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15 May 2007
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Cover Image
Cover Image
Microtubule organization assessed by confocal microscopy in the presence of an anticancer agent. Treatment of cancer cells with a low concentration of docetaxel as a single agent causes only minor aberrant mitotic figures, whereas ZD1839 (gefitinib) or celecoxib induces bundled microtubules. Recently, it was found that the addition of celecoxib and ZD1839 to docetaxel markedly increased the frequency of aberrant mitosis observed after 24 hours of treatment. For further details, please see Choe et al. on page 3015 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Editorial
Molecular Pathways
Perspective
Reviews
Human Cancer Biology
Microsatellite Instability Markers for Identifying Early-Onset Colorectal Cancers Caused by Germ-Line Mutations in DNA Mismatch Repair Genes
Leeanne J. Mead; Mark A. Jenkins; Joanne Young; Simon G. Royce; Letitia Smith; D. James B. St. John; Finlay Macrae; Graham G. Giles; John L. Hopper; Melissa C. Southey
Imaging, Diagnosis, Prognosis
KRAS Mutation Is an Important Predictor of Resistance to Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer
Erminia Massarelli; Marileila Varella-Garcia; Ximing Tang; Ana C. Xavier; Natalie C. Ozburn; Diane D. Liu; Benjamin N. Bekele; Roy S. Herbst; Ignacio I. Wistuba
Magnetic Resonance Imaging Determination of Tumor Grade and Early Response to Temozolomide in a Genetically Engineered Mouse Model of Glioma
Patrick McConville; Dolores Hambardzumyan; Jonathan B. Moody; Wilbur R. Leopold; Alicia R. Kreger; Michael J. Woolliscroft; Alnawaz Rehemtulla; Brian D. Ross; Eric C. Holland
A 10-Gene Classifier for Distinguishing Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma
Anil Vachani; Michael Nebozhyn; Sunil Singhal; Linda Alila; Elliot Wakeam; Ruth Muschel; Charles A. Powell; Patrick Gaffney; Bhuvanesh Singh; Marcia S. Brose; Leslie A. Litzky; John Kucharczuk; Larry R. Kaiser; J. Stephen Marron; Michael K. Showe; Steven M. Albelda; Louise C. Showe
Cyclooxygenase 2 Expression in Rectal Cancer Is of Prognostic Significance in Patients Receiving Preoperative Radiotherapy
Pieter de Heer; Marleen J.E.M. Gosens; Elza C. de Bruin; N. Geeske Dekker-Ensink; Hein Putter; Corrie A.M. Marijnen; Adriaan J.C. van den Brule; J. Han J.M. van Krieken; Harm J.T. Rutten; Peter J.K. Kuppen; Cornelis J.H. van de Velde; for the Dutch Colorectal Cancer Group
Cancer Therapy: Clinical
Intradermal CpG-B Activates Both Plasmacytoid and Myeloid Dendritic Cells in the Sentinel Lymph Node of Melanoma Patients
Barbara G. Molenkamp; Paul A.M. van Leeuwen; Sybren Meijer; Berbel J.R. Sluijter; Pepijn G.J.T.B. Wijnands; Arnold Baars; Alfons J.M. van den Eertwegh; Rik J. Scheper; Tanja D. de Gruijl
Immunization of High-Risk Breast Cancer Patients with Clustered sTn-KLH Conjugate plus the Immunologic Adjuvant QS-21
Teresa A. Gilewski; Govind Ragupathi; Maura Dickler; Shemeeakah Powell; Sonal Bhuta; Kathy Panageas; R. Rao Koganty; Jeannette Chin-Eng; Clifford Hudis; Larry Norton; Alan N. Houghton; Philip O. Livingston
Temozolomide as Monotherapy Is Effective in Treatment of Advanced Malignant Neuroendocrine Tumors
Sara Ekeblad; Anders Sundin; Eva Tiensuu Janson; Staffan Welin; Dan Granberg; Henrik Kindmark; Kristina Dunder; Gordana Kozlovacki; Håkan Örlefors; Mattias Sigurd; Kjell Öberg; Barbro Eriksson; Britt Skogseid
Epidermal Growth Factor Receptor Expression in High-Grade Osteosarcomas Is Associated with a Good Clinical Outcome
Christian Kersting; Carsten Gebert; Konstantin Agelopoulos; Hartmut Schmidt; Paul J. van Diest; Heribert Juergens; Winfried Winkelmann; Matthias Kevric; Georg Gosheger; Burkhard Brandt; Stefan Bielack; Horst Buerger
Cancer Therapy: Preclinical
Inhibition of Poly(ADP-Ribose) Polymerase Enhances Cell Death and Improves Tumor Growth Delay in Irradiated Lung Cancer Models
Jeffrey M. Albert; Carolyn Cao; Kwang Woon Kim; Christopher D. Willey; Ling Geng; Dakai Xiao; Hong Wang; Alan Sandler; David H. Johnson; Alexander D. Colevas; Jennifer Low; Mace L. Rothenberg; Bo Lu
AZD2171 Shows Potent Antitumor Activity Against Gastric Cancer Over-Expressing Fibroblast Growth Factor Receptor 2/Keratinocyte Growth Factor Receptor
Masayuki Takeda; Tokuzo Arao; Hideyuki Yokote; Teruo Komatsu; Kazuyoshi Yanagihara; Hiroki Sasaki; Yasuhide Yamada; Tomohide Tamura; Kazuya Fukuoka; Hiroshi Kimura; Nagahiro Saijo; Kazuto Nishio
Improved Oral Delivery of N-(4-Hydroxyphenyl)Retinamide with a Novel LYM-X-SORB Organized Lipid Complex
Barry J. Maurer; Ondrej Kalous; David W. Yesair; Xiaqin Wu; Jitka Janeba; Vanessa Maldonado; Vazgen Khankaldyyan; Tomas Frgala; Bee-Chun Sun; R. Travis McKee; Stephen W. Burgess; Walter A. Shaw; C. Patrick Reynolds
Cancer Prevention
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