Issues

This image depicts the membrane β-catenin staining merged with DAPI in DU145 cells. The P-cadherin/β-catenin signaling pathway not only stabilizes tumor and stromal cell-cell adhesions, it also represents a major regulatory mechanism for oncogenic signaling pathways. PF-03732010, a human monoclonal antibody against P-cadherin, functionally blocks the β-catenin signaling pathway and demonstrates antitumor and antimetastatic activity. Antagonizing P-cadherin with PF-03732010 represents a novel approach for anticancer therapy. For further details, please see the article by Zhang and colleagues on page 5177 of this issue.