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Volume 18, Issue 22
15 November 2012
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    Replication-incompetent Sendai virus particles were injected into orthotopic prostate cancers in NOD–SCID mice on day 29 after the inoculation of human prostate cancer PC3 cells. The dual 4′,6-diamidino-2-phenylindole (blue) and terminal deoxynucleotide transferase–mediated dUTP nick-end labeling (DAPI; green) staining showed that the TUNEL-positive apoptotic cells were dramatically increased in tumor regions. For details, see the article by Matsushima-Miyagi and colleagues on page 6271 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

Real-time Pathology to Guide Breast Surgery: Seeing Alone Is Not Believing
Irving J. Bigio
View articletitled, Real-time Pathology to Guide Breast Surgery: Seeing Alone Is Not Believing
Supplementary data
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Regulatory T Cells Move in When Gliomas Say “I DO”
Bryan D. Choi; Peter E. Fecci; John H. Sampson
View articletitled, Regulatory T Cells Move in When Gliomas Say “I DO”
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Molecular Pathways

Molecular Pathways: The Metabolic Regulator Estrogen-Related Receptor α as a Therapeutic Target in Cancer
Ching-yi Chang; Donald P. McDonnell
View articletitled, Molecular Pathways: The Metabolic Regulator Estrogen-Related Receptor α as a Therapeutic Target in Cancer
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Molecular Pathways: Regulation of Metabolism by RB
Brian F. Clem; Jason Chesney
View articletitled, Molecular Pathways: Regulation of Metabolism by RB
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Review

Accelerating Cancer Therapy Development: The Importance of Combination Strategies and Collaboration. Summary of an Institute of Medicine Workshop
Patricia M. LoRusso; Renzo Canetta; John A. Wagner; Erin P. Balogh; Sharyl J. Nass; Scott A. Boerner; John Hohneker
View articletitled, Accelerating Cancer Therapy Development: The Importance of Combination Strategies and Collaboration. Summary of an Institute of Medicine Workshop
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Human Cancer Biology

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival
Derek A. Wainwright; Irina V. Balyasnikova; Alan L. Chang; Atique U. Ahmed; Kyung-Sub Moon; Brenda Auffinger; Alex L. Tobias; Yu Han; Maciej S. Lesniak
View articletitled, IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival
Supplementary data
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Quantitative Immunofluorescence Reveals the Signature of Active B-cell Receptor Signaling in Diffuse Large B-cell Lymphoma
Agata M. Bogusz; Richard H.G. Baxter; Treeve Currie; Papiya Sinha; Aliyah R. Sohani; Jeffery L. Kutok; Scott J. Rodig
View articletitled, Quantitative Immunofluorescence Reveals the Signature of Active B-cell Receptor Signaling in Diffuse Large B-cell Lymphoma
Supplementary data
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Expression Profiling of Archival Tumors for Long-term Health Studies
Levi Waldron; Shuji Ogino; Yujin Hoshida; Kaori Shima; Amy E. McCart Reed; Peter T. Simpson; Yoshifumi Baba; Katsuhiko Nosho; Nicola Segata; Ana Cristina Vargas; Margaret C. Cummings; Sunil R. Lakhani; Gregory J. Kirkner; Edward Giovannucci; John Quackenbush; Todd R. Golub; Charles S. Fuchs; Giovanni Parmigiani; Curtis Huttenhower
View articletitled, Expression Profiling of Archival Tumors for Long-term Health Studies
Supplementary data
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Decreased NK Cells in Patients with Head and Neck Cancer Determined in Archival DNA
William P. Accomando; John K. Wiencke; E. Andres Houseman; Rondi A. Butler; Shichun Zheng; Heather H. Nelson; Karl T. Kelsey
View articletitled, Decreased NK Cells in Patients with Head and Neck Cancer Determined in Archival DNA
Supplementary data
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Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Kelly Boucher; Nancy Parquet; Raymond Widen; Kenneth Shain; Rachid Baz; Melissa Alsina; John Koomen; Claudio Anasetti; William Dalton; Lia E. Perez
View articletitled, Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Supplementary data
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Molecular Epidemiology of EGFR and KRAS Mutations in 3,026 Lung Adenocarcinomas: Higher Susceptibility of Women to Smoking-Related KRAS-Mutant Cancers
Snjezana Dogan; Ronglai Shen; Daphne C. Ang; Melissa L. Johnson; Sandra P. D'Angelo; Paul K. Paik; Edyta B. Brzostowski; Gregory J. Riely; Mark G. Kris; Maureen F. Zakowski; Marc Ladanyi
View articletitled, Molecular Epidemiology of <em>EGFR</em> and <em>KRAS</em> Mutations in 3,026 Lung Adenocarcinomas: Higher Susceptibility of Women to Smoking-Related <em>KRAS</em>-Mutant Cancers
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Establishment and Characterization of Novel Cell Lines from Sinonasal Undifferentiated Carcinoma
Yoko Takahashi; Michael E. Kupferman; Diana Bell; Tilahun Jiffar; June Goo Lee; Tong-Xin Xie; Ning-Wei Li; Mei Zhao; Mitchell J. Frederick; Alexander Gelbard; Jeffrey N. Myers; Ehab Y. Hanna
View articletitled, Establishment and Characterization of Novel Cell Lines from Sinonasal Undifferentiated Carcinoma
Supplementary data
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Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating Glycolysis
Parama Dey; Satyanarayana Rachagani; Subhankar Chakraborty; Pankaj K. Singh; Xiangshan Zhao; Channabasavaiah Basavaraju Gurumurthy; Judy M. Anderson; Subodh Lele; Michael A. Hollingsworth; Vimla Band; Surinder K. Batra
View articletitled, Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating Glycolysis
Supplementary data
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Proliferation in the Normal FTE Is a Hallmark of the Follicular Phase, Not BRCA Mutation Status
Sophia H.L. George; Anca Milea; Patricia A. Shaw
View articletitled, Proliferation in the Normal FTE Is a Hallmark of the Follicular Phase, Not BRCA Mutation Status
Supplementary data
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Cancer Therapy: Preclinical

Radioimmunotherapy of Fibroblast Activation Protein Positive Tumors by Rapidly Internalizing Antibodies
Eliane Fischer; Krishna Chaitanya; Thomas Wüest; Andreas Wadle; Andrew M. Scott; Maries van den Broek; Roger Schibli; Stefan Bauer; Christoph Renner
View articletitled, Radioimmunotherapy of Fibroblast Activation Protein Positive Tumors by Rapidly Internalizing Antibodies
Supplementary data
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Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK–Positive Non–Small Cell Lung Cancer
Junko Tanizaki; Isamu Okamoto; Takafumi Okabe; Kazuko Sakai; Kaoru Tanaka; Hidetoshi Hayashi; Hiroyasu Kaneda; Ken Takezawa; Kiyoko Kuwata; Haruka Yamaguchi; Erina Hatashita; Kazuto Nishio; Kazuhiko Nakagawa
View articletitled, Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK–Positive Non–Small Cell Lung Cancer
Supplementary data
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Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells
Warren Fiskus; Rekha Rao; Ramesh Balusu; Siddhartha Ganguly; Jianguo Tao; Eduardo Sotomayor; Uma Mudunuru; Jacqueline E. Smith; Stacey L. Hembruff; Peter Atadja; Victor E. Marquez; Kapil Bhalla
View articletitled, Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells
Supplementary data
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Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier
Laurent Salphati; Timothy P. Heffron; Bruno Alicke; Merry Nishimura; Kai Barck; Richard A. Carano; Jonathan Cheong; Kyle A. Edgar; Joan Greve; Samir Kharbanda; Hartmut Koeppen; Shari Lau; Leslie B. Lee; Jodie Pang; Emile G. Plise; Jenny L. Pokorny; Hani Bou Reslan; Jann N. Sarkaria; Jeffrey J. Wallin; Xiaolin Zhang; Stephen E. Gould; Alan G. Olivero; Heidi S. Phillips
View articletitled, Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier
Supplementary data
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In Vivo Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Trigger Vγ9Vδ2 T-cell Antitumor Cytotoxicity through ICAM-1 Engagement
Ismahène Benzaïd; Hannu Mönkkönen; Edith Bonnelye; Jukka Mönkkönen; Philippe Clézardin
View articletitled, <em>In Vivo</em> Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Trigger Vγ9Vδ2 T-cell Antitumor Cytotoxicity through ICAM-1 Engagement
Supplementary data
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Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: In Vitro and In Vivo Evidence
Maria T. Di Martino; Emanuela Leone; Nicola Amodio; Umberto Foresta; Marta Lionetti; Maria R. Pitari; Maria E. Gallo Cantafio; Annamaria Gullà; Francesco Conforti; Eugenio Morelli; Vera Tomaino; Marco Rossi; Massimo Negrini; Manlio Ferrarini; Michele Caraglia; Masood A. Shammas; Nikhil C. Munshi; Kenneth C. Anderson; Antonino Neri; Pierosandro Tagliaferri; Pierfrancesco Tassone
View articletitled, Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: <em>In Vitro</em> and <em>In Vivo</em> Evidence
Supplementary data
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TRAIL and Noxa Are Selectively Upregulated in Prostate Cancer Cells Downstream of the RIG-I/MAVS Signaling Pathway by Nonreplicating Sendai Virus Particles
Taeko Matsushima-Miyagi; Koji Hatano; Motonari Nomura; Liu Li-Wen; Tomoyuki Nishikawa; Kotaro Saga; Takashi Shimbo; Yasufumi Kaneda
View articletitled, TRAIL and Noxa Are Selectively Upregulated in Prostate Cancer Cells Downstream of the RIG-I/MAVS Signaling Pathway by Nonreplicating Sendai Virus Particles
Supplementary data
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Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor
Magalie Dosset; Yann Godet; Charline Vauchy; Laurent Beziaud; Yu Chun Lone; Christine Sedlik; Christelle Liard; Emeline Levionnois; Bertrand Clerc; Federico Sandoval; Etienne Daguindau; Simon Wain-Hobson; Eric Tartour; Pierre Langlade-Demoyen; Christophe Borg; Olivier Adotévi
View articletitled, Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor
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Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NK Cell Resistance in MLL-Rearranged Leukemia Expressing Inhibitory KIR Ligands but Not Activating Ligands
Wing Keung Chan; May Kung Sutherland; Ying Li; Jonathan Zalevsky; Sarah Schell; Wing Leung
View articletitled, Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NK Cell Resistance in <em>MLL</em>-Rearranged Leukemia Expressing Inhibitory KIR Ligands but Not Activating Ligands
Supplementary data
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Imaging, Diagnosis, Prognosis

Measurement of Tumor VEGF-A Levels with 89Zr-Bevacizumab PET as an Early Biomarker for the Antiangiogenic Effect of Everolimus Treatment in an Ovarian Cancer Xenograft Model
Arne R.M. van der Bilt; Anton G.T. Terwisscha van Scheltinga; Hetty Timmer-Bosscha; Carolien P. Schröder; Linda Pot; Jos G.W. Kosterink; Ate G.J. van der Zee; Marjolijn N. Lub-de Hooge; Steven de Jong; Elisabeth G.E. de Vries; Anna K.L. Reyners
View articletitled, Measurement of Tumor VEGF-A Levels with <sup>89</sup>Zr-Bevacizumab PET as an Early Biomarker for the Antiangiogenic Effect of Everolimus Treatment in an Ovarian Cancer Xenograft Model
Supplementary data
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Scatter Spectroscopic Imaging Distinguishes between Breast Pathologies in Tissues Relevant to Surgical Margin Assessment
Ashley M. Laughney; Venkataramanan Krishnaswamy; Elizabeth J. Rizzo; Mary C. Schwab; Richard J. Barth; Brian W. Pogue; Keith D. Paulsen; Wendy A. Wells
View articletitled, Scatter Spectroscopic Imaging Distinguishes between Breast Pathologies in Tissues Relevant to Surgical Margin Assessment
Supplementary data
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Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
Shunsuke Kondo; Satoshi Iwata; Taketo Yamada; Yusuke Inoue; Hiromi Ichihara; Yoshiko Kichikawa; Tomoki Katayose; Akiko Souta-Kuribara; Hiroto Yamazaki; Osamu Hosono; Hiroshi Kawasaki; Hirotoshi Tanaka; Yuichiro Hayashi; Michiie Sakamoto; Kazunori Kamiya; Nam H. Dang; Chikao Morimoto
View articletitled, Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
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Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors
Shinichi Yachida; Catherine M. White; Yoshiki Naito; Yi Zhong; Jacqueline A. Brosnan; Anne M. Macgregor-Das; Richard A. Morgan; Tyler Saunders; Daniel A. Laheru; Joseph M. Herman; Ralph H. Hruban; Alison P. Klein; Siân Jones; Victor Velculescu; Christopher L. Wolfgang; Christine A. Iacobuzio-Donahue
View articletitled, Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors
Supplementary data
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Serum Lactate Dehydrogenase Is Prognostic for Survival in Patients with Bone Metastases from Breast Cancer: A Retrospective Analysis in Bisphosphonate-Treated Patients
Janet E. Brown; Richard J. Cook; Allan Lipton; Robert E. Coleman
View articletitled, Serum Lactate Dehydrogenase Is Prognostic for Survival in Patients with Bone Metastases from Breast Cancer: A Retrospective Analysis in Bisphosphonate-Treated Patients
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Cancer Therapy: Clinical

Outcomes of Phase II Clinical Trials with Single-Agent Therapies in Advanced/Metastatic Non–Small Cell Lung Cancer Published between 2000 and 2009
Filip Janku; Donald A. Berry; Jing Gong; Henrique A. Parsons; David J. Stewart; Razelle Kurzrock
View articletitled, Outcomes of Phase II Clinical Trials with Single-Agent Therapies in Advanced/Metastatic Non–Small Cell Lung Cancer Published between 2000 and 2009
Supplementary data
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Using Pharmacokinetic and Pharmacodynamic Data in Early Decision Making Regarding Drug Development: A Phase I Clinical Trial Evaluating Tyrosine Kinase Inhibitor, AEE788
José Baselga; Alain C. Mita; Patrick Schöffski; Herlinde Dumez; Frederico Rojo; Josep Tabernero; Clifford DiLea; William Mietlowski; Christie Low; Jerry Huang; Margaret Dugan; Kathryn Parker; Eric Walk; Allan van Oosterom; Erika Martinelli; Chris H. Takimoto
View articletitled, Using Pharmacokinetic and Pharmacodynamic Data in Early Decision Making Regarding Drug Development: A Phase I Clinical Trial Evaluating Tyrosine Kinase Inhibitor, AEE788
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Predictive Biomarkers and Personalized Medicine

Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative
Apostolia-Maria Tsimberidou; Nancy G. Iskander; David S. Hong; Jennifer J. Wheler; Gerald S. Falchook; Siqing Fu; Sarina Piha-Paul; Aung Naing; Filip Janku; Rajyalakshmi Luthra; Yang Ye; Sijin Wen; Donald Berry; Razelle Kurzrock
View articletitled, Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative
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Association between VEGF Splice Isoforms and Progression-Free Survival in Metastatic Colorectal Cancer Patients Treated with Bevacizumab
David O. Bates; Paul J. Catalano; Kirsty E. Symonds; Alex H.R. Varey; Pramila Ramani; Peter J. O'Dwyer; Bruce J. Giantonio; Neal J. Meropol; Al Bowen Benson; Steven J. Harper
View articletitled, Association between VEGF Splice Isoforms and Progression-Free Survival in Metastatic Colorectal Cancer Patients Treated with Bevacizumab
Supplementary data
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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