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1 May 2008
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Cover Image
Strong PTOV1 expression is seen in high-grade prostatic intraepithelial neoplasia lesions from the prostate biopsy of a patient with cancer detected in the follow-up. For further details, please see the article by Morote and coworkers beginning on page 2617 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Molecular Pathways
Human Cancer Biology
High-Resolution Array-Based Comparative Genomic Hybridization of Bladder Cancers Identifies Mouse Double Minute 4 (MDM4) as an Amplification Target Exclusive of MDM2 and TP53
Abhi Veerakumarasivam; Helen E. Scott; Suet-Feung Chin; Anne Warren; Matthew J. Wallard; Donna Grimmer; Koichi Ichimura; Carlos Caldas; V. Peter Collins; David E. Neal; John D. Kelly
Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma
Yutaka Suehiro; Chi Wai Wong; Lucian R. Chirieac; Yutaka Kondo; Lanlan Shen; C. Renee Webb; Yee Wai Chan; Annie S.Y. Chan; Tsun Leung Chan; Tsung-Teh Wu; Asif Rashid; Yuichiro Hamanaka; Yuji Hinoda; Rhonda L. Shannon; Xuemei Wang; Jeffrey Morris; Jean-Pierre J. Issa; Siu Tsan Yuen; Suet Yi Leung; Stanley R. Hamilton
Secreted CXCL1 Is a Potential Mediator and Marker of the Tumor Invasion of Bladder Cancer
Hiroaki Kawanishi; Yoshiyuki Matsui; Masaaki Ito; Jun Watanabe; Takeshi Takahashi; Koji Nishizawa; Hiroyuki Nishiyama; Toshiyuki Kamoto; Yoshiki Mikami; Yoshinori Tanaka; Giman Jung; Hideo Akiyama; Hitoshi Nobumasa; Parry Guilford; Anthony Reeve; Yasushi Okuno; Gozoh Tsujimoto; Eijiro Nakamura; Osamu Ogawa
Imaging, Diagnosis, Prognosis
Prognostic Value of the Molecular Detection of Circulating Tumor Cells Using a Multimarker Reverse Transcription-PCR Assay for Cytokeratin 19, Mammaglobin A, and HER2 in Early Breast Cancer
Michail Ignatiadis; Galatea Kallergi; Maria Ntoulia; Maria Perraki; Stella Apostolaki; Maria Kafousi; Grigorios Chlouverakis; Efstathios Stathopoulos; Evi Lianidou; Vassilis Georgoulias; Dimitris Mavroudis
Regional Hypoxia in Glioblastoma Multiforme Quantified with [18F]Fluoromisonidazole Positron Emission Tomography before Radiotherapy: Correlation with Time to Progression and Survival
Alexander M. Spence; Mark Muzi; Kristin R. Swanson; Finbarr O'Sullivan; Jason K. Rockhill; Joseph G. Rajendran; Tom C.H. Adamsen; Jeanne M. Link; Paul E. Swanson; Kevin J. Yagle; Robert C. Rostomily; Daniel L. Silbergeld; Kenneth A. Krohn
Serial Analysis of Gene Expression Identifies Connective Tissue Growth Factor Expression as a Prognostic Biomarker in Gallbladder Cancer
Hector Alvarez; Alejandro Corvalan; Juan C. Roa; Pedram Argani; Francisco Murillo; Jennifer Edwards; Robert Beaty; Georg Feldmann; Seung-Mo Hong; Michael Mullendore; Ivan Roa; Luis Ibañez; Fernando Pimentel; Alfonso Diaz; Gregory J. Riggins; Anirban Maitra
Microdistribution of Targeted, Fluorescently Labeled Anti–Carcinoembryonic Antigen Antibody in Metastatic Colorectal Cancer: Implications for Radioimmunotherapy
Elena F. Fidarova; Ethaar El-Emir; Geoffrey M. Boxer; Uzma Qureshi; Jason L.J. Dearling; Mathew P. Robson; Richard H.J. Begent; Klaus R. Trott; R. Barbara Pedley
Use of Yeast-Secreted In vivo Biotinylated Recombinant Antibodies (Biobodies) in Bead-Based ELISA
Nathalie Scholler; Kimberly A. Lowe; Lindsay A. Bergan; Archana V. Kampani; Vivian Ng; Robin M. Forrest; Jason D. Thorpe; Jenny A. Gross; Barbara M. Garvik; Ronny Drapkin; Garnet L. Anderson; Nicole Urban
Quantitative Promoter Hypermethylation Analysis of Cancer-Related Genes in Salivary Gland Carcinomas: Comparison with Methylation-Specific PCR Technique and Clinical Significance
Eung-Seok Lee; Jean-Pierre Issa; Dianna B. Roberts; Michelle D. Williams; Randal S. Weber; Merrill S. Kies; Adel K. El-Naggar
Down-Regulation of Phosphatidylinositol 3′-Kinase/AKT/Molecular Target of Rapamycin Metabolic Pathway by Primary Letrozole-Based Therapy in Human Breast Cancer
Daniele Generali; Stephen B. Fox; Maria Pia Brizzi; Giovanni Allevi; Simone Bonardi; Sergio Aguggini; Manuela Milani; Alessandra Bersiga; Leticia Campo; Rossana Dionisio; Federica Vergoni; Roberto Giardini; Luigi Dogliotti; Alberto Bottini; Adrian L. Harris; Alfredo Berruti
Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer
Donal J. Brennan; Elton Rexhepaj; Sallyann L. O'Brien; Elaine McSherry; Darran P. O'Connor; Ailís Fagan; Aedín C. Culhane; Desmond G. Higgins; Karin Jirstrom; Robert C. Millikan; Goran Landberg; Michael J. Duffy; Stephen M. Hewitt; William M. Gallagher
Cancer Therapy: Clinical
The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: A First in Class Epothilone B Analogue in Late-Phase Clinical Development
Sanjay Goel; Marvin Cohen; S. Nilgün Çömezoglu; Lionel Perrin; François André; David Jayabalan; Lisa Iacono; Adriana Comprelli; Van T. Ly; Donglu Zhang; Carrie Xu; W. Griffith Humphreys; Hayley McDaid; Gary Goldberg; Susan B. Horwitz; Sridhar Mani
Cardiac Toxicity and Efficacy of Trastuzumab Combined with Pertuzumab in Patients with Trastuzumab-Insensitive Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer
Chia C. Portera; Janice M. Walshe; Douglas R. Rosing; Neelima Denduluri; Arlene W. Berman; Ujala Vatas; Margarita Velarde; Catherine K. Chow; Seth M. Steinberg; Diana Nguyen; Sherry X. Yang; Sandra M. Swain
Phase II, Open-Label Study Evaluating the Activity of Imatinib in Treating Life-Threatening Malignancies Known to Be Associated with Imatinib-Sensitive Tyrosine Kinases
Michael C. Heinrich; Heikki Joensuu; George D. Demetri; Christopher L. Corless; Jane Apperley; Jonathan A. Fletcher; Denis Soulieres; Stephan Dirnhofer; Amy Harlow; Ajia Town; Arin McKinley; Shane G. Supple; John Seymour; Lilla Di Scala; Allan van Oosterom; Richard Herrmann; Zariana Nikolova; and Grant McArthur; for the Imatinib Target Exploration Consortium Study B2225
A Phase I Study of the Safety and Pharmacokinetics of the Combination of Pertuzumab (rhuMab 2C4) and Capecitabine in Patients with Advanced Solid Tumors
Joan Albanell; Clara Montagut; Eileen T. Jones; Linda Pronk; Begoña Mellado; Janette Beech; Pere Gascon; Gerhard Zugmaier; Michael Brewster; Mark P. Saunders; Juan W. Valle
A Phase I Pharmacokinetic and Pharmacodynamic Correlative Study of the Antisense Bcl-2 Oligonucleotide G3139, in Combination with Carboplatin and Paclitaxel, in Patients with Advanced Solid Tumors
Glenn Liu; Jill Kolesar; Douglas G. McNeel; Catherine Leith; Kathy Schell; Jens Eickhoff; Fred Lee; Anne Traynor; Rebecca Marnocha; Dona Alberti; James Zwiebel; George Wilding
Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission
Catherine S.M. Diefenbach; Sacha Gnjatic; Paul Sabbatini; Carol Aghajanian; Martee L. Hensley; David R. Spriggs; Alexia Iasonos; Helen Lee; Bo Dupont; Sandra Pezzulli; Achim A. Jungbluth; Lloyd J. Old; Jakob Dupont
5-Fluorouracil Pharmacokinetics Predicts Disease-free Survival in Patients Administered Adjuvant Chemotherapy for Colorectal Cancer
Antonello Di Paolo; Monica Lencioni; Federica Amatori; Samantha Di Donato; Guido Bocci; Cinzia Orlandini; Marianna Lastella; Francesca Federici; Mauro Iannopollo; Alfredo Falcone; Sergio Ricci; Mario Del Tacca; Romano Danesi
A Phase 2 Clinical Trial of Deforolimus (AP23573, MK-8669), a Novel Mammalian Target of Rapamycin Inhibitor, in Patients with Relapsed or Refractory Hematologic Malignancies
David A. Rizzieri; Eric Feldman; John F. DiPersio; Nashat Gabrail; Wendy Stock; Roger Strair; Victor M. Rivera; Maher Albitar; Camille L. Bedrosian; Francis J. Giles
Treatment of Hormone-Refractory Prostate Cancer with Docetaxel or Mitoxantrone: Relationships between Prostate-Specific Antigen, Pain, and Quality of Life Response and Survival in the TAX-327 Study
Dominik R. Berthold; Gregory R. Pond; Martin Roessner; Ronald de Wit; Mario Eisenberger; and Ian F. Tannock; on behalf of the TAX-327 investigators
Cancer Therapy: Preclinical
The Acidic Tumor Microenvironment Promotes the Reconversion of Nitrite into Nitric Oxide: Towards a New and Safe Radiosensitizing Strategy
Françoise Frérart; Pierre Sonveaux; Géraldine Rath; Alexandra Smoos; Ahlam Meqor; Nicolas Charlier; Bénédicte F. Jordan; Julie Saliez; Agnès Noël; Chantal Dessy; Bernard Gallez; Olivier Feron
CS1, a Potential New Therapeutic Antibody Target for the Treatment of Multiple Myeloma
Eric D. Hsi; Roxanne Steinle; Balaji Balasa; Susann Szmania; Aparna Draksharapu; Benny P. Shum; Mahrukh Huseni; David Powers; Amulya Nanisetti; Yin Zhang; Audie G. Rice; Anne van Abbema; Melanie Wong; Gao Liu; Fenghuang Zhan; Myles Dillon; Shihao Chen; Susan Rhodes; Franklin Fuh; Naoya Tsurushita; Shankar Kumar; Vladimir Vexler; John D. Shaughnessy, Jr.; Bart Barlogie; Frits van Rhee; Mohamad Hussein; Daniel E.H. Afar; Marna B. Williams
GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma
Hans Reiser; Jianying Wang; Lee Chong; William J. Watkins; Adrian S. Ray; Riri Shibata; Gabriel Birkus; Tomas Cihlar; Sylvia Wu; Bei Li; Xiaohong Liu; Ilana N. Henne; Grushenka H.I. Wolfgang; Manoj Desai; Gerald R. Rhodes; Arnold Fridland; William A. Lee; William Plunkett; David Vail; Douglas H. Thamm; Robert Jeraj; Daniel B. Tumas
Posttransplant Administration of Cyclophosphamide and Donor Lymphocyte Infusion Induces Potent Antitumor Immunity to Solid Tumor
Masatoshi Eto; Yoriyuki Kamiryo; Ario Takeuchi; Masahiko Harano; Katsunori Tatsugami; Mamoru Harada; Keijiro Kiyoshima; Masumitsu Hamaguchi; Takanori Teshima; Masazumi Tsuneyoshi; Yasunobu Yoshikai; Seiji Naito
A Novel Transforming Growth Factor β Receptor Kinase Inhibitor, A-77, Prevents the Peritoneal Dissemination of Scirrhous Gastric Carcinoma
Hidemi Kawajiri; Masakazu Yashiro; Osamu Shinto; Kazunori Nakamura; Masashige Tendo; Satoru Takemura; Manabu Node; Yoshio Hamashima; Tetsuya Kajimoto; Tetsuji Sawada; Masaichi Ohira; Kosei Hirakawa
Cancer Prevention and Susceptibility
The Average Cumulative Risks of Breast and Ovarian Cancer for Carriers of Mutations in BRCA1 and BRCA2 Attending Genetic Counseling Units in Spain
Roger L. Milne; Ana Osorio; Teresa Ramón y Cajal; Ana Vega; Gemma Llort; Miguel de la Hoya; Orland Díez; M. Carmen Alonso; Conxi Lazaro; Ignacio Blanco; Ana Sánchez-de-Abajo; Trinidad Caldés; Ana Blanco; Begoña Graña; Mercedes Durán; Eladio Velasco; Isabel Chirivella; Eva Esteban Cardeñosa; María-Isabel Tejada; Elena Beristain; María-Dolores Miramar; María-Teresa Calvo; Eduardo Martínez; Carmen Guillén; Raquel Salazar; Carlos San Román; Antonis C. Antoniou; Miguel Urioste; Javier Benítez
Tagging Single Nucleotide Polymorphisms in Phosphoinositide-3-Kinase–Related Protein Kinase Genes Involved in DNA Damage “Checkpoints” and Lung Cancer Susceptibility
Zhibin Hu; Hongliang Liu; Haifeng Wang; Ruifen Miao; Weiwei Sun; Guangfu Jin; Ying Wang; Hongxia Ma; Li Jin; Qingyi Wei; Daru Lu; Wei Huang; Hongbing Shen
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