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Volume 14, Issue 12
15 June 2008
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    Cover Image

    issue cover
    A colon cancer tissue microarray containing 583 stage I-IV patients was stained for pan-cadherin, DAPI, and Met protein. Using novel automated curvature and intensity-based image analysis, epithelial membrane (red), cytoplasm (green) and nuclei (blue) were segmented. Stromal nuclei are shown in gray. The probability distribution of Met protein within each compartment was determined. A higher distribution of Met in the cytoplasm relative to the membrane was a significant predictor of survival in stage I and II patients. For further details, please see Ginty and colleagues on page 3814 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Commentary

Heterogeneity of Drug Target Expression Among Metastatic Lesions: Lessons from a Breast Cancer Autopsy Program
Patricia S. Steeg
View articletitled, Heterogeneity of Drug Target Expression Among Metastatic Lesions: Lessons from a Breast Cancer Autopsy Program
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CCR Practice of Translational Oncology

Is There a Role for Circulating Tumor Cells in the Management of Breast Cancer?
Daniel F. Hayes; Jeffrey Smerage
View articletitled, Is There a Role for Circulating Tumor Cells in the Management of Breast Cancer?
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Molecular Pathways

Advances in the Development of Cancer Therapeutics Directed against the RAS-Mitogen-Activated Protein Kinase Pathway
Judith S. Sebolt-Leopold
View articletitled, Advances in the Development of Cancer Therapeutics Directed against the RAS-Mitogen-Activated Protein Kinase Pathway
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CCR Focus

From the editor
Susan E. Bates, M.D.
View articletitled, From the editor
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Oncologic Phase 0 Trials Incorporating Clinical Pharmacodynamics: from Concept to Patient
James H. Doroshow; Ralph E. Parchment
View articletitled, Oncologic Phase 0 Trials Incorporating Clinical Pharmacodynamics: from Concept to Patient
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The Development of Phase I Cancer Trial Methodologies: the Use of Pharmacokinetic and Pharmacodynamic End Points Sets the Scene for Phase 0 Cancer Clinical Trials
A. Hilary Calvert; Ruth Plummer
View articletitled, The Development of Phase I Cancer Trial Methodologies: the Use of Pharmacokinetic and Pharmacodynamic End Points Sets the Scene for Phase 0 Cancer Clinical Trials
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Leveraging Exploratory Investigational New Drug Studies to Accelerate Drug Development
David Jacobson-Kram; George Mills
View articletitled, Leveraging Exploratory Investigational New Drug Studies to Accelerate Drug Development
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Designing Phase 0 Cancer Clinical Trials
Anthony J. Murgo; Shivaani Kummar; Larry Rubinstein; Martin Gutierrez; Jerry Collins; Robert Kinders; Ralph E. Parchment; Jiuping Ji; Seth M. Steinberg; Sherry X. Yang; Melinda Hollingshead; Alice Chen; Lee Helman; Robert Wiltrout; Joseph E. Tomaszewski; James H. Doroshow
View articletitled, Designing Phase 0 Cancer Clinical Trials
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Phase 0 Trials: An Industry Perspective
Helen Eliopoulos; Vincent Giranda; Robert Carr; Rita Tiehen; Terri Leahy; Gary Gordon
View articletitled, Phase 0 Trials: An Industry Perspective
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Patient Perspectives on Phase 0 Clinical Trials
Martin Gutierrez; Deborah Collyar
View articletitled, Patient Perspectives on Phase 0 Clinical Trials
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The Ethics of Phase 0 Oncology Trials
Emily Abdoler; Holly Taylor; David Wendler
View articletitled, The Ethics of Phase 0 Oncology Trials
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Review

Tissue-Based Research in Kidney Cancer: Current Challenges and Future Directions
Sabina Signoretti; Gennady Bratslavsky; Frederick M. Waldman; Victor E. Reuter; John Haaga; Maria Merino; George V. Thomas; Michael R. Pins; Towia Libermann; John Gillespie; Joseph E. Tomaszewski; Carolyn C. Compton; Andrew Hruszkewycz; W. Marston Linehan; Michael B. Atkins
View articletitled, Tissue-Based Research in Kidney Cancer: Current Challenges and Future Directions
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Human Cancer Biology

T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease
Christoph Bergmann; Laura Strauss; Yun Wang; Miroslaw J. Szczepanski; Stephan Lang; Jonas T. Johnson; Theresa L. Whiteside
View articletitled, T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease
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Somatic Mutations of JAK1 and JAK3 in Acute Leukemias and Solid Cancers
Eun Goo Jeong; Min Sung Kim; Hyo Kyung Nam; Chang Ki Min; Seok Lee; Yeun Jun Chung; Nam Jin Yoo; Sug Hyung Lee
View articletitled, Somatic Mutations of <em>JAK1</em> and <em>JAK3</em> in Acute Leukemias and Solid Cancers
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CIP2A Is Overexpressed in Gastric Cancer and Its Depletion Leads to Impaired Clonogenicity, Senescence, or Differentiation of Tumor Cells
Wenjuan Li; Zheng Ge; Cheng Liu; Zhifang Liu; Magnus Björkholm; Jihui Jia; Dawei Xu
View articletitled, CIP2A Is Overexpressed in Gastric Cancer and Its Depletion Leads to Impaired Clonogenicity, Senescence, or Differentiation of Tumor Cells
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Soluble ErbB3 Levels in Bone Marrow and Plasma of Men with Prostate Cancer
Sue-Hwa Lin; Yu-Chen Lee; Michel B. Choueiri; Sijin Wen; Paul Mathew; Xiangcang Ye; Kim-Anh Do; Nora M. Navone; Jeri Kim; Shi-Ming Tu; Li-Yuan Yu-Lee; Christopher J. Logothetis
View articletitled, Soluble ErbB3 Levels in Bone Marrow and Plasma of Men with Prostate Cancer
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A Metastasis Modifier Locus on Human Chromosome 8p in Uveal Melanoma Identified by Integrative Genomic Analysis
Michael D. Onken; Lori A. Worley; J. William Harbour
View articletitled, A Metastasis Modifier Locus on Human Chromosome 8p in Uveal Melanoma Identified by Integrative Genomic Analysis
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Association of p16 Homozygous Deletions with Clinicopathologic Characteristics and EGFR/KRAS/p53 Mutations in Lung Adenocarcinoma
Reika Iwakawa; Takashi Kohno; Yoichi Anami; Masayuki Noguchi; Kenji Suzuki; Yoshihiro Matsuno; Kazuhiko Mishima; Ryo Nishikawa; Fumio Tashiro; Jun Yokota
View articletitled, Association of p16 Homozygous Deletions with Clinicopathologic Characteristics and EGFR/KRAS/p53 Mutations in Lung Adenocarcinoma
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ssDNA-Binding Protein 2 Is Frequently Hypermethylated and Suppresses Cell Growth in Human Prostate Cancer
Jun-Wei Liu; Jatin K. Nagpal; Wenyue Sun; Juna Lee; Myoung Sook Kim; Kimberly L. Ostrow; Shaoyu Zhou; Carmen Jeronimo; Rui Henrique; Wim Van Criekinge; Chu So Moon; Joseph A. Califano; Barry Trink; David Sidransky
View articletitled, ssDNA-Binding Protein 2 Is Frequently Hypermethylated and Suppresses Cell Growth in Human Prostate Cancer
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BRCA1 and BRCA2 Mutation Prevalence and Clinical Characteristics of a Population-Based Series of Ovarian Cancer Cases from Denmark
Marie Soegaard; Susanne Kruger Kjaer; Mark Cox; Eva Wozniak; Estrid Høgdall; Claus Høgdall; Jan Blaakaer; Ian J. Jacobs; Simon A. Gayther; Susan J. Ramus
View articletitled, <em>BRCA1</em> and <em>BRCA2</em> Mutation Prevalence and Clinical Characteristics of a Population-Based Series of Ovarian Cancer Cases from Denmark
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Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma
Motohisa Tada; Fumihiko Kanai; Yasuo Tanaka; Keisuke Tateishi; Miki Ohta; Yoshinari Asaoka; Motoko Seto; Ryosuke Muroyama; Kenichi Fukai; Fumio Imazeki; Takao Kawabe; Osamu Yokosuka; Masao Omata
View articletitled, Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma
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Imaging, Diagnosis, Prognosis

Effect of Interleukin-10 Gene Polymorphisms on Clinical Outcome of Patients with Aggressive Non-Hodgkin's Lymphoma: An Exploratory Study
Dieter Kube; Thanh-Duc Hua; Frederike von Bonin; Nils Schoof; Samira Zeynalova; Marita Klöss; Daniela Gocht; Bernd Potthoff; Mladen Tzvetkov; Jürgen Brockmöller; Markus Löffler; Michael Pfreundschuh; Lorenz Trümper
View articletitled, Effect of <em>Interleukin-10</em> Gene Polymorphisms on Clinical Outcome of Patients with Aggressive Non-Hodgkin's Lymphoma: An Exploratory Study
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Improved Prediction of Disease Relapse after Radical Prostatectomy through a Panel of Preoperative Blood-Based Biomarkers
Shahrokh F. Shariat; Jose A. Karam; Jochen Walz; Claus G. Roehrborn; Francesco Montorsi; Vitaly Margulis; Fred Saad; Kevin M. Slawin; Pierre I. Karakiewicz
View articletitled, Improved Prediction of Disease Relapse after Radical Prostatectomy through a Panel of Preoperative Blood-Based Biomarkers
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Local Recurrence in Mismatch Repair–Proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-Infiltrating Lymphocytes
Inti Zlobec; Luigi M. Terracciano; Alessandro Lugli
View articletitled, Local Recurrence in Mismatch Repair–Proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8<sup>+</sup> Tumor-Infiltrating Lymphocytes
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RHAMM, p21 Combined Phenotype Identifies Microsatellite Instability-High Colorectal Cancers with a Highly Adverse Prognosis
Inti Zlobec; Kristi Baker; Luigi M. Terracciano; Alessandro Lugli
View articletitled, RHAMM, p21 Combined Phenotype Identifies Microsatellite Instability-High Colorectal Cancers with a Highly Adverse Prognosis
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Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Nasopharyngeal Carcinoma
Lih-Chyang Chen; Chuen Hsueh; Ngan-Ming Tsang; Ying Liang; Kai-Ping Chang; Sheng-Po Hao; Jau-Song Yu; Yu-Sun Chang
View articletitled, Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Nasopharyngeal Carcinoma
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The Relative Distribution of Membranous and Cytoplasmic Met Is a Prognostic Indicator in Stage I and II Colon Cancer
Fiona Ginty; Sudeshna Adak; Ali Can; Michael Gerdes; Melinda Larsen; Harvey Cline; Robert Filkins; Zhengyu Pang; Qing Li; Michael C. Montalto
View articletitled, The Relative Distribution of Membranous and Cytoplasmic Met Is a Prognostic Indicator in Stage I and II Colon Cancer
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Association of Megalin Genetic Polymorphisms with Prostate Cancer Risk and Prognosis
Sarah K. Holt; Danielle M. Karyadi; Erika M. Kwon; Janet L. Stanford; Peter S. Nelson; Elaine A. Ostrander
View articletitled, Association of <em>Megalin</em> Genetic Polymorphisms with Prostate Cancer Risk and Prognosis
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Imaging Immune Response In vivo: Cytolytic Action of Genetically Altered T Cells Directed to Glioblastoma Multiforme
Jelena Lazovic; Michael C. Jensen; Evette Ferkassian; Brenda Aguilar; Andrew Raubitschek; Russell E. Jacobs
View articletitled, Imaging Immune Response <em>In vivo</em>: Cytolytic Action of Genetically Altered T Cells Directed to Glioblastoma Multiforme
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Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging
Sang Bong Lee; Moinuddin Hassan; Robert Fisher; Oleg Chertov; Victor Chernomordik; Gabriela Kramer-Marek; Amir Gandjbakhche; Jacek Capala
View articletitled, Affibody Molecules for <em>In vivo</em> Characterization of HER2-Positive Tumors by Near-Infrared Imaging
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Cytokeratin 10 and Cytokeratin 19: Predictive Markers for Poor Prognosis in Hepatocellular Carcinoma Patients after Curative Resection
Xin-Rong Yang; Yang Xu; Guo-Ming Shi; Jia Fan; Jian Zhou; Yuan Ji; Hui-Chuan Sun; Shuang-Jian Qiu; Bing Yu; Qiang Gao; Yi-Zhou He; Weng-Zhen Qin; Rong-Xin Chen; Guo-Huan Yang; Bing Wu; Qing Lu; Zhi-Quan Wu; Zhao-You Tang
View articletitled, Cytokeratin 10 and Cytokeratin 19: Predictive Markers for Poor Prognosis in Hepatocellular Carcinoma Patients after Curative Resection
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Cancer Therapy: Clinical

Are There Any Ethnic Differences in Molecular Predictors of Erlotinib Efficacy in Advanced Non-Small Cell Lung Cancer?
Myung-Ju Ahn; Byeong-Bae Park; Jin Seok Ahn; Sang We Kim; Heung-Tae Kim; Jong Seog Lee; Jin Hyung Kang; Jae Yong Cho; Hong Suk Song; Se Hoon Park; Chang Hak Sohn; Sang Won Shin; Jin Hyuck Choi; Chang-Seok Ki; Chan Keum Park; Alison J. Holmes; Pasi A. Jänne; Keunchil Park
View articletitled, Are There Any Ethnic Differences in Molecular Predictors of Erlotinib Efficacy in Advanced Non-Small Cell Lung Cancer?
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A Phase II Pharmacodynamic Study of Erlotinib in Patients with Advanced Non–Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy
Enriqueta Felip; Federico Rojo; Martin Reck; Astrid Heller; Barbara Klughammer; Gemma Sala; Susana Cedres; Sergio Peralta; Heiko Maacke; Dorothee Foernzler; Marta Parera; Joachim Möcks; Cristina Saura; Ulrich Gatzemeier; José Baselga
View articletitled, A Phase II Pharmacodynamic Study of Erlotinib in Patients with Advanced Non–Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy
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Interaction of Cisplatin with the Human Organic Cation Transporter 2
Kelly K. Filipski; Walter J. Loos; Jaap Verweij; Alex Sparreboom
View articletitled, Interaction of Cisplatin with the Human Organic Cation Transporter 2
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Dasatinib Cellular Uptake and Efflux in Chronic Myeloid Leukemia Cells: Therapeutic Implications
Devendra K. Hiwase; Verity Saunders; Duncan Hewett; Amity Frede; Stephanie Zrim; Phuong Dang; Laura Eadie; L. Bik To; Junia Melo; Sharad Kumar; Timothy P. Hughes; Deborah L. White
View articletitled, Dasatinib Cellular Uptake and Efflux in Chronic Myeloid Leukemia Cells: Therapeutic Implications
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Phase I Study of GTI-2040, an Antisense to Ribonucleotide Reductase, in Combination with High-Dose Cytarabine in Patients with Acute Myeloid Leukemia
Rebecca B. Klisovic; William Blum; Xiaohui Wei; Shujun Liu; Zhongfa Liu; Zhiliang Xie; Tamara Vukosavljevic; Cheryl Kefauver; LeNguyen Huynh; Jiuxia Pang; James A. Zwiebel; Steven Devine; John C. Byrd; Michael R. Grever; Kenneth Chan; Guido Marcucci
View articletitled, Phase I Study of GTI-2040, an Antisense to Ribonucleotide Reductase, in Combination with High-Dose Cytarabine in Patients with Acute Myeloid Leukemia
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Concerted Potent Humoral Immune Responses to Autoantigens Are Associated with Tumor Destruction and Favorable Clinical Outcomes without Autoimmunity
Taylor Sittler; Jun Zhou; Joosang Park; Noah K. Yuen; Stefanie Sarantopoulos; Joseph Mollick; Ravi Salgia; Anita Giobbie-Hurder; Glenn Dranoff; F. Stephen Hodi
View articletitled, Concerted Potent Humoral Immune Responses to Autoantigens Are Associated with Tumor Destruction and Favorable Clinical Outcomes without Autoimmunity
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Phase II Study of Dasatinib in Philadelphia Chromosome–Negative Acute and Chronic Myeloid Diseases, Including Systemic Mastocytosis
Srdan Verstovsek; Ayalew Tefferi; Jorge Cortes; Susan O'Brien; Guillermo Garcia-Manero; Animesh Pardanani; Cem Akin; Stefan Faderl; Taghi Manshouri; Deborah Thomas; Hagop Kantarjian
View articletitled, Phase II Study of Dasatinib in Philadelphia Chromosome–Negative Acute and Chronic Myeloid Diseases, Including Systemic Mastocytosis
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Cancer Therapy: Preclinical

Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin
Bastiaan Evers; Rinske Drost; Eva Schut; Michiel de Bruin; Eline van der Burg; Patrick W.B. Derksen; Henne Holstege; Xiaoling Liu; Ellen van Drunen; H. Berna Beverloo; Graeme C.M. Smith; Niall M.B. Martin; Alan Lau; Mark J. O'Connor; Jos Jonkers
View articletitled, Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin
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Tumor Vascular Maturation and Improved Drug Delivery Induced by Methylselenocysteine Leads to Therapeutic Synergy with Anticancer Drugs
Arup Bhattacharya; Mukund Seshadri; Steven D. Oven; Károly Tóth; Mary M. Vaughan; Youcef M. Rustum
View articletitled, Tumor Vascular Maturation and Improved Drug Delivery Induced by Methylselenocysteine Leads to Therapeutic Synergy with Anticancer Drugs
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Intratumoral Coadministration of Hyaluronidase Enzyme and Oncolytic Adenoviruses Enhances Virus Potency in Metastatic Tumor Models
Shanthi Ganesh; Melissa Gonzalez-Edick; Douglas Gibbons; Melinda Van Roey; Karin Jooss
View articletitled, Intratumoral Coadministration of Hyaluronidase Enzyme and Oncolytic Adenoviruses Enhances Virus Potency in Metastatic Tumor Models
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Oncogenic and Angiogenic Growth Factors Accumulate during Routine Storage of Apheresis Platelet Concentrates
Julie Kanter; Samina Y. Khan; Marguerite Kelher; Lia Gore; Christopher C. Silliman
View articletitled, Oncogenic and Angiogenic Growth Factors Accumulate during Routine Storage of Apheresis Platelet Concentrates
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RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development
Justin Sausville; Alfredo A. Molinolo; Xiangfei Cheng; Jon Frampton; Naoko Takebe; J. Silvio Gutkind; Ricardo A. Feldman
View articletitled, RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors <em>In vivo</em> and Results in Hemangioma Development
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Suppression of proHB-EGF Carboxy-Terminal Fragment Nuclear Translocation: A New Molecular Target Therapy for Gastric Cancer
Takaya Shimura; Hiromi Kataoka; Naotaka Ogasawara; Eiji Kubota; Makoto Sasaki; Satoshi Tanida; Takashi Joh
View articletitled, Suppression of proHB-EGF Carboxy-Terminal Fragment Nuclear Translocation: A New Molecular Target Therapy for Gastric Cancer
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Transforming Growth Factor-β Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers
Africa Wallace; Veena Kapoor; Jing Sun; Paul Mrass; Wolfgang Weninger; Daniel F. Heitjan; Carl June; Larry R. Kaiser; Leona E. Ling; Steven M. Albelda
View articletitled, Transforming Growth Factor-β Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers
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Intraoperative 186Re-Liposome Radionuclide Therapy in a Head and Neck Squamous Cell Carcinoma Xenograft Positive Surgical Margin Model
Sean X. Wang; Ande Bao; Stephanie J. Herrera; William T. Phillips; Beth Goins; Cristina Santoyo; Frank R. Miller; Randal A. Otto
View articletitled, Intraoperative <sup>186</sup>Re-Liposome Radionuclide Therapy in a Head and Neck Squamous Cell Carcinoma Xenograft Positive Surgical Margin Model
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DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia
Elaine Willmore; Sarah L. Elliott; Tryfonia Mainou-Fowler; Geoffrey P. Summerfield; Graham H. Jackson; Fran O'Neill; Christopher Lowe; Anthony Carter; Robert Harris; Andrew R. Pettitt; Celine Cano-Soumillac; Roger J. Griffin; Ian G. Cowell; Caroline A. Austin; Barbara W. Durkacz
View articletitled, DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia
Supplementary data
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PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel
Lin Yang; Michelle J. Clarke; Brett L. Carlson; Ann C. Mladek; Mark A. Schroeder; Paul Decker; Wenting Wu; Gaspar J. Kitange; Patrick T. Grogan; Jennie M. Goble; Joon Uhm; Evanthia Galanis; Caterina Giannini; Heidi A. Lane; C. David James; Jann N. Sarkaria
View articletitled, PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel
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Increase in Brain Tumor Permeability in Glioma-Bearing Rats with Nitric Oxide Donors
Dali Yin; Xiao Wang; Bindu M. Konda; John M. Ong; Jinwei Hu; Manuel R. Sacapano; MinHee K. Ko; Andres J. Espinoza; Dwain K. Irvin; Yan Shu; Keith L. Black
View articletitled, Increase in Brain Tumor Permeability in Glioma-Bearing Rats with Nitric Oxide Donors
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Cancer Prevention and Susceptibility

MDM2 Promoter Polymorphism and Pancreatic Cancer Risk and Prognosis
Kofi Asomaning; Amy E. Reid; Wei Zhou; Rebecca S. Heist; Rihong Zhai; Li Su; Eunice L. Kwak; Lawrence Blaszkowsky; Andrew X. Zhu; David P. Ryan; David C. Christiani; Geoffrey Liu
View articletitled, MDM2 Promoter Polymorphism and Pancreatic Cancer Risk and Prognosis
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Phosphodiesterase 11A (PDE11A) and Genetic Predisposition to Adrenocortical Tumors
Rossella Libé; Amato Fratticci; Joel Coste; Frédérique Tissier; Anelia Horvath; Bruno Ragazzon; Fernande Rene-Corail; Lionel Groussin; Xavier Bertagna; Marie Laure Raffin-Sanson; Constantine A. Stratakis; Jérome Bertherat
View articletitled, Phosphodiesterase 11A (PDE11A) and Genetic Predisposition to Adrenocortical Tumors
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Correction

Correction: Letters on Computed Tomography Screening for Lung Cancer
View articletitled, Correction: Letters on Computed Tomography Screening for Lung Cancer
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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