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1 November 2007
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Cover Image
Cover Image
Immunocytochemical staining of p-MAPK (50% ++) at baseline on buccal mucosa cells in patient responder to gefitinib treatment (combination of percentage of positive cells and staining intensity [negative 0, weak 1+, moderate 2+ and strong 3+]) (×200 original magnification). For further details, please see the article by Loprevite and associates on page 6518 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Molecular Pathways
Human Cancer Biology
Amplicon Mapping and Expression Profiling Identify the Fas-Associated Death Domain Gene as a New Driver in the 11q13.3 Amplicon in Laryngeal/Pharyngeal Cancer
Johan H. Gibcus; Lorian Menkema; Mirjam F. Mastik; Mario A. Hermsen; Geertruida H. de Bock; Marie-Louise F. van Velthuysen; Robert P. Takes; Klaas Kok; Cesar A. Álvarez Marcos; Bernard F.A.M. van der Laan; Michiel W.M. van den Brekel; Johannes A. Langendijk; Philip M. Kluin; Jacqueline E. van der Wal; Ed Schuuring
Gene Expression Profiling from Formalin-Fixed Paraffin-Embedded Tumors of Pediatric Glioblastoma
Takrima Haque; Damien Faury; Steffen Albrecht; Enrique Lopez-Aguilar; Péter Hauser; Miklós Garami; Zoltán Hanzély; László Bognár; Rolando F. Del Maestro; Jeffrey Atkinson; Andre Nantel; Nada Jabado
Hypermethylation of Tachykinin-1 Is a Potential Biomarker in Human Esophageal Cancer
Zhe Jin; Alexandru Olaru; Jian Yang; Fumiaki Sato; Yulan Cheng; Takatsugu Kan; Yuriko Mori; Carmit Mantzur; Bogdan Paun; James P. Hamilton; Tetsuo Ito; Suna Wang; Stefan David; Rachana Agarwal; David G. Beer; John M. Abraham; Stephen J. Meltzer
Expression of Prenylated Rab Acceptor 1 Domain Family, Member 2 (PRAF2) in Neuroblastoma: Correlation with Clinical Features, Cellular Localization, and Cerulenin-Mediated Apoptosis Regulation
Dirk Geerts; Christopher J. Wallick; Dana-Lynn T. Koomoa; Jan Koster; Rogier Versteeg; Ramon Christopher V. Go; André S. Bachmann
Imaging, Diagnosis, Prognosis
A Self-Quenched Galactosamine-Serum Albumin-RhodamineX Conjugate: A “Smart” Fluorescent Molecular Imaging Probe Synthesized with Clinically Applicable Material for Detecting Peritoneal Ovarian Cancer Metastases
Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Andrew J. Gunn; Peter L. Choyke; Hisataka Kobayashi
Microphthalmia-Associated Transcription Factor Gene Amplification in Metastatic Melanoma Is a Prognostic Marker for Patient Survival, But Not a Predictive Marker for Chemosensitivity and Chemotherapy Response
Selma Ugurel; Roland Houben; David Schrama; Heike Voigt; Marc Zapatka; Dirk Schadendorf; Eva B. Bröcker; Jürgen C. Becker
Fluorine-18-α-Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer: A Clinicopathologic Study
Kyoichi Kaira; Noboru Oriuchi; Yoshimi Otani; Kimihiro Shimizu; Shigebumi Tanaka; Hisao Imai; Noriko Yanagitani; Noriaki Sunaga; Takeshi Hisada; Tamotsu Ishizuka; Kunio Dobashi; Yoshikatsu Kanai; Hitoshi Endou; Takashi Nakajima; Keigo Endo; Masatomo Mori
Cancer Therapy: Clinical
Immunologic and Clinical Outcomes of a Randomized Phase II Trial of Two Multipeptide Vaccines for Melanoma in the Adjuvant Setting
Craig L. Slingluff, Jr.; Gina R. Petroni; Kimberly A. Chianese-Bullock; Mark E. Smolkin; Sarah Hibbitts; Cheryl Murphy; Naomi Johansen; William W. Grosh; Galina V. Yamshchikov; Patrice Y. Neese; James W. Patterson; Robyn Fink; Patrice K. Rehm
Pathologic Complete Response to Trastuzumab-Based Neoadjuvant Therapy Is Related to the Level of HER-2 Amplification
Laurent Arnould; Patrick Arveux; Jerome Couturier; Marion Gelly-Marty; Catherine Loustalot; Francette Ettore; Christine Sagan; Martine Antoine; Frederique Penault-Llorca; Berangere Vasseur; Pierre Fumoleau; Bruno P. Coudert
Population Pharmacokinetics and Pharmacodynamics of Paclitaxel and Carboplatin in Ovarian Cancer Patients: A Study by the European Organization for Research and Treatment of Cancer-Pharmacology and Molecular Mechanisms Group and New Drug Development Group
Markus Joerger; Alwin D.R. Huitema; Dick J. Richel; Christian Dittrich; Nikolas Pavlidis; Evangelos Briasoulis; Jan B. Vermorken; Elena Strocchi; Andrea Martoni; Roberto Sorio; Henk P. Sleeboom; Miguel A. Izquierdo; Duncan I. Jodrell; Hilary Calvert; Alan V. Boddy; Harry Hollema; Regine Féty; Wjf J.F. Van der Vijgh; Georg Hempel; Etienne Chatelut; Mats Karlsson; Justin Wilkins; Brigitte Tranchand; Ad H.G.J. Schrijvers; Christian Twelves; Jos H. Beijnen; Jan H.M. Schellens
Cancer Therapy: Preclinical
Investigation of Two Dosing Schedules of Vandetanib (ZD6474), an Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, in Combination with Irinotecan in a Human Colon Cancer Xenograft Model
Teresa Troiani; Natalie J. Serkova; Daniel L. Gustafson; Thomas K. Henthorn; Owen Lockerbie; Andrea Merz; Michael Long; Mark Morrow; Fortunato Ciardiello; S. Gail Eckhardt
Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1α Autocrine Loop, and Reduces Orthotopic Tumor Growth
Sven A. Lang; Christian Moser; Andreas Gaumann; Dagmar Klein; Gabriel Glockzin; Felix C. Popp; Marc H. Dahlke; Pompiliu Piso; Hans J. Schlitt; Edward K. Geissler; Oliver Stoeltzing
Inhibition of Interleukin-6 Signaling with CNTO 328 Enhances the Activity of Bortezomib in Preclinical Models of Multiple Myeloma
Peter M. Voorhees; Qing Chen; Deborah J. Kuhn; George W. Small; Sally A. Hunsucker; John S. Strader; Robert E. Corringham; Mohamed H. Zaki; Jeffrey A. Nemeth; Robert Z. Orlowski
Defucosylated Anti–CC Chemokine Receptor 4 Monoclonal Antibody Combined with Immunomodulatory Cytokines: A Novel Immunotherapy for Aggressive/Refractory Mycosis Fungoides and Sézary Syndrome
Hiroki Yano; Takashi Ishida; Atsushi Inagaki; Toshihiko Ishii; Jianmin Ding; Shigeru Kusumoto; Hirokazu Komatsu; Shinsuke Iida; Hiroshi Inagaki; Ryuzo Ueda
Immunization with Mimotopes Prevents Growth of Carcinoembryonic Antigen–Positive Tumors in BALB/c Mice
Kira H. Brämswig; Regina Knittelfelder; Silke Gruber; Eva Untersmayr; Angelika B. Riemer; Krisztina Szalai; Reinhard Horvat; Robert Kammerer; Wolfgang Zimmermann; Christoph C. Zielinski; Otto Scheiner; Erika Jensen-Jarolim
Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells
Jong-Seok Kim; Young-Chul Lee; Ho-Tak Nam; Ge Li; Eun-Jin Yun; Kyoung-Sub Song; Kang-Sik Seo; Ji-Hoon Park; Jong-Woong Ahn; OkPyo Zee; Jong-Il Park; Wan-Hee Yoon; Kyu Lim; Byung-Doo Hwang
Buccal Mucosa Cells as In vivo Model to Evaluate Gefitinib Activity in Patients with Advanced Non–Small Cell Lung Cancer
Maura Loprevite; Marcello Tiseo; Maurizio Chiaramondia; Marzia Capelletti; Cecilia Bozzetti; Beatrice Bortesi; Nadia Naldi; Rita Nizzoli; Patrizia Dadati; Annalisa Kunkl; Daniela Zennaro; Costanza Lagrasta; Nicoletta Campanini; Elena Spiritelli; Roberta Camisa; Francesco Grossi; Guido Rindi; Vittorio Franciosi; Andrea Ardizzoni
Cancer Susceptibility and Prevention
5-Aminosalicylic Acid Given in the Remission Stage of Colitis Suppresses Colitis-Associated Cancer in a Mouse Colitis Model
Ikuko Ikeda; Ayako Tomimoto; Koichiro Wada; Toshio Fujisawa; Koji Fujita; Kyoko Yonemitsu; Yuichi Nozaki; Hiroki Endo; Hirokazu Takahashi; Masato Yoneda; Masahiko Inamori; Kensuke Kubota; Satoru Saito; Yoji Nagashima; Hitoshi Nakagama; Atsushi Nakajima
Repair Capacity for UV Light–Induced DNA Damage Associated with Risk of Nonmelanoma Skin Cancer and Tumor Progression
Li-E Wang; Chunying Li; Sara S. Strom; Leonard H. Goldberg; Abenaa Brewster; Zhaozheng Guo; Yawei Qiao; Gary L. Clayman; J. Jack Lee; Adel K. El-Naggar; Victor G. Prieto; Madeleine Duvic; Scott M. Lippman; Randal S. Weber; Margaret L. Kripke; Qingyi Wei
Letters to the Editor
Bortezomib-Mediated Up-Regulation of TRAIL-R1 and TRAIL-R2 Is Not Necessary for but Contributes to Sensitization of Primary Human Glioma Cells to TRAIL
Ronald Koschny; Jaromir Sykora; Henning Walczak; Tom M. Ganten; Tobias L. Haas; Martin R. Sprick; Heidrum Holland; Peter Ahnert; Wolfgang Krupp; Jürgen Meixensberger; Manfred Bauer
Corrections
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