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1 May 2009
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Immunofluorescent detection of EGFR mutation L858R present in the xenograft of NSCLC cell line H3255 using mutation-specific antibodies. Antibody detection of the two most common EGFR mutations in lung cancer has advantages over current DNA sequencing approaches. For further details see the article by Yu and colleagues on page 3023 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Molecular Pathways
Human Cancer Biology
Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer
Jian Yu; Susan Kane; Jiong Wu; Elisa Benedettini; Daiqiang Li; Cynthia Reeves; Gregory Innocenti; Randy Wetzel; Katherine Crosby; Alison Becker; Michelle Ferrante; Wan Cheung Cheung; Xiqiang Hong; Lucian R. Chirieac; Lynette M. Sholl; Herbert Haack; Bradley L. Smith; Roberto D. Polakiewicz; Yi Tan; Ting-Lei Gu; Massimo Loda; Xinmin Zhou; Michael J. Comb
Cancer Therapy: Preclinical
Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase
Peter Sabbatini; Jason L. Rowand; Arthur Groy; Susan Korenchuk; Qi Liu; Charity Atkins; Melissa Dumble; Jingsong Yang; Kelly Anderson; Brian J. Wilson; Kyle A. Emmitte; Sridhar K. Rabindran; Rakesh Kumar
Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo
Maria L.H. Vlaming; Zeliha Pala; Anita van Esch; Els Wagenaar; Dirk R. de Waart; Koen van de Wetering; Cornelia M.M. van der Kruijssen; Ronald P.J. Oude Elferink; Olaf van Tellingen; Alfred H. Schinkel
Imaging, Diagnosis, Prognosis
p53 Arg72Pro and MDM2 T309G Polymorphisms, Histology, and Esophageal Cancer Prognosis
David W. Cescon; Penelope A. Bradbury; Kofi Asomaning; Jessica Hopkins; Rihong Zhai; Wei Zhou; Zhaoxi Wang; Matthew Kulke; Li Su; Clement Ma; Wei Xu; Ariela L. Marshall; Rebecca Suk Heist; John C. Wain; Thomas J. Lynch, Jr.; David C. Christiani; Geoffrey Liu
Rectal Mucosal Microvascular Blood Supply Increase Is Associated with Colonic Neoplasia
Andrew J. Gomes; Hemant K. Roy; Vladimir Turzhitsky; Young Kim; Jeremy D. Rogers; Sarah Ruderman; Valentina Stoyneva; Michael J. Goldberg; Laura K. Bianchi; Eugene Yen; Alexey Kromine; Mohammed Jameel; Vadim Backman
Dynamic Contrast-Enhanced Magnetic Resonance Imaging Identifies a Subgroup of Patients with Asymptomatic Monoclonal Plasma Cell Disease and Pathologic Microcirculation
Jens Hillengass; Christian Zechmann; Tobias Bäuerle; Barbara Wagner-Gund; Christiane Heiss; Axel Benner; Anthony Ho; Kai Neben; Dirk Hose; Hans-Ulrich Kauczor; Hartmut Goldschmidt; Stefan Delorme; Thomas Moehler
KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer
Kengo Takeuchi; Young Lim Choi; Yuki Togashi; Manabu Soda; Satoko Hatano; Kentaro Inamura; Shuji Takada; Toshihide Ueno; Yoshihiro Yamashita; Yukitoshi Satoh; Sakae Okumura; Ken Nakagawa; Yuichi Ishikawa; Hiroyuki Mano
Utility of p16 Immunohistochemistry for the Identification of Lynch Syndrome
Artemio Payá; Cristina Alenda; Lucía Pérez-Carbonell; Estefanía Rojas; José-Luis Soto; Carmen Guillén; Adela Castillejo; Victor M. Barberá; Alfredo Carrato; Antoni Castells; Xavier Llor; Montserrat Andreu; Jim Koh; Greg H. Enders; Susana Benlloch; Rodrigo Jover
Cancer Therapy: Clinical
Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors
Ruth Plummer; Laura Vidal; Melanie Griffin; Mark Lesley; Johann de Bono; Sally Coulthard; Julieann Sludden; Lillian L. Siu; Eric X. Chen; Amit M. Oza; Gregory K. Reid; A. Robert McLeod; Jeffrey M. Besterman; Chooi Lee; Ian Judson; Hilary Calvert; Alan V. Boddy
A Phase I, Pharmacokinetic and Pharmacodynamic Study on Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer
Marwan G. Fakih; Lakshmi Pendyala; Gerald Fetterly; Karoli Toth; James A. Zwiebel; Igor Espinoza-Delgado; Alan Litwin; Youcef M. Rustum; Mary Ellen Ross; Julianne L. Holleran; Merrill J. Egorin
Cancer Prevention and Susceptibility
Evaluation of 8q24 and 17q Risk Loci and Prostate Cancer Mortality
Kathryn L. Penney; Claudia A. Salinas; Mark Pomerantz; Fredrick R. Schumacher; Christine A. Beckwith; Gwo-Shu Lee; William K. Oh; Oliver Sartor; Elaine A. Ostrander; Tobias Kurth; Jing Ma; Lorelei Mucci; Janet L. Stanford; Philip W. Kantoff; David J. Hunter; Meir J. Stampfer; Matthew L. Freedman
Letters to the Editor
Correction
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