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Volume 17, Issue 11
1 June 2011
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  • Cover Image

    Cover Image

    issue cover
    Dopamine receptor 2 (DR2) expression in SKOV3ip1 tumors in vivo. The cover figure shows immunofluorescence colocalization (yellow) of DR2 (red) CD31 (green). Nuclear staining is shown in blue. Dopamine replacement was effective in blocking the growth promoting effects of chronic stress in a mouse model of ovarian cancer. For further details, please see Moreno-Smith and coworkers on page 3649 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

Of Timing and Surrogates: A Way Forward for Cancer Chemoprevention
Patricia A. Thompson; Eugene W. Gerner
View articletitled, Of Timing and Surrogates: A Way Forward for Cancer Chemoprevention
Supplementary data
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CCR New Strategies

New Strategies in Barrett's Esophagus: Integrating Clonal Evolutionary Theory with Clinical Management
Brian J. Reid; Rumen Kostadinov; Carlo C. Maley
View articletitled, New Strategies in Barrett's Esophagus: Integrating Clonal Evolutionary Theory with Clinical Management
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CCR Drug Updates

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine
Martin A. Cheever; Celestia S. Higano
View articletitled, PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine
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Molecular Pathways

Targeting the BMK1 MAP Kinase Pathway in Cancer Therapy
Qingkai Yang; Jiing-Dwan Lee
View articletitled, Targeting the BMK1 MAP Kinase Pathway in Cancer Therapy
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Nicotinic Acetylcholine Receptor-Based Blockade: Applications of Molecular Targets for Cancer Therapy
Chih-Hsiung Wu; Chia-Hwa Lee; Yuan-Soon Ho
View articletitled, Nicotinic Acetylcholine Receptor-Based Blockade: Applications of Molecular Targets for Cancer Therapy
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Human Cancer Biology

Genomic Profiles Specific to Patient Ethnicity in Lung Adenocarcinoma
Philippe Broët; Cyril Dalmasso; Eng Huat Tan; Marco Alifano; Shenli Zhang; Jeanie Wu; Ming Hui Lee; Jean-François Régnard; Darren Lim; Heng Nung Koong; Thirugnanam Agasthian; Lance D. Miller; Elaine Lim; Sophie Camilleri-Broët; Patrick Tan
View articletitled, Genomic Profiles Specific to Patient Ethnicity in Lung Adenocarcinoma
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Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis
Matthias Holdhoff; Kerstin Schmidt; Frank Diehl; Nishant Aggrawal; Philipp Angenendt; Katharine Romans; Daniel L. Edelstein; Michael Torbenson; Kenneth W. Kinzler; Bert Vogelstein; Michael A. Choti; Luis A. Diaz, Jr.
View articletitled, Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis
Supplementary data
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KLF4-Mediated Negative Regulation of IFITM3 Expression Plays a Critical Role in Colon Cancer Pathogenesis
Dawei Li; Zhihai Peng; Huamei Tang; Ping Wei; Xiangyu Kong; Dongwang Yan; Fei Huang; Qiang Li; Xiangdong Le; Qi Li; Keping Xie
View articletitled, KLF4-Mediated Negative Regulation of IFITM3 Expression Plays a Critical Role in Colon Cancer Pathogenesis
Supplementary data
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HOXB7 as a Prognostic Factor and Mediator of Colorectal Cancer Progression
Wen-Ting Liao; Dan Jiang; Jian Yuan; Yan-Mei Cui; Xi-Wen Shi; Cui-Min Chen; Xiu-Wu Bian; Yong-Jian Deng; Yan-Qing Ding
View articletitled, HOXB7 as a Prognostic Factor and Mediator of Colorectal Cancer Progression
Supplementary data
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Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
Graham M. Poage; E. Andres Houseman; Brock C. Christensen; Rondi A. Butler; Michele Avissar-Whiting; Michael D. McClean; Tim Waterboer; Michael Pawlita; Carmen J. Marsit; Karl T. Kelsey
View articletitled, Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
Supplementary data
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BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model
Eric H. Raabe; Kah Suan Lim; Julia M. Kim; Alan Meeker; Xing-gang Mao; Guido Nikkhah; Jarek Maciaczyk; Ulf Kahlert; Deepali Jain; Eli Bar; Kenneth J. Cohen; Charles G. Eberhart
View articletitled, BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model
Supplementary data
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mRNA and microRNA Expression Profiles in Circulating Tumor Cells and Primary Tumors of Metastatic Breast Cancer Patients
Anieta M. Sieuwerts; Bianca Mostert; Joan Bolt-de Vries; Dieter Peeters; Felix E. de Jongh; Jacqueline M.L. Stouthard; Luc Y. Dirix; Peter A. van Dam; Anne Van Galen; Vanja de Weerd; Jaco Kraan; Petra van der Spoel; Raquel Ramírez-Moreno; Carolien H.M. van Deurzen; Marcel Smid; Jack X. Yu; John Jiang; Yixin Wang; Jan W. Gratama; Stefan Sleijfer; John A. Foekens; John W.M. Martens
View articletitled, mRNA and microRNA Expression Profiles in Circulating Tumor Cells and Primary Tumors of Metastatic Breast Cancer Patients
Supplementary data
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The EGFR Ligands Amphiregulin and Heparin-Binding EGF-like Growth Factor Promote Peritoneal Carcinomatosis in CXCR4-Expressing Gastric Cancer
Kazuo Yasumoto; Tadaaki Yamada; Atsuhiro Kawashima; Wei Wang; Qi Li; Ivan Shterev Donev; Shinji Tacheuchi; Hisatsugu Mouri; Kaname Yamashita; Koushiro Ohtsubo; Seiji Yano
View articletitled, The EGFR Ligands Amphiregulin and Heparin-Binding EGF-like Growth Factor Promote Peritoneal Carcinomatosis in CXCR4-Expressing Gastric Cancer
Supplementary data
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The Transcription Factor Evi-1 Is Overexpressed, Promotes Proliferation, and Is Prognostically Unfavorable in Infratentorial Ependymomas
Björn Koos; Sebastian Bender; Hendrik Witt; Sonja Mertsch; Jörg Felsberg; Rudi Beschorner; Andrey Korshunov; Barbara Riesmeier; Stefan Pfister; Werner Paulus; Martin Hasselblatt
View articletitled, The Transcription Factor Evi-1 Is Overexpressed, Promotes Proliferation, and Is Prognostically Unfavorable in Infratentorial Ependymomas
Supplementary data
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PDGF-D Improves Drug Delivery and Efficacy via Vascular Normalization, But Promotes Lymphatic Metastasis by Activating CXCR4 in Breast Cancer
Jieqiong Liu; Shan Liao; Yuhui Huang; Rekha Samuel; Tony Shi; Kamila Naxerova; Peigen Huang; Walid Kamoun; Rakesh K. Jain; Dai Fukumura; Lei Xu
View articletitled, PDGF-D Improves Drug Delivery and Efficacy via Vascular Normalization, But Promotes Lymphatic Metastasis by Activating CXCR4 in Breast Cancer
Supplementary data
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Dopamine Blocks Stress-Mediated Ovarian Carcinoma Growth
Myrthala Moreno-Smith; Chunhua Lu; Mian M.K. Shahzad; Guillermo N. Armaiz Pena; Julie K. Allen; Rebecca L. Stone; Lingegowda S. Mangala; Hee Dong Han; Hye Sun Kim; Donna Farley; Gabriel Lopez Berestein; Steve W. Cole; Susan K. Lutgendorf; Anil K. Sood
View articletitled, Dopamine Blocks Stress-Mediated Ovarian Carcinoma Growth
Supplementary data
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Cancer Therapy: Preclinical

Role of CXCR3 Ligands in IL-7/IL-7Rα-Fc–Mediated Antitumor Activity in Lung Cancer
Åsa Andersson; Minu K. Srivastava; Marni Harris-White; Min Huang; Li Zhu; David Elashoff; Robert M. Strieter; Steven M. Dubinett; Sherven Sharma
View articletitled, Role of CXCR3 Ligands in IL-7/IL-7Rα-Fc–Mediated Antitumor Activity in Lung Cancer
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A Low-Toxicity IL-2–Based Immunocytokine Retains Antitumor Activity Despite Its High Degree of IL-2 Receptor Selectivity
Stephen D. Gillies; Yan Lan; Thore Hettmann; Beatrice Brunkhorst; Yaping Sun; Stefan O. Mueller; Kin-Ming Lo
View articletitled, A Low-Toxicity IL-2–Based Immunocytokine Retains Antitumor Activity Despite Its High Degree of IL-2 Receptor Selectivity
Supplementary data
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A Novel Oncolytic Herpes Simplex Virus that Synergizes with Phosphoinositide 3-kinase/Akt Pathway Inhibitors to Target Glioblastoma Stem Cells
Ryuichi Kanai; Hiroaki Wakimoto; Robert L. Martuza; Samuel D. Rabkin
View articletitled, A Novel Oncolytic Herpes Simplex Virus that Synergizes with Phosphoinositide 3-kinase/Akt Pathway Inhibitors to Target Glioblastoma Stem Cells
Supplementary data
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Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts
Miriam E. Mossoba; Masanori Onda; Justin Taylor; Paul R. Massey; Shirin Treadwell; Elad Sharon; Raffit Hassan; Ira Pastan; Daniel H. Fowler
View articletitled, Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts
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Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
Leslie A. Parsels; Yushen Qian; Daria M. Tanska; Marisa Gross; Lili Zhao; Maria C. Hassan; Sankari Arumugarajah; Joshua D. Parsels; Linda Hylander-Gans; Diane M. Simeone; Deborah Morosini; Jeffrey L. Brown; Sonya D. Zabludoff; Jonathan Maybaum; Theodore S. Lawrence; Meredith A. Morgan
View articletitled, Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
Supplementary data
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Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer
Pablo E. Vivas-Mejia; Cristian Rodriguez-Aguayo; Hee-Dong Han; Mian M.K. Shahzad; Fatma Valiyeva; Mineko Shibayama; Arturo Chavez-Reyes; Anil K. Sood; Gabriel Lopez-Berestein
View articletitled, Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer
Supplementary data
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Imaging, Diagnosis, Prognosis

Accurate Classification of Diffuse Large B-Cell Lymphoma into Germinal Center and Activated B-Cell Subtypes Using a Nuclease Protection Assay on Formalin-Fixed, Paraffin-Embedded Tissues
Lisa M. Rimsza; George Wright; Mark Schwartz; Wing C. Chan; Elaine S. Jaffe; Randy D. Gascoyne; Elias Campo; Andreas Rosenwald; German Ott; James R. Cook; Raymond R. Tubbs; Rita M. Braziel; Jan Delabie; Tom P. Miller; Louis M. Staudt
View articletitled, Accurate Classification of Diffuse Large B-Cell Lymphoma into Germinal Center and Activated B-Cell Subtypes Using a Nuclease Protection Assay on Formalin-Fixed, Paraffin-Embedded Tissues
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Prognostic Significance of Truncating TP53 Mutations in Head and Neck Squamous Cell Carcinoma
Marlon Lindenbergh-van der Plas; Ruud H. Brakenhoff; Dirk J. Kuik; Marijke Buijze; Elisabeth Bloemena; Peter J.F. Snijders; C. René Leemans; Boudewijn J.M. Braakhuis
View articletitled, Prognostic Significance of Truncating <em>TP53</em> Mutations in Head and Neck Squamous Cell Carcinoma
Supplementary data
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The Role of KRAS rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing
Paul D. P. Pharoah; Rachel T. Palmieri; Susan J. Ramus; Simon A. Gayther; Irene L. Andrulis; Hoda Anton-Culver; Natalia Antonenkova; Antonis C. Antoniou; David Goldgar; Mary S. Beattie; Matthias W. Beckmann; Michael J. Birrer; Natalia Bogdanova; Kelly L. Bolton; Wendy Brewster; Angela Brooks-Wilson; Robert Brown; Ralf Butzow; Trinidad Caldes; Maria Adelaide Caligo; Ian Campbell; Jenny Chang-Claude; Y. Ann Chen; Linda S. Cook; Fergus J. Couch; Daniel W. Cramer; Julie M. Cunningham; Evelyn Despierre; Jennifer A. Doherty; Thilo Dörk; Matthias Dürst; Diana M. Eccles; Arif B. Ekici; Douglas Easton; Peter A. Fasching; Anna de Fazio; David A. Fenstermacher; James M. Flanagan; Brooke L. Fridley; Eitan Friedman; Bo Gao; Olga Sinilnikova; Aleksandra Gentry-Maharaj; Andrew K. Godwin; Ellen L. Goode; Marc T. Goodman; Jenny Gross; Thomas V. O. Hansen; Paul Harnett; Matti Rookus; Tuomas Heikkinen; Rebecca Hein; Claus Høgdall; Estrid Høgdall; Edwin S. Iversen; Anna Jakubowska; Sharon E. Johnatty; Beth Y. Karlan; Noah D. Kauff; Stanley B. Kaye; Georgia Chenevix-Trench; Linda E. Kelemen; Lambertus A. Kiemeney; Susanne Krüger Kjaer; Diether Lambrechts; James P. LaPolla; Conxi Lázaro; Nhu D. Le; Arto Leminen; Karin Leunen; Douglas A. Levine; Yi Lu; Lene Lundvall; Stuart Macgregor; Tamara Marees; Leon F. Massuger; John R. McLaughlin; Usha Menon; Marco Montagna; Kirsten B. Moysich; Steven A. Narod; Katherine L. Nathanson; Lotte Nedergaard; Roberta B. Ness; Heli Nevanlinna; Stefan Nickels; Ana Osorio; Jim Paul; Celeste Leigh Pearce; Catherine M. Phelan; Malcolm C. Pike; Paolo Radice; Mary Anne Rossing; Joellen M. Schildkraut; Thomas A. Sellers; Christian F. Singer; Honglin Song; Daniel O. Stram; Rebecca Sutphen; Annika Lindblom; Kathryn L. Terry; Ya-Yu Tsai; Anne M. van Altena; Ignace Vergote; Robert A. Vierkant; Allison F. Vitonis; Christine Walsh; Shan Wang-Gohrke; Barbara Wappenschmidt; Anna H. Wu; Argyrios Ziogas; Andrew Berchuck; Harvey A. Risch; for the BCFR Investigators
View articletitled, The Role of <em>KRAS</em> rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing
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The Sensitivity of [11C]Choline PET/CT to Localize Prostate Cancer Depends on the Tumor Configuration
Michael Souvatzoglou; Gregor Weirich; Sarah Schwarzenboeck; Tobias Maurer; Tibor Schuster; Ralph Alexander Bundschuh; Matthias Eiber; Ken Herrmann; Hubert Kuebler; Hans Juergen Wester; Heinz Hoefler; Juergen Gschwend; Markus Schwaiger; Uwe Treiber; Bernd Joachim Krause
View articletitled, The Sensitivity of [<sup>11</sup>C]Choline PET/CT to Localize Prostate Cancer Depends on the Tumor Configuration
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Biological Function and Prognostic Significance of Peroxisome Proliferator-Activated Receptor δ in Rectal Cancer
Lie Yang; Hong Zhang; Zong-Guang Zhou; Hui Yan; G Adell; Xiao-Feng Sun
View articletitled, Biological Function and Prognostic Significance of Peroxisome Proliferator-Activated Receptor δ in Rectal Cancer
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Prognostic Significance of p14ARF, p15INK4b, and p16INK4a Inactivation in Malignant Peripheral Nerve Sheath Tumors
Makoto Endo; Chikashi Kobayashi; Nokitaka Setsu; Yusuke Takahashi; Kenichi Kohashi; Hidetaka Yamamoto; Sadafumi Tamiya; Shuichi Matsuda; Yukihide Iwamoto; Masazumi Tsuneyoshi; Yoshinao Oda
View articletitled, Prognostic Significance of <em>p14<sup>ARF</sup></em>, <em>p15<sup>INK4b</sup></em>, and <em>p16<sup>INK4a</sup></em> Inactivation in Malignant Peripheral Nerve Sheath Tumors
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Isolation of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Using a Novel Cell Separation Strategy
Wen Xu; Lu Cao; Lei Chen; Jing Li; Xiao-Feng Zhang; Hai-Hua Qian; Xiao-Yan Kang; Yu Zhang; Jian Liao; Le-Hua Shi; Ye-Fa Yang; Meng-Chao Wu; Zheng-Feng Yin
View articletitled, Isolation of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Using a Novel Cell Separation Strategy
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Cancer Therapy: Clinical

Phase I Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-linking Agent, in Advanced Solid Tumors
Igor Puzanov; Wooin Lee; Alice P. Chen; M. Wade Calcutt; David L. Hachey; Wendy L. Vermeulen; Victoria J. Spanswick; Chih-Yi Liao; John A. Hartley; Jordan D. Berlin; Mace L. Rothenberg
View articletitled, Phase I Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-linking Agent, in Advanced Solid Tumors
Supplementary data
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Randomized Double-Blind Trial of Sulindac and Etodolac to Eradicate Aberrant Crypt Foci and to Prevent Sporadic Colorectal Polyps
Tetsuji Takayama; Hiroyuki Nagashima; Masahiro Maeda; Shuichi Nojiri; Michiaki Hirayama; Yoichiro Nakano; Yasuo Takahashi; Yasushi Sato; Hitoshi Sekikawa; Mitsuru Mori; Tomoko Sonoda; Tetsuo Kimura; Junji Kato; Yoshiro Niitsu
View articletitled, Randomized Double-Blind Trial of Sulindac and Etodolac to Eradicate Aberrant Crypt Foci and to Prevent Sporadic Colorectal Polyps
Supplementary data
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Predictive Biomarkers and Personalized Medicine

Effectiveness of Tyrosine Kinase Inhibitors on “Uncommon” Epidermal Growth Factor Receptor Mutations of Unknown Clinical Significance in Non–Small Cell Lung Cancer
Jenn-Yu Wu; Chong-Jen Yu; Yeun-Chung Chang; Chih-Hsin Yang; Jin-Yuan Shih; Pan-Chyr Yang
View articletitled, Effectiveness of Tyrosine Kinase Inhibitors on “Uncommon” Epidermal Growth Factor Receptor Mutations of Unknown Clinical Significance in Non–Small Cell Lung Cancer
Supplementary data
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Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients
Shoaib Afzal; Milena Gusella; Ben Vainer; Ulla B. Vogel; Jon T. Andersen; Kasper Broedbaek; Morten Petersen; Espen Jimenez-Solem; Laura Bertolaso; Carmen Barile; Roberto Padrini; Felice Pasini; Søren A. Jensen; Henrik E. Poulsen
View articletitled, Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients
Supplementary data
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Genetic Variations in Multiple Drug Action Pathways and Survival in Advanced Stage Non–Small Cell Lung Cancer Treated with Chemotherapy
Yafei Li; Zhifu Sun; Julie M. Cunningham; Marie C. Aubry; Jason A. Wampfler; Gary A. Croghan; Cassandra Johnson; Danli Wu; Jeremiah A. Aakre; Julian Molina; Liewei Wang; V. Shane Pankratz; Ping Yang
View articletitled, Genetic Variations in Multiple Drug Action Pathways and Survival in Advanced Stage Non–Small Cell Lung Cancer Treated with Chemotherapy
Supplementary data
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Diastolic Blood Pressure as a Biomarker of Axitinib Efficacy in Solid Tumors
Brian I. Rini; Joan H. Schiller; John P. Fruehauf; Ezra E.W. Cohen; Jamal C. Tarazi; Brad Rosbrook; Angel H. Bair; Alejandro D. Ricart; Anthony J. Olszanski; Kristen J. Letrent; Sinil Kim; Olivier Rixe
View articletitled, Diastolic Blood Pressure as a Biomarker of Axitinib Efficacy in Solid Tumors
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Corrections

Correction: A Novel Fusion Toxin Derived from an EpCAM-Specific Designed Ankyrin Repeat Protein Has Potent Antitumor Activity
View articletitled, Correction: A Novel Fusion Toxin Derived from an EpCAM-Specific Designed Ankyrin Repeat Protein Has Potent Antitumor Activity
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Correction: Peptide-Loaded Langerhans Cells, Despite Increased IL15 Secretion and T-Cell Activation In Vitro, Elicit Antitumor T-Cell Responses Comparable to Peptide-Loaded Monocyte-Derived Dendritic Cells In Vivo
View articletitled, Correction: Peptide-Loaded Langerhans Cells, Despite Increased IL15 Secretion and T-Cell Activation <em>In Vitro</em>, Elicit Antitumor T-Cell Responses Comparable to Peptide-Loaded Monocyte-Derived Dendritic Cells <em>In Vivo</em>
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Correction: The Relationship between Prostate-Specific Antigen and Prostate Cancer Risk: The Prostate Biopsy Collaborative Group
View articletitled, Correction: The Relationship between Prostate-Specific Antigen and Prostate Cancer Risk: The Prostate Biopsy Collaborative Group
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