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15 April 2011
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Cover Image
Cover Image
In this issue, Meng and coworkers show that the multi-functional protein LDL receptor-related protein-1 (LRP1) predicts favorable outcomes in patients with lung adenocarcinoma. LRP1 is expressed predominantly in stromal cells of both lung squamous cell carcinomas (shown in the cover image) and adenocarcinomas. The investigators show that transcellular actions of LRP1 inhibit cancer cell growth, suggesting that stromal cells expressing LRP1 improve clinical outcomes. For further details, please see Meng and colleagues on page 2426 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
Review
Human Cancer Biology
Identification of Loss of p16 Expression and Upregulation of MDR-1 as Genetic Events Resulting from Two Novel Chromosomal Translocations Found in a Plasmablastic Lymphoma of the Uterus
Eri Matsuki; Yoshitaka Miyakawa; Shuichi Asakawa; Yuiko Tsukada; Taketo Yamada; Kenji Yokoyama; Jun Kudoh; Yasuo Ikeda; Shinichiro Okamoto
Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents
Emilie P. Buddingh; Marieke L. Kuijjer; Ronald A.J. Duim; Horst Bürger; Konstantin Agelopoulos; Ola Myklebost; Massimo Serra; Fredrik Mertens; Pancras C.W. Hogendoorn; Arjan C. Lankester; Anne-Marie Cleton-Jansen
Yes-Associated Protein 1 Exhibits Oncogenic Property in Gastric Cancer and Its Nuclear Accumulation Associates with Poor Prognosis
Wei Kang; Joanna H.M. Tong; Anthony W.H. Chan; Tin-Lap Lee; Raymond W.M. Lung; Patrick P.S. Leung; Ken K.Y. So; Kaichun Wu; Daiming Fan; Jun Yu; Joseph J.Y. Sung; Ka-Fai To
EGFR L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients
Shi-Yi Yang; Tsung-Ying Yang; Kun-Chieh Chen; Yao-Jen Li; Kuo-Hsuan Hsu; Chi-Rne Tsai; Chih-Yi Chen; Chung-Ping Hsu; Jiun-Yi Hsia; Cheng-Yen Chuang; Ying-Huang Tsai; Kuan-Yu Chen; Ming-Shyan Huang; Wu-Chou Su; Yuh-Min Chen; Chao A. Hsiung; Chen-Yang Shen; Gee-Chen Chang; Pan-Chyr Yang; Chien-Jen Chen
Coordinated Cancer Germline Antigen Promoter and Global DNA Hypomethylation in Ovarian Cancer: Association with the BORIS/CTCF Expression Ratio and Advanced Stage
Anna Woloszynska-Read; Wa Zhang; Jihnhee Yu; Petra A. Link; Paulette Mhawech-Fauceglia; Golda Collamat; Stacey N. Akers; Kelly R. Ostler; Lucy A. Godley; Kunle Odunsi; Adam R. Karpf
Cancer Therapy: Preclinical
Oncogenic B-RAF Signaling in Melanoma Impairs the Therapeutic Advantage of Autophagy Inhibition
Jane L. Armstrong; Marco Corazzari; Shaun Martin; Vittoria Pagliarini; Laura Falasca; David S. Hill; Nicola Ellis; Salim Al Sabah; Christopher P.F. Redfern; Gian Maria Fimia; Mauro Piacentini; Penny E. Lovat
DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents
Annamaria Biroccio; Manuela Porru; Angela Rizzo; Erica Salvati; Carmen D'Angelo; Augusto Orlandi; Daniela Passeri; Marco Franceschin; Malcolm F.G. Stevens; Eric Gilson; Giovanni Beretta; Gabriella Zupi; Claudio Pisano; Franco Zunino; Carlo Leonetti
Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors
Marco Breinig; Philipp Mayer; Andreas Harjung; Benjamin Goeppert; Mona Malz; Roland Penzel; Olaf Neumann; Arndt Hartmann; Hendrik Dienemann; Giuseppe Giaccone; Peter Schirmacher; Michael André Kern; Gabriela Chiosis; Ralf Joachim Rieker
Targeted Therapy of VEGFR2 and EGFR Significantly Inhibits Growth of Anaplastic Thyroid Cancer in an Orthotopic Murine Model
Maria K. Gule; Yunyun Chen; Daisuke Sano; Mitchell J. Frederick; Ge Zhou; Mei Zhao; Zvonimir L. Milas; Chad E. Galer; Ying C. Henderson; Samar A. Jasser; David L. Schwartz; James A. Bankson; Jeffrey N. Myers; Stephen Y. Lai
High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy
Beate C. Litzenburger; Chad J. Creighton; Anna Tsimelzon; Bonita T. Chan; Susan G. Hilsenbeck; Tao Wang; Joan M. Carboni; Marco M. Gottardis; Fei Huang; Jenny C. Chang; Michael T. Lewis; Mothaffar F. Rimawi; Adrian V. Lee
Vorinostat Increases Expression of Functional Norepinephrine Transporter in Neuroblastoma In Vitro and In Vivo Model Systems
Swati S. More; Melissa Itsara; Xiaodong Yang; Ethan G. Geier; Michelle K. Tadano; Youngho Seo; Henry F. VanBrocklin; William A. Weiss; Sabine Mueller; Daphne A. Haas-Kogan; Steven G. DuBois; Katherine K. Matthay; Kathleen M. Giacomini
Acquisition of Chemoresistance and EMT Phenotype Is Linked with Activation of the Endothelin A Receptor Pathway in Ovarian Carcinoma Cells
Laura Rosanò; Roberta Cianfrocca; Francesca Spinella; Valeriana Di Castro; Maria Rita Nicotra; Alessandro Lucidi; Gabriella Ferrandina; Pier Giorgio Natali; Anna Bagnato
Dual Targeting of Phosphoinositide 3-Kinase and Mammalian Target of Rapamycin Using NVP-BEZ235 as a Novel Therapeutic Approach in Human Ovarian Carcinoma
Chintda Santiskulvong; Gottfried E. Konecny; Mirela Fekete; Kuang-Yui Michael Chen; Amer Karam; David Mulholland; Carol Eng; Hong Wu; Min Song; Oliver Dorigo
Imaging, Diagnosis, Prognosis
PET Tumor Metabolism in Locally Advanced Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: Value of Static versus Kinetic Measures of Fluorodeoxyglucose Uptake
Lisa K. Dunnwald; Robert K. Doot; Jennifer M. Specht; Julie R. Gralow; Georgiana K. Ellis; Robert B. Livingston; Hannah M. Linden; Vijayakrishna K. Gadi; Brenda F. Kurland; Erin K. Schubert; Mark Muzi; David A. Mankoff
Multiple Genetic Loci Modulate Lung Adenocarcinoma Clinical Staging
Elisa Frullanti; Antonella Galvan; Felicia S. Falvella; Giacomo Manenti; Francesca Colombo; Alberto Vannelli; Matteo Incarbone; Marco Alloisio; Mario Nosotti; Luigi Santambrogio; Anna Gonzalez-Neira; Ugo Pastorino; Tommaso A. Dragani
Abnormalities of the TITF-1 Lineage-Specific Oncogene in NSCLC: Implications in Lung Cancer Pathogenesis and Prognosis
Ximing Tang; Humam Kadara; Carmen Behrens; Diane D Liu; Yun Xiao; David Rice; Adi F. Gazdar; Junya Fujimoto; Cesar Moran; Marileila Varella-Garcia; J Jack Lee; Waun Ki Hong; Ignacio I. Wistuba
Polymorphisms in the Endothelin-1 and Endothelin A Receptor Genes and Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma
Yue-Feng Wen; Bin Qi; Huai Liu; Hao-Yuan Mo; Qiu-Yan Chen; Juan Li; Pei-Yu Huang; Yan-Fang Ye; Ying Zhang; Man-Quan Deng; Xiang Guo; Ming-Huang Hong; Ka-Jia Cao; Hai-Qiang Mai
Combined Promoter Methylation Analysis of CADM1 and MAL: An Objective Triage Tool for High-Risk Human Papillomavirus DNA–Positive Women
Albertus T. Hesselink; Daniëlle AM Heideman; Renske DM Steenbergen; Veerle M.H. Coupé; Renee M. Overmeer; Dorien Rijkaart; Johannes Berkhof; Chris J.L.M. Meijer; Peter J.F. Snijders
Can a Metastatic Gene Expression Profile Outperform Tumor Size as a Predictor of Occult Lymph Node Metastasis in Oral Cancer Patients?
Eduardo Méndez; Pawadee Lohavanichbutr; Wenhong Fan; John R. Houck; Tessa C. Rue; David R. Doody; Neal D. Futran; Melissa P. Upton; Bevan Yueh; Lue Ping Zhao; Stephen M. Schwartz; Chu Chen
Cancer Therapy: Clinical
Heat-Shock Induction of Tumor-Derived Danger Signals Mediates Rapid Monocyte Differentiation into Clinically Effective Dendritic Cells
Raquel Aguilera; Carlos Saffie; Andrés Tittarelli; Fermín E. González; Marcos Ramírez; Diego Reyes; Cristián Pereda; Daniel Hevia; Tamara García; Lorena Salazar; Arturo Ferreira; Marcela Hermoso; Ariadna Mendoza-Naranjo; Carlos Ferrada; Paola Garrido; Mercedes N. López; Flavio Salazar-Onfray
Phase I Trial of Weekly and Twice-Weekly Bortezomib with Rituximab, Cyclophosphamide, and Prednisone in Relapsed or Refractory Non–Hodgkin Lymphoma
John Gerecitano; Carol Portlock; Paul Hamlin; Craig H. Moskowitz; Ariela Noy; David Straus; Philip Schulman; Otilia Dumitrescu; Debra Sarasohn; Jennifer Pappanicholaou; Alexia Iasonos; Zhigang Zhang; Qianxing Mo; Endri Horanlli; Celeste N. Rojas; Andrew D. Zelenetz; Owen A. O'Connor
Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
Patricia M. LoRusso; Charles M. Rudin; Josina C. Reddy; Raoul Tibes; Glen J. Weiss; Mitesh J. Borad; Christine L. Hann; Julie R. Brahmer; Ilsung Chang; Walter C. Darbonne; Richard A. Graham; Kenn L. Zerivitz; Jennifer A. Low; Daniel D. Von Hoff
Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding
Richard A. Graham; Bert L. Lum; Sravanthi Cheeti; Jin Yan Jin; Karin Jorga; Daniel D. Von Hoff; Charles M. Rudin; Josina C. Reddy; Jennifer A. Low; Patricia M. LoRusso
Phase I/II Trial of Cetuximab and Erlotinib in Patients with Lung Adenocarcinoma and Acquired Resistance to Erlotinib
Yelena Y. Janjigian; Christopher G. Azzoli; Lee M. Krug; Leanne K. Pereira; Naiyer A. Rizvi; M Catherine Pietanza; Mark G. Kris; Michelle S. Ginsberg; William Pao; Vincent A. Miller; Gregory J. Riely
IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer
Michael S. Anglesio; Joshy George; Hagen Kulbe; Michael Friedlander; Danny Rischin; Charlotte Lemech; Jeremy Power; Jermaine Coward; Prue A. Cowin; Colin M. House; Probir Chakravarty; Kylie L. Gorringe; Ian G. Campbell; Australian Ovarian Cancer Study Group; Aikou Okamoto; Michael J. Birrer; David G. Huntsman; Anna de Fazio; Steve E. Kalloger; Frances Balkwill; C. Blake Gilks; David D. Bowtell
Predictive Biomarkers and Personalized Medicine
Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics
Jen-Tsan Chi; Donald E. Thrall; Chen Jiang; Stacey Snyder; Diane Fels; Chelsea Landon; Linda McCall; Lan Lan; Marlene Hauck; James R. MacFall; Benjamin L. Viglianti; Mark W. Dewhirst
Excision Repair Cross-Complementing Group 1 May Predict the Efficacy of Chemoradiation Therapy for Muscle-Invasive Bladder Cancer
Atsunari Kawashima; Masashi Nakayama; Yoichi Kakuta; Toyofumi Abe; Koji Hatano; Masatoshi Mukai; Akira Nagahara; Yasutomo Nakai; Daizo Oka; Hitoshi Takayama; Toshiaki Yoshioka; Yoshihiko Hoshida; Hiroaki Itatani; Kazuo Nishimura; Norio Nonomura
Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers
Xiaochen Wang; Xiyong Liu; Angela Ying-Jian Li; Lirong Chen; Lily Lai; Her Helen Lin; Shuya Hu; Lifang Yao; Jiaping Peng; Sofia Loera; Lijun Xue; Bingsen Zhou; Lun Zhou; Shu Zheng; Peiguo Chu; Suzhan Zhang; David Kong Ann; Yun Yen
Thymidylate Synthase and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated with Pemetrexed/Carboplatin
Paolo Andrea Zucali; Elisa Giovannetti; Annarita Destro; Manlio Mencoboni; Giovanni Luca Ceresoli; Letizia Gianoncelli; Elena Lorenzi; Fabio De Vincenzo; Matteo Simonelli; Matteo Perrino; Andrea Bruzzone; Erik Thunnissen; Gianni Tunesi; Laura Giordano; Massimo Roncalli; Godefridus J. Peters; Armando Santoro
Distinct p53 Gene Signatures Are Needed to Predict Prognosis and Response to Chemotherapy in ER-Positive and ER-Negative Breast Cancers
Charles Coutant; Roman Rouzier; Yuan Qi; Jacqueline Lehmann-Che; Giampaolo Bianchini; Takayuki Iwamoto; Gabriel N. Hortobagyi; W. Fraser Symmans; Serge Uzan; Fabrice Andre; Hugues de Thé; Lajos Pusztai
Correction
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