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15 July 2011
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Cover Image
BRAF overexpressing human astrocytes manifested complete growth arrest accompanied by senescence as shown by β-galactosidase activity. This mimics the clinical observation in which BRAF-KIAA1549 fused low-grade gliomas undergo early growth arrest and respond better to therapy. For further details, please see Hawkins and coworkers on page 4790 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Molecular Pathways
Human Cancer Biology
Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype
Kristine Dziurzynski; Jun Wei; Wei Qiao; Mustafa Aziz Hatiboglu; Ling-Yuan Kong; Adam Wu; Yongtao Wang; Daniel Cahill; Nicholas Levine; Sujit Prabhu; Ganesh Rao; Raymond Sawaya; Amy B. Heimberger
Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
Karine Jacob; Dongh-Anh Quang-Khuong; David T.W. Jones; Hendrik Witt; Sally Lambert; Steffen Albrecht; Olaf Witt; Catherine Vezina; Margret Shirinian; Damien Faury; Miklos Garami; Peter Hauser; Almos Klekner; Laszlo Bognar; Jean-Pierre Farmer; Jose-Luis Montes; Jeffrey Atkinson; Cynthia Hawkins; Andrey Korshunov; V. Peter Collins; Stefan M. Pfister; Uri Tabori; Nada Jabado
Cancer Therapy: Preclinical
Distinct Apoptotic Signaling Characteristics of the Anti-CD40 Monoclonal Antibody Dacetuzumab and Rituximab Produce Enhanced Antitumor Activity in Non-Hodgkin Lymphoma
Timothy S. Lewis; Renee S. McCormick; Kim Emmerton; Jeffrey T. Lau; Shang-Fan Yu; Julie A. McEarchern; Iqbal S. Grewal; Che-Leung Law
Molecular Target Characterization and Antimyeloma Activity of the Novel, Insulin-like Growth Factor 1 Receptor Inhibitor, GTx-134
Sheng-Ben Liang; Xiu-Zhi Yang; Young Trieu; Zhihua Li; Jessica Zive; Chungyee Leung-Hagesteijn; Ellen Wei; Sergey Zozulya; Christopher C. Coss; James T. Dalton; Ivan George Fantus; Suzanne Trudel
Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
Edmund K. Moon; Carmine Carpenito; Jing Sun; Liang-Chuan S. Wang; Veena Kapoor; Jarrod Predina; Daniel J. Powell, Jr.; James L. Riley; Carl H. June; Steven M. Albelda
Inhibiting the mTOR Pathway Synergistically Enhances Cytotoxicity in Ovarian Cancer Cells Induced by Etoposide through Upregulation of c-Jun
Hiroaki Itamochi; Tetsuro Oishi; Muneaki Shimada; Shinya Sato; Kazunori Uegaki; Jun Naniwa; Seiya Sato; Michiko Nonaka; Naoki Terakawa; Junzo Kigawa; Tasuku Harada
Imaging, Diagnosis, Prognosis
Prospective Analysis of Parametric Response Map–Derived MRI Biomarkers: Identification of Early and Distinct Glioma Response Patterns Not Predicted by Standard Radiographic Assessment
Craig J. Galbán; Thomas L. Chenevert; Charles R. Meyer; Christina Tsien; Theodore S. Lawrence; Daniel A. Hamstra; Larry Junck; Pia C. Sundgren; Timothy D. Johnson; Stefanie Galbán; Judith S. Sebolt-Leopold; Alnawaz Rehemtulla; Brian D. Ross
Detection of Promoter Hypermethylation in Salivary Rinses as a Biomarker for Head and Neck Squamous Cell Carcinoma Surveillance
André Lopes Carvalho; Rui Henrique; Carmen Jeronimo; Chetan S. Nayak; Ashok N. Reddy; Mohammad O. Hoque; Steven Chang; Mariana Brait; Wei-Wen Jiang; Michael M. Kim; Quia Claybourne; David Goldenberg; Zubair Khan; Tanbir Khan; William H. Westra; David Sidransky; Wayne Koch; Joseph A. Califano
BRAF-KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma
Cynthia Hawkins; Erin Walker; Nequesha Mohamed; Cindy Zhang; Karine Jacob; Margret Shirinian; Noa Alon; Daniel Kahn; Iris Fried; Katrin Scheinemann; Elena Tsangaris; Peter Dirks; Robert Tressler; Eric Bouffet; Nada Jabado; Uri Tabori
Fluoroestradiol Positron Emission Tomography Reveals Differences in Pharmacodynamics of Aromatase Inhibitors, Tamoxifen, and Fulvestrant in Patients with Metastatic Breast Cancer
Hannah M. Linden; Brenda F. Kurland; Lanell M. Peterson; Erin K. Schubert; Julie R. Gralow; Jennifer M. Specht; Georgiana K. Ellis; Thomas J. Lawton; Robert B. Livingston; Philip H. Petra; Jeanne M. Link; Kenneth A. Krohn; David A. Mankoff
Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography
Astrid A.M. van der Veldt; Mark Lubberink; Henri N. Greuter; Emile F.I. Comans; Gerarda J.M. Herder; Maqsood Yaqub; Robert C. Schuit; Arthur van Lingen; S. Nafees Rizvi; Martien P.J. Mooijer; Anneloes Y. Rijnders; Albert D. Windhorst; Egbert F. Smit; N. Harry Hendrikse; Adriaan A. Lammertsma
Cancer Therapy: Clinical
Central Nervous System Metastases in Patients with HER2-Positive Metastatic Breast Cancer: Incidence, Treatment, and Survival in Patients from registHER
Adam M. Brufsky; Musa Mayer; Hope S. Rugo; Peter A. Kaufman; Elizabeth Tan-Chiu; Debu Tripathy; Iulia Cristina Tudor; Lisa I. Wang; Melissa G. Brammer; Mona Shing; Marianne Ulcickas Yood; Denise A. Yardley
Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients
Michael A. Morse; Robert Chapman; John Powderly; Kimberly Blackwell; Tibor Keler; Jennifer Green; Renee Riggs; Li-Zhen He; Venky Ramakrishna; Laura Vitale; Biwei Zhao; Stephen A. Butler; Amy Hobeika; Takuya Osada; Thomas Davis; Timothy Clay; H. Kim Lyerly
Phase II Study of Abiraterone Acetate in Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer Displaying Bone Flare Discordant with Serologic Response
Charles J. Ryan; Shreya Shah; Eleni Efstathiou; Matthew R. Smith; Mary-Ellen Taplin; Glenn J. Bubley; Christopher J. Logothetis; Thian Kheoh; Christine Kilian; Christopher M. Haqq; Arturo Molina; Eric J. Small
Population Analysis of Erlotinib in Adults and Children Reveals Pharmacokinetic Characteristics as the Main Factor Explaining Tolerance Particularities in Children
Melanie White-Koning; Elodie Civade; Birgit Geoerger; Fabienne Thomas; Marie-Cécile Le Deley; Isabelle Hennebelle; Jean-Pierre Delord; Etienne Chatelut; Gilles Vassal
Predictive Biomarkers and Personalized Medicine
Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept
John F. de Groot; Yuji Piao; Hai Tran; Mark Gilbert; Hua-Kang Wu; Jun Liu; B. Nebiyou Bekele; Tim Cloughesy; Minesh Mehta; H. Ian Robins; Andrew Lassman; Lisa DeAngelis; Kevin Camphausen; Alice Chen; WKA Yung; Michael Prados; Patrick Y. Wen; John V. Heymach
Impact of Clinical and Pathologic Features on Tumor-Infiltrating Lymphocyte Expansion from Surgically Excised Melanoma Metastases for Adoptive T-cell Therapy
Richard W. Joseph; Vijay R. Peddareddigari; Ping Liu; Priscilla W. Miller; Willem W. Overwijk; Nebiyou B. Bekele; Merrick I. Ross; Jeffrey E. Lee; Jeffrey E. Gershenwald; Anthony Lucci; Victor G. Prieto; John D. McMannis; Nicholas Papadopoulos; Kevin Kim; Jade Homsi; Agop Bedikian; Wen-Jen Hwu; Patrick Hwu; Laszlo G. Radvanyi
Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy
Michael I. Koukourakis; Alexandra Giatromanolaki; Efthimios Sivridis; Kevin C. Gatter; Tanja Trarbach; Gunnar Folprecht; Michael M. Shi; David Lebwohl; Tarja Jalava; Dirk Laurent; Gerold Meinhardt; Adrian L. Harris
Increased Detection Sensitivity for KRAS Mutations Enhances the Prediction of Anti-EGFR Monoclonal Antibody Resistance in Metastatic Colorectal Cancer
Francesca Molinari; Lara Felicioni; Michela Buscarino; Sara De Dosso; Fiamma Buttitta; Sara Malatesta; Alessandra Movilia; Marco Luoni; Renzo Boldorini; Oscar Alabiso; Salvatore Girlando; Barbara Soini; Alessandra Spitale; Federica Di Nicolantonio; Piercarlo Saletti; Stefano Crippa; Luca Mazzucchelli; Antonio Marchetti; Alberto Bardelli; Milo Frattini
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