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1 September 2008
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Cover Image
Cover Image
Molecular dynamics simulation of TMTP1. TMTP1 peptide is solved in a water cubic periodic box. Ten amino acid residues form a cyclic peptide via a disulfide bond between the two cysteines that respectively lie at the head and the tail. The line view of TMP1 peptide with side chains and the internal hydrogen bonds. For further details, please see Luo et al on page 5494 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Molecular Pathways
Report from the FDA
Tasigna for Chronic and Accelerated Phase Philadelphia Chromosome–Positive Chronic Myelogenous Leukemia Resistant to or Intolerant of Imatinib
Maitreyee Hazarika; Xiaoping Jiang; Qi Liu; Shwu-Luan Lee; Roshni Ramchandani; Christine Garnett; Micheal S. Orr; Rajeshwari Sridhara; Brian Booth; John K. Leighton; William Timmer; Ravi Harapanhalli; Ramzi Dagher; Robert Justice; Richard Pazdur
Human Cancer Biology
Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas
Satoru Kikuchi; Kazufumi Honda; Hitoshi Tsuda; Nobuyoshi Hiraoka; Issei Imoto; Tomoo Kosuge; Tomoko Umaki; Kaoru Onozato; Miki Shitashige; Umio Yamaguchi; Masaya Ono; Akihiko Tsuchida; Tatsuya Aoki; Johji Inazawa; Setsuo Hirohashi; Tesshi Yamada
Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression
Celina G. Kleer; Noga Bloushtain-Qimron; Yu-Hui Chen; Daniel Carrasco; Min Hu; Jun Yao; Stine-Kathrein Kraeft; Laura C. Collins; Michael S. Sabel; Pedram Argani; Rebecca Gelman; Stuart J. Schnitt; Ian E. Krop; Kornelia Polyak
Cancer Therapy: Preclinical
Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation
Guo Zhang; Margaret A. Park; Clint Mitchell; Hossein Hamed; Mohamed Rahmani; Aditi Pandya Martin; David T. Curiel; Adly Yacoub; Martin Graf; Ray Lee; John D. Roberts; Paul B. Fisher; Steven Grant; Paul Dent
Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth
Yvonne G. Lin; Anand Immaneni; William M. Merritt; Lingegowda S. Mangala; Seung Wook Kim; Mian M.K. Shahzad; Yvonne T.M. Tsang; Guillermo N. Armaiz-Pena; Chunhua Lu; Aparna A. Kamat; Liz Y. Han; Whitney A. Spannuth; Alpa M. Nick; Charles N. Landen, Jr.; Kwong K. Wong; Michael J. Gray; Robert L. Coleman; Diane C. Bodurka; William R. Brinkley; Anil K. Sood
Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2
Tobias Martens; Yvonne Laabs; Hauke S. Günther; Dirk Kemming; Zhenping Zhu; Larry Witte; Christian Hagel; Manfred Westphal; Katrin Lamszus
Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase
Junji Matsui; Yasuhiro Funahashi; Toshimitsu Uenaka; Tatsuo Watanabe; Akihiko Tsuruoka; Makoto Asada
Combined Vascular Endothelial Growth Factor Receptor/Epidermal Growth Factor Receptor Blockade with Chemotherapy for Treatment of Local, Uterine, and Metastatic Soft Tissue Sarcoma
Wenhong Ren; Borys Korchin; Guy Lahat; Caimiao Wei; Svetlana Bolshakov; Theresa Nguyen; William Merritt; Adam Dicker; Alexander Lazar; Anil Sood; Raphael E. Pollock; Dina Lev
Imaging, Diagnosis, Prognosis
Genetic Clustering of Clear Cell Renal Cell Carcinoma Based on Array-Comparative Genomic Hybridization: Its Association with DNA Methylation Alteration and Patient Outcome
Eri Arai; Saori Ushijima; Hitoshi Tsuda; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Association of an Extracellular Matrix Gene Cluster with Breast Cancer Prognosis and Endocrine Therapy Response
Jozien Helleman; Maurice P.H.M. Jansen; Kirsten Ruigrok-Ritstier; Iris L. van Staveren; Maxime P. Look; Marion E. Meijer-van Gelder; Anieta M. Sieuwerts; Jan G.M. Klijn; Stefan Sleijfer; John A. Foekens; Els M.J.J. Berns
Cancer Therapy: Clinical
Gemtuzumab Ozogamicin as Part of Reduced-Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients with Relapsed Acute Myeloid Leukemia
Martin Bornhäuser; Thomas Illmer; Uta Oelschlaegel; Johannes Schetelig; Rainer Ordemann; Markus Schaich; Mathias Hänel; Ulrich Schuler; Christian Thiede; Alexander Kiani; Uwe Platzbecker; Gerhard Ehninger
ABCB1 (MDR 1) Polymorphisms and Progression-Free Survival among Women with Ovarian Cancer following Paclitaxel/Carboplatin Chemotherapy
Sharon E. Johnatty; Jonathan Beesley; Jim Paul; Sian Fereday; Amanda B. Spurdle; Penelope M. Webb; Karen Byth; Sharon Marsh; Howard McLeod; AOCS Study Group; Paul R. Harnett; Robert Brown; Anna deFazio; Georgia Chenevix-Trench
A Phase I Study of EKB-569 in Combination with Capecitabine in Patients with Advanced Colorectal Cancer
Dan Laheru; Gary Croghan; Ronald Bukowski; Michelle Rudek; Wells Messersmith; Charles Erlichman; Robert Pelley; Antonio Jimeno; Ross Donehower; Joseph Boni; Richat Abbas; Patricia Martins; Charles Zacharchuk; Manuel Hidalgo
Treatment of Metastatic Melanoma Using Interleukin-2 Alone or in Conjunction with Vaccines
Franz O. Smith; Stephanie G. Downey; Jacob A. Klapper; James C. Yang; Richard M. Sherry; Richard E. Royal; Udai S. Kammula; Marybeth S. Hughes; Nicholas P. Restifo; Catherine L. Levy; Donald E. White; Seth M. Steinberg; Steven A. Rosenberg
A Phase I Study of Bexarotene, a Retinoic X Receptor Agonist, in Non-M3 Acute Myeloid Leukemia
Donald E. Tsai; Selina M. Luger; Charalambos Andreadis; Dan T. Vogl; Allison Kemner; Melissa Potuzak; Ami Goradia; Alison W. Loren; Alexander E. Perl; Stephen J. Schuster; David L. Porter; Edward A. Stadtmauer; Steven C. Goldstein; James E. Thompson; Cezary Swider; Adam Bagg; Anthony R. Mato; Martin Carroll
CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
W. Nicholas Haining; Jeffrey Davies; Holger Kanzler; Linda Drury; Thomas Brenn; John Evans; Jill Angelosanto; Steven Rivoli; Kate Russell; Suzanne George; Paul Sims; Donna Neuberg; Xiaochun Li; Jeffrey Kutok; Jeffrey Morgan; Patrick Wen; George Demetri; Robert L. Coffman; Lee M. Nadler
Cancer Prevention and Susceptibility
Effect of Genetic Variability within 8q24 on Aggressiveness Patterns at Diagnosis and Familial Status of Prostate Cancer
Olivier Cussenot; Abdel-Rahmène Azzouzi; Gladys Bantsimba-Malanda; Cecile Gaffory; Philippe Mangin; Luc Cormier; Georges Fournier; Antoine Valeri; Lionel Jouffe; Morgan Roupret; Gaelle Fromont; Mathilde Sibony; Eva Comperat; Géraldine Cancel-Tassin
Letters to the Editor
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