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Volume 17, Issue 16
15 August 2011
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    Cover Image

    issue cover
    Immunohistochemical analysis confirmed that YM155 reduced survivin protein levels, whereas docetaxel treatment increased p34 Thr-survivin protein at G2/M mitotic arrest. Furthermore, the concomitant treatment YM155 apparently decreased the docetaxel-induced survivin upregulation below the basal level in SK-MEL-5 human malignant melanoma cell. For further details, please see Yamanaka and colleagues on page 5423 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

Overcoming Antiangiogenic Resistance
James C. Yao; Alexandria Phan
View articletitled, Overcoming Antiangiogenic Resistance
Supplementary data
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CCR Perspectives in Drug Approval

The European Medicines Agency: An Overview of Its Mission, Responsibilities, and Recent Initiatives in Cancer Drug Regulation
Francesco Pignatti; Iordanis Gravanis; Ralf Herold; Spiros Vamvakas; Bertil Jonsson; Michel Marty
View articletitled, The European Medicines Agency: An Overview of Its Mission, Responsibilities, and Recent Initiatives in Cancer Drug Regulation
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Molecular Pathways

Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis
Michele De Palma; Luigi Naldini
View articletitled, Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis
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Prostate Cancer Immunotherapy
Kenneth F. May, Jr.; James L. Gulley; Charles G. Drake; Glenn Dranoff; Philip W. Kantoff
View articletitled, Prostate Cancer Immunotherapy
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Special Report

SWOG Cooperative Group Biorepository Resource: Access for Scientific Research Studies
Carolyn J. Hoban; Wilbur Franklin; Kenneth J. Kopecky; Laurence H. Baker
View articletitled, SWOG Cooperative Group Biorepository Resource: Access for Scientific Research Studies
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Review

Prognostic Immune Markers in Non–Small Cell Lung Cancer
Kei Suzuki; Stefan S. Kachala; Kyuichi Kadota; Ronglai Shen; Qianxing Mo; David G. Beer; Valerie W. Rusch; William D. Travis; Prasad S. Adusumilli
View articletitled, Prognostic Immune Markers in Non–Small Cell Lung Cancer
Supplementary data
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Human Cancer Biology

Novel Functional Germline Variants in the VEGF Receptor 2 Gene and Their Effect on Gene Expression and Microvessel Density in Lung Cancer
Dylan M. Glubb; Elisa Cerri; Alexandra Giese; Wei Zhang; Osman Mirza; Emma E. Thompson; Peixian Chen; Soma Das; Jacek Jassem; Witold Rzyman; Mark W. Lingen; Ravi Salgia; Fred R. Hirsch; Rafal Dziadziuszko; Kurt Ballmer-Hofer; Federico Innocenti
View articletitled, Novel Functional Germline Variants in the VEGF Receptor 2 Gene and Their Effect on Gene Expression and Microvessel Density in Lung Cancer
Supplementary data
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Clonal Relationship of Classical Hodgkin Lymphoma and Its Recurrences
Ellen C. Obermann; Nadine Mueller; Alexander Rufle; Thomas Menter; Esther Mueller-Garamvoelgyi; Gieri Cathomas; Stephan Dirnhofer; Alexandar Tzankov
View articletitled, Clonal Relationship of Classical Hodgkin Lymphoma and Its Recurrences
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FGFR Signaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo
Rachel Sharpe; Alex Pearson; Maria T. Herrera-Abreu; Damian Johnson; Alan Mackay; Jonathan C. Welti; Rachael Natrajan; Andrew R. Reynolds; Jorge S. Reis-Filho; Alan Ashworth; Nicholas C. Turner
View articletitled, FGFR Signaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both <em>In Vitro</em> and <em>In Vivo</em>
Supplementary data
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Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis
Sharanjot Saini; Shahana Majid; Soichiro Yamamura; Laura Tabatabai; Seong O. Suh; Varahram Shahryari; Yi Chen; Guoren Deng; Yuichiro Tanaka; Rajvir Dahiya
View articletitled, Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis
Supplementary data
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Cancer Therapy: Preclinical

Brivanib, a Dual FGF/VEGF Inhibitor, Is Active Both First and Second Line against Mouse Pancreatic Neuroendocrine Tumors Developing Adaptive/Evasive Resistance to VEGF Inhibition
Elizabeth Allen; Ian B. Walters; Douglas Hanahan
View articletitled, Brivanib, a Dual FGF/VEGF Inhibitor, Is Active Both First and Second Line against Mouse Pancreatic Neuroendocrine Tumors Developing Adaptive/Evasive Resistance to VEGF Inhibition
Supplementary data
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In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells
Dharminder Chauhan; Ze Tian; Bin Zhou; Deborah Kuhn; Robert Orlowski; Noopur Raje; Paul Richardson; Kenneth C. Anderson
View articletitled, <em>In Vitro</em> and <em>In Vivo</em> Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells
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Gastric Cancer Growth Control by BEZ235 In Vivo Does Not Correlate with PI3K/mTOR Target Inhibition but with [18F]FLT Uptake
Thorsten Fuereder; Thomas Wanek; Pamina Pflegerl; Agnes Jaeger-Lansky; Doris Hoeflmayer; Sabine Strommer; Claudia Kuntner; Friedrich Wrba; Johannes Werzowa; Michael Hejna; Markus Müller; Oliver Langer; Volker Wacheck
View articletitled, Gastric Cancer Growth Control by BEZ235 <em>In Vivo</em> Does Not Correlate with PI3K/mTOR Target Inhibition but with [<sup>18</sup>F]FLT Uptake
Supplementary data
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Regression of Glioma in Rat Models by Intranasal Application of Parvovirus H-1
Irina Kiprianova; Nadja Thomas; Ali Ayache; Manuel Fischer; Barbara Leuchs; Michèle Klein; Jean Rommelaere; Jörg R. Schlehofer
View articletitled, Regression of Glioma in Rat Models by Intranasal Application of Parvovirus H-1
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Determinants of Successful CD8+ T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice
Christopher A. Klebanoff; Luca Gattinoni; Douglas C. Palmer; Pawel Muranski; Yun Ji; Christian S. Hinrichs; Zachary A. Borman; Sid P. Kerkar; Christopher D. Scott; Steven E. Finkelstein; Steven A. Rosenberg; Nicholas P. Restifo
View articletitled, Determinants of Successful CD8<sup>+</sup> T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice
Supplementary data
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PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase
Yi-He Ling; Miguel Aracil; Yiyu Zou; Ziqiang Yuan; Bo Lu; José Jimeno; Ana Maria Cuervo; Roman Perez-Soler
View articletitled, PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase
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Targeting Src in Mucinous Ovarian Carcinoma
Koji Matsuo; Masato Nishimura; Justin N. Bottsford-Miller; Jie Huang; Kakajan Komurov; Guillermo N. Armaiz-Pena; Mian M.K. Shahzad; Rebecca L. Stone; Ju Won Roh; Angela M. Sanguino; Chunhua Lu; Dwight D. Im; Neil B. Rosenshien; Atsuko Sakakibara; Tadayoshi Nagano; Masato Yamasaki; Takayuki Enomoto; Tadashi Kimura; Prahlad T. Ram; Kathleen M. Schmeler; Gary E. Gallick; Kwong K. Wong; Michael Frumovitz; Anil K. Sood
View articletitled, Targeting Src in Mucinous Ovarian Carcinoma
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Lupeol, a Novel Androgen Receptor Inhibitor: Implications in Prostate Cancer Therapy
Hifzur Rahman Siddique; Shrawan Kumar Mishra; R. Jeffery Karnes; Mohammad Saleem
View articletitled, Lupeol, a Novel Androgen Receptor Inhibitor: Implications in Prostate Cancer Therapy
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Induction of HLA-DP4–Restricted Anti-Survivin Th1 and Th2 Responses Using an Artificial Antigen-Presenting Cell
Makito Tanaka; Marcus O. Butler; Sascha Ansén; Osamu Imataki; Alla Berezovskaya; Lee M. Nadler; Naoto Hirano
View articletitled, Induction of HLA-DP4–Restricted Anti-Survivin Th1 and Th2 Responses Using an Artificial Antigen-Presenting Cell
Supplementary data
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Resveratrol Selectively Induces DNA Damage, Independent of Smad4 Expression, in Its Efficacy against Human Head and Neck Squamous Cell Carcinoma
Alpna Tyagi; Mallikarjuna Gu; Takenori Takahata; Barbara Frederick; Chapla Agarwal; Sunitha Siriwardana; Rajesh Agarwal; Robert A. Sclafani
View articletitled, Resveratrol Selectively Induces DNA Damage, Independent of <em>Smad4</em> Expression, in Its Efficacy against Human Head and Neck Squamous Cell Carcinoma
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Role of Smac in Determining the Chemotherapeutic Response of Esophageal Squamous Cell Carcinoma
Yang Xu; Lanping Zhou; Jing Huang; Fang Liu; Jian Yu; Qimin Zhan; Lin Zhang; Xiaohang Zhao
View articletitled, Role of Smac in Determining the Chemotherapeutic Response of Esophageal Squamous Cell Carcinoma
Supplementary data
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Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models
Kentaro Yamanaka; Takahito Nakahara; Tomohiro Yamauchi; Aya Kita; Masahiro Takeuchi; Fumiko Kiyonaga; Naoki Kaneko; Masao Sasamata
View articletitled, Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models
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Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90
Pramod P. Mehta; Pamela Whalen; Sangita M. Baxi; Pei-Pei Kung; Shinji Yamazaki; Min-Jean Yin
View articletitled, Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90
Supplementary data
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Imaging, Diagnosis, Prognosis

Prognostic Model for Survival in Patients with Metastatic Renal Cell Carcinoma: Results from the International Kidney Cancer Working Group
Judith Manola; Patrick Royston; Paul Elson; Jennifer Bacik McCormack; Madhu Mazumdar; Sylvie Négrier; Bernard Escudier; Tim Eisen; Janice Dutcher; Michael Atkins; Daniel Y.C. Heng; Toni K. Choueiri; Robert Motzer; Ronald Bukowski; for the International Kidney Cancer Working Group
View articletitled, Prognostic Model for Survival in Patients with Metastatic Renal Cell Carcinoma: Results from the International Kidney Cancer Working Group
Supplementary data
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BARD1 Expression Predicts Outcome in Colon Cancer
Judith C. Sporn; Torsten Hothorn; Barbara Jung
View articletitled, BARD1 Expression Predicts Outcome in Colon Cancer
Supplementary data
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Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma
Zuo-Lin Xiang; Zhao-Chong Zeng; Jia Fan; Zhao-You Tang; Hai-Ying Zeng; Dong-Mei Gao
View articletitled, Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma
Supplementary data
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Cancer Therapy: Clinical

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide
Stuart A. Grossman; Xiaobu Ye; Glenn Lesser; Andrew Sloan; Hetty Carraway; Serena Desideri; Steven Piantadosi; for the NABTT CNS Consortium
View articletitled, Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide
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A Phase II Study of Pazopanib in Asian Patients with Recurrent/Metastatic Nasopharyngeal Carcinoma
Wan-Teck Lim; Quan-Sing Ng; Percy Ivy; Swan-Swan Leong; Onkar Singh; Balram Chowbay; Fei Gao; Choon Hua Thng; Boon-Cher Goh; Daniel Shao-Weng Tan; Tong San Koh; Chee-Keong Toh; Eng-Huat Tan
View articletitled, A Phase II Study of Pazopanib in Asian Patients with Recurrent/Metastatic Nasopharyngeal Carcinoma
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Predictive Biomarkers and Personalized Medicine

Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients
R. Stephanie Huang; Sharon E. Johnatty; Eric R. Gamazon; Hae Kyung Im; Dana Ziliak; Shiwei Duan; Wei Zhang; Emily O. Kistner; Peixian Chen; Jonathan Beesley; Shuangli Mi; Peter H. O'Donnell; Yarden S. Fraiman; Soma Das; Nancy J. Cox; Yi Lu; Stuart MacGregor; Ellen L. Goode; Robert A. Vierkant; Brooke L. Fridley; Estrid Hogdall; Susanne K. Kjaer; Allan Jensen; Kirsten B. Moysich; Matthew Grasela; Kunle Odunsi; Robert Brown; Jim Paul; Diether Lambrechts; Evelyn Despierre; Ignace Vergote; Jenny Gross; Beth Y. Karlan; Anna deFazio; Georgia Chenevix-Trench; for the Australian Ovarian Cancer Study Group; M. Eileen Dolan
View articletitled, Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients
Supplementary data
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Membranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor Predicts Outcome after Chemoradiotherapy of Lymph Node–Negative Cervical Cancer
Cathinka Halle; Malin Lando; Debbie Hege Svendsrud; Trevor Clancy; Marit Holden; Kolbein Sundfør; Gunnar B. Kristensen; Ruth Holm; Heidi Lyng
View articletitled, Membranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor Predicts Outcome after Chemoradiotherapy of Lymph Node–Negative Cervical Cancer
Supplementary data
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XPF Expression Correlates with Clinical Outcome in Squamous Cell Carcinoma of the Head and Neck
Alec Vaezi; XiaoZhe Wang; Shama Buch; William Gooding; Lin Wang; Raja R. Seethala; David T. Weaver; Alan D. D'Andrea; Athanassios Argiris; Marjorie Romkes; Laura J. Niedernhofer; Jennifer R. Grandis
View articletitled, XPF Expression Correlates with Clinical Outcome in Squamous Cell Carcinoma of the Head and Neck
Supplementary data
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Corrections

Correction: Regulation of HMGA1 Expression by MicroRNA-296 Affects Prostate Cancer Growth and Invasion
View articletitled, Correction: Regulation of <em>HMGA1</em> Expression by <em>MicroRNA-296</em> Affects Prostate Cancer Growth and Invasion
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Correction: Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate
View articletitled, Correction: Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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