Issues

The TP53 tumor suppressor gene is located at 17p13.1. 17p13 allelic losses are very frequent in adrenocortical cancer, and somatic mutations of TP53 are observed in a third of these neoplasms. In malignant adrenocortical tumors, somatic TP53 mutations are associated with p53 accumulation, as determined by immunohistochemistry. The larger figure shows a nuclear staining for p53 in an adrenocortical cancer with a TP53 mutation. By contrast, the smaller figure shows that staining for p53 is not significant in a tumor without TP53 mutation (<1% of cells). For further details, please see Libè et al. on page 844 of this issue.