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15 May 2012
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Methylation of the tumor suppressor gene Ras association domain family 1A (RASSF1A) is an independent adverse prognostic factor in patients with early-stage non–small cell lung carcinoma treated in the phase III trial on perioperative chemotherapy, IFCT-0002. The cover image is a photomicrograph showing RASSF1A protein distribution in immortalized interphasic bronchial epithelial cells, HBEC3, using confocal microscopy. RASSF1A is stained in red (Alexa-fluo red-labeled secondary antibody). Nuclei are shown in light purple (DAPI). For details, see the article by de Fraipont and colleagues on page 2976 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
From the Editor
CCR Focus
Perspective
Review
Human Cancer Biology
MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma
Nelly Burnichon; Alberto Cascón; Francesca Schiavi; Nicole Paes Morales; Iñaki Comino-Méndez; Nasséra Abermil; Lucía Inglada-Pérez; Aguirre A. de Cubas; Laurence Amar; Marta Barontini; Sandra Bernaldo de Quirós; Jérôme Bertherat; Yves-Jean Bignon; Marinus J. Blok; Sara Bobisse; Salud Borrego; Maurizio Castellano; Philippe Chanson; María-Dolores Chiara; Eleonora P.M. Corssmit; Mara Giacchè; Ronald R. de Krijger; Tonino Ercolino; Xavier Girerd; Encarna B. Gómez-García; Álvaro Gómez-Graña; Isabelle Guilhem; Frederik J. Hes; Emiliano Honrado; Esther Korpershoek; Jacques W.M. Lenders; Rocío Letón; Arjen R. Mensenkamp; Anna Merlo; Luigi Mori; Arnaud Murat; Peggy Pierre; Pierre-François Plouin; Tamara Prodanov; Miguel Quesada-Charneco; Nan Qin; Elena Rapizzi; Victoria Raymond; Nicole Reisch; Giovanna Roncador; Macarena Ruiz-Ferrer; Frank Schillo; Alexander P.A. Stegmann; Carlos Suarez; Elisa Taschin; Henri J.L.M. Timmers; Carli M.J. Tops; Miguel Urioste; Felix Beuschlein; Karel Pacak; Massimo Mannelli; Patricia L. M. Dahia; Giuseppe Opocher; Graeme Eisenhofer; Anne-Paule Gimenez-Roqueplo; Mercedes Robledo
Molecular Profiling of Pancreatic Neuroendocrine Tumors in Sporadic and Von Hippel-Lindau Patients
Daniela Speisky; Aurélie Duces; Ivan Bièche; Vinciane Rebours; Pascal Hammel; Alain Sauvanet; Stéphane Richard; Pierre Bedossa; Michel Vidaud; Arnaud Murat; Patricia Niccoli; Jean-Yves Scoazec; Philippe Ruszniewski; Anne Couvelard; for the GTE Group (Groupe d'Etude des Tumeurs Endocrines)
Cancer Therapy: Preclinical
L-BLP25 Vaccine plus Letrozole Induces a TH1 Immune Response and Has Additive Antitumor Activity in MUC1-Expressing Mammary Tumors in Mice
Neelima R. Mehta; Gregory T. Wurz; Rebekah A. Burich; Brittany E. Greenberg; Stephen Griffey; Audrey Gutierrez; Katie E. Bell; Jamie L. McCall; Michael Wolf; Michael DeGregorio
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Analysis of Spontaneous Tumor-Specific CD4 T-cell Immunity in Lung Cancer Using Promiscuous HLA-DR Telomerase-Derived Epitopes: Potential Synergistic Effect with Chemotherapy Response
Yann Godet; Elizabeth Fabre; Magalie Dosset; Michele Lamuraglia; Emeline Levionnois; Patrice Ravel; Nadine Benhamouda; Aurélie Cazes; Françoise Le Pimpec-Barthes; Beatrice Gaugler; Pierre Langlade-Demoyen; Xavier Pivot; Philippe Saas; Bernard Maillère; Eric Tartour; Christophe Borg; Olivier Adotévi
Pharmacokinetics and Safety of Bortezomib in Patients with Advanced Malignancies and Varying Degrees of Liver Dysfunction: Phase I NCI Organ Dysfunction Working Group Study NCI-6432
Patricia M. LoRusso; Karthik Venkatakrishnan; Ramesh K. Ramanathan; John Sarantopoulos; Daniel Mulkerin; Stephen I. Shibata; Anne Hamilton; Afshin Dowlati; Sridhar Mani; Michelle A. Rudek; Chris H. Takimoto; Rachel Neuwirth; Dixie-Lee Esseltine; Percy Ivy
Predictive Biomarkers and Personalized Medicine
An Apoptosis Methylation Prognostic Signature for Early Lung Cancer in the IFCT-0002 Trial
Florence de Fraipont; Guénaëlle Levallet; Christian Creveuil; Emmanuel Bergot; Michèle Beau-Faller; Mounia Mounawar; Nicolas Richard; Martine Antoine; Isabelle Rouquette; Marie-Christine Favrot; Didier Debieuvre; Denis Braun; Virginie Westeel; Elisabeth Quoix; Elisabeth Brambilla; Pierre Hainaut; Denis Moro-Sibilot; Franck Morin; Bernard Milleron; Gérard Zalcman; on behalf of the Intergroupe Francophone de Cancérologie Thoracique (IFCT)
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