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1 September 2007
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Irradiation of endothelial cells in vitro induces the surface exposure of anionic phospholipids, principally phosphatidylserine (shown in green in the figure). Irradiation of human lung tumors in mice likewise induces exposure of phosphatidylserine on tumor vascular endothelium. Targeting the exposed phosphatidylserine with a monoclonal antibody (2aG4) leads to host-cell mediated destruction of tumor vessels and reductions in tumor growth in the mice. Bavituximab, a chimeric version of 2aG4 in clinical trials, has the potential to improve the efficacy of radiation therapy in cancer patients by amplifying damage to tumor vasculature. For details, see the article by He and associates on page 5211 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Editorials
The Biology Behind
Molecular Pathways
Human Cancer Biology
Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative
Alfredo A. Molinolo; Stephen M. Hewitt; Panomwat Amornphimoltham; Somboon Keelawat; Samraeung Rangdaeng; Abelardo Meneses García; Ana R. Raimondi; Rafael Jufe; María Itoiz; Yan Gao; Dhananjaya Saranath; George S. Kaleebi; George H. Yoo; Lee Leak; Ernest M. Myers; Satoru Shintani; David Wong; H. Davis Massey; W. Andrew Yeudall; Fulvio Lonardo; John Ensley; J. Silvio Gutkind
Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process
Kanako Hoshi; Hideki Takakura; Yasumasa Mitani; Kenji Tatsumi; Nobuyoshi Momiyama; Yasushi Ichikawa; Shinji Togo; Toru Miyagi; Yuki Kawai; Yasushi Kogo; Takeshi Kikuchi; Chiaki Kato; Takahiro Arakawa; Syuji Uno; Paul E. Cizdziel; Alexander Lezhava; Noburou Ogawa; Yoshihide Hayashizaki; Hiroshi Shimada
Is There a Human Homologue to the Murine Proteolysis-Inducing Factor?
Barbara M. Wieland; Grant D. Stewart; Richard J.E. Skipworth; Kathryn Sangster; Kenneth C.H. Fearon; James A. Ross; Tony J. Reiman; Jay Easaw; Marina Mourtzakis; Vishesh Kumar; Brian J. Pak; Kathryn Calder; Gerasimos Filippatos; Dimitris T. Kremastinos; Monica Palcic; Vickie E. Baracos
Isolation and Molecular Profiling of Bone Marrow Micrometastases Identifies TWIST1 as a Marker of Early Tumor Relapse in Breast Cancer Patients
Mark A. Watson; Lourdes R. Ylagan; Kathryn M. Trinkaus; William E. Gillanders; Michael J. Naughton; Katherine N. Weilbaecher; Timothy P. Fleming; Rebecca L. Aft
Melanoma Cells Exhibit Variable Signal Transducer and Activator of Transcription 1 Phosphorylation and a Reduced Response to IFN-α Compared with Immune Effector Cells
Gregory B. Lesinski; John Trefry; Melanie Brasdovich; Sri Vidya Kondadasula; Korkor Sackey; Jason M. Zimmerer; Abhik Ray Chaudhury; Lianbo Yu; Xiaoli Zhang; Tim R. Crespin; Michael J. Walker; William E. Carson, III
Deletion of a Small Consensus Region at 6q15, Including the MAP3K7 Gene, Is Significantly Associated with High-Grade Prostate Cancers
Wennuan Liu; Bao-Li Chang; Scott Cramer; Patrick P. Koty; Tao Li; Jishan Sun; Aubrey R. Turner; Chris Von Kap-Herr; Peggy Bobby; Jianyu Rao; S. Lilly Zheng; William B. Isaacs; Jianfeng Xu
Cyclooxygenase-2 and Platelet-Derived Growth Factor Receptors as Potential Targets in Treating Aggressive Fibromatosis
Stefano Signoroni; Milo Frattini; Tiziana Negri; Elisa Pastore; Elena Tamborini; Paola Casieri; Marta Orsenigo; Luca Da Riva; Paolo Radice; Paola Sala; Alessandro Gronchi; Lucio Bertario; Marco A. Pierotti; Silvana Pilotti
Imaging, Diagnosis, Prognosis
Inactivation of HOXA Genes by Hypermethylation in Myeloid and Lymphoid Malignancy is Frequent and Associated with Poor Prognosis
Gordon Strathdee; Tessa L. Holyoake; Alyson Sim; Anton Parker; David G. Oscier; Junia V. Melo; Stefan Meyer; Tim Eden; Anne M. Dickinson; Joanne C. Mountford; Heather G. Jorgensen; Richard Soutar; Robert Brown
Clinical Significance of Serum Mesothelin in Patients with Mesothelioma and Lung Cancer
Alfonso Cristaudo; Rudy Foddis; Agnese Vivaldi; Giovanni Guglielmi; Nicola Dipalma; Rosangela Filiberti; Monica Neri; Marcello Ceppi; Michela Paganuzzi; Gian Paolo Ivaldi; Manlio Mencoboni; Pier Aldo Canessa; Nicolino Ambrosino; Antonio Chella; Luciano Mutti; Riccardo Puntoni
Methylation of Tumor-Related Genes in Neoadjuvant-Treated Gastric Cancer: Relation to Therapy Response and Clinicopathologic and Molecular Features
Rudolf Napieralski; Katja Ott; Markus Kremer; Karen Becker; Anne-Laure Boulesteix; Florian Lordick; Jörg Rüdiger Siewert; Heinz Höfler; Gisela Keller
Significance of HER2 Low-Level Copy Gain in Barrett's Cancer: Implications for Fluorescence In situ Hybridization Testing in Tissues
Sandra Rauser; Roland Weis; Herbert Braselmann; Marcus Feith; Hubert J. Stein; Rupert Langer; Peter Hutzler; Michael Hausmann; Silke Lassmann; Jörg Rüdiger Siewert; Heinz Höfler; Martin Werner; Axel Walch
Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders Constitute a Distinct Clinicopathologic Group: A Study of 96 Patients
Takashi Oyama; Kazuhito Yamamoto; Naoko Asano; Aya Oshiro; Ritsuro Suzuki; Yoshitoyo Kagami; Yasuo Morishima; Kengo Takeuchi; Toshiyuki Izumo; Shigeo Mori; Koichi Ohshima; Junji Suzumiya; Naoya Nakamura; Masafumi Abe; Koichi Ichimura; Yumiko Sato; Tadashi Yoshino; Tomoki Naoe; Yoshie Shimoyama; Yoshikazu Kamiya; Tomohiro Kinoshita; Shigeo Nakamura
Cancer Therapy: Clinical
Prospective Assessment of Discontinuation and Reinitiation of Erlotinib or Gefitinib in Patients with Acquired Resistance to Erlotinib or Gefitinib Followed by the Addition of Everolimus
Gregory J. Riely; Mark G. Kris; Binsheng Zhao; Tim Akhurst; Daniel T. Milton; Erin Moore; Leslie Tyson; William Pao; Naiyer A. Rizvi; Lawrence H. Schwartz; Vincent A. Miller
Cancer Therapy: Preclinical
Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo
Joell J. Gills; Jaclyn LoPiccolo; Junji Tsurutani; Robert H. Shoemaker; Carolyn J.M. Best; Mones S. Abu-Asab; Jennifer Borojerdi; Noel A. Warfel; Erin R. Gardner; Matthew Danish; M. Christine Hollander; Shigeru Kawabata; Maria Tsokos; William D. Figg; Patricia S. Steeg; Phillip A. Dennis
Corrections
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