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Volume 13, Issue 16
15 August 2007
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    Cover Image

    issue cover
    Pericyte marker alpha smooth muscle actin (α-SMA, red) and vascular endothelial growth factor receptor-2 (VEGFR-2, green) double immunofluorescence staining was shown in Ewing’s sarcoma tumors. The yellow area indicates cells that express both VEGFR-2 and α-SMA. For further details, please see Zhou and associates on page 4867 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Editorials

Is There a Future for Ductal Lavage?
Carol J. Fabian
View articletitled, Is There a Future for Ductal Lavage?
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ErbB-Dependent Signaling as a Determinant of Trastuzumab Resistance
Rakesh Kumar
View articletitled, ErbB-Dependent Signaling as a Determinant of Trastuzumab Resistance
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The Biology Behind

Loss of Secreted Frizzled-Related Protein-1 Expression in Renal Cell Carcinoma Reveals a Critical Tumor Suppressor Function
Jeffrey S. Rubin; Donald P. Bottaro
View articletitled, Loss of Secreted Frizzled-Related Protein-1 Expression in Renal Cell Carcinoma Reveals a Critical Tumor Suppressor Function
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CCR Drug Updates

Panitumumab, a Monoclonal Anti–Epidermal Growth Factor Receptor Antibody in Colorectal Cancer: Another One or the One?
Wells A. Messersmith; Manuel Hidalgo
View articletitled, Panitumumab, a Monoclonal Anti–Epidermal Growth Factor Receptor Antibody in Colorectal Cancer: Another One or the One?
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Molecular Pathways

Pseudohypoxic Pathways in Renal Cell Carcinoma
Gennady Bratslavsky; Sunil Sudarshan; Len Neckers; W. Marston Linehan
View articletitled, Pseudohypoxic Pathways in Renal Cell Carcinoma
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Membrane-Associated Estrogen Receptor Signaling Pathways in Human Cancers
Richard J. Pietras; Diana C. Márquez-Garbán
View articletitled, Membrane-Associated Estrogen Receptor Signaling Pathways in Human Cancers
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Review

Interleukin-12: Biological Properties and Clinical Application
Michele Del Vecchio; Emilio Bajetta; Stefania Canova; Michael T. Lotze; Amy Wesa; Giorgio Parmiani; Andrea Anichini
View articletitled, Interleukin-12: Biological Properties and Clinical Application
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Human Cancer Biology

Nicotine Induces Hypoxia-Inducible Factor-1α Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor–Mediated Signaling Pathways
Qunzhou Zhang; Xudong Tang; Zuo-Feng Zhang; Rita Velikina; Shihong Shi; Anh D. Le
View articletitled, Nicotine Induces Hypoxia-Inducible Factor-1α Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor–Mediated Signaling Pathways
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High Skp2 Expression Characterizes High-Risk Neuroblastomas Independent of MYCN Status
Frank Westermann; Kai-Oliver Henrich; Jun S. Wei; Werner Lutz; Matthias Fischer; Rainer König; Ruprecht Wiedemeyer; Volker Ehemann; Benedikt Brors; Karen Ernestus; Ivo Leuschner; Axel Benner; Javed Khan; Manfred Schwab
View articletitled, High <em>Skp2</em> Expression Characterizes High-Risk Neuroblastomas Independent of <em>MYCN</em> Status
Supplementary data
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The Development and Characterization of a Human Midgut Carcinoid Cell Line
George Van Buren, II; Asif Rashid; Anthony D. Yang; Eddie K. Abdalla; Michael J. Gray; Wenbiao Liu; Ray Somcio; Fan Fan; E. Ramsay Camp; James C. Yao; Lee M. Ellis
View articletitled, The Development and Characterization of a Human Midgut Carcinoid Cell Line
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The Cancer/Testis Antigen Melanoma-Associated Antigen-A3/A6 Is a Novel Target of Fibroblast Growth Factor Receptor 2-IIIb through Histone H3 Modifications in Thyroid Cancer
Tetsuo Kondo; Xuegong Zhu; Sylvia L. Asa; Shereen Ezzat
View articletitled, The Cancer/Testis Antigen Melanoma-Associated Antigen-A3/A6 Is a Novel Target of Fibroblast Growth Factor Receptor 2-IIIb through Histone H3 Modifications in Thyroid Cancer
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INI1 Induces Interferon Signaling and Spindle Checkpoint in Rhabdoid Tumors
Alexei Morozov; Seung Jae Lee; Zhi-Kai Zhang; Velasco Cimica; David Zagzag; Ganjam V. Kalpana
View articletitled, INI1 Induces Interferon Signaling and Spindle Checkpoint in Rhabdoid Tumors
Supplementary data
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High-Resolution Single Nucleotide Polymorphism Array Analysis of Epithelial Ovarian Cancer Reveals Numerous Microdeletions and Amplifications
Kylie L. Gorringe; Sharoni Jacobs; Ella R. Thompson; Anita Sridhar; Wen Qiu; David Y.H. Choong; Ian G. Campbell
View articletitled, High-Resolution Single Nucleotide Polymorphism Array Analysis of Epithelial Ovarian Cancer Reveals Numerous Microdeletions and Amplifications
Supplementary data
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Secreted Frizzled-Related Protein 1 Loss Contributes to Tumor Phenotype of Clear Cell Renal Cell Carcinoma
Michelle L. Gumz; Hongzhi Zou; Pamela A. Kreinest; April C. Childs; Leandra S. Belmonte; Shauna N. LeGrand; Kevin J. Wu; Bruce A. Luxon; Mala Sinha; Alexander S. Parker; L-Z. Sun; David A. Ahlquist; Christopher G. Wood; John A. Copland
View articletitled, Secreted Frizzled-Related Protein 1 Loss Contributes to Tumor Phenotype of Clear Cell Renal Cell Carcinoma
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OSU-03012, a Novel Celecoxib Derivative, Is Cytotoxic to Myeloma Cells and Acts through Multiple Mechanisms
Shuhong Zhang; Attaya Suvannasankha; Colin D. Crean; Valerie L. White; Amy Johnson; Ching-Shih Chen; Sherif S. Farag
View articletitled, OSU-03012, a Novel Celecoxib Derivative, Is Cytotoxic to Myeloma Cells and Acts through Multiple Mechanisms
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Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer
Tse-Ming Hong; Yuh-Ling Chen; Yi-Ying Wu; Ang Yuan; Yu-Chih Chao; Yi-Chuan Chung; Ming-Heng Wu; Shuenn-Chen Yang; Szu-Hua Pan; Jin-Yuan Shih; Wing-Kai Chan; Pan-Chyr Yang
View articletitled, Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer
Supplementary data
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Epithelial to Mesenchymal Transition: Expression of the Regulators Snail, Slug, and Twist in Pancreatic Cancer
Birgit Hotz; Marco Arndt; Sonja Dullat; Sarah Bhargava; Heinz-J. Buhr; Hubert G. Hotz
View articletitled, Epithelial to Mesenchymal Transition: Expression of the Regulators Snail, Slug, and Twist in Pancreatic Cancer
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Comprehensive Analysis of Copy Number and Allele Status Identifies Multiple Chromosome Defects Underlying Follicular Lymphoma Pathogenesis
Charles W. Ross; Peter D. Ouillette; Chris M. Saddler; Kerby A. Shedden; Sami N. Malek
View articletitled, Comprehensive Analysis of Copy Number and Allele Status Identifies Multiple Chromosome Defects Underlying Follicular Lymphoma Pathogenesis
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PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer
Yoshiyuki Watanabe; Minoru Toyota; Yutaka Kondo; Hiromu Suzuki; Takashi Imai; Mutsumi Ohe-Toyota; Reo Maruyama; Masanori Nojima; Yasushi Sasaki; Yoshitaka Sekido; Hiroyoshi Hiratsuka; Yasuhisa Shinomura; Kohzoh Imai; Fumio Itoh; Takashi Tokino
View articletitled, PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer
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Imaging, Diagnosis, Prognosis

Activated Mammalian Target of Rapamycin Is an Adverse Prognostic Factor in Patients with Biliary Tract Adenocarcinoma
Beata Herberger; Harald Puhalla; Martina Lehnert; Fritz Wrba; Sabine Novak; Anita Brandstetter; Birgit Gruenberger; Thomas Gruenberger; Robert Pirker; Martin Filipits
View articletitled, Activated Mammalian Target of Rapamycin Is an Adverse Prognostic Factor in Patients with Biliary Tract Adenocarcinoma
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Cyclin E–Associated Kinase Activity Predicts Response to Platinum-Based Chemotherapy
Isabelle Bedrosian; Christine Lee; Susan L. Tucker; Shana L. Palla; Karen Lu; Khandan Keyomarsi
View articletitled, Cyclin E–Associated Kinase Activity Predicts Response to Platinum-Based Chemotherapy
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One-step Nucleic Acid Amplification for Intraoperative Detection of Lymph Node Metastasis in Breast Cancer Patients
Masahiko Tsujimoto; Kadzuki Nakabayashi; Katsuhide Yoshidome; Tomoyo Kaneko; Takuji Iwase; Futoshi Akiyama; Yo Kato; Hitoshi Tsuda; Shigeto Ueda; Kazuhiko Sato; Yasuhiro Tamaki; Shinzaburo Noguchi; Tatsuki R. Kataoka; Hiromu Nakajima; Yoshifumi Komoike; Hideo Inaji; Koichiro Tsugawa; Koyu Suzuki; Seigo Nakamura; Motonari Daitoh; Yasuhiro Otomo; Nariaki Matsuura
View articletitled, One-step Nucleic Acid Amplification for Intraoperative Detection of Lymph Node Metastasis in Breast Cancer Patients
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Decreased Expression of Retinoid Receptors in Melanoma: Entailment in Tumorigenesis and Prognosis
Nitin Chakravarti; Reuben Lotan; Abdul H. Diwan; Carla L. Warneke; Marcella M. Johnson; Victor G. Prieto
View articletitled, Decreased Expression of Retinoid Receptors in Melanoma: Entailment in Tumorigenesis and Prognosis
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Erythropoietin and Erythropoietin Receptor Coexpression Is Associated with Poor Survival in Stage I Non–Small Cell Lung Cancer
Pierre Saintigny; Benjamin Besse; Patrice Callard; Anne-Claire Vergnaud; Sébastien Czernichow; Magali Colombat; Philippe Girard; Pierre Validire; Jean-Luc Breau; Jean-François Bernaudin; Jean-Charles Soria
View articletitled, Erythropoietin and Erythropoietin Receptor Coexpression Is Associated with Poor Survival in Stage I Non–Small Cell Lung Cancer
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Cancer Therapy: Clinical

Oxaliplatin Pharmacokinetics and Pharmacodynamics in Adult Cancer Patients with Impaired Renal Function
Chris H. Takimoto; Martin A. Graham; Graham Lockwood; Chee M. Ng; Andrew Goetz; Dennis Greenslade; Scot C. Remick; Sunil Sharma; Sridhar Mani; Ramesh K. Ramanathan; Timothy W. Synold; James H. Doroshow; Anne Hamilton; Daniel L. Mulkerin; Percy Ivy; Merrill J. Egorin; Jean L. Grem
View articletitled, Oxaliplatin Pharmacokinetics and Pharmacodynamics in Adult Cancer Patients with Impaired Renal Function
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Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses
Ingo Fricke; Noweeda Mirza; Jakob Dupont; Craig Lockhart; Autumn Jackson; Ji-Hyun Lee; Jeffrey A. Sosman; Dmitry I. Gabrilovich
View articletitled, Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses
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Phase I Targeted Combination Trial of Sorafenib and Erlotinib in Patients with Advanced Solid Tumors
Ignacio Duran; Sebastien J. Hotté; Holger Hirte; Eric X. Chen; Martha MacLean; Sandra Turner; Lixia Duan; Gregory R. Pond; Chetan Lathia; Scott Walsh; John J. Wright; Janet Dancey; Lillian L. Siu
View articletitled, Phase I Targeted Combination Trial of Sorafenib and Erlotinib in Patients with Advanced Solid Tumors
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Phase I and Pharmacokinetic Study of the (6-Maleimidocaproyl)Hydrazone Derivative of Doxorubicin
Clemens Unger; Brigitte Häring; Michael Medinger; Joachim Drevs; Simone Steinbild; Felix Kratz; Klaus Mross
View articletitled, Phase I and Pharmacokinetic Study of the (6-Maleimidocaproyl)Hydrazone Derivative of Doxorubicin
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Cancer Therapy: Preclinical

Suppression of Ewing's Sarcoma Tumor Growth, Tumor Vessel Formation, and Vasculogenesis Following Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy
Zhichao Zhou; Marcela F. Bolontrade; Krishna Reddy; Xiaoping Duan; Hui Guan; Ling Yu; Daniel J. Hicklin; Eugenie S. Kleinerman
View articletitled, Suppression of Ewing's Sarcoma Tumor Growth, Tumor Vessel Formation, and Vasculogenesis Following Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy
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Sorafenib Inhibits the Imatinib-Resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor
Tianhua Guo; Narasimhan P. Agaram; Grace C. Wong; Glory Hom; David D'Adamo; Robert G. Maki; Gary K. Schwartz; Darren Veach; Bayard D. Clarkson; Samuel Singer; Ronald P. DeMatteo; Peter Besmer; Cristina R. Antonescu
View articletitled, Sorafenib Inhibits the Imatinib-Resistant <em>KIT</em><sup><em>T670I</em></sup> Gatekeeper Mutation in Gastrointestinal Stromal Tumor
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Hydroxamic Acid Analogue Histone Deacetylase Inhibitors Attenuate Estrogen Receptor-α Levels and Transcriptional Activity: A Result of Hyperacetylation and Inhibition of Chaperone Function of Heat Shock Protein 90
Warren Fiskus; Yuan Ren; Alex Mohapatra; Purva Bali; Aditya Mandawat; Rekha Rao; Bryan Herger; Yonghua Yang; Peter Atadja; Jie Wu; Kapil Bhalla
View articletitled, Hydroxamic Acid Analogue Histone Deacetylase Inhibitors Attenuate Estrogen Receptor-α Levels and Transcriptional Activity: A Result of Hyperacetylation and Inhibition of Chaperone Function of Heat Shock Protein 90
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Enhanced Antitumor Effect of Combined Triptolide and Ionizing Radiation
Wei Wang; Shanmin Yang; Ying Su; Zhenyu Xiao; Chunyou Wang; Xinfeng Li; Ling Lin; Bruce M. Fenton; Scott F. Paoni; Ivan Ding; Peter Keng; Paul Okunieff; Lurong Zhang
View articletitled, Enhanced Antitumor Effect of Combined Triptolide and Ionizing Radiation
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p53 Aerosol Formulation with Low Toxicity and High Efficiency for Early Lung Cancer Treatment
Yiyu Zou; Carmen Tornos; Xuan Qiu; Marie Lia; Roman Perez-Soler
View articletitled, p53 Aerosol Formulation with Low Toxicity and High Efficiency for Early Lung Cancer Treatment
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Human Breast Cancer Cells Selected for Resistance to Trastuzumab In vivo Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network
Christoph A. Ritter; Marianela Perez-Torres; Cammie Rinehart; Marta Guix; Teresa Dugger; Jeffrey A. Engelman; Carlos L. Arteaga
View articletitled, Human Breast Cancer Cells Selected for Resistance to Trastuzumab <em>In vivo</em> Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network
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Phosphodiesterase 4 Inhibitors Augment Levels of Glucocorticoid Receptor in B Cell Chronic Lymphocytic Leukemia but Not in Normal Circulating Hematopoietic Cells
John A. Meyers; Josephine Taverna; Jorge Chaves; Anthony Makkinje; Adam Lerner
View articletitled, Phosphodiesterase 4 Inhibitors Augment Levels of Glucocorticoid Receptor in B Cell Chronic Lymphocytic Leukemia but Not in Normal Circulating Hematopoietic Cells
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Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging
Ana P. Cotrim; Fuminori Hyodo; Ken-Ichiro Matsumoto; Anastasia L. Sowers; John A. Cook; Bruce J. Baum; Murali C. Krishna; James B. Mitchell
View articletitled, Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging
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Apoptosis Induction in Human Melanoma Cells by Inhibition of MEK Is Caspase-Independent and Mediated by the Bcl-2 Family Members PUMA, Bim, and Mcl-1
Yu Fang Wang; Chen Chen Jiang; Kelly Anne Kiejda; Susan Gillespie; Xu Dong Zhang; Peter Hersey
View articletitled, Apoptosis Induction in Human Melanoma Cells by Inhibition of MEK Is Caspase-Independent and Mediated by the Bcl-2 Family Members PUMA, Bim, and Mcl-1
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Cancer Prevention

Comparison of Ductal Lavage and Random Periareolar Fine Needle Aspiration as Tissue Acquisition Methods in Early Breast Cancer Prevention Trials
Banu Arun; Vicente Valero; Catherine Logan; Kristine Broglio; Edgardo Rivera; Abenaa Brewster; Guosheng Yin; Marjorie Green; Henry Kuerer; Yun Gong; Doris Browne; Gabriel N. Hortobagyi; Nour Sneige
View articletitled, Comparison of Ductal Lavage and Random Periareolar Fine Needle Aspiration as Tissue Acquisition Methods in Early Breast Cancer Prevention Trials
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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