Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 17, Issue 13
1 July 2011
Issue Cover
All Issues
  • Cover Image

    Cover Image

    issue cover
    Immunohistochemical double-fluorescence analysis of an adamantinomatous craniopharyngioma in human brain. Activated EGFR (green) can be detected in tumor cells with nuclear β-catenin (red) accumulation (yellow). Cell nuclei (blue) were counterstained with Höchst. For further details, please see Hölsken and coworkers on page 4367 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
Open the PDF for in another window

CCR Translations

Getting Personal with Melanoma
Helen Heslop
View articletitled, Getting Personal with Melanoma
Supplementary data
Open the PDF for in another window

CCR New Strategies

New Strategies in Non–Small Cell Lung Cancer: Improving Outcomes in Chemoradiotherapy for Locally Advanced Disease
Ramesh Rengan; Amit M. Maity; James P. Stevenson; Stephen M. Hahn
View articletitled, New Strategies in Non–Small Cell Lung Cancer: Improving Outcomes in Chemoradiotherapy for Locally Advanced Disease
Open the PDF for in another window

Molecular Pathways

WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
Philip C. De Witt Hamer; Shahryar E. Mir; David Noske; Cornelis J.F. Van Noorden; Tom Würdinger
View articletitled, WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
Open the PDF for in another window
Adaptive Changes Result in Activation of Alternate Signaling Pathways and Acquisition of Resistance to Aromatase Inhibitors
Angela Brodie; Gauri Sabnis
View articletitled, Adaptive Changes Result in Activation of Alternate Signaling Pathways and Acquisition of Resistance to Aromatase Inhibitors
Open the PDF for in another window

Review

Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?
Jay D. Naik; Christopher J. Twelves; Peter J. Selby; Richard G. Vile; John D. Chester
View articletitled, Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?
Open the PDF for in another window

Perspective

Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!
Iris J.H. van Vlodrop; Hanneke E.C. Niessen; Sarah Derks; Marcella M.L.L. Baldewijns; Wim van Criekinge; James G. Herman; Manon van Engeland
View articletitled, Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!
Open the PDF for in another window

Human Cancer Biology

Programmed Death Ligand 1 Is Expressed by Non–Hodgkin Lymphomas and Inhibits the Activity of Tumor-Associated T Cells
David J. Andorsky; Reiko E. Yamada; Jonathan Said; Geraldine S. Pinkus; David J. Betting; John M. Timmerman
View articletitled, Programmed Death Ligand 1 Is Expressed by Non–Hodgkin Lymphomas and Inhibits the Activity of Tumor-Associated T Cells
Supplementary data
Open the PDF for in another window
Primary Central Nervous System Lymphomas: A Validation Study of Array-Based Comparative Genomic Hybridization in Formalin-Fixed Paraffin-Embedded Tumor Specimens
Esteban Braggio; Ellen Remstein McPhail; William Macon; M. Beatriz Lopes; David Schiff; Mark Law; Stephanie Fink; Debra Sprau; Caterina Giannini; Ahmet Dogan; Rafael Fonseca; Brian Patrick O'Neill
View articletitled, Primary Central Nervous System Lymphomas: A Validation Study of Array-Based Comparative Genomic Hybridization in Formalin-Fixed Paraffin-Embedded Tumor Specimens
Open the PDF for in another window
KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer
Lilach Abramovitz; Tamar Rubinek; Hagai Ligumsky; Shikha Bose; Iris Barshack; Camila Avivi; Bella Kaufman; Ido Wolf
View articletitled, KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer
Supplementary data
Open the PDF for in another window
BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer
Sheetal Bhan; Sandeep S. Negi; Chunbo Shao; Chad A. Glazer; Alice Chuang; Daria A. Gaykalova; Wenyue Sun; David Sidransky; Patrick K. Ha; Joseph A. Califano
View articletitled, BORIS Binding to the Promoters of Cancer Testis Antigens, <em>MAGEA2</em>, <em>MAGEA3</em>, and <em>MAGEA4</em>, Is Associated with Their Transcriptional Activation in Lung Cancer
Open the PDF for in another window
Clinical Significance of miR-146a in Gastric Cancer Cases
Ryunosuke Kogo; Koshi Mimori; Fumiaki Tanaka; Shizuo Komune; Masaki Mori
View articletitled, Clinical Significance of <em>miR-146a</em> in Gastric Cancer Cases
Supplementary data
Open the PDF for in another window
PLK1 Is Transcriptionally Activated by NF-κB during Cell Detachment and Enhances Anoikis Resistance through Inhibiting β-Catenin Degradation in Esophageal Squamous Cell Carcinoma
De-Chen Lin; Yu Zhang; Qin-Jing Pan; Hai Yang; Zhi-Zhou Shi; Zhi-Hui Xie; Bo-Shi Wang; Jia-Jie Hao; Tong-Tong Zhang; Xin Xu; Qi-Min Zhan; Ming-Rong Wang
View articletitled, PLK1 Is Transcriptionally Activated by NF-κB during Cell Detachment and Enhances Anoikis Resistance through Inhibiting β-Catenin Degradation in Esophageal Squamous Cell Carcinoma
Supplementary data
Open the PDF for in another window
Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β
Jennifer Lohr; Thomas Ratliff; Andrea Huppertz; Yingzi Ge; Christine Dictus; Rezvan Ahmadi; Stefan Grau; Nobuyoshi Hiraoka; Volker Eckstein; Rupert C. Ecker; Thomas Korff; Andreas von Deimling; Andreas Unterberg; Philipp Beckhove; Christel Herold-Mende
View articletitled, Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β
Supplementary data
Open the PDF for in another window
MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin
Tricia Nardiello; Achim A. Jungbluth; Anna Mei; Maurizio DiLiberto; Xiangao Huang; Ania Dabrowski; Valéria C.C. Andrade; Rebecca Wasserstrum; Scott Ely; Ruben Niesvizky; Roger Pearse; Morton Coleman; David S. Jayabalan; Nina Bhardwaj; Lloyd J. Old; Selina Chen-Kiang; Hearn Jay Cho
View articletitled, MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin
Supplementary data
Open the PDF for in another window
Integrated, Genome-Wide Screening for Hypomethylated Oncogenes in Salivary Gland Adenoid Cystic Carcinoma
Chunbo Shao; Wenyue Sun; Marietta Tan; Chad A. Glazer; Sheetal Bhan; Xiaoli Zhong; Carole Fakhry; Rajni Sharma; William H. Westra; Mohammad O. Hoque; Christopher A. Moskaluk; David Sidransky; Joseph A. Califano; Patrick K. Ha
View articletitled, Integrated, Genome-Wide Screening for Hypomethylated Oncogenes in Salivary Gland Adenoid Cystic Carcinoma
Open the PDF for in another window
NGAL Expression Is Elevated in Both Colorectal Adenoma–Carcinoma Sequence and Cancer Progression and Enhances Tumorigenesis in Xenograft Mouse Models
Yan Sun; Kenji Yokoi; Hui Li; Jun Gao; Limei Hu; Ben Liu; Kexin Chen; Stanley R. Hamilton; Dominic Fan; Baocun Sun; Wei Zhang
View articletitled, NGAL Expression Is Elevated in Both Colorectal Adenoma–Carcinoma Sequence and Cancer Progression and Enhances Tumorigenesis in Xenograft Mouse Models
Open the PDF for in another window
Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma
Audrey Vincent; Noriyuki Omura; Seung-Mo Hong; Andrew Jaffe; James Eshleman; Michael Goggins
View articletitled, Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma
Supplementary data
Open the PDF for in another window
FGFR-4 Arg388 Enhances Prostate Cancer Progression via Extracellular Signal–Related Kinase and Serum Response Factor Signaling
Wendong Yu; Shu Feng; Olga Dakhova; Chad J. Creighton; Yi Cai; Jianghua Wang; Rile Li; Anna Frolov; Gustavo Ayala; Michael Ittmann
View articletitled, <em>FGFR-4</em> Arg<sup>388</sup> Enhances Prostate Cancer Progression via Extracellular Signal–Related Kinase and Serum Response Factor Signaling
Open the PDF for in another window
EGFR Signaling Regulates Tumor Cell Migration in Craniopharyngiomas
Annett Hölsken; Matthias Gebhardt; Michael Buchfelder; Rudolf Fahlbusch; Ingmar Blümcke; Rolf Buslei
View articletitled, EGFR Signaling Regulates Tumor Cell Migration in Craniopharyngiomas
Open the PDF for in another window

Cancer Therapy: Preclinical

Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors
Jessica K. Altman; Antonella Sassano; Surinder Kaur; Heather Glaser; Barbara Kroczynska; Amanda J. Redig; Suzanne Russo; Sharon Barr; Leonidas C. Platanias
View articletitled, Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors
Supplementary data
Open the PDF for in another window
FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation
Abdel Kareem Azab; Feda Azab; Phong Quang; Patricia Maiso; Antonio Sacco; Hai T. Ngo; Yang Liu; Yong Zhang; Brittany L. Morgan; Aldo M. Roccaro; Irene M. Ghobrial
View articletitled, FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation
Open the PDF for in another window
Epidermal Growth Factor Receptor Inhibition Augments the Expression of MHC Class I and II Genes
Brian P. Pollack; Bishu Sapkota; Todd V. Cartee
View articletitled, Epidermal Growth Factor Receptor Inhibition Augments the Expression of MHC Class I and II Genes
Supplementary data
Open the PDF for in another window
Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion
Yirong Li; Martin Ligr; James P. McCarron; Garrett Daniels; David Zhang; Xin Zhao; Fei Ye; Jinhua Wang; Xiaomei Liu; Iman Osman; Simon K. Mencher; Hebert Lepor; Long G. Wang; Peng Lee
View articletitled, Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion
Supplementary data
Open the PDF for in another window
Dual Blockade of EGFR and c-Met Abrogates Redundant Signaling and Proliferation in Head and Neck Carcinoma Cells
Hai Xu; Laura P. Stabile; Christopher T. Gubish; William E. Gooding; Jennifer R. Grandis; Jill M. Siegfried
View articletitled, Dual Blockade of EGFR and c-Met Abrogates Redundant Signaling and Proliferation in Head and Neck Carcinoma Cells
Supplementary data
Open the PDF for in another window
SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth In Vivo
Shuang Zhang; Zhixing Cao; Hongwei Tian; Guobo Shen; Yongping Ma; Huanzhang Xie; Yalin Liu; Chengjian Zhao; Senyi Deng; Yang Yang; Renlin Zheng; Weiwei Li; Na Zhang; Shengyong Liu; Wei Wang; Lixia Dai; Shuai Shi; Lin Cheng; Youli Pan; Shan Feng; Xia Zhao; Hongxin Deng; Shengyong Yang; Yuquan Wei
View articletitled, SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth <em>In Vivo</em>
Supplementary data
Open the PDF for in another window
Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies
Dana Faratian; Annelien J.M. Zweemer; Yoko Nagumo; Andrew H. Sims; Morwenna Muir; Michael Dodds; Peter Mullen; Inhwa Um; Charlene Kay; Max Hasmann; David J. Harrison; Simon P. Langdon
View articletitled, Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies
Supplementary data
Open the PDF for in another window
The Activity of Trabectedin As a Single Agent or in Combination with Everolimus for Clear Cell Carcinoma of the Ovary
Seiji Mabuchi; Takeshi Hisamatsu; Chiaki Kawase; Masami Hayashi; Kenjiro Sawada; Kazuya Mimura; Kazuhiro Takahashi; Toshifumi Takahashi; Hirohisa Kurachi; Tadashi Kimura
View articletitled, The Activity of Trabectedin As a Single Agent or in Combination with Everolimus for Clear Cell Carcinoma of the Ovary
Supplementary data
Open the PDF for in another window
The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model
Arun K. Sharma; Christina L. Kline; Arthur Berg; Shantu Amin; Rosalyn B. Irby
View articletitled, The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model
Open the PDF for in another window

Imaging, Diagnosis, Prognosis

Distinguishing Inflammation from Tumor and Peritumoral Edema by Myeloperoxidase Magnetic Resonance Imaging
Anne Kleijn; John W. Chen; Jason S. Buhrman; Gregory R. Wojtkiewicz; Yoshiko Iwamoto; Martine L. Lamfers; Anat O. Stemmer-Rachamimov; Samuel D. Rabkin; Ralph Weissleder; Robert L. Martuza; Giulia Fulci
View articletitled, Distinguishing Inflammation from Tumor and Peritumoral Edema by Myeloperoxidase Magnetic Resonance Imaging
Supplementary data
Open the PDF for in another window
An Epigenetic Marker Panel for Detection of Lung Cancer Using Cell-Free Serum DNA
Shahnaz Begum; Mariana Brait; Santanu Dasgupta; Kimberly L. Ostrow; Marianna Zahurak; André L. Carvalho; Joseph A. Califano; Steven N. Goodman; William H. Westra; Mohammad Obaidul Hoque; David Sidransky
View articletitled, An Epigenetic Marker Panel for Detection of Lung Cancer Using Cell-Free Serum DNA
Supplementary data
Open the PDF for in another window
Changes in Tumor Density in Patients with Advanced Hepatocellular Carcinoma Treated with Sunitinib
Sandrine Faivre; Magaly Zappa; Valérie Vilgrain; Eveline Boucher; Jean-Yves Douillard; Ho Y. Lim; Jun S. Kim; Seock-Ah Im; Yoon-Koo Kang; Mohamed Bouattour; Safi Dokmak; Chantal Dreyer; Marie-Paule Sablin; Camille Serrate; Ann-Lii Cheng; Silvana Lanzalone; Xun Lin; Maria J. Lechuga; Eric Raymond
View articletitled, Changes in Tumor Density in Patients with Advanced Hepatocellular Carcinoma Treated with Sunitinib
Open the PDF for in another window
Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma
Amin Ismail; Santhoshi Bandla; Marie Reveiller; Liana Toia; Zhongren Zhou; William E. Gooding; Irina Kalatskaya; Lincoln Stein; Mary D'Souza; Virginia R. Litle; Jeffrey H. Peters; Arjun Pennathur; James D. Luketich; Tony E. Godfrey
View articletitled, Early G<sub>1</sub> Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma
Supplementary data
Open the PDF for in another window
EFEMP1 as a Novel DNA Methylation Marker for Prostate Cancer: Array-Based DNA Methylation and Expression Profiling
Yong-June Kim; Hyung-Yoon Yoon; Seon-Kyu Kim; Young-Won Kim; Eun-Jung Kim; Isaac Yi Kim; Wun-Jae Kim
View articletitled, <em>EFEMP1</em> as a Novel DNA Methylation Marker for Prostate Cancer: Array-Based DNA Methylation and Expression Profiling
Open the PDF for in another window
Association of CHFR Promoter Methylation with Disease Recurrence in Locally Advanced Colon Cancer
Motofumi Tanaka; Ping Chang; Yanan Li; Donghui Li; Michael Overman; Dipen M. Maru; Salil Sethi; Jonathan Phillips; Gail L. Bland; James L. Abbruzzese; Cathy Eng
View articletitled, Association of <em>CHFR</em> Promoter Methylation with Disease Recurrence in Locally Advanced Colon Cancer
Open the PDF for in another window

Cancer Therapy: Clinical

Cancer Patients Treated with Sunitinib or Sorafenib Have Sufficient Antibody and Cellular Immune Responses to Warrant Influenza Vaccination
Sasja F. Mulder; Joannes F.M. Jacobs; Michel A.M. Olde Nordkamp; Joep M.D. Galama; Ingrid M.E. Desar; Ruurd Torensma; Steven Teerenstra; Peter F.A. Mulders; Kris C.P. Vissers; Cornelis J.A. Punt; I. Jolanda M. de Vries; Carla M.L. van Herpen
View articletitled, Cancer Patients Treated with Sunitinib or Sorafenib Have Sufficient Antibody and Cellular Immune Responses to Warrant Influenza Vaccination
Supplementary data
Open the PDF for in another window
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
Steven A. Rosenberg; James C. Yang; Richard M. Sherry; Udai S. Kammula; Marybeth S. Hughes; Giao Q. Phan; Deborah E. Citrin; Nicholas P. Restifo; Paul F. Robbins; John R. Wunderlich; Kathleen E. Morton; Carolyn M. Laurencot; Seth M. Steinberg; Donald E. White; Mark E. Dudley
View articletitled, Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
Supplementary data
Open the PDF for in another window
Randomized Trial of Autologous Cellular Immunotherapy with Sipuleucel-T in Androgen-Dependent Prostate Cancer
Tomasz M. Beer; Guy T. Bernstein; John M. Corman; L. Michael Glode; Simon J. Hall; Wayne L. Poll; Paul F. Schellhammer; Lori A. Jones; Yi Xu; Jelle W. Kylstra; Mark W. Frohlich
View articletitled, Randomized Trial of Autologous Cellular Immunotherapy with Sipuleucel-T in Androgen-Dependent Prostate Cancer
Open the PDF for in another window
Telomerase Peptide Vaccination Combined with Temozolomide: A Clinical Trial in Stage IV Melanoma Patients
Jon Amund Kyte; Gustav Gaudernack; Svein Dueland; Sissel Trachsel; Lars Julsrud; Steinar Aamdal
View articletitled, Telomerase Peptide Vaccination Combined with Temozolomide: A Clinical Trial in Stage IV Melanoma Patients
Supplementary data
Open the PDF for in another window

Predictive Biomarkers and Personalized Medicine

Multiple Loci Modulate Opioid Therapy Response for Cancer Pain
Antonella Galvan; Frank Skorpen; Pål Klepstad; Anne Kari Knudsen; Torill Fladvad; Felicia S. Falvella; Alessandra Pigni; Cinzia Brunelli; Augusto Caraceni; Stein Kaasa; Tommaso A. Dragani
View articletitled, Multiple Loci Modulate Opioid Therapy Response for Cancer Pain
Open the PDF for in another window
Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?
Christian Hartmann; Bettina Hentschel; Marcos Tatagiba; Johannes Schramm; Oliver Schnell; Clemens Seidel; Robert Stein; Guido Reifenberger; Torsten Pietsch; Andreas von Deimling; Markus Loeffler; Michael Weller; for the German Glioma Network
View articletitled, Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?
Supplementary data
Open the PDF for in another window
Effect of eIF3a on Response of Lung Cancer Patients to Platinum-Based Chemotherapy by Regulating DNA Repair
Ji-Ye Yin; Jie Shen; Zi-Zheng Dong; Qiong Huang; Mei-Zuo Zhong; De-Yun Feng; Hong-Hao Zhou; Jian-Ting Zhang; Zhao-Qian Liu
View articletitled, Effect of eIF3a on Response of Lung Cancer Patients to Platinum-Based Chemotherapy by Regulating DNA Repair
Supplementary data
Open the PDF for in another window

Letters to the Editor

Gefitinib versus Docetaxel for Previously Treated NSCLC—Letter
Davide Tassinari; Luigi Lazzari-Agli; Paola Tombesi; Sergio Sartori
View articletitled, Gefitinib versus Docetaxel for Previously Treated NSCLC—Letter
Open the PDF for in another window
Gefitinib versus Docetaxel for Previously Treated NSCLC—Response
Dae Ho Lee; Sang-We Kim
View articletitled, Gefitinib versus Docetaxel for Previously Treated NSCLC—Response
Open the PDF for in another window
Modeling the Tumor Growth Profiles in Xenograft Experiments—Letter
Ioannis D. Bassukas
View articletitled, Modeling the Tumor Growth Profiles in Xenograft Experiments—Letter
Open the PDF for in another window
Modeling the Tumor Growth Profiles in Xenograft Experiments—Response
Lili Zhao; Meredith A. Morgan; Leslie A. Parsels; Jonathan Maybaum; Theodore S. Lawrence; Daniel Normolle
View articletitled, Modeling the Tumor Growth Profiles in Xenograft Experiments—Response
Open the PDF for in another window
Clinical Trial Development as a Predictor of Accrual Performance—Letter
Anneke T. Schroen
View articletitled, Clinical Trial Development as a Predictor of Accrual Performance—Letter
Open the PDF for in another window
Clinical Trial Development as a Predictor of Accrual Performance—Response
Steven K. Cheng; David M. Dilts
View articletitled, Clinical Trial Development as a Predictor of Accrual Performance—Response
Open the PDF for in another window

Advertisement

  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

AACR Journals

 

 

  • Copyright © 2023 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept