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15 January 2007
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Cover Image
Cover Image
Three-dimensional representation of the results from the principal components analysis. Immunohistochemical staining scores were used to visualize the relations between the analyzed tumor samples. Coloring scheme was adopted from the K-means clustering results. The closer two samples appear in the three-dimensional space the more similar are their respective expression patterns. For further details, please see Diallo-Danebrock et al. on page 488 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
The Biology Behind
Molecular Pathways
Human Cancer Biology
Microarray-Based Identification of Tenascin C and Tenascin XB, Genes Possibly Involved in Tumorigenesis Associated with Neurofibromatosis Type 1
Pascale Lévy; Hugues Ripoche; Ingrid Laurendeau; Vladimir Lazar; Nicolas Ortonne; Béatrice Parfait; Karen Leroy; Janine Wechsler; Isabelle Salmon; Pierre Wolkenstein; Philippe Dessen; Michel Vidaud; Dominique Vidaud; Ivan Bièche
Gene Expression Signature and the Prediction of Ulcerative Colitis–Associated Colorectal Cancer by DNA Microarray
Toshiaki Watanabe; Takashi Kobunai; Etsuko Toda; Takamitsu Kanazawa; Yoshihiro Kazama; Junichiro Tanaka; Toshiaki Tanaka; Yoko Yamamoto; Keisuke Hata; Tetsu Kojima; Tadashi Yokoyama; Tsuyoshi Konishi; Yoshihiro Okayama; Yoshikazu Sugimoto; Toshinori Oka; Shin Sasaki; Yohichi Ajioka; Tetsuichiro Muto; Hirokazu Nagawa
Imaging, Diagnosis, Prognosis
Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography Predicts Tumor Differentiation, P-glycoprotein Expression, and Outcome after Resection in Hepatocellular Carcinoma
Satoru Seo; Etsuro Hatano; Tatsuya Higashi; Tadashi Hara; Masaharu Tada; Nobuyuki Tamaki; Keiko Iwaisako; Iwao Ikai; Shinji Uemoto
Increased Expression of Insulin-like Growth Factor-II Messenger RNA–Binding Protein 1 Is Associated with Tumor Progression in Patients with Lung Cancer
Tatsuya Kato; Satoshi Hayama; Takumi Yamabuki; Nobuhisa Ishikawa; Masaki Miyamoto; Tomoo Ito; Eiju Tsuchiya; Satoshi Kondo; Yusuke Nakamura; Yataro Daigo
Prognostic Role of the Reduced Folate Carrier, the Major Membrane Transporter for Methotrexate, in Childhood Acute Lymphoblastic Leukemia: A Report from the Children's Oncology Group
Yubin Ge; Christina L. Haska; Katherine LaFiura; Meenakshi Devidas; Stephen B. Linda; Mingjun Liu; Ronald Thomas; Jeffrey W. Taub; Larry H. Matherly
An Integrated Clinical-Genomics Approach Identifies a Candidate Multi-Analyte Blood Test for Serous Ovarian Carcinoma
Ivo Meinhold-Heerlein; Dirk Bauerschlag; Yingyao Zhou; Lisa M. Sapinoso; Keith Ching; Henry Frierson, Jr.; Karen Bräutigam; Jalid Sehouli; Elmar Stickeler; Dominique Könsgen; Felix Hilpert; Constantin S. von Kaisenberg; Jacobus Pfisterer; Thomas Bauknecht; Walter Jonat; Norbert Arnold; Garret M. Hampton
Lumbar Bone Marrow Microcirculation Measurements from Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is a Predictor of Event-Free Survival in Progressive Multiple Myeloma
Jens Hillengass; Klaus Wasser; Stefan Delorme; Fabian Kiessling; Christian Zechmann; Axel Benner; Hans-Ulrich Kauczor; Anthony D. Ho; Hartmut Goldschmidt; Thomas M. Moehler
Protein Expression Profiling in High-Risk Breast Cancer Patients Treated with High-Dose or Conventional Dose–Dense Chemotherapy
Raihanatou Diallo-Danebrock; Evelyn Ting; Oleg Gluz; Alexander Herr; Svjetlana Mohrmann; Helene Geddert; Achim Rody; Karl-Ludwig Schaefer; Stephan E. Baldus; Arndt Hartmann; Peter J. Wild; Michael Burson; Helmut E. Gabbert; Ulrike Nitz; Christopher Poremba
Multiple Gene Expression Classifiers from Different Array Platforms Predict Poor Prognosis of Colorectal Cancer
Yu-Hsin Lin; Jan Friederichs; Michael A. Black; Jörg Mages; Robert Rosenberg; Parry J. Guilford; Vicky Phillips; Mark Thompson-Fawcett; Nikola Kasabov; Tumi Toro; Arend E. Merrie; Andre van Rij; Han-Seung Yoon; John L. McCall; Jörg Rüdiger Siewert; Bernhard Holzmann; Anthony E. Reeve
Centromere Protein H Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Overall Patient Survival
Wen-Ting Liao; Li-Bing Song; Hui-Zhong Zhang; Xing Zhang; Ling Zhang; Wan-Li Liu; Yan Feng; Bao-Hong Guo; Hai-Qiang Mai; Su-Mei Cao; Man-Zhi Li; Hai-De Qin; Yi-Xin Zeng; Mu-Sheng Zeng
Cancer Therapy: Clinical
A Phase I Study of Pemetrexed, Carboplatin, and Concurrent Radiotherapy in Patients with Locally Advanced or Metastatic Non–Small Cell Lung or Esophageal Cancer
Tanguy Y. Seiwert; Philip P. Connell; Ann M. Mauer; Philip C. Hoffman; Christopher M. George; Livia Szeto; Ravi Salgia; Katherine E. Posther; Binh Nguyen; Daniel J. Haraf; Everett E. Vokes
Phase 1b Dose Escalation Study of Erlotinib in Combination with Infusional 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Advanced Solid Tumors
Axel-R. Hanauske; Jim Cassidy; Javier Sastre; Claus Bolling; Robert J. Jones; Ashok Rakhit; Scott Fettner; Ulrich Brennscheidt; Andrea Feyereislova; Eduardo Díaz-Rubio
A Phase I Study of Immunization Using Particle-Mediated Epidermal Delivery of Genes for gp100 and GM-CSF into Uninvolved Skin of Melanoma Patients
Ryan D. Cassaday; Paul M. Sondel; David M. King; Michael D. Macklin; Jacek Gan; Tom F. Warner; Cindy L. Zuleger; Alan J. Bridges; Heidi G. Schalch; Kyung Mann Kim; Jacquelyn A. Hank; David M. Mahvi; Mark R. Albertini
Regulation of Hepatocyte Growth Factor Activator Inhibitor 2 by Hypoxia in Breast Cancer
Daniele Generali; Stephen B. Fox; Alfredo Berruti; John W. Moore; Maria Pia Brizzi; Nilay Patel; Giovanni Allevi; Simone Bonardi; Sergio Aguggini; Alessandra Bersiga; Leticia Campo; Luigi Dogliotti; Alberto Bottini; Adrian L. Harris
Antigenic Profiling of Glioma Cells to Generate Allogeneic Vaccines or Dendritic Cell–Based Therapeutics
Jian Gang Zhang; Junichi Eguchi; Carol A. Kruse; German G. Gomez; Habib Fakhrai; Stephanie Schroter; Wenxue Ma; Neil Hoa; Boris Minev; Christina Delgado; H. Terry Wepsic; Hideho Okada; Martin R. Jadus
Cancer Therapy: Preclinical
CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo
Archie N. Tse; Katherine G. Rendahl; Tahir Sheikh; Haider Cheema; Kim Aardalen; Millicent Embry; Sylvia Ma; Edward J. Moler; Zhi Jie Ni; Daniel E. Lopes de Menezes; Barbara Hibner; Thomas G. Gesner; Gary K. Schwartz
Copper-67 Radioimmunotherapy and Growth Inhibition by Anti–L1-Cell Adhesion Molecule Monoclonal Antibodies in a Therapy Model of Ovarian Cancer Metastasis
Karin Knogler; Jürgen Grünberg; Kurt Zimmermann; Susan Cohrs; Michael Honer; Simon Ametamey; Peter Altevogt; Mina Fogel; P. August Schubiger; Ilse Novak-Hofer
Glucocorticoids Modulate Tumor Radiation Response through a Decrease in Tumor Oxygen Consumption
Nathalie Crokart; Bénédicte F. Jordan; Christine Baudelet; Gregory O. Cron; Julie Hotton; Kim Radermacher; Vincent Grégoire; Nelson Beghein; Philippe Martinive; Caroline Bouzin; Olivier Feron; Bernard Gallez
Early Detection and Rapid Isolation of Leukemia-Reactive Donor T Cells for Adoptive Transfer Using the IFN-γ Secretion Assay
Inge Jedema; Pauline Meij; Esther Steeneveld; Mels Hoogendoorn; Bart A. Nijmeijer; Marian van de Meent; Simone A.P. van Luxemburg-Heijs; Roel Willemze; J.H. Frederik Falkenburg
Cyclophosphamide Enhances the Antitumor Efficacy of Adoptively Transferred Immune Cells through the Induction of Cytokine Expression, B-Cell and T-Cell Homeostatic Proliferation, and Specific Tumor Infiltration
Laura Bracci; Federica Moschella; Paola Sestili; Valentina La Sorsa; Mara Valentini; Irene Canini; Sara Baccarini; Sonia Maccari; Carlo Ramoni; Filippo Belardelli; Enrico Proietti
Cancer Prevention
Reduced Mammographic Density with Use of a Gonadotropin-Releasing Hormone Agonist–Based Chemoprevention Regimen in BRCA1 Carriers
Jeffrey N. Weitzel; Saundra S. Buys; William H. Sherman; Anna Marie Daniels; Giske Ursin; John R. Daniels; Deborah J. MacDonald; Kathleen R. Blazer; Malcolm C. Pike; Darcy V. Spicer
Innovations and Challenges in Renal Cancer
Innovations and Challenges in Renal Cell Carcinoma: Summary Statement from the Second Cambridge Conference
Michael B. Atkins; Marc S. Ernstoff; Robert A. Figlin; Keith T. Flaherty; Daniel J. George; William G. Kaelin, Jr.; Eugene D. Kwon; Towia A. Libermann; W. Marston Linehan; David F. McDermott; Augusto C. Ochoa; Allan J. Pantuck; Brian I. Rini; Mark A. Rosen; Jeffrey A. Sosman; Vikas P. Sukhatme; Johannes W. Vieweg; Christopher G. Wood; Laura King
Identification of the Genes for Kidney Cancer: Opportunity for Disease-Specific Targeted Therapeutics
W. Marston Linehan; Peter A. Pinto; Ramaprasad Srinivasan; Maria Merino; Peter Choyke; Lynda Choyke; Jonathan Coleman; Jorge Toro; Gladys Glenn; Cathy Vocke; Bert Zbar; Laura S. Schmidt; Donald Bottaro; Len Neckers
Developing a Rational Tumor Vaccine Therapy for Renal Cell Carcinoma: Immune Yin and Yang
Marc S. Ernstoff; Todd S. Crocenzi; John D. Seigne; Nancy A. Crosby; Bernard F. Cole; Jan L. Fisher; Jill C. Uhlenhake; Diane Mellinger; Cathy Foster; Conrad J. Farnham; Kathleen Mackay; Zbigniew M. Szczepiorkowski; Susan M. Webber; Alan R. Schned; Robert D. Harris; Richard J. Barth, Jr.; John A. Heaney; Randolph J. Noelle
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