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Volume 18, Issue 3
1 February 2012
Clinical Cancer Research Cover Image for Volume 18, Issue 3
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  • Cover Image

    Cover Image

    Issue cover image
    A section of endometrial tumor xenografted in a mouse injected with Wi38 fibroblasts that fail to support tumor vascularization. Immunofluorescence analysis with antibodies against CD31 (green) and Ki67 (red) shows lack of CD31-positive vasculature and Ki67-positive proliferating cells exclusively in the peripheral tumor layer (bottom), whereas injection of omental adipose stromal cells increases tumor proliferation and vascularization. For details, see the article by Klopp and colleagues on page 771 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
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CCR Translations

New Treatments for Rhabdomyosarcoma: The Importance of Target Practice
Frederic G. Barr
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Molecular Pathways

Molecular Pathways: Targeting Mechanisms of Asbestos and Erionite Carcinogenesis in Mesothelioma
Michele Carbone; Haining Yang
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CCR Focus

A Millennium Goal for Cancer
Susan E. Bates
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Overview of the AACR Clinical and Translational Cancer Research Think Tank Meeting
Kenneth C. Anderson; Raymond N. DuBois
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Impact of Genomics on Personalized Cancer Medicine
Carlos L. Arteaga; José Baselga
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Making Personalized Cancer Medicine a Reality: Challenges and Opportunities in the Development of Biomarkers and Companion Diagnostics
David R. Parkinson; Bruce E. Johnson; George W. Sledge
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Genetically Modified Mouse Models for Biomarker Discovery and Preclinical Drug Testing
Raju Kucherlapati
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Imaging: Strategies, Controversies, and Opportunities
Ronald Blasberg; David Piwnica-Worms
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Reports from the 2010 Clinical and Translational Cancer Research Think Tank Meeting: Design Strategies for Personalized Therapy Trials
Donald A. Berry; Roy S. Herbst; Eric H. Rubin
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Review

Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence
David Páez; Melissa J. Labonte; Pierre Bohanes; Wu Zhang; Leonor Benhanim; Yan Ning; Takeru Wakatsuki; Fotios Loupakis; Heinz-Josef Lenz
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Human Cancer Biology

Notch Signaling Promotes Growth and Invasion in Uveal Melanoma
Laura Asnaghi; Katayoon B. Ebrahimi; Karisa C. Schreck; Eli E. Bar; Michael L. Coonfield; W. Robert Bell; James Handa; Shannath L. Merbs; J. William Harbour; Charles G. Eberhart
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Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features
Vassiliki Tzelepi; Jiexin Zhang; Jing-Fang Lu; Brittany Kleb; Guanglin Wu; Xinhai Wan; Anh Hoang; Eleni Efstathiou; Kanishka Sircar; Nora M. Navone; Patricia Troncoso; Shoudan Liang; Christopher J. Logothetis; Sankar N. Maity; Ana M. Aparicio
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Expansion of a CD8+PD-1+ Replicative Senescence Phenotype in Early Stage CLL Patients Is Associated with Inverted CD4:CD8 Ratios and Disease Progression
Claudia Nunes; Ryan Wong; Malcolm Mason; Chris Fegan; Stephen Man; Chris Pepper
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Primary Colorectal Cancers and Their Subsequent Hepatic Metastases Are Genetically Different: Implications for Selection of Patients for Targeted Treatment
Joost S. Vermaat; Isaac J. Nijman; Marco J. Koudijs; Frank L. Gerritse; Stefan J. Scherer; Michal Mokry; Wijnand M. Roessingh; Nico Lansu; Ewart de Bruijn; Richard van Hillegersberg; Paul J. van Diest; Edwin Cuppen; Emile E. Voest
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Genome-Wide CpG Island Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas
Seung-Mo Hong; Noriyuki Omura; Audrey Vincent; Ang Li; Spencer Knight; Jun Yu; Ralph H. Hruban; Michael Goggins
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Upregulated IL-19 in Breast Cancer Promotes Tumor Progression and Affects Clinical Outcome
Chung-Hsi Hsing; Hung-Chi Cheng; Yu-Hsiang Hsu; Chien-Hui Chan; Ching-Hua Yeh; Chien-Feng Li; Ming-Shi Chang
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Activation of β-Catenin Signaling in Androgen Receptor–Negative Prostate Cancer Cells
Xinhai Wan; Jie Liu; Jing-Fang Lu; Vassiliki Tzelepi; Jun Yang; Michael W. Starbuck; Lixia Diao; Jing Wang; Eleni Efstathiou; Elba S. Vazquez; Patricia Troncoso; Sankar N. Maity; Nora M. Navone
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MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon Cancer
Cristina Migliore; Valentina Martin; Vera P. Leoni; Angelo Restivo; Luigi Atzori; Annalisa Petrelli; Claudio Isella; Luigi Zorcolo; Ivana Sarotto; Giuseppe Casula; Paolo M. Comoglio; Amedeo Columbano; Silvia Giordano
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Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways
Neerav Shukla; Nabahet Ameur; Ismail Yilmaz; Khedoudja Nafa; Chyau-Yueh Lau; Angela Marchetti; Laetitia Borsu; Frederic G. Barr; Marc Ladanyi
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Cancer Therapy: Preclinical

Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer
Jessica D. Sun; Qian Liu; Jingli Wang; Dharmendra Ahluwalia; Damien Ferraro; Yan Wang; Jian-Xin Duan; W. Steve Ammons; John G. Curd; Mark D. Matteucci; Charles P. Hart
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Omental Adipose Tissue–Derived Stromal Cells Promote Vascularization and Growth of Endometrial Tumors
Ann H. Klopp; Yan Zhang; Travis Solley; Felipe Amaya-Manzanares; Frank Marini; Michael Andreeff; Bisrat Debeb; Wendy Woodward; Rosemarie Schmandt; Russell Broaddus; Karen Lu; Mikhail G. Kolonin
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Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Keryn M. Lucas; Nethia Mohana-Kumaran; Diana Lau; Xu Dong Zhang; Peter Hersey; David C. Huang; Wolfgang Weninger; Nikolas K. Haass; John D. Allen
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Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
Roberto Tonelli; Alan McIntyre; Consuelo Camerin; Zoë S. Walters; Korinne Di Leo; Joanna Selfe; Stefania Purgato; Edoardo Missiaglia; Andrea Tortori; Jane Renshaw; Annalisa Astolfi; Kathryn R. Taylor; Salvatore Serravalle; Ryan Bishop; Cristina Nanni; Linda J. Valentijn; Andrea Faccini; Ivo Leuschner; Serena Formica; Jorge S. Reis-Filho; Valentina Ambrosini; Khin Thway; Monica Franzoni; Brenda Summersgill; Rosangela Marchelli; Patrizia Hrelia; Giorgio Cantelli-Forti; Stefano Fanti; Roberto Corradini; Andrea Pession; Janet Shipley
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Imaging, Diagnosis, Prognosis

Methylated RASSF1a Is the First Specific DNA Marker for Minimal Residual Disease Testing in Neuroblastoma
Janine Stutterheim; Fatima Ait Ichou; Emmy den Ouden; Rogier Versteeg; Huib N. Caron; Godelieve A.M. Tytgat; C. Ellen van der Schoot
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External Validation of Diagnostic Models to Estimate the Risk of Malignancy in Adnexal Masses
Caroline Van Holsbeke; Ben Van Calster; Tom Bourne; Silvia Ajossa; Antonia C. Testa; Stefano Guerriero; Robert Fruscio; Andrea Alberto Lissoni; Artur Czekierdowski; Luca Savelli; Sabine Van Huffel; Lil Valentin; Dirk Timmerman
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Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors
Pauline Lagarde; Gaëlle Pérot; Audrey Kauffmann; Céline Brulard; Valérie Dapremont; Isabelle Hostein; Agnès Neuville; Agnieszka Wozniak; Raf Sciot; Patrick Schöffski; Alain Aurias; Jean-Michel Coindre; Maria Debiec-Rychter; Frédéric Chibon
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Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer
Richard H. Kimura; Robert Teed; Benjamin J. Hackel; Marybeth A. Pysz; Courtney Z. Chuang; Ataya Sathirachinda; Jürgen K. Willmann; Sanjiv S. Gambhir
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Tumor Infiltration by T Lymphocytes Expressing Chemokine Receptor 7 (CCR7) Is Predictive of Favorable Outcome in Patients with Advanced Colorectal Carcinoma
Pierpaolo Correale; Maria Saveria Rotundo; Cirino Botta; Maria Teresa Del Vecchio; Chiara Ginanneschi; Antonella Licchetta; Raffaele Conca; Serena Apollinari; Fabio De Luca; Pierfrancesco Tassone; Pierosandro Tagliaferri
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Cancer Therapy: Clinical

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction
Dung T. Le; Dirk G. Brockstedt; Ran Nir-Paz; Johannes Hampl; Shruti Mathur; John Nemunaitis; Daniel H. Sterman; Raffit Hassan; Eric Lutz; Bentley Moyer; Martin Giedlin; Jana-Lynn Louis; Elizabeth A. Sugar; Alice Pons; Andrea L. Cox; Jordana Levine; Aimee Luck Murphy; Peter Illei; Thomas W. Dubensky, Jr; Joseph E. Eiden; Elizabeth M. Jaffee; Daniel A. Laheru
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Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer
Adam D. Steg; Kerri S. Bevis; Ashwini A. Katre; Angela Ziebarth; Zachary C. Dobbin; Ronald D. Alvarez; Kui Zhang; Michael Conner; Charles N. Landen
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Predictive Biomarkers and Personalized Medicine

Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer
Vincent A. de Weger; Annelies W. Turksma; Quirinus J.M. Voorham; Zelda Euler; Herman Bril; Alfons J. van den Eertwegh; Elisabeth Bloemena; Herbert M. Pinedo; Jan B. Vermorken; Harm van Tinteren; Gerrit A. Meijer; Erik Hooijberg
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Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803
Shuji Ogino; Kaori Shima; Jeffrey A. Meyerhardt; Nadine J. McCleary; Kimmie Ng; Donna Hollis; Leonard B. Saltz; Robert J. Mayer; Paul Schaefer; Renaud Whittom; Alexander Hantel; Al B. Benson, III; Donna Spiegelman; Richard M. Goldberg; Monica M. Bertagnolli; Charles S. Fuchs
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Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness
Nyam-Osor Chimge; Sanjeev K. Baniwal; Jingqin Luo; Simon Coetzee; Omar Khalid; Benjamin P. Berman; Debu Tripathy; Matthew J. Ellis; Baruch Frenkel
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Letter to the Editor

Targeting Proteasomal Protein Degradation in Cancer–Letter
William K.K. Wu
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Correction

Correction: Improving T-cell Therapy for Relapsed EBV-Negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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