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1 October 2008
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Cover Image
Cover Image
Immunofluorescent image showing localization of phospho-epidermal growth factor receptor (EGFR, green) and F-actin (red) in MDA-MB231 breast cancer cells stimulated with epidermal growth factor for 30 minutes. In stimulated cells, EGFR undergoes phosphorylation at tyrosine 1086 and the activated EGFR localizes to the newly formed membrane ruffles, important for cancer cell motility and invasion, around the cells rich in F-actin. Colocalization of phospho-EGFR (green) with F-actin is seen in yellow. For further details, please see Molli and co-workers on page 6161 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Molecular Pathways
CCR Focus
Human Cancer Biology
CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer
Yu-Wei Cheng; Hanna Pincas; Manny D. Bacolod; Gunter Schemmann; Sarah F. Giardina; Jianmin Huang; Sandra Barral; Kamran Idrees; Sajid A. Khan; Zhaoshi Zeng; Shoshana Rosenberg; Daniel A. Notterman; Jurg Ott; Philip Paty; Francis Barany
Immunohistochemical and Biogenetic Features of Diffuse-Type Tenosynovial Giant Cell Tumors: The Potential Roles of Cyclin A, P53, and Deletion of 15q in Sarcomatous Transformation
Hsuan-Ying Huang; Robert B. West; Ching-Cherng Tzeng; Matt van de Rijn; Jun-Wen Wang; Shih-Cheng Chou; Wen-Wei Huang; Hock-Liew Eng; Ching-Nan Lin; Shih-Chen Yu; Jing-Mei Wu; Chiu-Chin Lu; Chien-Feng Li
Deletions of CDKN2C in Multiple Myeloma: Biological and Clinical Implications
Paola E. Leone; Brian A. Walker; Matthew W. Jenner; Laura Chiecchio; GianPaolo Dagrada; Rebecca K.M. Protheroe; David C. Johnson; Nicholas J. Dickens; Jose Luis Brito; Monica Else; David Gonzalez; Fiona M. Ross; Selina Chen-Kiang; Faith E. Davies; Gareth J. Morgan
Cancer Therapy: Preclinical
Cotreatment with Vorinostat Enhances Activity of MK-0457 (VX-680) against Acute and Chronic Myelogenous Leukemia Cells
Warren Fiskus; Yongchao Wang; Rajeshree Joshi; Rekha Rao; Yonghua Yang; Jianguang Chen; Ravindra Kolhe; Ramesh Balusu; Kelly Eaton; Pearl Lee; Celalettin Ustun; Anand Jillella; Carolyn A. Buser; Stephen Peiper; Kapil Bhalla
Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models of Human Hepatocellular Carcinoma
Hung Huynh; Van Chanh Ngo; Joseph Fargnoli; Mark Ayers; Khee Chee Soo; Heng Nung Koong; Choon Hua Thng; Hock Soo Ong; Alexander Chung; Pierce Chow; Pamela Pollock; Sara Byron; Evelyn Tran
BKM1740, an Acyl-Tyrosine Bisphosphonate Amide Derivative, Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells by Inducing Apoptosis
Seong Il Seo; Lajos Gera; Haiyen E. Zhau; Wei Ping Qian; Shareen Iqbal; Nicole A. Johnson; Shumin Zhang; Majd Zayzafoon; John Stewart; Ruoxiang Wang; Leland W.K. Chung; Daqing Wu
N-(2,6-Dimethoxypyridine-3-yl)-9-Methylcarbazole-3-Sulfonamide as a Novel Tubulin Ligand against Human Cancer
Yue-Ming Wang; Lai-Xing Hu; Zhen-Ming Liu; Xue-Fu You; Sheng-Hua Zhang; Jing-Rong Qu; Zhuo-Rong Li; Yan Li; Wei-Jia Kong; Hong-Wei He; Rong-Guang Shao; Liang-Ren Zhang; Zong-Gen Peng; David W. Boykin; Jian-Dong Jiang
Liposome-Encapsulated Curcumin Suppresses Growth of Head and Neck Squamous Cell Carcinoma In vitro and in Xenografts through the Inhibition of Nuclear Factor κB by an AKT-Independent Pathway
Dorothy Wang; Mysore S. Veena; Kerry Stevenson; Christopher Tang; Baran Ho; Jeffrey D. Suh; Victor M. Duarte; Kym F. Faull; Kapil Mehta; Eri S. Srivatsan; Marilene B. Wang
Imaging, Diagnosis, Prognosis
Identification of GRP75 as an Independent Favorable Prognostic Marker of Neuroblastoma by a Proteomics Analysis
Wen-Ming Hsu; Hsinyu Lee; Hsueh-Fen Juan; Yu-Yin Shih; Bo-Jeng Wang; Chien-Yuan Pan; Yung-Ming Jeng; Hsiu-Hao Chang; Meng-Yao Lu; Kai-Hsin Lin; Hong-Shiee Lai; Wei-Jao Chen; Yeou-Guang Tsay; Yung-Feng Liao; Fon-Jou Hsieh
Shedding of Distinct Cryptic Collagen Epitope (HU177) in Sera of Melanoma Patients
Bruce Ng; Jan Zakrzewski; Melanie Warycha; Paul J. Christos; Dean F. Bajorin; Richard L. Shapiro; Russell S. Berman; Anna C. Pavlick; David Polsky; Madhu Mazumdar; Anthony Montgomery; Leonard Liebes; Peter C. Brooks; Iman Osman
Cancer Therapy: Clinical
A Phase I-II Study of Docetaxel and Atrasentan in Men with Castration-Resistant Metastatic Prostate Cancer
Andrew J. Armstrong; Patricia Creel; James Turnbull; Cassandra Moore; Tracy A. Jaffe; Sherri Haley; William Petros; Sarah Yenser; Jon P. Gockerman; Darryl Sleep; Herbert Hurwitz; Daniel J. George
Single Nucleotide Polymorphisms, Apoptosis, and the Development of Severe Late Adverse Effects After Radiotherapy
David Azria; Mahmut Ozsahin; Andrew Kramar; Sheila Peters; David P. Atencio; Nigel E.A. Crompton; Françoise Mornex; André Pèlegrin; Jean-Bernard Dubois; René-Olivier Mirimanoff; Barry S. Rosenstein
Zoledronic Acid Markedly Improves Bone Mineral Density for Patients with Monoclonal Gammopathy of Undetermined Significance and Bone Loss
James R. Berenson; Ori Yellin; Ralph V. Boccia; Marshall Flam; Siu-Fun Wong; Olcay Batuman; Mehdi M. Moezi; Donald Woytowitz; Herbert Duvivier; Youram Nassir; Regina A. Swift
A Phase I Trial of Pemetrexed Plus Gemcitabine Given Biweekly with B-Vitamin Support in Solid Tumor Malignancies or Advanced Epithelial Ovarian Cancer
Martee L. Hensley; Joseph Larkin; Matthew Fury; Scott Gerst; D. Fritz Tai; Paul Sabbatini; Jason Konner; Mauro Orlando; Tiana L. Goss; Carol A. Aghajanian
Fluorescence In situ Hybridization Subgroup Analysis of TRIBUTE, a Phase III Trial of Erlotinib Plus Carboplatin and Paclitaxel in Non–Small Cell Lung Cancer
Fred R. Hirsch; Marileila Varella-Garcia; Rafal Dziadziuszko; Yun Xiao; Sujatha Gajapathy; Margaret Skokan; Ming Lin; Vincent O'Neill; Paul A. Bunn, Jr.
Phase I Trial of Erlotinib Combined with Cisplatin and Radiotherapy for Patients with Locally Advanced Cervical Squamous Cell Cancer
Angélica Nogueira-Rodrigues; Cláudio C. do Carmo; Célia Viegas; Felipe Erlich; Cláudia Camisão; Karina Fontão; Roberta Lima; Daniel Herchenhorn; Renato G. Martins; Giulliana M. Moralez; Isabele A. Small; Carlos G. Ferreira
Prevention of Anastrozole-Induced Bone Loss with Monthly Oral Ibandronate during Adjuvant Aromatase Inhibitor Therapy for Breast Cancer
James E. Lester; David Dodwell; Omprakash P. Purohit; Sandra A. Gutcher; Susan P. Ellis; Ruth Thorpe; Janet M. Horsman; Janet E. Brown; Rosemary A. Hannon; Robert E. Coleman
Cancer Prevention and Susceptibility
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