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15 November 2008
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Cover Image
Cover Image
HDAC6 inhibition prevents aggresome formation in UPS-stressed ovarian cancer cells. ES-2 ovarian cancer cells were incubated for 24 hours with 5 nmol/L PS-341 proteasome inhibitor, 10 nmol/L NK84 HDAC6 inhibitor or both, and cellular DNA (blue), ubiquitin (green), and vimentin (red) were viewed by immunofluorescent staining. For further details, please see Bazzaro and coworkers on page 7340 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Molecular Pathways
Human Cancer Biology
Clonal Evolution in t(14;18)-Positive Follicular Lymphoma, Evidence for Multiple Common Pathways, and Frequent Parallel Clonal Evolution
Francesco d'Amore; Eric Chan; Javeed Iqbal; Huimin Geng; Ken Young; Li Xiao; Michelle M. Hess; Warren G. Sanger; Lynette Smith; Carsten Wiuf; Oskar Hagberg; Kai Fu; Wing C. Chan; Bhavana J. Dave
Surgery followed by Persistence of High-Grade Squamous Intraepithelial Lesions Is Associated with the Induction of a Dysfunctional HPV16-Specific T-Cell Response
Peggy J. de Vos van Steenwijk; Sytse J. Piersma; Marij J.P. Welters; Jeanette M. van der Hulst; Gertjan Fleuren; Bart W.J. Hellebrekers; Gemma G. Kenter; Sjoerd H. van der Burg
Identification of the Molecular Mechanisms for Dedifferentiation at the Invasion Front of Colorectal Cancer by a Gene Expression Analysis
Yoshimasa Oku; Takashi Shimoji; Katsunari Takifuji; Tsukasa Hotta; Shozo Yokoyama; Kenji Matsuda; Takashi Higashiguchi; Toshiji Tominaga; Toru Nasu; Koichi Tamura; Masaaki Matsuura; Satoshi Miyata; Yo Kato; Hiroki Yamaue; Yoshio Miki
Endosialin Protein Expression and Therapeutic Target Potential in Human Solid Tumors: Sarcoma versus Carcinoma
Cecile Rouleau; Maritza Curiel; William Weber; Robert Smale; Leslie Kurtzberg; James Mascarello; Carol Berger; Gina Wallar; Rebecca Bagley; Nakayuki Honma; Kazumasa Hasegawa; Isao Ishida; Shiro Kataoka; Beth L. Thurberg; Khodadad Mehraein; Bruce Horten; Glenn Miller; Beverly A. Teicher
Overexpression of Indoleamine 2,3-Dioxygenase in Human Endometrial Carcinoma Cells Induces Rapid Tumor Growth in a Mouse Xenograft Model
Norio Yoshida; Kazuhiko Ino; Yoshiyuki Ishida; Hiroaki Kajiyama; Eiko Yamamoto; Kiyosumi Shibata; Mikio Terauchi; Akihiro Nawa; Hidetoshi Akimoto; Osamu Takikawa; Ken-ichi Isobe; Fumitaka Kikkawa
Cancer Therapy: Preclinical
Irinophore C, a Novel Nanoformulation of Irinotecan, Alters Tumor Vascular Function and Enhances the Distribution of 5-Fluorouracil and Doxorubicin
Jennifer H.E. Baker; Jeffrey Lam; Alaistair H. Kyle; Jonathan Sy; Thomas Oliver; Steven J. Co; Wieslawa H. Dragowska; Euan Ramsay; Malathi Anantha; Thomas J. Ruth; Michael J. Adam; Andrew Yung; Piotr Kozlowski; Andrew I. Minchinton; Sylvia S.W. Ng; Marcel B. Bally; Donald T.T. Yapp
Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3
Dana D. Hu-Lowe; Helen Y. Zou; Maren L. Grazzini; Max E. Hallin; Grant R. Wickman; Karin Amundson; Jeffrey H. Chen; David A. Rewolinski; Shinji Yamazaki; Ellen Y. Wu; Michele A. McTigue; Brion W. Murray; Robert S. Kania; Patrick O'Connor; David R. Shalinsky; Steve L. Bender
G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors
Carlo Leonetti; Marco Scarsella; Giuseppe Riggio; Angela Rizzo; Erica Salvati; Maurizio D'Incalci; Lidia Staszewsky; Roberta Frapolli; Malcolm F. Stevens; Antonella Stoppacciaro; Marcella Mottolese; Barbara Antoniani; Eric Gilson; Gabriella Zupi; Annamaria Biroccio
Induction of Both CD8+ and CD4+ T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1
Cristina Maccalli; Veronica Di Cristanziano; Valentina Fodale; Domenico Corsi; Giuseppina D'Agostino; Valentina Petrangeli; Luca Laurenti; Sofia Guida; Arabella Mazzocchi; Flavio Arienti; Maria P. Perrone; Chiara Castelli; Licia Rivoltini; Vittorina Zagonel; Marco Tartaglia; Giorgio Parmiani; Filippo Belardelli
Enhanced Antitumor Efficacy of Clinical-Grade Vasculature-Targeted Liposomal Doxorubicin
Fabio Pastorino; Daniela Di Paolo; Federica Piccardi; Beatrice Nico; Domenico Ribatti; Antonio Daga; Gabriella Baio; Carlo E. Neumaier; Chiara Brignole; Monica Loi; Danilo Marimpietri; Gabriella Pagnan; Michele Cilli; Eugene A. Lepekhin; Seema V. Garde; Renato Longhi; Angelo Corti; Theresa M. Allen; Jinzi J. Wu; Mirco Ponzoni
Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity
Robin J. Prestwich; Fiona Errington; Elizabeth J. Ilett; Ruth S.M. Morgan; Karen J. Scott; Timothy Kottke; Jill Thompson; Ewan E. Morrison; Kevin J. Harrington; Hardev S. Pandha; Peter J. Selby; Richard G. Vile; Alan A. Melcher
Imaging, Diagnosis, Prognosis
Loss of Nuclear p27 Expression and Its Prognostic Role in Relation to Cyclin E and p53 Mutation in Gastroenteropancreatic Neuroendocrine Tumors
Patricia Grabowski; Jörg Schrader; Julia Wagner; Dieter Hörsch; Rudolf Arnold; Christian N. Arnold; Inna Georgieva; Harald Stein; Martin Zeitz; Peter T. Daniel; Isrid Sturm
Prediction of Recurrence-Free Survival in Postoperative Non–Small Cell Lung Cancer Patients by Using an Integrated Model of Clinical Information and Gene Expression
Eung-Sirk Lee; Dae-Soon Son; Sung-Hyun Kim; Jinseon Lee; Jisuk Jo; Joungho Han; Heesue Kim; Hyun Joo Lee; Hye Young Choi; Youngja Jung; Miyeon Park; Yu Sung Lim; Kwhanmien Kim; Young Mog Shim; Byung Chul Kim; Kyusang Lee; Nam Huh; Christopher Ko; Kyunghee Park; Jae Won Lee; Yong Soo Choi; Jhingook Kim
Molecular Imaging of Therapeutic Response to Epidermal Growth Factor Receptor Blockade in Colorectal Cancer
H. Charles Manning; Nipun B. Merchant; A. Coe Foutch; John M. Virostko; Shelby K. Wyatt; Chirayu Shah; Eliot T. McKinley; Jingping Xie; Nathan J. Mutic; M. Kay Washington; Bonnie LaFleur; Mohammed Noor Tantawy; Todd E. Peterson; M. Sib Ansari; Ronald M. Baldwin; Mace L. Rothenberg; Darryl J. Bornhop; John C. Gore; Robert J. Coffey
[18F]Fluorothymidine Positron Emission Tomography before and 7 Days after Gefitinib Treatment Predicts Response in Patients with Advanced Adenocarcinoma of the Lung
Hee-Jung Sohn; You-Jung Yang; Jin-Sook Ryu; Seung Jun Oh; Ki Chun Im; Dae Hyuk Moon; Dae Ho Lee; Cheolwon Suh; Jung-Shin Lee; Sang-We Kim
Relationship Between Tumor and Plasma Levels of hTERT mRNA in Patients with Colorectal Cancer: Implications for Monitoring of Neoplastic Disease
Liliana Terrin; Enrica Rampazzo; Salvatore Pucciarelli; Marco Agostini; Roberta Bertorelle; Giovanni Esposito; Paola DelBianco; Donato Nitti; Anita De Rossi
Relapse-Free Survival in Breast Cancer Patients Is Associated with a Gene Expression Signature Characteristic for Inflammatory Breast Cancer
Steven Van Laere; Tim Beissbarth; Ilse Van der Auwera; Gert Van den Eynden; Xuan Bich Trinh; Hilde Elst; Paul Van Hummelen; Peter van Dam; Eric Van Marck; Peter Vermeulen; Luc Dirix
Cancer Therapy: Clinical
Bortezomib-Mediated Inhibition of Steroid Receptor Coactivator-3 Degradation Leads to Activated Akt
Gustavo Ayala; Jun Yan; Rile Li; Yi Ding; Timothy C. Thompson; Martha P. Mims; Teresa G. Hayes; Vivian MacDonnell; R. Garret Lynch; Anna Frolov; Brian J. Miles; Thomas M. Wheeler; J. Wade Harper; Ming-Jer Tsai; Michael M. Ittmann; Dov Kadmon
Clinical and Pharmacologic Study of the Novel Prodrug Delimotecan (MEN 4901/T-0128) in Patients with Solid Tumors
Stephan A. Veltkamp; Els O. Witteveen; Angela Capriati; Attilio Crea; Fabio Animati; Marja Voogel-Fuchs; Ingeborg J.G.M. van den Heuvel; Jos H. Beijnen; Emile E. Voest; Jan H.M. Schellens
Polymorphisms and Clinical Outcome in Recurrent Ovarian Cancer Treated with Cyclophosphamide and Bevacizumab
Anne M. Schultheis; Georg Lurje; Katrin E. Rhodes; Wu Zhang; Dongyun Yang; Agustin A. Garcia; Robert Morgan; David Gandara; Sidney Scudder; Amit Oza; Hal Hirte; Gini Fleming; Lynda Roman; Heinz-Josef Lenz
Nuclear Factor-κB Modulation in Patients Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia
Roger K. Strair; Mecide Gharibo; Dale Schaar; Arnold Rubin; Jonathan Harrison; Joseph Aisner; Hsin-Ching Lin; Yong Lin; Lauri Goodell; Monika Anand; Binaifer Balsara; Liesel Dudek; Arnold Rabson; Daniel J. Medina
Cancer Prevention and Susceptibility
Letters to the Editor
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