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1 May 2006
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Three-dimensional display of NY-BR-1 protein expression in invasive breast cancer cells by confocal microscopy. NY-BR-1 is a differentiation antigen of mammary epithelial cells and a potential target for immunotherapy of breast carcinoma. Nuclear chromatin is stained in red. Diffuse cytoplasmic (green) and also nuclear (yellow; superimposed) staining of NY-BR-1 protein can be seen. The expression of NY-BR-1 is lost with tumor progression. For further details, see Varga et al. on page 2745 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
The Biology Behind
Molecular Pathways
Human Cancer Biology
Ectopic Expression of the Proto-oncogene Mer in Pediatric T-Cell Acute Lymphoblastic Leukemia
Douglas K. Graham; Dana B. Salzberg; Joanne Kurtzberg; Susan Sather; Glenn K. Matsushima; Amy K. Keating; Xiayuan Liang; Mark A. Lovell; Sara A. Williams; Thomas L. Dawson; Michael J. Schell; Adil A. Anwar; H. Ralph Snodgrass; H. Shelton Earp
Tumor-Driven Paracrine Platelet-Derived Growth Factor Receptor α Signaling Is a Key Determinant of Stromal Cell Recruitment in a Model of Human Lung Carcinoma
Max L. Tejada; Lanlan Yu; Jianying Dong; Kenneth Jung; Gloria Meng; Franklin V. Peale; Gretchen D. Frantz; Linda Hall; XiaoHuan Liang; Hans-Peter Gerber; Napoleone Ferrara
Identification of HLA-A2- or HLA-A24-Restricted CTL Epitopes Possibly Useful for Glypican-3-Specific Immunotherapy of Hepatocellular Carcinoma
Hiroyuki Komori; Tetsuya Nakatsura; Satoru Senju; Yoshihiro Yoshitake; Yutaka Motomura; Yoshiaki Ikuta; Daiki Fukuma; Kazunori Yokomine; Michiko Harao; Toru Beppu; Masanori Matsui; Toshihiko Torigoe; Noriyuki Sato; Hideo Baba; Yasuharu Nishimura
Genomic Alterations in Human Malignant Glioma Cells Associate with the Cell Resistance to the Combination Treatment with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand and Chemotherapy
Yueh-Chun Li; Ching-Cherng Tzeng; Jin H. Song; Fuu-Jen Tsia; Lie-Jiau Hsieh; Shu-Ju Liao; Chang-Hai Tsai; Erwin G. Van Meir; Chunhai Hao; Chyi-Chyang Lin
Thymidylate Synthase Expression in Colon Carcinomas with Microsatellite Instability
Frank A. Sinicrope; Rafaela L. Rego; Kevin C. Halling; Nathan R. Foster; Daniel J. Sargent; Betsy La Plant; Amy J. French; Carmen J. Allegra; John A. Laurie; Richard M. Goldberg; Thomas E. Witzig; Stephen N. Thibodeau
Preferential Nuclear and Cytoplasmic NY-BR-1 Protein Expression in Primary Breast Cancer and Lymph Node Metastases
Zsuzsanna Varga; Jean-Philippe Theurillat; Valeriy Filonenko; Bernd Sasse; Bernhard Odermatt; Achim A. Jungbluth; Yao-Tseng Chen; Lloyd J. Old; Alexander Knuth; Dirk Jäger; Holger Moch
Imaging, Diagnosis, Prognosis
Expression of Novel Molecules, MICAL2-PV (MICAL2 Prostate Cancer Variants), Increases with High Gleason Score and Prostate Cancer Progression
Shingo Ashida; Mutsuo Furihata; Toyomasa Katagiri; Kenji Tamura; Yoshio Anazawa; Hiroki Yoshioka; Tsuneharu Miki; Tomoaki Fujioka; Taro Shuin; Yusuke Nakamura; Hidewaki Nakagawa
Prognostic DNA Methylation Biomarkers in Ovarian Cancer
Susan H. Wei; Curtis Balch; Henry H. Paik; Yoo-Sung Kim; Rae Lynn Baldwin; Sandya Liyanarachchi; Lang Li; Zailong Wang; Joseph C. Wan; Ramana V. Davuluri; Beth Y. Karlan; Gillian Gifford; Robert Brown; Sun Kim; Tim H-M. Huang; Kenneth P. Nephew
Overexpression of Both CXC Chemokine Receptor 4 and Vascular Endothelial Growth Factor Proteins Predicts Early Distant Relapse in Stage II-III Colorectal Cancer Patients
Alessandro Ottaiano; Renato Franco; Annarita Aiello Talamanca; Giuseppina Liguori; Fabiana Tatangelo; Paolo Delrio; Guglielmo Nasti; Emiddio Barletta; Gaetano Facchini; Bruno Daniele; Arturo Di Blasi; Maria Napolitano; Caterina Ieranò; Rosa Calemma; Enrico Leonardi; Vittorio Albino; Valentina De Angelis; Marzia Falanga; Vincenzo Boccia; Maurizio Capuozzo; Valerio Parisi; Gerardo Botti; Giuseppe Castello; Rosario Vincenzo Iaffaioli; Stefania Scala
Cancer Therapy: Clinical
A Phase I/II Trial Testing Immunization of Hepatocellular Carcinoma Patients with Dendritic Cells Pulsed with Four α-Fetoprotein Peptides
Lisa H. Butterfield; Antoni Ribas; Vivian B. Dissette; Yohan Lee; Jin Quan Yang; Pilar De la Rocha; Sonia D. Duran; Jackie Hernandez; Elisabeth Seja; Douglas M. Potter; William H. McBride; Richard Finn; John A. Glaspy; James S. Economou
Tumor-Specific CD8+ T Cell Reactivity in the Sentinel Lymph Node of GM-CSF–Treated Stage I Melanoma Patients is Associated with High Myeloid Dendritic Cell Content
Ronald J.C.L.M. Vuylsteke; Barbara G. Molenkamp; Paul A.M. van Leeuwen; Sybren Meijer; Pepijn G.J.T.B. Wijnands; John B.A.G. Haanen; Rik J. Scheper; Tanja D. de Gruijl
A Phase I Study of a New Nucleoside Analogue, OSI-7836, Using Two Administration Schedules in Patients with Advanced Solid Malignancies
Chooi P. Lee; Maja J.A. de Jonge; Anne E. O'Donnell; Kristel L. Schothorst; Janet Hanwell; Jon B. Chick; Rik A. Brooimans; Laurel M. Adams; Daniel W. Drolet; Johann S. de Bono; Stan B. Kaye; Ian R. Judson; Jaap Verweij
Cancer Therapy: Preclinical
Nonfucosylated Therapeutic IgG1 Antibody Can Evade the Inhibitory Effect of Serum Immunoglobulin G on Antibody-Dependent Cellular Cytotoxicity through its High Binding to FcγRIIIa
Shigeru Iida; Hirofumi Misaka; Miho Inoue; Mami Shibata; Ryosuke Nakano; Naoko Yamane-Ohnuki; Masako Wakitani; Keiichi Yano; Kenya Shitara; Mitsuo Satoh
The Combination of the Proteasome Inhibitor Bortezomib and the Bcl-2 Antisense Molecule Oblimersen Sensitizes Human B-Cell Lymphomas to Cyclophosphamide
Owen A. O'Connor; Emily A. Smith; Lorraine E. Toner; Julie Teruya-Feldstein; Stanley Frankel; Mark Rolfe; Xiaohui Wei; Shujun Liu; Guido Marcucci; Kenneth K. Chan; Asher Chanan-Khan
Gefitinib Inhibits the Growth and Invasion of Urothelial Carcinoma Cell Lines in which Akt and MAPK Activation Is Dependent on Constitutive Epidermal Growth Factor Receptor Activation
Gaëlle Nicolle; Ahmad Daher; Pascale Maillé; Marcel Vermey; Sylvain Loric; Ashraf Bakkar; Hervé Wallerand; Dimitrios Vordos; Francis Vacherot; Sixtina Gil Diez de Medina; Claude C. Abbou; Theodore Van der Kwast; Jean-Paul Thiery; François Radvanyi; Dominique K. Chopin
Cancer Prevention
Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences
Carmen Hoh; David Boocock; Tim Marczylo; Rajinder Singh; David P. Berry; Ashley R. Dennison; David Hemingway; Andrew Miller; Kevin West; Stephanie Euden; Giuseppe Garcea; Peter B. Farmer; William P. Steward; Andreas J. Gescher
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