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15 February 2009
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Confocal fluorescence microscopy image of the caveolae-mediated endocytic uptake of cisplatin nanocapsules by IGROV-1 human ovarian carcinoma cells. The core of the nanocapsules was fluorescently labeled with fluoresceinated cisplatin (green) and the lipid bilayer coat with a Bodipy 581-modified lipid (red). For further details, please see the article by Hamelers and colleagues on page 1259 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Molecular Pathways
Review
Human Cancer Biology
Uncovering Growth-Suppressive MicroRNAs in Lung Cancer
Xi Liu; Lorenzo F. Sempere; Fabrizio Galimberti; Sarah J. Freemantle; Candice Black; Konstantin H. Dragnev; Yan Ma; Steven Fiering; Vincent Memoli; Hua Li; James DiRenzo; Murray Korc; Charles N. Cole; Mads Bak; Sakari Kauppinen; Ethan Dmitrovsky
Cancer Therapy: Preclinical
Combining the Endoplasmic Reticulum Stress–Inducing Agents Bortezomib and Fenretinide as a Novel Therapeutic Strategy for Metastatic Melanoma
David S. Hill; Shaun Martin; Jane L. Armstrong; Ross Flockhart; Joge J. Tonison; Dominic G. Simpson; Mark A. Birch-Machin; Christopher P.F. Redfern; Penny E. Lovat
The Combined Therapeutic Effects of Bortezomib and Fenretinide on Neuroblastoma Cells Involve Endoplasmic Reticulum Stress Response
Gabriella Pagnan; Daniela Di Paolo; Roberta Carosio; Fabio Pastorino; Danilo Marimpietri; Chiara Brignole; Annalisa Pezzolo; Monica Loi; Luis J.V. Galietta; Federica Piccardi; Michele Cilli; Beatrice Nico; Domenico Ribatti; Vito Pistoia; Mirco Ponzoni
Preclinical Studies in Support of Defibrotide for the Treatment of Multiple Myeloma and Other Neoplasias
Constantine S. Mitsiades; Cecile Rouleau; Cinara Echart; Krishna Menon; Beverly Teicher; Maria Distaso; Antonio Palumbo; Mario Boccadoro; Kenneth C. Anderson; Massimo Iacobelli; Paul G. Richardson
Inhibition of Poly(ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma
Rachel A. Daniel; Agata L. Rozanska; Huw D. Thomas; Evan A. Mulligan; Yvette Drew; Deborah J. Castelbuono; Zdenek Hostomsky; E. Ruth Plummer; Alan V. Boddy; Deborah A. Tweddle; Nicola J. Curtin; Steven C. Clifford
AKT/mTOR Pathway Activation and BCL-2 Family Proteins Modulate the Sensitivity of Human Small Cell Lung Cancer Cells to RAD001
Marin Marinov; Algirdas Ziogas; Olivier E. Pardo; Liwen Terence Tan; Tony Dhillon; Francesco A. Mauri; Heidi A. Lane; Nicholas R. Lemoine; Uwe Zangemeister-Wittke; Michael J. Seckl; Alexandre Arcaro
Marked Activity of Irinotecan and Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the Mammalian Target of Rapamycin/Hypoxia-Inducible Factor-1α Axis
Erwan Pencreach; Eric Guérin; Céline Nicolet; Isabelle Lelong-Rebel; Anne-Claire Voegeli; Pierre Oudet; Annette K. Larsen; Marie-Pierre Gaub; Dominique Guenot
Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy
Maria Quanz; Nathalie Berthault; Christophe Roulin; Maryline Roy; Aurélie Herbette; Céline Agrario; Christophe Alberti; Véronique Josserand; Jean-Luc Coll; Xavier Sastre-Garau; Jean-Marc Cosset; Lionel Larue; Jian-Sheng Sun; Marie Dutreix
Antitumor Activity of an Oncolytic Adenoviral-CD40 Ligand (CD154) Transgene Construct in Human Breast Cancer Cells
Erica M. Gomes; Margret S. Rodrigues; Anagha P. Phadke; Lindsay D. Butcher; Cherry Starling; Salina Chen; Dongkun Chang; Ruben Hernandez-Alcoceba; Joseph T. Newman; Marvin J. Stone; Alex W. Tong
Imaging, Diagnosis, Prognosis
A Genetic Expression Profile Associated with Oral Cancer Identifies a Group of Patients at High Risk of Poor Survival
Eduardo Méndez; John R. Houck; David R. Doody; Wenhong Fan; Pawadee Lohavanichbutr; Tessa C. Rue; Bevan Yueh; Neal D. Futran; Melissa P. Upton; D. Gregory Farwell; Patrick J. Heagerty; Lue Ping Zhao; Stephen M. Schwartz; Chu Chen
A TaqMan Low-Density Array to Predict Outcome in Advanced Hodgkin's Lymphoma Using Paraffin-Embedded Samples
Beatriz Sánchez-Espiridión; Abel Sánchez-Aguilera; Carlos Montalbán; Carmen Martin; Rafael Martinez; Joaquín González-Carrero; Concepción Poderos; Carmen Bellas; Manuel F. Fresno; Cesar Morante; Maria J. Mestre; Miguel Mendez; Francisco Mazorra; Eulogio Conde; Angel Castaño; Pedro Sánchez-Godoy; José F. Tomas; Manolo M. Morente; Miguel A. Piris; Juan F. García; for the Spanish Hodgkin's Lymphoma Study Group
Cancer Therapy: Clinical
Genetic and Epigenetic SLC18A2 Silencing in Prostate Cancer Is an Independent Adverse Predictor of Biochemical Recurrence after Radical Prostatectomy
Karina Dalsgaard Sørensen; Peter Johannes Wild; Ashkan Mortezavi; Katja Adolf; Niels Tørring; Sara Heebøll; Benedicte Parm Ulhøi; Peter Ottosen; Tullio Sulser; Thomas Hermanns; Holger Moch; Michael Borre; Torben Falck Ørntoft; Lars Dyrskjøt
Hand-Foot Skin Reaction Increases with Cumulative Sorafenib Dose and with Combination Anti-Vascular Endothelial Growth Factor Therapy
Nilofer S. Azad; Jeanny B. Aragon-Ching; William L. Dahut; Martin Gutierrez; William D. Figg; Lokesh Jain; Seth M. Steinberg; Maria L. Turner; Elise C. Kohn; Heidi H. Kong
Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas
Dariush Etemadmoghadam; Anna deFazio; Rameen Beroukhim; Craig Mermel; Joshy George; Gad Getz; Richard Tothill; Aikou Okamoto; Maria B. Raeder; AOCS Study Group; Paul Harnett; Stephen Lade; Lars A. Akslen; Anna V. Tinker; Bianca Locandro; Kathryn Alsop; Yoke-Eng Chiew; Nadia Traficante; Sian Fereday; Daryl Johnson; Stephen Fox; William Sellers; Mitsuyoshi Urashima; Helga B. Salvesen; Matthew Meyerson; David Bowtell
A Phase I Trial to Determine the Safety, Tolerability, and Maximum Tolerated Dose of Deforolimus in Patients with Advanced Malignancies
Christine M. Hartford; Apurva A. Desai; Linda Janisch; Theodore Karrison; Victor M. Rivera; Lori Berk; John W. Loewy; Hedy Kindler; Walter M. Stadler; Heather L. Knowles; Camille Bedrosian; Mark J. Ratain
Pharmacodynamic Effects of Seliciclib, an Orally Administered Cell Cycle Modulator, in Undifferentiated Nasopharyngeal Cancer
Wen-Son Hsieh; Ross Soo; Bee-Keow Peh; Thomas Loh; Difeng Dong; Donny Soh; Lim-Soon Wong; Simon Green; Judy Chiao; Chun-Ying Cui; Yoke-Fong Lai; Soo-Chin Lee; Benjamin Mow; Richie Soong; Manuel Salto-Tellez; Boon-Cher Goh
Immunogenicity and Antitumor Effects of Vaccination with Peptide Vaccine +/− Granulocyte-Monocyte Colony-Stimulating Factor and/or IFN-α2b in Advanced Metastatic Melanoma: Eastern Cooperative Oncology Group Phase II Trial E1696
John M. Kirkwood; Sandra Lee; Stergios J. Moschos; Mark R. Albertini; John C. Michalak; Cindy Sander; Theresa Whiteside; Lisa H. Butterfield; Louis Weiner
Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer
Nancy U. Lin; Véronique Diéras; Devchand Paul; Dominique Lossignol; Christos Christodoulou; Hans-Joachim Stemmler; Henri Roché; Minetta C. Liu; Richard Greil; Eva Ciruelos; Sibylle Loibl; Stefania Gori; Andrew Wardley; Denise Yardley; Adam Brufsky; Joanne L. Blum; Stephen D. Rubin; Bernie Dharan; Klaudia Steplewski; Denise Zembryki; Cristina Oliva; Debasish Roychowdhury; Paolo Paoletti; Eric P. Winer
Overexpression of Class III β-Tubulin Predicts Good Response to Taxane-Based Chemotherapy in Ovarian Clear Cell Adenocarcinoma
Daisuke Aoki; Yoshinao Oda; Satoshi Hattori; Ken-ichi Taguchi; Yoshihiro Ohishi; Yuji Basaki; Shinji Oie; Nao Suzuki; Suminori Kono; Masazumi Tsuneyoshi; Mayumi Ono; Takashi Yanagawa; Michihiko Kuwano
Population Pharmacokinetics of Romidepsin in Patients with Cutaneous T-Cell Lymphoma and Relapsed Peripheral T-Cell Lymphoma
Sukyung Woo; Erin R. Gardner; Xiaohong Chen; Sandra B. Ockers; Caitlin E. Baum; Tristan M. Sissung; Douglas K. Price; Robin Frye; Richard L. Piekarz; Susan E. Bates; William D. Figg
Letters to the Editor
Quantitative Analysis of Circulating Tumor Cells as a Survival Predictor in Metastatic Castration–Resistant Prostate Cancer: Missing Parts in a Superb Study
Johann S. de Bono; Christopher Parker; Howard I. Scher; R. Bruce Montgomery; M. Craig Miller; Henk Tissing; Gerald V. Doyle; Leon W.W.M. Terstappen; Kenneth J. Pienta; Derek Raghavan
Corrections
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