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Volume 16, Issue 14
15 July 2010
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    Cover Image

    issue cover
    Transmission electron micrograph shows 100 nm lipid vesicles that contain a highly concentrated complex of arsenic trioxide (> 270 mmol/L). This nanoparticulate formulation (termed “nanobin”) markedly improves the pharmacokinetics of the cytotoxic agent, resulting in enhanced antitumor efficacy in a murine model of breast cancer. Nanobin encapsulation of arsenic trioxide may increase its therapeutic utility in breast cancer and potentially other solid tumors. For further details, please see the article by Ahn and colleagues on page 3607 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

PIKing the Right Patient
Alexa B. Turke; Jeffrey A. Engelman
View articletitled, PIKing the Right Patient
Supplementary data
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Molecular Pathways

Advances in Targeting Src in the Treatment of Breast Cancer and Other Solid Malignancies
Erica L. Mayer; Ian E. Krop
View articletitled, Advances in Targeting Src in the Treatment of Breast Cancer and Other Solid Malignancies
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Prostate Stem Cell Antigen: A Jekyll and Hyde Molecule?
Norihisa Saeki; Jian Gu; Teruhiko Yoshida; Xifeng Wu
View articletitled, Prostate Stem Cell Antigen: A Jekyll and Hyde Molecule?
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Human Cancer Biology

Identification of Differentially Methylated Genes in Normal Prostate Tissues from African American and Caucasian Men
Bernard Kwabi-Addo; Songping Wang; Woonbok Chung; Jaroslav Jelinek; Steven R. Patierno; Bi-Dar Wang; Ramez Andrawis; Norman H. Lee; Victor Apprey; Jean-Pierre Issa; Michael Ittmann
View articletitled, Identification of Differentially Methylated Genes in Normal Prostate Tissues from African American and Caucasian Men
Supplementary data
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Vascular Endothelial Growth Factor Receptors VEGFR-2 and VEGFR-3 Are Localized Primarily to the Vasculature in Human Primary Solid Cancers
Neil R. Smith; Dawn Baker; Neil H. James; Kirsty Ratcliffe; Martin Jenkins; Susan E. Ashton; Graham Sproat; Ruth Swann; Neil Gray; Anderson Ryan; Juliane M. Jürgensmeier; Chris Womack
View articletitled, Vascular Endothelial Growth Factor Receptors VEGFR-2 and VEGFR-3 Are Localized Primarily to the Vasculature in Human Primary Solid Cancers
Supplementary data
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Cancer-Testis Antigens and Immunosurveillance in Human Cutaneous Squamous Cell and Basal Cell Carcinomas
Anne Walter; Marjam J. Barysch; Silvia Behnke; Piotr Dziunycz; Bruno Schmid; Erika Ritter; Sacha Gnjatic; Glen Kristiansen; Holger Moch; Alexander Knuth; Reinhard Dummer; Maries van den Broek
View articletitled, Cancer-Testis Antigens and Immunosurveillance in Human Cutaneous Squamous Cell and Basal Cell Carcinomas
Supplementary data
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L1 Cell Adhesion Molecule Is a Novel Therapeutic Target in Intrahepatic Cholangiocarcinoma
Jeong-Ki Min; Jin-Man Kim; Shengjin Li; Jung Whoi Lee; Hyunho Yoon; Chun Jeih Ryu; Soung Hoo Jeon; Jae-Hyek Lee; Jin Young Kim; Hee Kwan Yoon; Young Kwan Lee; Bong-Hui Kim; Yeon Sung Son; Hong Seo Choi; Nam-Kyu Lim; Dae-Ghon Kim; Hyo Jeong Hong
View articletitled, L1 Cell Adhesion Molecule Is a Novel Therapeutic Target in Intrahepatic Cholangiocarcinoma
Supplementary data
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Functional Mapping of Receptor Tyrosine Kinases in Myxoid Liposarcoma
Tiziana Negri; Emanuela Virdis; Silvia Brich; Fabio Bozzi; Elena Tamborini; Eva Tarantino; Genny Jocollè; Giuliana Cassinelli; Federica Grosso; Roberta Sanfilippo; Patrizia Casalini; Angela Greco; Marco A. Pierotti; Silvana Pilotti
View articletitled, Functional Mapping of Receptor Tyrosine Kinases in Myxoid Liposarcoma
Supplementary data
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Cancer Therapy: Preclinical

Successful Eradication of Established Peritoneal Ovarian Tumors in SCID-Beige Mice following Adoptive Transfer of T Cells Genetically Targeted to the MUC16 Antigen
Alena A. Chekmasova; Thapi D. Rao; Yan Nikhamin; Kay J. Park; Douglas A. Levine; David R. Spriggs; Renier J. Brentjens
View articletitled, Successful Eradication of Established Peritoneal Ovarian Tumors in SCID-Beige Mice following Adoptive Transfer of T Cells Genetically Targeted to the MUC16 Antigen
Supplementary data
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A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer
Richard W. Ahn; Feng Chen; Haimei Chen; Stephan T. Stern; Jeffrey D. Clogston; Anil K. Patri; Meera R. Raja; Elden P. Swindell; Vamsi Parimi; Vincent L. Cryns; Thomas V. O'Halloran
View articletitled, A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer
Supplementary data
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Angiopoietin-2 Interferes with Anti-VEGFR2–Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas
Sung-Suk Chae; Walid S. Kamoun; Christian T. Farrar; Nathaniel D. Kirkpatrick; Elisabeth Niemeyer; Annemarie M.A. de Graaf; A. Gregory Sorensen; Lance L. Munn; Rakesh K. Jain; Dai Fukumura
View articletitled, Angiopoietin-2 Interferes with Anti-VEGFR2–Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas
Supplementary data
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The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma
Daniel C. Cho; Matthew B. Cohen; David J. Panka; Michael Collins; Musie Ghebremichael; Michael B. Atkins; Sabina Signoretti; James W. Mier
View articletitled, The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma
Supplementary data
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Augmentation of Radiation Response by Motesanib, a Multikinase Inhibitor that Targets Vascular Endothelial Growth Factor Receptors
Tim J. Kruser; Deric L. Wheeler; Eric A. Armstrong; Mari Iida; Kevin R. Kozak; Albert J. van der Kogel; Johan Bussink; Angela Coxon; Anthony Polverino; Paul M. Harari
View articletitled, Augmentation of Radiation Response by Motesanib, a Multikinase Inhibitor that Targets Vascular Endothelial Growth Factor Receptors
Supplementary data
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Pralatrexate Is Synergistic with the Proteasome Inhibitor Bortezomib in In vitro and In vivo Models of T-Cell Lymphoid Malignancies
Enrica Marchi; Luca Paoluzzi; Luigi Scotto; Venkatraman E. Seshan; Jasmine M. Zain; Pier Luigi Zinzani; Owen A. O'Connor
View articletitled, Pralatrexate Is Synergistic with the Proteasome Inhibitor Bortezomib in <em>In vitro</em> and <em>In vivo</em> Models of T-Cell Lymphoid Malignancies
Supplementary data
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Angiogenin Regulation by Estradiol in Breast Tissue: Tamoxifen Inhibits Angiogenin Nuclear Translocation and Antiangiogenin Therapy Reduces Breast Cancer Growth In vivo
Ulrika W. Nilsson; Annelie Abrahamsson; Charlotta Dabrosin
View articletitled, Angiogenin Regulation by Estradiol in Breast Tissue: Tamoxifen Inhibits Angiogenin Nuclear Translocation and Antiangiogenin Therapy Reduces Breast Cancer Growth <em>In vivo</em>
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Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models
Carol O'Brien; Jeffrey J. Wallin; Deepak Sampath; Debraj GuhaThakurta; Heidi Savage; Elizabeth A. Punnoose; Jane Guan; Leanne Berry; Wei Wei Prior; Lukas C. Amler; Marcia Belvin; Lori S. Friedman; Mark R. Lackner
View articletitled, Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models
Supplementary data
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Development of an Orthotopic Model of Invasive Pancreatic Cancer in an Immunocompetent Murine Host
William W. Tseng; Daniel Winer; Justin A. Kenkel; Okmi Choi; Alan H. Shain; Jonathan R. Pollack; Randy French; Andrew M. Lowy; Edgar G. Engleman
View articletitled, Development of an Orthotopic Model of Invasive Pancreatic Cancer in an Immunocompetent Murine Host
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Potent Antitumor Activity in Experimental Hepatocellular Carcinoma by Adenovirus-Mediated Coexpression of TRAIL and shRNA against COX-2
Qing Chen; Wenjia Lou; Junjie Shen; Leina Ma; Zhi Yang; Li Liu; Jingjing Luo; Cheng Qian
View articletitled, Potent Antitumor Activity in Experimental Hepatocellular Carcinoma by Adenovirus-Mediated Coexpression of <em>TRAIL</em> and shRNA against <em>COX-2</em>
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Imaging, Diagnosis, Prognosis

Prognostic Significance of Telomerase Polymorphism in Non–Small Cell Lung Cancer
Raquel Catarino; António Araújo; Ana Coelho; Mónica Gomes; Augusto Nogueira; Carlos Lopes; Rui M. Medeiros
View articletitled, Prognostic Significance of Telomerase Polymorphism in Non–Small Cell Lung Cancer
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Mature MicroRNA Sequence Polymorphism in MIR196A2 Is Associated with Risk and Prognosis of Head and Neck Cancer
Brock C. Christensen; Michele Avissar-Whiting; Lauren G. Ouellet; Rondi A. Butler; Heather H. Nelson; Michael D. McClean; Carmen J. Marsit; Karl T. Kelsey
View articletitled, Mature MicroRNA Sequence Polymorphism in <em>MIR196A2</em> Is Associated with Risk and Prognosis of Head and Neck Cancer
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Dynamic Single-Cell Network Profiles in Acute Myelogenous Leukemia Are Associated with Patient Response to Standard Induction Therapy
Steven M. Kornblau; Mark D. Minden; David B. Rosen; Santosh Putta; Aileen Cohen; Todd Covey; David C. Spellmeyer; Wendy J. Fantl; Urte Gayko; Alessandra Cesano
View articletitled, Dynamic Single-Cell Network Profiles in Acute Myelogenous Leukemia Are Associated with Patient Response to Standard Induction Therapy
Supplementary data
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High Levels of Nucleolar Expression of Nucleolin Are Associated with Better Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma
Lan Peng; John Liang; Hua Wang; Xianzhou Song; Asif Rashid; Henry F. Gomez; Lynda J. Corley; James L. Abbruzzese; Jason B. Fleming; Douglas B. Evans; Huamin Wang
View articletitled, High Levels of Nucleolar Expression of Nucleolin Are Associated with Better Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma
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Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features
Luisa M. Solis; Carmen Behrens; Wenli Dong; Milind Suraokar; Natalie C. Ozburn; Cesar A. Moran; Alejandro H. Corvalan; Shyam Biswal; Stephen G. Swisher; B. Nebiyou Bekele; John D. Minna; David J. Stewart; Ignacio I. Wistuba
View articletitled, Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features
Supplementary data
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Ten Common Genetic Variants Associated with Colorectal Cancer Risk Are Not Associated with Survival after Diagnosis
Albert Tenesa; Evropi Theodoratou; Farhat V.N. Din; Susan M. Farrington; Roseanne Cetnarskyj; Rebecca A. Barnetson; Mary E. Porteous; Harry Campbell; Malcolm G. Dunlop
View articletitled, Ten Common Genetic Variants Associated with Colorectal Cancer Risk Are Not Associated with Survival after Diagnosis
Supplementary data
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Development of Autoantibody Signatures as Novel Diagnostic Biomarkers of Non–Small Cell Lung Cancer
Lingling Wu; Wenjun Chang; Jinfeng Zhao; Yongwei Yu; Xiaojie Tan; Tong Su; Lijun Zhao; Shengdong Huang; Shiyuan Liu; Guangwen Cao
View articletitled, Development of Autoantibody Signatures as Novel Diagnostic Biomarkers of Non–Small Cell Lung Cancer
Supplementary data
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Intercohort Gene Expression Co-Analysis Reveals Chemokine Receptors as Prognostic Indicators in Ewing's Sarcoma
Idriss M. Bennani-Baiti; Aaron Cooper; Elizabeth R. Lawlor; Maximilian Kauer; Jozef Ban; Dave N.T. Aryee; Heinrich Kovar
View articletitled, Intercohort Gene Expression Co-Analysis Reveals Chemokine Receptors as Prognostic Indicators in Ewing's Sarcoma
Supplementary data
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A Functional Variant of Tandem Repeats in Human Telomerase Gene Was Associated with Survival of Patients with Early Stages of Non–Small Cell Lung Cancer
Luo Wang; Li-E Wang; Li Mao; Margaret R. Spitz; Qingyi Wei
View articletitled, A Functional Variant of Tandem Repeats in Human Telomerase Gene Was Associated with Survival of Patients with Early Stages of Non–Small Cell Lung Cancer
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Cancer Therapy: Clinical

A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Two Schedules of Vorinostat in Combination with 5-Fluorouracil and Leucovorin in Patients with Refractory Solid Tumors
Marwan G. Fakih; Gerald Fetterly; Merrill J. Egorin; Josephia R. Muindi; Igor Espinoza-Delgado; James A. Zwiebel; Alan Litwin; Julianne L. Holleran; Kangsheng Wang; Robert B. Diasio
View articletitled, A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Two Schedules of Vorinostat in Combination with 5-Fluorouracil and Leucovorin in Patients with Refractory Solid Tumors
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Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin
Ulka N. Vaishampayan; Angelika M. Burger; Edward A. Sausville; Lance K. Heilbrun; Jing Li; M. Naomi Horiba; Merrill J. Egorin; Percy Ivy; Simon Pacey; Patricia M. LoRusso
View articletitled, Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin
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Letter to the Editor

Comparison of Choi and Hans' Algorithms by Immunohistochemistry and Quantitative Reverse Transcriptase-PCR – Letter
Erica Ballabio; Jianxiang Chi; Giovanna Roncador; Alison H. Banham; Christian S.R. Hatton; Charles H. Lawrie
View articletitled, Comparison of Choi and Hans' Algorithms by Immunohistochemistry and Quantitative Reverse Transcriptase-PCR – Letter
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Corrections

Correction: Establishment and Characterization of a Panel of Human Uveal Melanoma Xenografts Derived from Primary and/or Metastatic Tumors
View articletitled, Correction: Establishment and Characterization of a Panel of Human Uveal Melanoma Xenografts Derived from Primary and/or Metastatic Tumors
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Correction: Performing Phase I Clinical Trials of Anticancer Agents: Perspectives from within the European Union and Japan
View articletitled, Correction: Performing Phase I Clinical Trials of Anticancer Agents: Perspectives from within the European Union and Japan
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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