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15 September 2009
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Loss of poly(ADP-ribosyl)ation of CTCF is associated with cell proliferation. Confocal microscopy analysis of proliferating cells from normal breast tissue primary cultures. Cells were costained with the antibody specifically recognizing the form of CTCF deficient for poly(ADP-ribosyl)ation (green) and CK-14, a marker for myoepithelial cells (red). For further details please see the article by Docquier and colleagues on page 5762 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Molecular Pathways
CCR Special Focus
Perspective
Report from the Radiation Therapy Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2008
Paul Okunieff; Lisa A. Kachnic; Louis S. Constine; Clifton D. Fuller; Laurie E. Gaspar; Daniel F. Hayes; Jean Hooks; Clifton Ling; Frank L. Meyskens, Jr.; Philip A. Philip; David Raben; Stephen R. Smalley; Gregory P. Swanson; Beverly A. Teicher; Charles R. Thomas, Jr.; Bhadrasain Vikram; Michael J. Zelefsky; Laurence H. Baker
Review
Human Cancer Biology
Wnt Antagonist Gene DKK2 Is Epigenetically Silenced and Inhibits Renal Cancer Progression through Apoptotic and Cell Cycle Pathways
Hiroshi Hirata; Yuji Hinoda; Koichi Nakajima; Ken Kawamoto; Nobuyuki Kikuno; Kazumori Kawakami; Soichiro Yamamura; Koji Ueno; Shahana Majid; Sharanjot Saini; Nobuhisa Ishii; Rajvir Dahiya
Clinical and Biological Significance of CDK4 Amplification in Well-Differentiated and Dedifferentiated Liposarcomas
Antoine Italiano; Laurence Bianchini; Elisabet Gjernes; Frédérique Keslair; Dominique Ranchere-Vince; Jean-Marc Dumollard; Juliette Haudebourg; Agnès Leroux; Claire Mainguené; Philippe Terrier; Frédéric Chibon; Jean-Michel Coindre; Florence Pedeutour
Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer
Soundararajan Krishnaswamy; Rajani Kanteti; Jonathan S. Duke-Cohan; Sivakumar Loganathan; Wanqing Liu; Patrick C. Ma; Martin Sattler; Patrick A. Singleton; Nithya Ramnath; Federico Innocenti; Dan L. Nicolae; Zheng Ouyang; Jie Liang; John Minna; Mark F. Kozloff; Mark K. Ferguson; Viswanathan Natarajan; Yi-Ching Wang; Joe G.N. Garcia; Everett E. Vokes; Ravi Salgia
Phosphatidylinositol 3′-Kinase Catalytic Subunit α Gene Amplification Contributes to the Pathogenesis of Mantle Cell Lymphoma
Amanda Psyrri; Sotirios Papageorgiou; Elisavet Liakata; Andreas Scorilas; Dimitra Rontogianni; Christos K. Kontos; Pinelopi Argyriou; Dimitrios Pectasides; Nikolaos Harhalakis; Vassiliki Pappa; Aggeliki Kolialexi; Christina Economopoulou; Frida Kontsioti; Eirini Maratou; George Dimitriadis; Panagiota Economopoulou; Theofanis Economopoulos
EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines
Dorine A. Bax; Nathalie Gaspar; Suzanne E. Little; Lynley Marshall; Lara Perryman; Marie Regairaz; Marta Viana-Pereira; Raisa Vuononvirta; Swee Y. Sharp; Jorge S. Reis-Filho; João N. Stávale; Safa Al-Sarraj; Rui M. Reis; Gilles Vassal; Andrew D.J. Pearson; Darren Hargrave; David W. Ellison; Paul Workman; Chris Jones
Progesterone Inhibition of Wnt/β-Catenin Signaling in Normal Endometrium and Endometrial Cancer
Yongyi Wang; Payman Hanifi-Moghaddam; Eline E. Hanekamp; Helenius J. Kloosterboer; Patrick Franken; Jos Veldscholte; Helena C. van Doorn; Patricia C. Ewing; J. Julie Kim; J. Anton Grootegoed; Curt W. Burger; Riccardo Fodde; Leen J. Blok
Cancer Therapy: Preclinical
Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer
Mohamed S. Arredouani; Bin Lu; Manoj Bhasin; Miriam Eljanne; Wen Yue; Juan-Miguel Mosquera; Glenn J. Bubley; Vivian Li; Mark A. Rubin; Towia A. Libermann; Martin G. Sanda
Candidate Biomarkers of Response to an Experimental Cancer Drug Identified through a Large-scale RNA Interference Genetic Screen
Jasper Mullenders; Wolfgang von der Saal; Miranda M.W. van Dongen; Ulrike Reiff; Rogier van Willigen; Roderick L. Beijersbergen; Georg Tiefenthaler; Christian Klein; René Bernards
Induction of Bim Expression Contributes to the Antitumor Synergy Between Sorafenib and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibitor CI-1040 in Hepatocellular Carcinoma
Da-Liang Ou; Ying-Chun Shen; Ja-Der Liang; Jun-Yang Liou; Sung-Liang Yu; Hsiang-Hsuan Fan; Da-Sheng Wang; Yen-Shen Lu; Chiun Hsu; Ann-Lii Cheng
High-Dose Zoledronic Acid Impacts Bone Remodeling with Effects on Osteoblastic Lineage and Bone Mechanical Properties
Samantha Pozzi; Sonia Vallet; Siddhartha Mukherjee; Diana Cirstea; Nileshwari Vaghela; Loredana Santo; Eyal Rosen; Hiroshi Ikeda; Yutaka Okawa; Tanyel Kiziltepe; Jesse Schoonmaker; Wanling Xie; Teru Hideshima; Edie Weller; Mary L. Bouxsein; Nikhil C. Munshi; Kenneth C. Anderson; Noopur Raje
Imaging, Diagnosis, Prognosis
Metabolic Tumor Volume of [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Predicts Short-Term Outcome to Radiotherapy With or Without Chemotherapy in Pharyngeal Cancer
Man Ki Chung; Han-Sin Jeong; Sang Gyu Park; Jeon Yeob Jang; Young-Ik Son; Joon Young Choi; Seung Hyup Hyun; Keunchil Park; Myung-Ju Ahn; Yong Chan Ahn; Hyung-Jin Kim; Young-Hyeh Ko; Chung-Hwan Baek
Circulating Levels of Soluble KIT Serve as a Biomarker for Clinical Outcome in Gastrointestinal Stromal Tumor Patients Receiving Sunitinib following Imatinib Failure
Samuel E. DePrimo; Xin Huang; Martin E. Blackstein; Christopher R. Garrett; Charles S. Harmon; Patrick Schöffski; Manisha H. Shah; Jaap Verweij; Charles M. Baum; George D. Demetri
Low p27 Expression Predicts Early Relapse and Death in Postmenopausal Hormone Receptor–Positive Breast Cancer Patients Receiving Adjuvant Tamoxifen Therapy
Martin Filipits; Margaretha Rudas; Harald Heinzl; Raimund Jakesz; Ernst Kubista; Sigurd Lax; Walter Schippinger; Otto Dietze; Richard Greil; Wolfgang Stiglbauer; Werner Kwasny; Alexander Nader; Michael Stierer; Michael F.X. Gnant; for the Austrian Breast and Colorectal Cancer Study Group
Cancer Therapy: Clinical
A Multi-Institutional Phase II Study of the Efficacy and Tolerability of Lapatinib in Patients with Advanced Hepatocellular Carcinomas
Tanios Bekaii-Saab; Joseph Markowitz; Nichole Prescott; Wolfgang Sadee; Nyla Heerema; Lai Wei; Zunyan Dai; Audrey Papp; Angela Campbell; Kristy Culler; Catherine Balint; Bert O'Neil; Ruey-min Lee; Mark Zalupski; Janet Dancey; Helen Chen; Michael Grever; Charis Eng; Miguel Villalona-Calero
Molecular Target Modulation, Imaging, and Clinical Evaluation of Gastrointestinal Stromal Tumor Patients Treated with Sunitinib Malate after Imatinib Failure
George D. Demetri; Michael C. Heinrich; Jonathan A. Fletcher; Christopher D.M. Fletcher; Annick D. Van den Abbeele; Christopher L. Corless; Cristina R. Antonescu; Suzanne George; Jeffrey A. Morgan; Ming Hui Chen; Carlo L. Bello; Xin Huang; Darrel P. Cohen; Charles M. Baum; Robert G. Maki
A Phase I Study of Single-Agent Nilotinib or in Combination with Imatinib in Patients with Imatinib-Resistant Gastrointestinal Stromal Tumors
George D. Demetri; Paolo G. Casali; Jean-Yves Blay; Margaret von Mehren; Jeffrey A. Morgan; Rossella Bertulli; Isabelle Ray-Coquard; Philippe Cassier; Monica Davey; Hossein Borghaei; Daniel Pink; Maria Debiec-Rychter; Wing Cheung; Stuart M. Bailey; Maria Luisa Veronese; Annette Reichardt; Elena Fumagalli; Peter Reichardt
A Phase I Trial of Immunotherapy with Lapuleucel-T (APC8024) in Patients with Refractory Metastatic Tumors that Express HER-2/neu
Prema P. Peethambaram; Michelle E. Melisko; Kristine J. Rinn; Steven R. Alberts; Nicole M. Provost; Lori A. Jones; Robert B. Sims; Lisa R. C. Lin; Mark W. Frohlich; John W. Park
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