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1 April 2009
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Phosphorylation of Trask in tumor cells detaching into the luminal space of a tubular adenoma. A section of tubular adenoma was stained by immunohistochemistry using anti-p-Trask antibodies, revealing frequent nonphysiological phosphorylation of Trask and tumor cell shedding in this tumor. For further details, please see the article by Wong and colleagues on page 2311 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Molecular Pathways
Perspective
Review
Human Cancer Biology
CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
Carola Reindl; Hilmar Quentmeier; Konstantin Petropoulos; Philipp A. Greif; Tobias Benthaus; Bob Argiropoulos; Gudrun Mellert; Sridhar Vempati; Justus Duyster; Christian Buske; Stefan K. Bohlander; Keith R. Humphries; Wolfgang Hiddemann; Karsten Spiekermann
PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas
David S.P. Tan; Maryou B.K. Lambros; Sydonia Rayter; Rachael Natrajan; Radost Vatcheva; Qiong Gao; Caterina Marchiò; Felipe C. Geyer; Kay Savage; Suzanne Parry; Kerry Fenwick; Narinder Tamber; Alan Mackay; Tim Dexter; Charles Jameson; W. Glenn McCluggage; Alistair Williams; Ashley Graham; Dana Faratian; Mona El-Bahrawy; Adam J. Paige; Hani Gabra; Martin E. Gore; Marketa Zvelebil; Christopher J. Lord; Stanley B. Kaye; Alan Ashworth; Jorge S. Reis-Filho
microRNA-451 Regulates Macrophage Migration Inhibitory Factor Production and Proliferation of Gastrointestinal Cancer Cells
Eva Bandres; Nerea Bitarte; Fernando Arias; Jackeline Agorreta; Puri Fortes; Xabi Agirre; Ruth Zarate; Juan A. Diaz-Gonzalez; Natalia Ramirez; Jesus J. Sola; Paula Jimenez; Javier Rodriguez; Jesus Garcia-Foncillas
Triple-Negative Breast Cancer: Distinguishing between Basal and Nonbasal Subtypes
Emad A. Rakha; Somaia E. Elsheikh; Muhammed A. Aleskandarany; Hany O. Habashi; Andrew R. Green; Desmond G. Powe; Maysa E. El-Sayed; Ahmed Benhasouna; Jean-Sébastien Brunet; Lars A. Akslen; Andy J. Evans; Roger Blamey; Jorge S. Reis-Filho; William D. Foulkes; Ian O. Ellis
Phosphorylation of the src Epithelial Substrate Trask Is Tightly Regulated in Normal Epithelia but Widespread in Many Human Epithelial Cancers
Ching Hang Wong; Frederick L. Baehner; Danislav S. Spassov; Deepika Ahuja; Donghui Wang; Byron Hann; Jimmy Blair; Kevan Shokat; Alana L. Welm; Mark M. Moasser
Cancer Therapy: Preclinical
Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment
Jurjen S. Lagas; Robert A.B. van Waterschoot; Vicky A.C.J. van Tilburg; Michel J. Hillebrand; Nienke Lankheet; Hilde Rosing; Jos H. Beijnen; Alfred H. Schinkel
Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer
Francisco G. Pernas; Clint T. Allen; Mary E. Winters; Bin Yan; Jay Friedman; Bhavana Dabir; Kunal Saigal; Gerhard S. Mundinger; Xiaojiang Xu; John C. Morris; Katherine R. Calvo; Carter Van Waes; Zhong Chen
Dose-Dependent Increases in Circulating TGF-α and Other EGFR Ligands Act As Pharmacodynamic Markers for Optimal Biological Dosing of Cetuximab and Are Tumor Independent
Anthony J. Mutsaers; Giulio Francia; Shan Man; Christina R. Lee; John M.L. Ebos; Yan Wu; Larry Witte; Scott Berry; Malcolm Moore; Robert S. Kerbel
Imaging, Diagnosis, Prognosis
Cdc7 Kinase Is a Predictor of Survival and a Novel Therapeutic Target in Epithelial Ovarian Carcinoma
Anjana A. Kulkarni; Sarah R. Kingsbury; Slavica Tudzarova; Hye-Kyung Hong; Marco Loddo; Mohammed Rashid; Sara Rodriguez-Acebes; Andrew T. Prevost; Jonathan A. Ledermann; Kai Stoeber; Gareth H. Williams
High Tumor Metabolic Activity as Measured by Fluorodeoxyglucose Positron Emission Tomography Is Associated with Poor Prognosis in Limited and Extensive Stage Small-Cell Lung Cancer
Young Joo Lee; Arthur Cho; Byoung Chul Cho; Mijin Yun; Se Kyu Kim; Joon Chang; Jin Wook Moon; In Kyu Park; Hye Jin Choi; Joo-Hang Kim
Relationship Between Angiotensin-Converting Enzyme Gene Polymorphism and Body Composition, Functional Performance, and Blood Biomarkers in Advanced Cancer Patients
Antonio Vigano; Barbara Trutschnigg; Robert D. Kilgour; Nancy Hamel; Laura Hornby; Enriqueta Lucar; William Foulkes; Michel L. Tremblay; José A. Morais
Microarray Analysis of Early Stage Serous Ovarian Cancers Shows Profiles Predictive of Favorable Outcome
Andrew Berchuck; Edwin S. Iversen; Jingqin Luo; Jennifer P. Clarke; Hisani Horne; Douglas A. Levine; Jeff Boyd; Miguel A. Alonso; Angeles Alvarez Secord; Marcus Q. Bernardini; Jason C. Barnett; Todd Boren; Susan K. Murphy; Holly K. Dressman; Jeffrey R. Marks; Johnathan M. Lancaster
Medulloblastoma Variants: Age-Dependent Occurrence and Relation to Gorlin Syndrome—A New Clinical Perspective
Maria Luisa Garrè; Armando Cama; Francesca Bagnasco; Giovanni Morana; Felice Giangaspero; Massimo Brisigotti; Claudio Gambini; Marco Forni; Andrea Rossi; Riccardo Haupt; Paolo Nozza; Salvina Barra; Gianluca Piatelli; GianMaria Viglizzo; Valeria Capra; William Bruno; Lorenza Pastorino; Maura Massimino; Miriam Tumolo; Paola Fidani; Sandro Dallorso; Riccardo Fabian Schumacher; Claudia Milanaccio; Torsten Pietsch
Androgen Receptor Levels and Association with PIK3CA Mutations and Prognosis in Breast Cancer
Ana M. Gonzalez-Angulo; Katherine Stemke-Hale; Shana L. Palla; Mark Carey; Roshan Agarwal; Funda Meric-Berstam; Tiffany A. Traina; Clifford Hudis; Gabriel N. Hortobagyi; William L. Gerald; Gordon B. Mills; Bryan T. Hennessy
Cancer Therapy: Clinical
Potentiation of a Topoisomerase I Inhibitor, Karenitecin, by the Histone Deacetylase Inhibitor Valproic Acid in Melanoma: Translational and Phase I/II Clinical Trial
Adil I. Daud; Jana Dawson; Ronald C. DeConti; Elona Bicaku; Douglas Marchion; Sem Bastien; Frederick A. Hausheer, III; Richard Lush; Anthony Neuger; Daniel M. Sullivan; Pamela N. Munster
Clinical and Biological Effects of Valproic Acid as a Histone Deacetylase Inhibitor on Tumor and Surrogate Tissues: Phase I/II Trial of Valproic acid and Epirubicin/FEC
Pamela Munster; Douglas Marchion; Elona Bicaku; Mira Lacevic; Jongphil Kim; Barbara Centeno; Adil Daud; Anthony Neuger; Susan Minton; Daniel Sullivan
Melan-A–specific Cytotoxic T Cells Are Associated with Tumor Regression and Autoimmunity Following Treatment with Anti-CTLA-4
Oliver Klein; Lisa M. Ebert; Theo Nicholaou; Judy Browning; Sarah E. Russell; Marina Zuber; Heather M. Jackson; Nektaria Dimopoulos; Bee Shin Tan; Axel Hoos; Immanuel F. Luescher; Ian D. Davis; Weisan Chen; Jonathan Cebon
EBV-Related Lymphoproliferative Disease Complicating Therapy with the Anti-CD2 Monoclonal Antibody, Siplizumab, in Patients with T-Cell Malignancies
Deirdre O'Mahony; John C. Morris; Maryalice Stetler-Stevenson; Helen Matthews; Margaret R. Brown; Thomas Fleisher; Stefania Pittaluga; Mark Raffeld; Paul S. Albert; Dirk Reitsma; Karen Kaucic; Luz Hammershaimb; Thomas A. Waldmann; John E. Janik
Identification of CD20 C-Terminal Deletion Mutations Associated with Loss of CD20 Expression in Non-Hodgkin's Lymphoma
Yasuhito Terui; Yuji Mishima; Natsuhiko Sugimura; Kiyotsugu Kojima; Takuma Sakurai; Yuko Mishima; Ryoko Kuniyoshi; Akiko Taniyama; Masahiro Yokoyama; Sakura Sakajiri; Kengo Takeuchi; Chie Watanabe; Shunji Takahashi; Yoshinori Ito; Kiyohiko Hatake
Limited Amounts of Dendritic Cells Migrate into the T-Cell Area of Lymph Nodes but Have High Immune Activating Potential in Melanoma Patients
Pauline Verdijk; Erik H.J.G. Aarntzen; W. Joost Lesterhuis; A.C. Inge Boullart; Ellemieke Kok; Michelle M. van Rossum; Simon Strijk; Femke Eijckeler; Johannes J. Bonenkamp; Joannes F.M. Jacobs; Willeke Blokx; J. Han J.M. vanKrieken; Irma Joosten; Otto C. Boerman; Wim J.G. Oyen; Gosse Adema; Cornelis J.A. Punt; Carl G. Figdor; I. Jolanda M. de Vries
A Phase I Study with Neratinib (HKI-272), an Irreversible Pan ErbB Receptor Tyrosine Kinase Inhibitor, in Patients with Solid Tumors
Kwok-K. Wong; Paula M. Fracasso; Ronald M. Bukowski; Thomas J. Lynch; Pamela N. Munster; Geoffrey I. Shapiro; Pasi A. Jänne; Joseph P. Eder; Michael J. Naughton; Matthew J. Ellis; Suzanne F. Jones; Tarek Mekhail; Charles Zacharchuk; Jennifer Vermette; Richat Abbas; Susan Quinn; Christine Powell; Howard A. Burris
Susceptibility and Prevention
Association of MDM2 SNP309, Age of Onset, and Gender in Cutaneous Melanoma
Elnaz F. Firoz; Melanie Warycha; Jan Zakrzewski; Danuta Pollens; Guimin Wang; Richard Shapiro; Russell Berman; Anna Pavlick; Prashiela Manga; Harry Ostrer; Julide Tok Celebi; Hideko Kamino; Farbod Darvishian; Linda Rolnitzky; Judith D. Goldberg; Iman Osman; David Polsky
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