; Barbara J. Gitlitz; Mitesh J. Borad; Philip J. Gold; Elena G. Chiorean; Gregory M. Springett; Richat Abbas; Shefali Agarwal; Nathalie Bardy-Bouxin; Poe-Hirr Hsyu; Eric Leip; Kathleen Turnbull; Charles Zacharchuk; Wells A. Messersmith
Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
Giuliano Ciarimboli; Cynthia S. Lancaster; Eberhard Schlatter; Ryan M. Franke; Jason A. Sprowl; Hermann Pavenstädt; Vivian Massmann; Denise Guckel; Ron H. J. Mathijssen; Wenjian Yang; Ching-Hon Pui; Mary V. Relling; Edwin Herrmann; Alex Sparreboom
Phase I Study of the Combination of Sorafenib and Temsirolimus in Patients with Metastatic Melanoma
Michael A. Davies; Patricia S. Fox; Nicholas E. Papadopoulos; Agop Y. Bedikian; Wen-Jen Hwu; Alexander J. Lazar; Victor G. Prieto; Kirk S. Culotta; Timothy L. Madden; Quanyun Xu; Sha Huang; Wanleng Deng; Chaan S. Ng; Sanjay Gupta; Wenbin Liu; Janet E. Dancey; John J. Wright; Roland L. Bassett; Patrick Hwu; Kevin B. Kim
Phase II Trial of Temozolomide in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer, with Assessment of Methylguanine-DNA Methyltransferase as a Potential Biomarker
M. Catherine Pietanza; Kyuichi Kadota; Kety Huberman; Camelia S. Sima; John J. Fiore; Dyana K. Sumner; William D. Travis; Adriana Heguy; Michelle S. Ginsberg; Andrei I. Holodny; Timothy A. Chan; Naiyer A. Rizvi; Christopher G. Azzoli; Gregory J. Riely; Mark G. Kris; Lee M. Krug
Immunochemotherapy with Intensive Consolidation for Primary CNS Lymphoma: A Pilot Study and Prognostic Assessment by Diffusion-Weighted MRI
Matthew J. Wieduwilt; Francisco Valles; Samar Issa; Caroline M. Behler; James Hwang; Michael McDermott; Patrick Treseler; Joan O'Brien; Marc A. Shuman; Soonmee Cha; Lloyd E. Damon; James L. Rubenstein
Predictive Biomarkers and Personalized Medicine
Clarifying the Spectrum of Driver Oncogene Mutations in Biomarker-Verified Squamous Carcinoma of Lung: Lack of EGFR/KRAS and Presence of PIK3CA/AKT1 Mutations
Natasha Rekhtman; Paul K. Paik; Maria E. Arcila; Laura J. Tafe; Geoffrey R. Oxnard; Andre L. Moreira; William D. Travis; Maureen F. Zakowski; Mark G. Kris; Marc Ladanyi
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