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Volume 17, Issue 13
1 July 2011
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    Cover Image

    issue cover
    Immunohistochemical double-fluorescence analysis of an adamantinomatous craniopharyngioma in human brain. Activated EGFR (green) can be detected in tumor cells with nuclear β-catenin (red) accumulation (yellow). Cell nuclei (blue) were counterstained with Höchst. For further details, please see Hölsken and coworkers on page 4367 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

Getting Personal with Melanoma
Helen Heslop
View articletitled, Getting Personal with Melanoma
Supplementary data
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CCR New Strategies

New Strategies in Non–Small Cell Lung Cancer: Improving Outcomes in Chemoradiotherapy for Locally Advanced Disease
Ramesh Rengan; Amit M. Maity; James P. Stevenson; Stephen M. Hahn
View articletitled, New Strategies in Non–Small Cell Lung Cancer: Improving Outcomes in Chemoradiotherapy for Locally Advanced Disease
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Molecular Pathways

WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
Philip C. De Witt Hamer; Shahryar E. Mir; David Noske; Cornelis J.F. Van Noorden; Tom Würdinger
View articletitled, WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
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Adaptive Changes Result in Activation of Alternate Signaling Pathways and Acquisition of Resistance to Aromatase Inhibitors
Angela Brodie; Gauri Sabnis
View articletitled, Adaptive Changes Result in Activation of Alternate Signaling Pathways and Acquisition of Resistance to Aromatase Inhibitors
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Review

Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?
Jay D. Naik; Christopher J. Twelves; Peter J. Selby; Richard G. Vile; John D. Chester
View articletitled, Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?
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Perspective

Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!
Iris J.H. van Vlodrop; Hanneke E.C. Niessen; Sarah Derks; Marcella M.L.L. Baldewijns; Wim van Criekinge; James G. Herman; Manon van Engeland
View articletitled, Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!
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Human Cancer Biology

Programmed Death Ligand 1 Is Expressed by Non–Hodgkin Lymphomas and Inhibits the Activity of Tumor-Associated T Cells
David J. Andorsky; Reiko E. Yamada; Jonathan Said; Geraldine S. Pinkus; David J. Betting; John M. Timmerman
View articletitled, Programmed Death Ligand 1 Is Expressed by Non–Hodgkin Lymphomas and Inhibits the Activity of Tumor-Associated T Cells
Supplementary data
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Primary Central Nervous System Lymphomas: A Validation Study of Array-Based Comparative Genomic Hybridization in Formalin-Fixed Paraffin-Embedded Tumor Specimens
Esteban Braggio; Ellen Remstein McPhail; William Macon; M. Beatriz Lopes; David Schiff; Mark Law; Stephanie Fink; Debra Sprau; Caterina Giannini; Ahmet Dogan; Rafael Fonseca; Brian Patrick O'Neill
View articletitled, Primary Central Nervous System Lymphomas: A Validation Study of Array-Based Comparative Genomic Hybridization in Formalin-Fixed Paraffin-Embedded Tumor Specimens
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KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer
Lilach Abramovitz; Tamar Rubinek; Hagai Ligumsky; Shikha Bose; Iris Barshack; Camila Avivi; Bella Kaufman; Ido Wolf
View articletitled, KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer
Supplementary data
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BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer
Sheetal Bhan; Sandeep S. Negi; Chunbo Shao; Chad A. Glazer; Alice Chuang; Daria A. Gaykalova; Wenyue Sun; David Sidransky; Patrick K. Ha; Joseph A. Califano
View articletitled, BORIS Binding to the Promoters of Cancer Testis Antigens, <em>MAGEA2</em>, <em>MAGEA3</em>, and <em>MAGEA4</em>, Is Associated with Their Transcriptional Activation in Lung Cancer
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Clinical Significance of miR-146a in Gastric Cancer Cases
Ryunosuke Kogo; Koshi Mimori; Fumiaki Tanaka; Shizuo Komune; Masaki Mori
View articletitled, Clinical Significance of <em>miR-146a</em> in Gastric Cancer Cases
Supplementary data
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PLK1 Is Transcriptionally Activated by NF-κB during Cell Detachment and Enhances Anoikis Resistance through Inhibiting β-Catenin Degradation in Esophageal Squamous Cell Carcinoma
De-Chen Lin; Yu Zhang; Qin-Jing Pan; Hai Yang; Zhi-Zhou Shi; Zhi-Hui Xie; Bo-Shi Wang; Jia-Jie Hao; Tong-Tong Zhang; Xin Xu; Qi-Min Zhan; Ming-Rong Wang
View articletitled, PLK1 Is Transcriptionally Activated by NF-κB during Cell Detachment and Enhances Anoikis Resistance through Inhibiting β-Catenin Degradation in Esophageal Squamous Cell Carcinoma
Supplementary data
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Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β
Jennifer Lohr; Thomas Ratliff; Andrea Huppertz; Yingzi Ge; Christine Dictus; Rezvan Ahmadi; Stefan Grau; Nobuyoshi Hiraoka; Volker Eckstein; Rupert C. Ecker; Thomas Korff; Andreas von Deimling; Andreas Unterberg; Philipp Beckhove; Christel Herold-Mende
View articletitled, Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β
Supplementary data
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MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin
Tricia Nardiello; Achim A. Jungbluth; Anna Mei; Maurizio DiLiberto; Xiangao Huang; Ania Dabrowski; Valéria C.C. Andrade; Rebecca Wasserstrum; Scott Ely; Ruben Niesvizky; Roger Pearse; Morton Coleman; David S. Jayabalan; Nina Bhardwaj; Lloyd J. Old; Selina Chen-Kiang; Hearn Jay Cho
View articletitled, MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin
Supplementary data
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Integrated, Genome-Wide Screening for Hypomethylated Oncogenes in Salivary Gland Adenoid Cystic Carcinoma
Chunbo Shao; Wenyue Sun; Marietta Tan; Chad A. Glazer; Sheetal Bhan; Xiaoli Zhong; Carole Fakhry; Rajni Sharma; William H. Westra; Mohammad O. Hoque; Christopher A. Moskaluk; David Sidransky; Joseph A. Califano; Patrick K. Ha
View articletitled, Integrated, Genome-Wide Screening for Hypomethylated Oncogenes in Salivary Gland Adenoid Cystic Carcinoma
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NGAL Expression Is Elevated in Both Colorectal Adenoma–Carcinoma Sequence and Cancer Progression and Enhances Tumorigenesis in Xenograft Mouse Models
Yan Sun; Kenji Yokoi; Hui Li; Jun Gao; Limei Hu; Ben Liu; Kexin Chen; Stanley R. Hamilton; Dominic Fan; Baocun Sun; Wei Zhang
View articletitled, NGAL Expression Is Elevated in Both Colorectal Adenoma–Carcinoma Sequence and Cancer Progression and Enhances Tumorigenesis in Xenograft Mouse Models
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Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma
Audrey Vincent; Noriyuki Omura; Seung-Mo Hong; Andrew Jaffe; James Eshleman; Michael Goggins
View articletitled, Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma
Supplementary data
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FGFR-4 Arg388 Enhances Prostate Cancer Progression via Extracellular Signal–Related Kinase and Serum Response Factor Signaling
Wendong Yu; Shu Feng; Olga Dakhova; Chad J. Creighton; Yi Cai; Jianghua Wang; Rile Li; Anna Frolov; Gustavo Ayala; Michael Ittmann
View articletitled, <em>FGFR-4</em> Arg<sup>388</sup> Enhances Prostate Cancer Progression via Extracellular Signal–Related Kinase and Serum Response Factor Signaling
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EGFR Signaling Regulates Tumor Cell Migration in Craniopharyngiomas
Annett Hölsken; Matthias Gebhardt; Michael Buchfelder; Rudolf Fahlbusch; Ingmar Blümcke; Rolf Buslei
View articletitled, EGFR Signaling Regulates Tumor Cell Migration in Craniopharyngiomas
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Cancer Therapy: Preclinical

Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors
Jessica K. Altman; Antonella Sassano; Surinder Kaur; Heather Glaser; Barbara Kroczynska; Amanda J. Redig; Suzanne Russo; Sharon Barr; Leonidas C. Platanias
View articletitled, Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors
Supplementary data
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FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation
Abdel Kareem Azab; Feda Azab; Phong Quang; Patricia Maiso; Antonio Sacco; Hai T. Ngo; Yang Liu; Yong Zhang; Brittany L. Morgan; Aldo M. Roccaro; Irene M. Ghobrial
View articletitled, FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation
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Epidermal Growth Factor Receptor Inhibition Augments the Expression of MHC Class I and II Genes
Brian P. Pollack; Bishu Sapkota; Todd V. Cartee
View articletitled, Epidermal Growth Factor Receptor Inhibition Augments the Expression of MHC Class I and II Genes
Supplementary data
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Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion
Yirong Li; Martin Ligr; James P. McCarron; Garrett Daniels; David Zhang; Xin Zhao; Fei Ye; Jinhua Wang; Xiaomei Liu; Iman Osman; Simon K. Mencher; Hebert Lepor; Long G. Wang; Peng Lee
View articletitled, Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion
Supplementary data
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Dual Blockade of EGFR and c-Met Abrogates Redundant Signaling and Proliferation in Head and Neck Carcinoma Cells
Hai Xu; Laura P. Stabile; Christopher T. Gubish; William E. Gooding; Jennifer R. Grandis; Jill M. Siegfried
View articletitled, Dual Blockade of EGFR and c-Met Abrogates Redundant Signaling and Proliferation in Head and Neck Carcinoma Cells
Supplementary data
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SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth In Vivo
Shuang Zhang; Zhixing Cao; Hongwei Tian; Guobo Shen; Yongping Ma; Huanzhang Xie; Yalin Liu; Chengjian Zhao; Senyi Deng; Yang Yang; Renlin Zheng; Weiwei Li; Na Zhang; Shengyong Liu; Wei Wang; Lixia Dai; Shuai Shi; Lin Cheng; Youli Pan; Shan Feng; Xia Zhao; Hongxin Deng; Shengyong Yang; Yuquan Wei
View articletitled, SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth <em>In Vivo</em>
Supplementary data
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Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies
Dana Faratian; Annelien J.M. Zweemer; Yoko Nagumo; Andrew H. Sims; Morwenna Muir; Michael Dodds; Peter Mullen; Inhwa Um; Charlene Kay; Max Hasmann; David J. Harrison; Simon P. Langdon
View articletitled, Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies
Supplementary data
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The Activity of Trabectedin As a Single Agent or in Combination with Everolimus for Clear Cell Carcinoma of the Ovary
Seiji Mabuchi; Takeshi Hisamatsu; Chiaki Kawase; Masami Hayashi; Kenjiro Sawada; Kazuya Mimura; Kazuhiro Takahashi; Toshifumi Takahashi; Hirohisa Kurachi; Tadashi Kimura
View articletitled, The Activity of Trabectedin As a Single Agent or in Combination with Everolimus for Clear Cell Carcinoma of the Ovary
Supplementary data
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The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model
Arun K. Sharma; Christina L. Kline; Arthur Berg; Shantu Amin; Rosalyn B. Irby
View articletitled, The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model
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Imaging, Diagnosis, Prognosis

Distinguishing Inflammation from Tumor and Peritumoral Edema by Myeloperoxidase Magnetic Resonance Imaging
Anne Kleijn; John W. Chen; Jason S. Buhrman; Gregory R. Wojtkiewicz; Yoshiko Iwamoto; Martine L. Lamfers; Anat O. Stemmer-Rachamimov; Samuel D. Rabkin; Ralph Weissleder; Robert L. Martuza; Giulia Fulci
View articletitled, Distinguishing Inflammation from Tumor and Peritumoral Edema by Myeloperoxidase Magnetic Resonance Imaging
Supplementary data
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An Epigenetic Marker Panel for Detection of Lung Cancer Using Cell-Free Serum DNA
Shahnaz Begum; Mariana Brait; Santanu Dasgupta; Kimberly L. Ostrow; Marianna Zahurak; André L. Carvalho; Joseph A. Califano; Steven N. Goodman; William H. Westra; Mohammad Obaidul Hoque; David Sidransky
View articletitled, An Epigenetic Marker Panel for Detection of Lung Cancer Using Cell-Free Serum DNA
Supplementary data
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Changes in Tumor Density in Patients with Advanced Hepatocellular Carcinoma Treated with Sunitinib
Sandrine Faivre; Magaly Zappa; Valérie Vilgrain; Eveline Boucher; Jean-Yves Douillard; Ho Y. Lim; Jun S. Kim; Seock-Ah Im; Yoon-Koo Kang; Mohamed Bouattour; Safi Dokmak; Chantal Dreyer; Marie-Paule Sablin; Camille Serrate; Ann-Lii Cheng; Silvana Lanzalone; Xun Lin; Maria J. Lechuga; Eric Raymond
View articletitled, Changes in Tumor Density in Patients with Advanced Hepatocellular Carcinoma Treated with Sunitinib
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Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma
Amin Ismail; Santhoshi Bandla; Marie Reveiller; Liana Toia; Zhongren Zhou; William E. Gooding; Irina Kalatskaya; Lincoln Stein; Mary D'Souza; Virginia R. Litle; Jeffrey H. Peters; Arjun Pennathur; James D. Luketich; Tony E. Godfrey
View articletitled, Early G<sub>1</sub> Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma
Supplementary data
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EFEMP1 as a Novel DNA Methylation Marker for Prostate Cancer: Array-Based DNA Methylation and Expression Profiling
Yong-June Kim; Hyung-Yoon Yoon; Seon-Kyu Kim; Young-Won Kim; Eun-Jung Kim; Isaac Yi Kim; Wun-Jae Kim
View articletitled, <em>EFEMP1</em> as a Novel DNA Methylation Marker for Prostate Cancer: Array-Based DNA Methylation and Expression Profiling
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Association of CHFR Promoter Methylation with Disease Recurrence in Locally Advanced Colon Cancer
Motofumi Tanaka; Ping Chang; Yanan Li; Donghui Li; Michael Overman; Dipen M. Maru; Salil Sethi; Jonathan Phillips; Gail L. Bland; James L. Abbruzzese; Cathy Eng
View articletitled, Association of <em>CHFR</em> Promoter Methylation with Disease Recurrence in Locally Advanced Colon Cancer
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Cancer Therapy: Clinical

Cancer Patients Treated with Sunitinib or Sorafenib Have Sufficient Antibody and Cellular Immune Responses to Warrant Influenza Vaccination
Sasja F. Mulder; Joannes F.M. Jacobs; Michel A.M. Olde Nordkamp; Joep M.D. Galama; Ingrid M.E. Desar; Ruurd Torensma; Steven Teerenstra; Peter F.A. Mulders; Kris C.P. Vissers; Cornelis J.A. Punt; I. Jolanda M. de Vries; Carla M.L. van Herpen
View articletitled, Cancer Patients Treated with Sunitinib or Sorafenib Have Sufficient Antibody and Cellular Immune Responses to Warrant Influenza Vaccination
Supplementary data
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Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
Steven A. Rosenberg; James C. Yang; Richard M. Sherry; Udai S. Kammula; Marybeth S. Hughes; Giao Q. Phan; Deborah E. Citrin; Nicholas P. Restifo; Paul F. Robbins; John R. Wunderlich; Kathleen E. Morton; Carolyn M. Laurencot; Seth M. Steinberg; Donald E. White; Mark E. Dudley
View articletitled, Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
Supplementary data
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Randomized Trial of Autologous Cellular Immunotherapy with Sipuleucel-T in Androgen-Dependent Prostate Cancer
Tomasz M. Beer; Guy T. Bernstein; John M. Corman; L. Michael Glode; Simon J. Hall; Wayne L. Poll; Paul F. Schellhammer; Lori A. Jones; Yi Xu; Jelle W. Kylstra; Mark W. Frohlich
View articletitled, Randomized Trial of Autologous Cellular Immunotherapy with Sipuleucel-T in Androgen-Dependent Prostate Cancer
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Telomerase Peptide Vaccination Combined with Temozolomide: A Clinical Trial in Stage IV Melanoma Patients
Jon Amund Kyte; Gustav Gaudernack; Svein Dueland; Sissel Trachsel; Lars Julsrud; Steinar Aamdal
View articletitled, Telomerase Peptide Vaccination Combined with Temozolomide: A Clinical Trial in Stage IV Melanoma Patients
Supplementary data
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Predictive Biomarkers and Personalized Medicine

Multiple Loci Modulate Opioid Therapy Response for Cancer Pain
Antonella Galvan; Frank Skorpen; Pål Klepstad; Anne Kari Knudsen; Torill Fladvad; Felicia S. Falvella; Alessandra Pigni; Cinzia Brunelli; Augusto Caraceni; Stein Kaasa; Tommaso A. Dragani
View articletitled, Multiple Loci Modulate Opioid Therapy Response for Cancer Pain
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Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?
Christian Hartmann; Bettina Hentschel; Marcos Tatagiba; Johannes Schramm; Oliver Schnell; Clemens Seidel; Robert Stein; Guido Reifenberger; Torsten Pietsch; Andreas von Deimling; Markus Loeffler; Michael Weller; for the German Glioma Network
View articletitled, Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?
Supplementary data
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Effect of eIF3a on Response of Lung Cancer Patients to Platinum-Based Chemotherapy by Regulating DNA Repair
Ji-Ye Yin; Jie Shen; Zi-Zheng Dong; Qiong Huang; Mei-Zuo Zhong; De-Yun Feng; Hong-Hao Zhou; Jian-Ting Zhang; Zhao-Qian Liu
View articletitled, Effect of eIF3a on Response of Lung Cancer Patients to Platinum-Based Chemotherapy by Regulating DNA Repair
Supplementary data
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Letters to the Editor

Gefitinib versus Docetaxel for Previously Treated NSCLC—Letter
Davide Tassinari; Luigi Lazzari-Agli; Paola Tombesi; Sergio Sartori
View articletitled, Gefitinib versus Docetaxel for Previously Treated NSCLC—Letter
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Gefitinib versus Docetaxel for Previously Treated NSCLC—Response
Dae Ho Lee; Sang-We Kim
View articletitled, Gefitinib versus Docetaxel for Previously Treated NSCLC—Response
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Modeling the Tumor Growth Profiles in Xenograft Experiments—Letter
Ioannis D. Bassukas
View articletitled, Modeling the Tumor Growth Profiles in Xenograft Experiments—Letter
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Modeling the Tumor Growth Profiles in Xenograft Experiments—Response
Lili Zhao; Meredith A. Morgan; Leslie A. Parsels; Jonathan Maybaum; Theodore S. Lawrence; Daniel Normolle
View articletitled, Modeling the Tumor Growth Profiles in Xenograft Experiments—Response
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Clinical Trial Development as a Predictor of Accrual Performance—Letter
Anneke T. Schroen
View articletitled, Clinical Trial Development as a Predictor of Accrual Performance—Letter
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Clinical Trial Development as a Predictor of Accrual Performance—Response
Steven K. Cheng; David M. Dilts
View articletitled, Clinical Trial Development as a Predictor of Accrual Performance—Response
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