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15 December 2012
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Cover Image
Cover Image
The photomicrograph is of a metastatic, trastuzumab-refractory, HER2-amplified breast cancer with loss of PTEN expression by immunohistochemistry. The normal stromal cells interspersed in the tumor display strong PTEN staining (brown), whereas the cancer cells show complete absence of stain. The primary tumor (pretrastuzumab treatment) from this patient showed equivalent PTEN staining in the stromal cells and cancer cells. For details, see the article by Chandarlapaty and colleagues on page 6784 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Molecular Pathways
Review
Human Cancer Biology
Identification of KIF5B-RET and GOPC-ROS1 Fusions in Lung Adenocarcinomas through a Comprehensive mRNA-Based Screen for Tyrosine Kinase Fusions
Yoshiyuki Suehara; Maria Arcila; Lu Wang; Adnan Hasanovic; Daphne Ang; Tatsuo Ito; Yuki Kimura; Alexander Drilon; Udayan Guha; Valerie Rusch; Mark G. Kris; Maureen F. Zakowski; Naiyer Rizvi; Raya Khanin; Marc Ladanyi
Cancer Therapy: Preclinical
Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
Shaoman Yin; Stefan Kaluz; Narra S. Devi; Adnan A. Jabbar; Rita G. de Noronha; Jiyoung Mun; Zhaobin Zhang; Purushotham R. Boreddy; Wei Wang; Zhibo Wang; Thomas Abbruscato; Zhengjia Chen; Jeffrey J. Olson; Ruiwen Zhang; Mark M. Goodman; K.C. Nicolaou; Erwin G. Van Meir
HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells
Nadire Duru; Ming Fan; Demet Candas; Cheikh Menaa; Hsin-Chen Liu; Danupon Nantajit; Yunfei Wen; Kai Xiao; Angela Eldridge; Brett A. Chromy; Shiyong Li; Douglas R. Spitz; Kit S. Lam; Max S. Wicha; Jian Jian Li
Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non–Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models
Jingchuan Zhang; Lin Zhang; Xinying Su; Ming Li; Liang Xie; Florian Malchers; ShuQiong Fan; XiaoLu Yin; YanPing Xu; Kunji Liu; Zhengwei Dong; Guanshan Zhu; Ziliang Qian; Lili Tang; Ping Zhan; Qunsheng Ji; Elaine Kilgour; Paul D. Smith; A. Nigel Brooks; Roman K. Thomas; Paul R. Gavine
A Novel Therapeutic Regimen to Eradicate Established Solid Tumors with an Effective Induction of Tumor-Specific Immunity
James R. Tysome; Xiaozhu Li; Shengdian Wang; Pengju Wang; Dongling Gao; Pan Du; Dong Chen; Rathi Gangeswaran; Louisa S. Chard; Ming Yuan; Ghassan Alusi; Nicholas R. Lemoine; Yaohe Wang
Imaging, Diagnosis, Prognosis
miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro
Laoighse Mulrane; Stephen F. Madden; Donal J. Brennan; Gabriela Gremel; Sharon F. McGee; Sara McNally; Finian Martin; John P. Crown; Karin Jirström; Desmond G. Higgins; William M. Gallagher; Darran P. O'Connor
Identification of Serum Proton NMR Metabolomic Fingerprints Associated with Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis
Pierre Nahon; Roland Amathieu; Mohamed N. Triba; Nadia Bouchemal; Jean-Charles Nault; Marianne Ziol; Olivier Seror; Gilles Dhonneur; Jean-Claude Trinchet; Michel Beaugrand; Laurence Le Moyec
Cancer Therapy: Clinical
Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias
Judith E. Karp; Brian M. Thomas; Jacqueline M. Greer; Christopher Sorge; Steven D. Gore; Keith W. Pratz; B. Douglas Smith; Karen S. Flatten; Kevin Peterson; Paula Schneider; Karen Mackey; Tomoko Freshwater; Mark J. Levis; Michael A. McDevitt; Hetty E. Carraway; Douglas E. Gladstone; Margaret M. Showel; Sabine Loechner; David A. Parry; Jo Ann Horowitz; Randi Isaacs; Scott H. Kaufmann
Adoptive Transfer of Autologous T Cells Improves T-cell Repertoire Diversity and Long-term B-cell Function in Pediatric Patients with Neuroblastoma
Stephan A. Grupp; Eline Luning Prak; Jean Boyer; Kenyetta R. McDonald; Suzanne Shusterman; Edward Thompson; Colleen Callahan; Abbas F. Jawad; Bruce L. Levine; Carl H. June; Kathleen E. Sullivan
Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer
Sylvia Adams; Lina Kozhaya; Frank Martiniuk; Tze-Chiang Meng; Luis Chiriboga; Leonard Liebes; Tsivia Hochman; Nicholas Shuman; Deborah Axelrod; James Speyer; Yelena Novik; Amy Tiersten; Judith D. Goldberg; Silvia C. Formenti; Nina Bhardwaj; Derya Unutmaz; Sandra Demaria
Predictive Biomarkers and Personalized Medicine
Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
Laszlo G. Radvanyi; Chantale Bernatchez; Minying Zhang; Patricia S. Fox; Priscilla Miller; Jessica Chacon; Richard Wu; Gregory Lizee; Sandy Mahoney; Gladys Alvarado; Michelle Glass; Valen E. Johnson; John D. McMannis; Elizabeth Shpall; Victor Prieto; Nicholas Papadopoulos; Kevin Kim; Jade Homsi; Agop Bedikian; Wen-Jen Hwu; Sapna Patel; Merrick I. Ross; Jeffrey E. Lee; Jeffrey E. Gershenwald; Anthony Lucci; Richard Royal; Janice N. Cormier; Michael A. Davies; Rahmatu Mansaray; Orenthial J. Fulbright; Christopher Toth; Renjith Ramachandran; Seth Wardell; Audrey Gonzalez; Patrick Hwu
Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
Jill M. Spoerke; Carol O'Brien; Ling Huw; Hartmut Koeppen; Jane Fridlyand; Rainer K. Brachmann; Peter M. Haverty; Ajay Pandita; Sankar Mohan; Deepak Sampath; Lori S. Friedman; Leanne Ross; Garret M. Hampton; Lukas C. Amler; David S. Shames; Mark R. Lackner
Letters to the Editor
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