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Volume 14, Issue 8
15 April 2008
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    issue cover
    CXCL5 expression (red) in the rat colon cancer cell line CC531S (nuclei, green). Low level of CXCL5 expression is associated with aggressive tumor growth in a rat model and predicts decreased survival rates in patients treated with surgery for colorectal cancer. A positive correlation between levels of CXCL5 and intratumoral CD8+ T-cell infiltration in colon cancer suggests that CXCL5 is involved in themigration of immune cells into the tumor and might be implicated in the antitumor immune response. For further details, please see Speetjens and coworkers on page 2276 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Molecular Pathways

Targeting Ras in Myeloid Leukemias
Benjamin S. Braun; Kevin Shannon
View articletitled, Targeting Ras in Myeloid Leukemias
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Human Cancer Biology

Epidermal Growth Factor Receptor Controls Flat Dysplastic Aberrant Crypt Foci Development and Colon Cancer Progression in the Rat Azoxymethane Model
Urszula Dougherty; Amikar Sehdev; Sonia Cerda; Reba Mustafi; Nathaniel Little; Weihua Yuan; Sujatha Jagadeeswaran; Anusara Chumsangsri; Jorge Delgado; Maria Tretiakova; Loren Joseph; John Hart; Ezra E.W. Cohen; Lata Aluri; Alessandro Fichera; Marc Bissonnette
View articletitled, Epidermal Growth Factor Receptor Controls Flat Dysplastic Aberrant Crypt Foci Development and Colon Cancer Progression in the Rat Azoxymethane Model
Supplementary data
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Endometrial Glandular Dysplasia with Frequent p53 Gene Mutation: A Genetic Evidence Supporting Its Precancer Nature for Endometrial Serous Carcinoma
Lin Jia; Yongjuan Liu; Xiaofang Yi; Alexander Miron; Christopher P. Crum; Beihua Kong; Wenxin Zheng
View articletitled, Endometrial Glandular Dysplasia with Frequent p53 Gene Mutation: A Genetic Evidence Supporting Its Precancer Nature for Endometrial Serous Carcinoma
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Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma
Johannes A. Mayr; David Meierhofer; Franz Zimmermann; Rene Feichtinger; Christian Kögler; Manfred Ratschek; Nikolaus Schmeller; Wolfgang Sperl; Barbara Kofler
View articletitled, Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma
Supplementary data
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Disrupted Expression of CXCL5 in Colorectal Cancer Is Associated with Rapid Tumor Formation in Rats and Poor Prognosis in Patients
Frank M. Speetjens; Peter J.K. Kuppen; Maro H. Sandel; Anand G. Menon; Danny Burg; Cornelis J.H. van de Velde; Rob A.E.M. Tollenaar; Hans J.G.M. de Bont; J. Fred Nagelkerke
View articletitled, Disrupted Expression of CXCL5 in Colorectal Cancer Is Associated with Rapid Tumor Formation in Rats and Poor Prognosis in Patients
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KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors
Séverine Tabone-Eglinger; Frédéric Subra; Hiba El Sayadi; Laurent Alberti; Eric Tabone; Jean-Philippe Michot; Nathalie Théou-Anton; Antoinette Lemoine; Jean-Yves Blay; Jean-François Emile
View articletitled, <em>KIT</em> Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors
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Imaging, Diagnosis, Prognosis

Escherichia coli Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging
Peter Brader; Jochen Stritzker; Christopher C. Riedl; Pat Zanzonico; Shangde Cai; Eva M. Burnazi; E.Rashid Ghani; Hedvig Hricak; Aladar A. Szalay; Yuman Fong; Ronald Blasberg
View articletitled, <em>Escherichia coli</em> Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging
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Ornithine Decarboxylase G316A Genotype Is Prognostic for Colorectal Adenoma Recurrence and Predicts Efficacy of Aspirin Chemoprevention
Richard A. Hubner; Kenneth R. Muir; Jo-Fen Liu; Richard F.A. Logan; Matthew J. Grainge; Richard S. Houlston; Members of the UKCAP Consortium
View articletitled, Ornithine Decarboxylase G316A Genotype Is Prognostic for Colorectal Adenoma Recurrence and Predicts Efficacy of Aspirin Chemoprevention
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Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival
Kazuhiko Ino; Eiko Yamamoto; Kiyosumi Shibata; Hiroaki Kajiyama; Norio Yoshida; Mikio Terauchi; Akihiro Nawa; Tetsuro Nagasaka; Osamu Takikawa; Fumitaka Kikkawa
View articletitled, Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival
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Increased Expression of Id Family Proteins in Small Cell Lung Cancer and its Prognostic Significance
Laleh Kamalian; John R. Gosney; Shiva S. Forootan; Christopher S. Foster; Zheng Z. Bao; Carol Beesley; Youqiang Ke
View articletitled, Increased Expression of Id Family Proteins in Small Cell Lung Cancer and its Prognostic Significance
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Up-Regulation of Peroxiredoxin 1 in Lung Cancer and Its Implication as a Prognostic and Therapeutic Target
Joo-Heon Kim; Paul N. Bogner; Sun-Hee Baek; Nithya Ramnath; Ping Liang; Hak-Ryul Kim; Chris Andrews; Young-Mee Park
View articletitled, Up-Regulation of Peroxiredoxin 1 in Lung Cancer and Its Implication as a Prognostic and Therapeutic Target
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Clinical Significance of High Mobility Group A2 in Human Gastric Cancer and Its Relationship to let-7 MicroRNA Family
Kazuo Motoyama; Hiroshi Inoue; Yoshito Nakamura; Hiroyuki Uetake; Kenichi Sugihara; Masaki Mori
View articletitled, Clinical Significance of High Mobility Group A2 in Human Gastric Cancer and Its Relationship to <em>let-7</em> MicroRNA Family
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Vascularization in Primary Breast Carcinomas: Its Prognostic Significance and Relationship with Tumor Cell Dissemination
Hari Prasad Dhakal; Bjørn Naume; Marit Synnestvedt; Elin Borgen; Rolf Kaaresen; Ellen Schlichting; Gro Wiedswang; Assia Bassarova; Karl-Erik Giercksky; Jahn M. Nesland
View articletitled, Vascularization in Primary Breast Carcinomas: Its Prognostic Significance and Relationship with Tumor Cell Dissemination
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Amphiregulin Is a Promising Prognostic Marker for Liver Metastases of Colorectal Cancer
Michiyo Yamada; Yasushi Ichikawa; Shigeru Yamagishi; Nobuyoshi Momiyama; Mitsuyoshi Ota; Syoichi Fujii; Kuniya Tanaka; Shinji Togo; Shigeo Ohki; Hiroshi Shimada
View articletitled, Amphiregulin Is a Promising Prognostic Marker for Liver Metastases of Colorectal Cancer
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The Use of Magnetic Resonance Imaging to Noninvasively Detect Genetic Signatures in Oligodendroglioma
Robert Brown; Magdalena Zlatescu; Angelique Sijben; Gloria Roldan; Jay Easaw; Peter Forsyth; Ian Parney; Robert Sevick; Elizabeth Yan; Douglas Demetrick; David Schiff; Gregory Cairncross; Ross Mitchell
View articletitled, The Use of Magnetic Resonance Imaging to Noninvasively Detect Genetic Signatures in Oligodendroglioma
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Activation of Placenta-Specific Transcription Factor Distal-less Homeobox 5 Predicts Clinical Outcome in Primary Lung Cancer Patients
Tatsuya Kato; Nagato Sato; Atsushi Takano; Masaki Miyamoto; Hitoshi Nishimura; Eiju Tsuchiya; Satoshi Kondo; Yusuke Nakamura; Yataro Daigo
View articletitled, Activation of Placenta-Specific Transcription Factor <em>Distal-less</em> Homeobox 5 Predicts Clinical Outcome in Primary Lung Cancer Patients
Supplementary data
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A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck
Carmen J. Marsit; Candice C. Black; Marshall R. Posner; Karl T. Kelsey
View articletitled, A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck
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Urinary Biomarkers Predict Brain Tumor Presence and Response to Therapy
Edward R. Smith; David Zurakowski; Ali Saad; R. Michael Scott; Marsha A. Moses
View articletitled, Urinary Biomarkers Predict Brain Tumor Presence and Response to Therapy
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Clinical, Radiographic, and Biochemical Characterization of Multiple Myeloma Patients with Osteonecrosis of the Jaw
Noopur Raje; Sook-Bin Woo; Karen Hande; Jeffrey T. Yap; Paul G. Richardson; Sonia Vallet; Nathaniel Treister; Teru Hideshima; Niall Sheehy; Shweta Chhetri; Brendan Connell; Wanling Xie; Yu-Tzu Tai; Agnieszka Szot-Barnes; Mei Tian; Robert L. Schlossman; Edie Weller; Nikhil C. Munshi; Annick D. Van Den Abbeele; Kenneth C. Anderson
View articletitled, Clinical, Radiographic, and Biochemical Characterization of Multiple Myeloma Patients with Osteonecrosis of the Jaw
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Understanding the Biological Basis of Autofluorescence Imaging for Oral Cancer Detection: High-Resolution Fluorescence Microscopy in Viable Tissue
Ina Pavlova; Michelle Williams; Adel El-Naggar; Rebecca Richards-Kortum; Ann Gillenwater
View articletitled, Understanding the Biological Basis of Autofluorescence Imaging for Oral Cancer Detection: High-Resolution Fluorescence Microscopy in Viable Tissue
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Cancer Therapy: Clinical

Prediction of Broad Spectrum Resistance of Tumors towards Anticancer Drugs
Thomas Efferth; V. Badireenath Konkimalla; Yi-Fen Wang; Axel Sauerbrey; Silke Meinhardt; Felix Zintl; Jürgen Mattern; Manfred Volm
View articletitled, Prediction of Broad Spectrum Resistance of Tumors towards Anticancer Drugs
Supplementary data
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Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells
Sylvain Ladoire; Laurent Arnould; Lionel Apetoh; Bruno Coudert; Francois Martin; Bruno Chauffert; Pierre Fumoleau; François Ghiringhelli
View articletitled, Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3<sup>+</sup> Regulatory T Cells
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Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions
Brian S. Shumway; Laura A. Kresty; Peter E. Larsen; Jared C. Zwick; Bo Lu; Henry W. Fields; Russell J. Mumper; Gary D. Stoner; Susan R. Mallery
View articletitled, Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions
Supplementary data
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Sunitinib for Treatment of Advanced Renal Cell Cancer: Primary Tumor Response
Astrid A.M. van der Veldt; Martijn R. Meijerink; Alfons J.M. van den Eertwegh; Axel Bex; Gijsbert de Gast; John B.A.G. Haanen; Epie Boven
View articletitled, Sunitinib for Treatment of Advanced Renal Cell Cancer: Primary Tumor Response
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Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer
Steven Attia; Jens Eickhoff; George Wilding; Douglas McNeel; Jules Blank; Harish Ahuja; Alcee Jumonville; Michael Eastman; Daniel Shevrin; Michael Glode; Dona Alberti; Mary Jane Staab; Dottie Horvath; Jane Straus; Rebecca Marnocha; Glenn Liu
View articletitled, Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer
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A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia
Rebecca B. Klisovic; Wendy Stock; Spero Cataland; Marko I. Klisovic; Shujun Liu; William Blum; Margaret Green; Olatoyosi Odenike; Lucy Godley; Jennifer Vanden Burgt; Emily Van Laar; Michael Cullen; A. Robert Macleod; Jeffrey M. Besterman; Gregory K. Reid; John C. Byrd; Guido Marcucci
View articletitled, A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia
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Cancer Therapy: Preclinical

Treatment of Cancer with a Novel Dual-Targeted Conditionally Replicative Adenovirus Armed with mda-7/IL-24 Gene
Jingjing Luo; Qingmei Xia; Rui Zhang; Chen Lv; Wei Zhang; Yingxin Wang; Qiang Cui; Li Liu; Rong Cai; Cheng Qian
View articletitled, Treatment of Cancer with a Novel Dual-Targeted Conditionally Replicative Adenovirus Armed with <em>mda-7/IL-24</em> Gene
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Inhibiting Fatty Acid Synthase for Chemoprevention of Chemically Induced Lung Tumors
Hajime Orita; Jonathan Coulter; Ellen Tully; Francis P. Kuhajda; Edward Gabrielson
View articletitled, Inhibiting Fatty Acid Synthase for Chemoprevention of Chemically Induced Lung Tumors
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EXEL-7647 Inhibits Mutant Forms of ErbB2 Associated with Lapatinib Resistance and Neoplastic Transformation
Torsten Trowe; Sotiria Boukouvala; Keith Calkins; Richard E. Cutler, Jr.; Ryan Fong; Roel Funke; Steven B. Gendreau; Yong D. Kim; Nicole Miller; John R. Woolfrey; Valentina Vysotskaia; Jing Ping Yang; Mary E. Gerritsen; David J. Matthews; Peter Lamb; Timothy S. Heuer
View articletitled, EXEL-7647 Inhibits Mutant Forms of ErbB2 Associated with Lapatinib Resistance and Neoplastic Transformation
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Therapeutic Significance of Elevated Tissue Transglutaminase Expression in Pancreatic Cancer
Amit Verma; Sushovan Guha; Parmeswaran Diagaradjane; Ajaikumar B. Kunnumakkara; Angela M. Sanguino; Gabriel Lopez-Berestein; Anil K. Sood; Bharat B. Aggarwal; Sunil Krishnan; Juri G. Gelovani; Kapil Mehta
View articletitled, Therapeutic Significance of Elevated Tissue Transglutaminase Expression in Pancreatic Cancer
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Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib
Ralf Weichsel; Carolin Dix; Linda Wooldridge; Matthew Clement; Angharad Fenton-May; Andrew K. Sewell; Josef Zezula; Elisabeth Greiner; Emma Gostick; David A. Price; Hermann Einsele; Ruth Seggewiss
View articletitled, Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib
Supplementary data
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Noninvasive Imaging of Apoptosis and Its Application in Cancer Therapeutics
Julia M. Coppola; Brian D. Ross; Alnawaz Rehemtulla
View articletitled, Noninvasive Imaging of Apoptosis and Its Application in Cancer Therapeutics
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Dopamine Increases the Efficacy of Anticancer Drugs in Breast and Colon Cancer Preclinical Models
Chandrani Sarkar; Debanjan Chakroborty; Uttio Roy Chowdhury; Partha Sarathi Dasgupta; Sujit Basu
View articletitled, Dopamine Increases the Efficacy of Anticancer Drugs in Breast and Colon Cancer Preclinical Models
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Letters to the Editor

Deaths among Patients with Screen-Detected Lung Cancer
Gerard A. Silvestri
View articletitled, Deaths among Patients with Screen-Detected Lung Cancer
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Computed Tomography Screening for Lung Cancer
Peter Bach
View articletitled, Computed Tomography Screening for Lung Cancer
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Reply to the Letters to the Editor from Bach and Silvestri
Claudia I. Henschke
View articletitled, Reply to the Letters to the Editor from Bach and Silvestri
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Biomarkers In Early Clinical Trials: the Committed and the Skeptics
Udai Banerji; Johann de Bono; Ian Judson; Stanley Kaye; Paul Workman
View articletitled, Biomarkers In Early Clinical Trials: the Committed and the Skeptics
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Reply to the Letter to the Editor from Banerji et al
Bernardo Goulart; Thomas G. Roberts; Jeffrey Clark; Bruce A. Chabner
View articletitled, Reply to the Letter to the Editor from Banerji et al
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T-Cell Response in B-Cell Lymphomas: Favorable or Unfavorable?
Joost J. Oudejans; Jettie J.F. Muris; Saskia A.G.M. Cillessen; Chris J.L.M. Meijer
View articletitled, T-Cell Response in B-Cell Lymphomas: Favorable or Unfavorable?
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Reply to the Letter to the Editor from Banerji et al
Mark J. Ratain; Robert H. Glassman
View articletitled, Reply to the Letter to the Editor from Banerji et al
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Reply to the Letter to the Editor from Oudejans et al
Kung-Chao Chang; Dan Jones
View articletitled, Reply to the Letter to the Editor from Oudejans et al
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Survival in Microsatellite-Unstable Colorectal Cancer
Toshiaki Watanabe; Yoko Yamamoto; Hideki Yamada; Tamuro Hayama; Yoshiko Aoyagi; Keisuke Nakamura; Hajime Shibuya; Takashi Kobunai
View articletitled, Survival in Microsatellite-Unstable Colorectal Cancer
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Reply to the Letter to the Editor from Watanabe et al
Alberto Malesci; Luigi Laghi; Paolo Bianchi
View articletitled, Reply to the Letter to the Editor from Watanabe et al
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Population Pharmacokinetc/Pharmacodynamic Modeling of Paclitaxel and Carboplatin in Ovarian Cancer
Merrill J. Egorin
View articletitled, Population Pharmacokinetc/Pharmacodynamic Modeling of Paclitaxel and Carboplatin in Ovarian Cancer
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Reply to the Letter to the Editor from Egorin
Markus Joerger; Jan H.N. Schelleus
View articletitled, Reply to the Letter to the Editor from Egorin
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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