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1 September 2010
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This is an original study providing, from preclinical models to patients, a reliable proof of 18FDG-PET/CT efficiency as a surrogate marker for the early evaluation of EGFR-TKI (erlotinib) efficacy that may improve diagnostic accuracy of molecular effect (ERK1/2). The image represents a facial sagittal section of an 18FDG-PET/CT of a patient with an oropharyngeal head and neck squamous cell carcinoma. It reveals a tumor 18FDG uptake before patient exposure to erlotinib. For further details, please see the article by Vergez and colleagues on page 4434 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Highlights
Editorial
CCR Translations
CCR New Strategies
Molecular Pathways
Report from the FDA
U.S. Food and Drug Administration Approval: Ofatumumab for the Treatment of Patients with Chronic Lymphocytic Leukemia Refractory to Fludarabine and Alemtuzumab
Steven J. Lemery; Jenny Zhang; Mark D. Rothmann; Jun Yang; Justin Earp; Hong Zhao; Andrew McDougal; Anne Pilaro; Raymond Chiang; Joseph E. Gootenberg; Patricia Keegan; Richard Pazdur
Human Cancer Biology
Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F
Windy Berkofsky-Fessler; Monica Buzzai; Marianne K-H. Kim; Steven Fruchtman; Vesna Najfeld; Dong-Joon Min; Fabricio F. Costa; Jared M. Bischof; Marcelo B. Soares; Melanie Jane McConnell; Weijia Zhang; Ross Levine; D. Gary Gilliland; Raffaele Calogero; Jonathan D. Licht
Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
Sara De Brouwer; Katleen De Preter; Candy Kumps; Piotr Zabrocki; Michaël Porcu; Ellen M. Westerhout; Arjan Lakeman; Jo Vandesompele; Jasmien Hoebeeck; Tom Van Maerken; Anne De Paepe; Geneviève Laureys; Johannes H. Schulte; Alexander Schramm; Caroline Van Den Broecke; Joëlle Vermeulen; Nadine Van Roy; Klaus Beiske; Marleen Renard; Rosa Noguera; Olivier Delattre; Isabelle Janoueix-Lerosey; Per Kogner; Tommy Martinsson; Akira Nakagawara; Miki Ohira; Huib Caron; Angelika Eggert; Jan Cools; Rogier Versteeg; Frank Speleman
Upregulation of SOX9 in Lung Adenocarcinoma and Its Involvement in the Regulation of Cell Growth and Tumorigenicity
Shih Sheng Jiang; Wen-Tsen Fang; Ya-Hsiue Hou; Shiu-Feng Huang; B. Linju Yen; Junn-Liang Chang; Shih-Miao Li; Hui-Ping Liu; Ying-Lan Liu; Chih-Ting Huang; Yu-Wei Li; Te-Hsuan Jang; Shih-Hsuan Chan; Su Jing Yang; Chao A. Hsiung; Cheng-Wen Wu; Lu-Hai Wang; I-Shou Chang
The Relationship between Prostate-Specific Antigen and Prostate Cancer Risk: The Prostate Biopsy Collaborative Group
Andrew J. Vickers; Angel M. Cronin; Monique J. Roobol; Jonas Hugosson; J. Stephen Jones; Michael W. Kattan; Eric Klein; Freddie Hamdy; David Neal; Jenny Donovan; Dipen J. Parekh; Donna Ankerst; George Bartsch; Helmut Klocker; Wolfgang Horninger; Amine Benchikh; Gilles Salama; Arnauld Villers; Steve J. Freedland; Daniel M. Moreira; Fritz H. Schröder; Hans Lilja
Cancer Therapy: Preclinical
Induction of B-Chronic Lymphocytic Leukemia Cell Apoptosis by Arsenic Trioxide Involves Suppression of the Phosphoinositide 3-Kinase/Akt Survival Pathway via c-jun-NH2 Terminal Kinase Activation and PTEN Upregulation
Javier Redondo-Muñoz; Elizabeth Escobar-Díaz; Mercedes Hernández del Cerro; Atanasio Pandiella; María José Terol; José A. García-Marco; Angeles García-Pardo
Imaging, Diagnosis, Prognosis
Neurotensin Receptor 1 Determines the Outcome of Non–Small Cell Lung Cancer
Marco Alifano; Frédérique Souazé; Sandra Dupouy; Sophie Camilleri-Broët; Mohamad Younes; Sadi-Menad Ahmed-Zaïd; Takashi Takahashi; Alessandra Cancellieri; Stefania Damiani; Maurizio Boaron; Philippe Broët; Lance D. Miller; Christian Gespach; Jean François Regnard; Patricia Forgez
Notch1 Expression Predicts an Unfavorable Prognosis and Serves as a Therapeutic Target of Patients with Neuroblastoma
Hsiu-Hao Chang; Hsinyu Lee; Ming-Kuan Hu; Po-Nien Tsao; Hsueh-Fen Juan; Min-Chuan Huang; Yu-Yin Shih; Bo-Jeng Wang; Yung-Ming Jeng; Christina Ling Chang; Shiu-Feng Huang; Yeou-Guang Tsay; Fon-Jou Hsieh; Kai-Hsin Lin; Wen-Ming Hsu; Yung-Feng Liao
Preclinical and Clinical Evidence that Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography with Computed Tomography Is a Reliable Tool for the Detection of Early Molecular Responses to Erlotinib in Head and Neck Cancer
Sébastien Vergez; Jean-Pierre Delord; Fabienne Thomas; Philippe Rochaix; Olivier Caselles; Thomas Filleron; Séverine Brillouet; Pierre Canal; Frédéric Courbon; Ben C. Allal
Cancer Therapy: Clinical
Histopathologic and Immunohistochemical Characterization of Rash to Human Epidermal Growth Factor Receptor 1 (HER1) and HER1/2 Inhibitors in Cancer Patients
Beatrice Nardone; Kimberly Nicholson; Marissa Newman; Joan Guitart; Pedram Gerami; Nicholas Talarico; Ximing J. Yang; Alfred Rademaker; Dennis P. West; Mario E. Lacouture
The Effectiveness of Off-Protocol Adjuvant Chemotherapy for Patients with Urothelial Carcinoma of the Urinary Bladder
Robert S. Svatek; Shahrokh F. Shariat; Robert E. Lasky; Eila C. Skinner; Giacomo Novara; Seth P. Lerner; Yves Fradet; Patrick J. Bastian; Wassim Kassouf; Pierre I. Karakiewicz; Hans-Martin Fritsche; Stefan C. Müller; Jonathan I. Izawa; Vincenzo Ficarra; Arthur I. Sagalowsky; Mark P. Schoenberg; Arlene O. Siefker-Radtke; Randall E. Millikan; Colin P.N. Dinney
Predictive Biomarkers and Personalized Medicine
Correction
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