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15 December 2007
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Cover Image
Cover Image
Enzymes including AKT and phospholipase C gamma (PLCg) mediate many of their functions through localization to the cell membrane via their PH domains. Such localization is shown here for PLCg using a green fluorescent protein tag. Perifosine inhibits the localization of the PH domain of AKT but not of PLCg to the cell membrane. For further details, please see Hennessy and colleagues on page 7421 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Editorial
The Clinical Connection
CCR Practice of Translational Oncology
Molecular Pathways
CCR Focus
Review
Human Cancer Biology
Estrogen Receptor Status Could Modulate the Genomic Pattern in Familial and Sporadic Breast Cancer
Lorenzo Melchor; Emiliano Honrado; Jia Huang; Sara Álvarez; Tara L. Naylor; María J. García; Ana Osorio; David Blesa; Michael R. Stratton; Barbara L. Weber; Juan C. Cigudosa; Nazneen Rahman; Katherine L. Nathanson; Javier Benítez
Imaging, Diagnosis, Prognosis
BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials
Madeleine M.A. Tilanus-Linthorst; Inge-Marie Obdeijn; Wim C.J. Hop; Petrina A. Causer; Martin O. Leach; Ellen Warner; Linda Pointon; Kimberley Hill; Jan G.M. Klijn; Ruth M.L. Warren; Fiona J. Gilbert
Proteomic Profiling Identifies Afamin as a Potential Biomarker for Ovarian Cancer
David Jackson; Rachel A. Craven; Richard C. Hutson; Ina Graze; Paul Lueth; Robert P. Tonge; Joanne L. Hartley; Janice A. Nickson; Steve J. Rayner; Colin Johnston; Benjamin Dieplinger; Michael Hubalek; Nafisa Wilkinson; Timothy J. Perren; Sean Kehoe; Geoffrey D. Hall; Guenter Daxenbichler; Hans Dieplinger; Peter J. Selby; Rosamonde E. Banks
Cancer Therapy: Clinical
Pharmacokinetic and Tumor Distribution Characteristics of Temsirolimus in Patients with Recurrent Malignant Glioma
John G. Kuhn; Susan M. Chang; Patrick Y. Wen; Timothy F. Cloughesy; Harry Greenberg; David Schiff; Charles Conrad; Karen L. Fink; H. Ian Robins; Minesh Mehta; Lisa DeAngelis; Jeffrey Raizer; Kenneth Hess; Kathleen R. Lamborn; Janet Dancey; Michael D. Prados; for the North American Brain Tumor Consortium and the National Cancer Institute
Cancer Therapy: Preclinical
Differential Effects of Combined Ad5-Δ24RGD and Radiation Therapy in In vitro versus In vivo Models of Malignant Glioma
Martine L.M. Lamfers; Sander Idema; Lisette Bosscher; Stan Heukelom; Sharif Moeniralm; Ida H. van der Meulen-Muileman; Renée M. Overmeer; Paul van der Valk; Victor W. van Beusechem; Winald R. Gerritsen; W. Peter Vandertop; Clemens M.F. Dirven
Clinical and Biological Significance of Vascular Endothelial Growth Factor in Endometrial Cancer
Aparna A. Kamat; William M. Merritt; Donna Coffey; Yvonne G. Lin; Pooja R. Patel; Russell Broaddus; Elizabeth Nugent; Liz Y. Han; Charles N. Landen, Jr.; Whitney A. Spannuth; Chunhua Lu; Robert L. Coleman; David M. Gershenson; Anil K. Sood
Cancer Susceptibility and Prevention
A Novel Polymorphism in the Promoter Region of ERBB4 Is Associated with Breast and Colorectal Cancer Risk
Matjaž Rokavec; Christina Justenhoven; Werner Schroth; Monica Adina Istrate; Susanne Haas; Hans-Peter Fischer; Caren Vollmert; Thomas Illig; Ute Hamann; Yon-Dschun Ko; Damjan Glavač; Hiltrud Brauch
Letters to the Editor
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