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15 October 2010
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Cover Image
Cover Image
A humanized, monoclonal antibody against PDGFRα was able to inhibit both early colonization of the bone and late progression of skeletal lesions in a murine model of prostate cancer metastasis. The image shows a metastatic tumor produced in the proximal femur by green fluorescent PC3-ML cells, four weeks after being inoculated via the hematogenous route. For further details, please see the article by Russell and colleagues on page 5002 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in Clinical Cancer Research
Molecular Pathways
Report from the FDA
Folotyn (Pralatrexate Injection) for the Treatment of Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma: U.S. Food and Drug Administration Drug Approval Summary
Shakun M. Malik; Ke Liu; Xu Qiang; Rajeshwari Sridhara; Shenghui Tang; W. David McGuinn, Jr.; S. Leigh Verbois; Anshu Marathe; Gene M. Williams; Julie Bullock; Christoffer Tornoe; Sue Ching Lin; Terrance Ocheltree; Milinda Vialpando; Alice Kacuba; Robert Justice; Richard Pazdur
Human Cancer Biology
EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Yuichi Sakairi; Takahiro Nakajima; Kazuhiro Yasufuku; Dai Ikebe; Hajime Kageyama; Manabu Soda; Kengo Takeuchi; Makiko Itami; Toshihiko Iizasa; Ichiro Yoshino; Hiroyuki Mano; Hideki Kimura
Cancer Therapy: Preclinical
Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
Kevin O. Hicks; Bronwyn G. Siim; Jagdish K. Jaiswal; Frederik B. Pruijn; Annie M. Fraser; Rita Patel; Alison Hogg; H.D. Sarath Liyanage; Mary Jo Dorie; J. Martin Brown; William A. Denny; Michael P. Hay; William R. Wilson
Novel Models of Myxoid Liposarcoma Xenografts Mimicking the Biological and Pharmacologic Features of Human Tumors
Roberta Frapolli; Elena Tamborini; Emanuela Virdis; Ezia Bello; Eva Tarantino; Sergio Marchini; Federica Grosso; Roberta Sanfilippo; Alessandro Gronchi; Juan Carlos Tercero; Gabriella Peloso; Paolo Casali; Silvana Pilotti; Maurizio D'Incalci
A Proteasome Inhibitor, Bortezomib, Inhibits Breast Cancer Growth and Reduces Osteolysis by Downregulating Metastatic Genes
Marci D. Jones; Julie C. Liu; Thomas K. Barthel; Sadiq Hussain; Erik Lovria; Dengfeng Cheng; Jesse A. Schoonmaker; Sudhanshu Mulay; David C. Ayers; Mary L. Bouxsein; Gary S. Stein; Siddhartha Mukherjee; Jane B. Lian
Synergistic Antitumor Activity of Sorafenib in Combination with Epidermal Growth Factor Receptor Inhibitors in Colorectal and Lung Cancer Cells
Erika Martinelli; Teresa Troiani; Floriana Morgillo; Gabriella Rodolico; Donata Vitagliano; Maria Pia Morelli; Concetta Tuccillo; Loredana Vecchione; Anna Capasso; Michele Orditura; Ferdinando De Vita; S. Gail Eckhardt; Massimo Santoro; Liberato Berrino; Fortunato Ciardiello
Imaging, Diagnosis, Prognosis
Pancreatic Cancer Screening in a Prospective Cohort of High-Risk Patients: A Comprehensive Strategy of Imaging and Genetics
Elizabeth C. Verna; Caroline Hwang; Peter D. Stevens; Heidrun Rotterdam; Stavros N. Stavropoulos; Carolyn D. Sy; Martin A. Prince; Wendy K. Chung; Robert L. Fine; John A. Chabot; Harold Frucht
Gene Expression Analysis Identifies Potential Biomarkers of Neurofibromatosis Type 1 Including Adrenomedullin
Trent R. Hummel; Walter J. Jessen; Shyra J. Miller; Lan Kluwe; Victor F. Mautner; Margaret R. Wallace; Conxi Lázaro; Grier P. Page; Paul F. Worley; Bruce J. Aronow; Elizabeth K. Schorry; Nancy Ratner
Cancer Therapy: Clinical
Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients
Joannes F.M. Jacobs; Cornelis J.A. Punt; W. Joost Lesterhuis; Roger P.M. Sutmuller; H. Mary-lène H. Brouwer; Nicole M. Scharenborg; Ina S. Klasen; Luuk B. Hilbrands; Carl G. Figdor; I. Jolanda M. de Vries; Gosse J. Adema
A Phase I/II Trial Combining High-Dose Melphalan and Autologous Transplant with Bortezomib for Multiple Myeloma: A Dose- and Schedule-Finding Study
Sagar Lonial; Jonathan Kaufman; Mourad Tighiouart; Ajay Nooka; Amelia A. Langston; Leonard T. Heffner; Claire Torre; Stephanie McMillan; Heather Renfroe; R. Donald Harvey; Mary J. Lechowicz; H. Jean Khoury; Christopher R. Flowers; Edmund K. Waller
Correction
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