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1 October 2011
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Cover Image
Cover Image
Growth of experimental glioma imaged in real time by in vivo multiphoton microscopy. Thisallows the study of the characteristic pattern of glioma growth and angiogenesis, and morphologic and functional vascular changes in response to antiangiogenic treatment. The cover image shows an U87 glioma expressing RFP (red) and tumor vessels (green, FITC dextran)30 days after brain implantation (tumor diameter 3 mm). The image represents a maximum intensity projection of the mouse brain up to a depth of 350 μm. For details, see the article by von Baumgarten and colleagues on page 6192 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR New Strategies
Molecular Pathways
Review
Human Cancer Biology
Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras
John P. Eggers; Paul M. Grandgenett; Eric C. Collisson; Michelle E. Lewallen; Jarrod Tremayne; Pankaj K. Singh; Benjamin J. Swanson; Judy M. Andersen; Thomas C. Caffrey; Robin R. High; Michel Ouellette; Michael A. Hollingsworth
Cancer Therapy: Preclinical
Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells
Carmen Visus; Yangyang Wang; Antonio Lozano-Leon; Robert L. Ferris; Susan Silver; Miroslaw J. Szczepanski; Randall E. Brand; Cristina R. Ferrone; Theresa L. Whiteside; Soldano Ferrone; Albert B. DeLeo; Xinhui Wang
Dual EGFR/HER2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Withdrawal by Suppressing ErbB3
Liqun Chen; Benjamin A. Mooso; Maitreyee K. Jathal; Anisha Madhav; Sherra D. Johnson; Elyse van Spyk; Margarita Mikhailova; Alexandra Zierenberg-Ripoll; Lingru Xue; Ruth L. Vinall; Ralph W. deVere White; Paramita M. Ghosh
Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation
Zhen-Bin Ding; Bo Hui; Ying-Hong Shi; Jian Zhou; Yuan-Fei Peng; Cheng-Yu Gu; Hua Yang; Guo-Ming Shi; Ai-Wu Ke; Xiao-Ying Wang; Kang Song; Zhi Dai; Ying-Hao Shen; Jia Fan
Imaging, Diagnosis, Prognosis
Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Francesc Balaguer; Leticia Moreira; Juan Jose Lozano; Alexander Link; Georgina Ramirez; Yan Shen; Miriam Cuatrecasas; Mildred Arnold; Stephen J. Meltzer; Sapna Syngal; Elena Stoffel; Rodrigo Jover; Xavier Llor; Antoni Castells; C. Richard Boland; Meritxell Gironella; Ajay Goel
Evaluation of Human Papilloma Virus Diagnostic Testing in Oropharyngeal Squamous Cell Carcinoma: Sensitivity, Specificity, and Prognostic Discrimination
Andrew G. Schache; Triantafilos Liloglou; Janet M. Risk; Anastasia Filia; Terence M. Jones; Jon Sheard; Julia A. Woolgar; Timothy R. Helliwell; Asterios Triantafyllou; Max Robinson; Philip Sloan; Colin Harvey-Woodworth; Daniel Sisson; Richard J. Shaw
Identification of Epstein-Barr Virus–Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer
Ryohei Nishino; Atsushi Takano; Hideto Oshita; Nobuhisa Ishikawa; Hirohiko Akiyama; Hiroyuki Ito; Haruhiko Nakayama; Yohei Miyagi; Eiju Tsuchiya; Nobuoki Kohno; Yusuke Nakamura; Yataro Daigo
Cancer Therapy: Clinical
A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors
Francesco Atzori; Josep Tabernero; Andrés Cervantes; Ludmila Prudkin; Jordi Andreu; Edith Rodríguez-Braun; Amparo Domingo; Jorge Guijarro; Cristina Gamez; Jordi Rodon; Serena Di Cosimo; Holly Brown; Jason Clark; James S. Hardwick; Robert A. Beckman; William D. Hanley; Karl Hsu; Emiliano Calvo; Susana Roselló; Ronald B. Langdon; José Baselga
A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors
Josep Tabernero; Luc Dirix; Patrick Schöffski; Andrés Cervantes; Jose Antonio Lopez-Martin; Jaume Capdevila; Ludy van Beijsterveldt; Suso Platero; Brett Hall; Zhilong Yuan; Roland Knoblauch; Sen Hong Zhuang
Maintained Sensitivity to EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Lung Cancer Recurring after Adjuvant Erlotinib or Gefitinib
Geoffrey R. Oxnard; Yelena Y. Janjigian; Maria E. Arcila; Camelia S. Sima; Samantha L. Kass; Gregory J. Riely; William Pao; Mark G. Kris; Marc Ladanyi; Christopher G. Azzoli; Vincent A. Miller
Cetuximab Pharmacokinetics Influences Progression-Free Survival of Metastatic Colorectal Cancer Patients
Nicolas Azzopardi; Thierry Lecomte; David Ternant; Michelle Boisdron-Celle; Friedrich Piller; Alain Morel; Valérie Gouilleux-Gruart; Céline Vignault-Desvignes; Hervé Watier; Erick Gamelin; Gilles Paintaud
Predictive Biomarkers and Personalized Medicine
BAD Phosphorylation Determines Ovarian Cancer Chemosensitivity and Patient Survival
Douglas C. Marchion; Hope M. Cottrill; Yin Xiong; Ning Chen; Elona Bicaku; William J. Fulp; Nisha Bansal; Hye Sook Chon; Xiaomang B. Stickles; Siddharth G. Kamath; Ardeshir Hakam; Lihua Li; Dan Su; Carolina Moreno; Patricia L. Judson; Andrew Berchuck; Robert M. Wenham; Sachin M. Apte; Jesus Gonzalez-Bosquet; Gregory C. Bloom; Steven A. Eschrich; Said Sebti; Dung-Tsa Chen; Johnathan M. Lancaster
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