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Volume 16, Issue 5
1 March 2010
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    Cover Image

    issue cover
    The featured image is a lung adenocarcinoma stained with a novel, highly sensitive and specific antibody recognizing the ALK oncoprotein (brown staining) and counterstained with hematoxylin (blue staining). The tumor was shown to harbor a rearrangement of the ALK locus by genetic analysis. This assay will facilitate the routine identification of ALK-rearranged lung adenocarcinomas in clinical practice and detect lung cancers that may be responsive to ALK inhibitors. For details, see the article by Mino-Kenudson and colleagues on page 1561 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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Editor's Note

Introducing New Strategies in...
James L. Abbruzzese, M.D.; Alexander M.M. Eggermont, M.D., Ph.D.; Eric H. Rubin, M.D.
View articletitled, Introducing <em>New Strategies in...</em>
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CCR New Strategies

New Strategies in Kidney Cancer: Therapeutic Advances through Understanding the Molecular Basis of Response and Resistance
Brian I. Rini
View articletitled, New Strategies in Kidney Cancer: Therapeutic Advances through Understanding the Molecular Basis of Response and Resistance
Supplementary data
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CCR Translations

Does Lapatinib Work against HER2-negative Breast Cancers?
Ingrid A. Mayer; Carlos L. Arteaga
View articletitled, Does Lapatinib Work against HER2-negative Breast Cancers?
Supplementary data
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Statistics in Clinical Cancer Research

Testing Clonal Relatedness of Tumors Using Array Comparative Genomic Hybridization: A Statistical Challenge
Irina Ostrovnaya; Colin B. Begg
View articletitled, Testing Clonal Relatedness of Tumors Using Array Comparative Genomic Hybridization: A Statistical Challenge
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CCR Drug Updates

Everolimus
Peter J. Houghton
View articletitled, Everolimus
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Molecular Pathways

HER3 Comes of Age: New Insights into Its Functions and Role in Signaling, Tumor Biology, and Cancer Therapy
Marcia R. Campbell; Dhara Amin; Mark M. Moasser
View articletitled, HER3 Comes of Age: New Insights into Its Functions and Role in Signaling, Tumor Biology, and Cancer Therapy
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Cyclooxygenase-2 and Cancer Treatment: Understanding the Risk Should Be Worth the Reward
David G. Menter; Richard L. Schilsky; Raymond N. DuBois
View articletitled, Cyclooxygenase-2 and Cancer Treatment: Understanding the Risk Should Be Worth the Reward
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Human Cancer Biology

High-Resolution Array Comparative Genomic Hybridization in Sporadic and Celiac Disease–Related Small Bowel Adenocarcinomas
Begoña Diosdado; Tineke E. Buffart; Russell Watkins; Beatriz Carvalho; Bauke Ylstra; Marianne Tijssen; Anne S. Bolijn; Fraser Lewis; Karen Maude; Caroline Verbeke; Iris D. Nagtegaal; Heike Grabsch; Chris J.J. Mulder; Phil Quirke; Peter Howdle; Gerrit A. Meijer
View articletitled, High-Resolution Array Comparative Genomic Hybridization in Sporadic and Celiac Disease–Related Small Bowel Adenocarcinomas
Supplementary data
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Critical Role of Gα12 and Gα13 for Human Small Cell Lung Cancer Cell Proliferation In vitro and Tumor Growth In vivo
Marius Grzelinski; Olaf Pinkenburg; Thomas Büch; Maike Gold; Stefanie Stohr; Hermann Kalwa; Thomas Gudermann; Achim Aigner
View articletitled, Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <em>In vitro</em> and Tumor Growth <em>In vivo</em>
Supplementary data
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Association of TGF-β1 Genetic Variants with HPV16-positive Oropharyngeal Cancer
Xiaoxiang Guan; Erich M. Sturgis; Dapeng Lei; Zhensheng Liu; Kristina R. Dahlstrom; Qingyi Wei; Guojun Li
View articletitled, Association of <em>TGF-β1</em> Genetic Variants with HPV16-positive Oropharyngeal Cancer
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ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway through Zinc Finger Transcription Factor CREB
Yuqing Zhang; Uddalak Bharadwaj; Craig D. Logsdon; Changyi Chen; Qizhi Yao; Min Li
View articletitled, ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway through Zinc Finger Transcription Factor CREB
Supplementary data
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Neuroblastoma Progression Correlates with Downregulation of the Lymphangiogenesis Inhibitor sVEGFR-2
Jürgen Becker; Helena Pavlakovic; Fabian Ludewig; Fabiola Wilting; Herbert A. Weich; Romulo Albuquerque; Jayakrishna Ambati; Jörg Wilting
View articletitled, Neuroblastoma Progression Correlates with Downregulation of the Lymphangiogenesis Inhibitor sVEGFR-2
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Cancer Therapy: Preclinical

Patient-Derived First Generation Xenografts of Non–Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy
Xin Dong; Jun Guan; John C. English; Julia Flint; John Yee; Kenneth Evans; Nevin Murray; Calum MacAulay; Raymond T. Ng; Peter W. Gout; Wan L. Lam; Janessa Laskin; Victor Ling; Stephen Lam; Yuzhuo Wang
View articletitled, Patient-Derived First Generation Xenografts of Non–Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy
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Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non–Small Cell Lung Cancer
Stefanie Hammer; Anette Sommer; Iduna Fichtner; Michael Becker; Jana Rolff; Johannes Merk; Ulrich Klar; Jens Hoffmann
View articletitled, Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non–Small Cell Lung Cancer
Supplementary data
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An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity
Zachary C. Hartman; Junping Wei; Takuya Osada; Oliver Glass; Gangjun Lei; Xiao-Yi Yang; Sharon Peplinski; Dong-Wan Kim; Wenle Xia; Neil Spector; Jeffrey Marks; William Barry; Amy Hobeika; Gayathri Devi; Andrea Amalfitano; Michael A. Morse; H. Kim Lyerly; Timothy M. Clay
View articletitled, An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity
Supplementary data
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Lestaurtinib Enhances the Antitumor Efficacy of Chemotherapy in Murine Xenograft Models of Neuroblastoma
Radhika Iyer; Audrey E. Evans; Xiaoxue Qi; Ruth Ho; Jane E. Minturn; Huaqing Zhao; Naomi Balamuth; John M. Maris; Garrett M. Brodeur
View articletitled, Lestaurtinib Enhances the Antitumor Efficacy of Chemotherapy in Murine Xenograft Models of Neuroblastoma
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Lapatinib Restores Hormone Sensitivity with Differential Effects on Estrogen Receptor Signaling in Cell Models of Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer with Acquired Endocrine Resistance
Alexandra F. Leary; Suzanne Drury; Simone Detre; Sunil Pancholi; Anne E. Lykkesfeldt; Lesley-Ann Martin; Mitch Dowsett; Stephen R.D. Johnston
View articletitled, Lapatinib Restores Hormone Sensitivity with Differential Effects on Estrogen Receptor Signaling in Cell Models of Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer with Acquired Endocrine Resistance
Supplementary data
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Preclinical Investigation of PEGylated Tumor Necrosis Factor α in Dogs with Spontaneous Tumors: Phase I Evaluation
Douglas H. Thamm; Ilene D. Kurzman; Mike A. Clark; E.J. Ehrhart, III; Susan L. Kraft; Daniel L. Gustafson; David M. Vail
View articletitled, Preclinical Investigation of PEGylated Tumor Necrosis Factor α in Dogs with Spontaneous Tumors: Phase I Evaluation
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Lapatinib, a Dual EGFR and HER2 Kinase Inhibitor, Selectively Inhibits HER2-Amplified Human Gastric Cancer Cells and is Synergistic with Trastuzumab In vitro and In vivo
Zev A. Wainberg; Adrian Anghel; Amrita J. Desai; Raul Ayala; Tong Luo; Brent Safran; Marlena S. Fejzo; J. Randolph Hecht; Dennis J. Slamon; Richard S. Finn
View articletitled, Lapatinib, a Dual EGFR and HER2 Kinase Inhibitor, Selectively Inhibits HER2-Amplified Human Gastric Cancer Cells and is Synergistic with Trastuzumab <em>In vitro</em> and <em>In vivo</em>
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Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma
Toshihiko Ishii; Takashi Ishida; Atae Utsunomiya; Atsushi Inagaki; Hiroki Yano; Hirokazu Komatsu; Shinsuke Iida; Kazunori Imada; Takashi Uchiyama; Shiro Akinaga; Kenya Shitara; Ryuzo Ueda
View articletitled, Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma
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Imaging, Diagnosis, Prognosis

Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature
Katleen De Preter; Joëlle Vermeulen; Benedikt Brors; Olivier Delattre; Angelika Eggert; Matthias Fischer; Isabelle Janoueix-Lerosey; Cinzia Lavarino; John M. Maris; Jaume Mora; Akira Nakagawara; André Oberthuer; Miki Ohira; Gudrun Schleiermacher; Alexander Schramm; Johannes H. Schulte; Qun Wang; Frank Westermann; Frank Speleman; Jo Vandesompele
View articletitled, Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature
Supplementary data
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Evaluation of Treatment-Associated Inflammatory Response on Diffusion-Weighted Magnetic Resonance Imaging and 2-[18F]-Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography Imaging Biomarkers
Craig J. Galbán; Mahaveer S. Bhojani; Kuei C. Lee; Charles R. Meyer; Marcian E. Van Dort; Kyle K. Kuszpit; Robert A. Koeppe; Rajesh Ranga; Bradford A. Moffat; Timothy D. Johnson; Thomas L. Chenevert; Alnawaz Rehemtulla; Brian D. Ross
View articletitled, Evaluation of Treatment-Associated Inflammatory Response on Diffusion-Weighted Magnetic Resonance Imaging and 2-[<sup>18</sup>F]-Fluoro-2-Deoxy-<span class="small-caps">d</span>-Glucose-Positron Emission Tomography Imaging Biomarkers
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Low Level Her2 Overexpression Is Associated with Rapid Tumor Cell Proliferation and Poor Prognosis in Prostate Cancer
Sarah Minner; Birte Jessen; Lars Stiedenroth; Eike Burandt; Jens Köllermann; Martina Mirlacher; Andreas Erbersdobler; Christian Eichelberg; Margit Fisch; Tim Henrik Brümmendorf; Carsten Bokemeyer; Ronald Simon; Thomas Steuber; Markus Graefen; Hartwig Huland; Guido Sauter; Thorsten Schlomm
View articletitled, Low Level Her2 Overexpression Is Associated with Rapid Tumor Cell Proliferation and Poor Prognosis in Prostate Cancer
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A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK-Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry
Mari Mino-Kenudson; Lucian R. Chirieac; Kenny Law; Jason L. Hornick; Neal Lindeman; Eugene J. Mark; David W. Cohen; Bruce E. Johnson; Pasi A. Jänne; A. John Iafrate; Scott J. Rodig
View articletitled, A Novel, Highly Sensitive Antibody Allows for the Routine Detection of <em>ALK</em>-Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry
Supplementary data
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Evaluation of the ETS-Related Gene mRNA in Urine for the Detection of Prostate Cancer
Kevin R. Rice; Yongmei Chen; Amina Ali; Eric J. Whitman; Amy Blase; Mona Ibrahim; Sally Elsamanoudi; Stephen Brassell; Bungo Furusato; Norbert Stingle; Isabell A. Sesterhenn; Gyorgy Petrovics; Siobhan Miick; Harry Rittenhouse; Jack Groskopf; David G. McLeod; Shiv Srivastava
View articletitled, Evaluation of the <em>ETS</em>-Related Gene mRNA in Urine for the Detection of Prostate Cancer
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Melanoma MicroRNA Signature Predicts Post-Recurrence Survival
Miguel F. Segura; Ilana Belitskaya-Lévy; Amy E. Rose; Jan Zakrzewski; Avital Gaziel; Douglas Hanniford; Farbod Darvishian; Russell S. Berman; Richard L. Shapiro; Anna C. Pavlick; Iman Osman; Eva Hernando
View articletitled, Melanoma MicroRNA Signature Predicts Post-Recurrence Survival
Supplementary data
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Development of Immunohistochemistry Assays to Assess GALNT14 and FUT3/6 in Clinical Trials of Dulanermin and Drozitumab
Howard M. Stern; Mary Padilla; Klaus Wagner; Lukas Amler; Avi Ashkenazi
View articletitled, Development of Immunohistochemistry Assays to Assess GALNT14 and FUT3/6 in Clinical Trials of Dulanermin and Drozitumab
Supplementary data
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IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
Martin J. van den Bent; Hendrikus J. Dubbink; Yannick Marie; Alba A. Brandes; Martin J.B. Taphoorn; Pieter Wesseling; Marc Frenay; Cees C. Tijssen; Denis Lacombe; Ahmed Idbaih; Ronald van Marion; Johan M. Kros; Winand N.M. Dinjens; Thierry Gorlia; Marc Sanson
View articletitled, <em>IDH1</em> and <em>IDH2</em> Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
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Cancer Therapy: Clinical

Cyclooxygenase-2 Inhibition Does Not Improve the Reduction in Ductal Carcinoma In situ Proliferation with Aromatase Inhibitor Therapy: Results of the ERISAC Randomized Placebo-Controlled Trial
Nigel J. Bundred; Angela Cramer; Julie Morris; Lorna Renshaw; Kwok-Leung Cheung; Pamela Flint; Rachael Johnson; Oliver Young; Göran Landberg; Sue Grassby; Lorraine Turner; Andrew Baildam; Lester Barr; J. Michael Dixon
View articletitled, Cyclooxygenase-2 Inhibition Does Not Improve the Reduction in Ductal Carcinoma <em>In situ</em> Proliferation with Aromatase Inhibitor Therapy: Results of the ERISAC Randomized Placebo-Controlled Trial
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The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanced Cancer
Udai Banerji; D. Ross Camidge; Henk M.W. Verheul; Roshan Agarwal; Debashis Sarker; Stan B. Kaye; Ingrid M.E. Desar; Johanna N.H. Timmer-Bonte; S. Gail Eckhardt; Karl D. Lewis; Kathryn H. Brown; Mireille V. Cantarini; Clive Morris; Sarah M.A. George; Paul D. Smith; Carla M.L. van Herpen
View articletitled, The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanced Cancer
Supplementary data
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Estrogen Receptor-α Phosphorylation at Serine 305, Nuclear p21-Activated Kinase 1 Expression, and Response to Tamoxifen in Postmenopausal Breast Cancer
Josefine Bostner; Lambert Skoog; Tommy Fornander; Bo Nordenskjöld; Olle Stål
View articletitled, Estrogen Receptor-α Phosphorylation at Serine 305, Nuclear p21-Activated Kinase 1 Expression, and Response to Tamoxifen in Postmenopausal Breast Cancer
Supplementary data
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A Phase II Clinical Trial of Ixabepilone (Ixempra; BMS-247550; NSC 710428), an Epothilone B Analog, in Patients with Metastatic Renal Cell Carcinoma
Hui Huang; Michael Menefee; Maureen Edgerly; Sen Zhuang; Herb Kotz; Marianne Poruchynsky; Lyn Mickley Huff; Susan Bates; Tito Fojo
View articletitled, A Phase II Clinical Trial of Ixabepilone (Ixempra; BMS-247550; NSC 710428), an Epothilone B Analog, in Patients with Metastatic Renal Cell Carcinoma
Supplementary data
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Diverse Patterns of T-Cell Response against Multiple Newly Identified Human Y Chromosome–Encoded Minor Histocompatibility Epitopes
Yishai Ofran; Haesook T. Kim; Vladimir Brusic; Loren Blake; Michael Mandrell; Catherine J. Wu; Stefanie Sarantopoulos; Roberto Bellucci; Derin B. Keskin; Robert J. Soiffer; Joseph H. Antin; Jerome Ritz
View articletitled, Diverse Patterns of T-Cell Response against Multiple Newly Identified Human Y Chromosome–Encoded Minor Histocompatibility Epitopes
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Pharmacokinetic and Pharmacodynamic Modeling of an Anti–Interleukin-6 Chimeric Monoclonal Antibody (Siltuximab) in Patients with Metastatic Renal Cell Carcinoma
Thomas Puchalski; Uma Prabhakar; Qun Jiao; Birge Berns; Hugh M. Davis
View articletitled, Pharmacokinetic and Pharmacodynamic Modeling of an Anti–Interleukin-6 Chimeric Monoclonal Antibody (Siltuximab) in Patients with Metastatic Renal Cell Carcinoma
Supplementary data
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Modulation of Lymphocyte Regulation for Cancer Therapy: A Phase II Trial of Tremelimumab in Advanced Gastric and Esophageal Adenocarcinoma
Christy Ralph; Eyad Elkord; Deborah J. Burt; Jackie F. O'Dwyer; Eric B. Austin; Peter L. Stern; Robert E. Hawkins; Fiona C. Thistlethwaite
View articletitled, Modulation of Lymphocyte Regulation for Cancer Therapy: A Phase II Trial of Tremelimumab in Advanced Gastric and Esophageal Adenocarcinoma
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Phase 1 Experience with an Anti-Glycotope Monoclonal Antibody, RAV12, in Recurrent Adenocarcinoma
Howard A. Burris, III; Lee S. Rosen; Caio M. Rocha-Lima; John Marshall; Suzanne Jones; Roger B. Cohen; Lori A. Kunkel; Deryk Loo; Jan Baughman; Stanford J. Stewart; Nancy Lewis
View articletitled, Phase 1 Experience with an Anti-Glycotope Monoclonal Antibody, RAV12, in Recurrent Adenocarcinoma
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Susceptibility and Prevention

Implications of LINE1 Methylation for Bladder Cancer Risk in Women
Charlotte S. Wilhelm; Karl T. Kelsey; Rondi Butler; Silvia Plaza; Luc Gagne; M. Scot Zens; Angeline S. Andrew; Steven Morris; Heather H. Nelson; Alan R. Schned; Margaret R. Karagas; Carmen J. Marsit
View articletitled, Implications of LINE1 Methylation for Bladder Cancer Risk in Women
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Letters to the Editor

Is High-Grade Prostate Cancer Easier to Find in Smaller Prostates Because There Is More High-Grade Disease to Find? – Letter
Patrick Walsh
View articletitled, Is High-Grade Prostate Cancer Easier to Find in Smaller Prostates Because There Is More High-Grade Disease to Find? – Letter
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Is High-Grade Prostate Cancer Easier to Find in Smaller Prostates Because There Is More High-Grade Disease to Find? – Response
Joseph Presti, Jr.
View articletitled, Is High-Grade Prostate Cancer Easier to Find in Smaller Prostates Because There Is More High-Grade Disease to Find? – Response
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Corrections

Correction: PIK3CA Mutations Predict Local Recurrences in Rectal Cancer Patients
View articletitled, Correction: <em>PIK3CA</em> Mutations Predict Local Recurrences in Rectal Cancer Patients
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Correction: MicroRNA Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus: Associations with Survival
View articletitled, Correction: MicroRNA Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus: Associations with Survival
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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