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15 March 2011
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Cover Image
Cover Image
In mice bearing orthotopic SKOV3ip1 human ovarian tumors, the diaphragms contained lymphatic vessels of increased density and branching and lymphatic valve structures disappeared completely. Lymphatic valves were visualized by using anti-CD31 (green) and LYVE-1 (blue) double staining in whole mounts of the diaphragm. For further details, please see Liao and coworkers on page 1415 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
CCR Focus
Human Cancer Biology
Involvement of the TGF-β and β-Catenin Pathways in Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer
Maartje G. Noordhuis; Rudolf S.N. Fehrmann; G. Bea A. Wisman; Esther R. Nijhuis; Jelmer J. van Zanden; Perry D. Moerland; Emiel Ver Loren van Themaat; Haukeline H. Volders; Mirjam Kok; Klaske A. ten Hoor; Harry Hollema; Elisabeth G.E. de Vries; Geertruida H. de Bock; Ate G.J. van der Zee; Ed Schuuring
Cancer Therapy: Preclinical
Reduced Dose and Intermittent Treatment with Lapatinib and Trastuzumab for Potent Blockade of the HER Pathway in HER2/neu-Overexpressing Breast Tumor Xenografts
Mothaffar F. Rimawi; Lisa S. Wiechmann; Yen-Chao Wang; Catherine Huang; Ilenia Migliaccio; Meng-Fen Wu; Carolina Gutierrez; Susan G. Hilsenbeck; Grazia Arpino; Suleiman Massarweh; Robin Ward; Robert Soliz; C. Kent Osborne; Rachel Schiff
Antitumor Activity of BIBF 1120, a Triple Angiokinase Inhibitor, and Use of VEGFR2+pTyr+ Peripheral Blood Leukocytes as a Pharmacodynamic Biomarker In Vivo
Kanae Kudo; Tokuzo Arao; Kaoru Tanaka; Tomoyuki Nagai; Kazuyuki Furuta; Kazuko Sakai; Hiroyasu Kaneda; Kazuko Matsumoto; Daisuke Tamura; Keiichi Aomatsu; Marco A. De Velasco; Yoshihiko Fujita; Nagahiro Saijo; Masatoshi Kudo; Kazuto Nishio
SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis
Joseph P. Ritchie; Vishnu C. Ramani; Yongsheng Ren; Annamaria Naggi; Giangiacomo Torri; Benito Casu; Sergio Penco; Claudio Pisano; Paolo Carminati; Monica Tortoreto; Franco Zunino; Israel Vlodavsky; Ralph D. Sanderson; Yang Yang
Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo
Peramaiyan Rajendran; Tina H. Ong; Luxi Chen; Feng Li; Muthu K. Shanmugam; Shireen Vali; Taher Abbasi; Shweta Kapoor; Ashish Sharma; Alan Prem Kumar; Kam M. Hui; Gautam Sethi
Imaging, Diagnosis, Prognosis
A20, ABIN-1/2, and CARD11 Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma
Gehong Dong; Estelle Chanudet; Naiyan Zeng; Alex Appert; Yun-Wen Chen; Wing-Yan Au; Rifat A. Hamoudi; A. James Watkins; Hongtao Ye; Hongxiang Liu; Zifen Gao; Shih-Sung Chuang; Gopesh Srivastava; Ming-Qing Du
Genomic and Clinical Analysis of Amplification of the 13q31 Chromosomal Region in Alveolar Rhabdomyosarcoma: A Report from the Children's Oncology Group
Jennifer L. Reichek; Fenghai Duan; Lynette M. Smith; Donna M. Gustafson; Roddy S. O'Connor; Chune Zhang; Mandy J. Dunlevy; Julie M. Gastier-Foster; Frederic G. Barr
Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas
David S.P. Tan; Marjan Iravani; W. Glenn McCluggage; Maryou B.K. Lambros; Fernanda Milanezi; Alan Mackay; Charles Gourley; Felipe C. Geyer; Radost Vatcheva; Joanne Millar; Karen Thomas; Rachael Natrajan; Kay Savage; Kerry Fenwick; Alistair Williams; Charles Jameson; Mona El-Bahrawy; Martin E. Gore; Hani Gabra; Stanley B. Kaye; Alan Ashworth; Jorge S. Reis-Filho
Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer
Joo Mi Yi; Mashaal Dhir; Leander Van Neste; Stephanie R. Downing; Jana Jeschke; Sabine C. Glöckner; Marilia de Freitas Calmon; Craig M. Hooker; Juan M. Funes; Chris Boshoff; Kim M. Smits; Manon van Engeland; Matty P. Weijenberg; Christine A. Iacobuzio-Donahue; James G. Herman; Kornel E. Schuebel; Stephen B. Baylin; Nita Ahuja
Cancer Therapy: Clinical
A Phase I Study of the Heat Shock Protein 90 Inhibitor Alvespimycin (17-DMAG) Given Intravenously to Patients with Advanced Solid Tumors
Simon Pacey; Richard H. Wilson; Mike Walton; Martin M. Eatock; Anthea Hardcastle; Anna Zetterlund; Hendrik-Tobias Arkenau; Javier Moreno-Farre; Udai Banerji; Belle Roels; Heidi Peachey; Wynne Aherne; Johan S. de Bono; Florence Raynaud; Paul Workman; Ian Judson
Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas
Anastasios Stathis; Sebastien J. Hotte; Eric X. Chen; Holger W. Hirte; Amit M. Oza; Patricia Moretto; Sheila Webster; Anne Laughlin; Lee-Anne Stayner; Shauna McGill; Lisa Wang; Wen-jiang Zhang; Igor Espinoza-Delgado; Julianne L. Holleran; Merrill J. Egorin; Lillian L. Siu
Predictive Biomarkers and Personalized Medicine
Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer
Gottfried E. Konecny; Boris Winterhoff; Teodora Kolarova; Jingwei Qi; Kanthinh Manivong; Judy Dering; Guorong Yang; Meenal Chalukya; He-Jing Wang; Lee Anderson; Kimberly R. Kalli; Richard S. Finn; Charles Ginther; Siân Jones; Victor E. Velculescu; Darren Riehle; William A. Cliby; Sophia Randolph; Maria Koehler; Lynn C. Hartmann; Dennis J. Slamon
Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Lung Cancer: Distinct Natural History of Patients with Tumors Harboring the T790M Mutation
Geoffrey R. Oxnard; Maria E. Arcila; Camelia S. Sima; Gregory J. Riely; Juliann Chmielecki; Mark G. Kris; William Pao; Marc Ladanyi; Vincent A. Miller
Failure of Downregulation of Survivin Following Neoadjuvant Radiochemotherapy in Rectal Cancer Is Associated with Distant Metastases and Shortened Survival
Thilo Sprenger; Franz Rödel; Tim Beissbarth; Lena-Christin Conradi; Hilka Rothe; Kia Homayounfar; Hendrik A. Wolff; B. Michael Ghadimi; Müjdat Yildirim; Heinz Becker; Claus Rödel; Torsten Liersch
ERCC1 and ERCC2 Polymorphisms Predict Clinical Outcomes of Oxaliplatin-Based Chemotherapies in Gastric and Colorectal Cancer: A Systemic Review and Meta-analysis
Ming Yin; Jingrong Yan; Eva Martinez-Balibrea; Francesco Graziano; Heinz-Josef Lenz; Hyo-Jin Kim; Jacques Robert; Seock-Ah Im; Wei-Shu Wang; Marie-Christine Etienne-Grimaldi; Qingyi Wei
Corrections
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