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1 April 2006
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About the Cover:
GBM xenografts maintained by serial passage in the flank of nude mice were used to establish intracranial tumors for therapy testing. In this intracranial tumor from GBM8, intense brown immunohistochemical staining and increased red signal on FISH show highly level epidermal growth factor receptor (EGFR) expression and gene amplification, respectively. The radiation sensitivity of 13 xenograft lines was evaluated in an orthotopic therapy model and there was no associationbetween EGFR amplification (present in 7 of the 13 tumors) and radiation response. For further details, see Sarkaria et al. on page 2264. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Editorials
The Biology Behind
Molecular Pathways
Cooperative Group Bulletin Board
Phase II Clinical Trial Design: Methods in Translational Research from the Genitourinary Committee at the Eastern Cooperative Oncology Group
Robert Gray; Judith Manola; Scott Saxman; John Wright; Jan Dutcher; Michael Atkins; Michael Carducci; William See; Christopher Sweeney; Glenn Liu; Mark Stein; Robert Dreicer; George Wilding; Robert S. DiPaola
Human Cancer Biology
Delineation, Functional Validation, and Bioinformatic Evaluation of Gene Expression in Thyroid Follicular Carcinomas with the PAX8-PPARG Translocation
Thomas J. Giordano; Amy Y.M. Au; Rork Kuick; Dafydd G. Thomas; Daniel R. Rhodes; Kenneth G. Wilhelm, Jr.; Michelle Vinco; David E. Misek; Donita Sanders; Zhaowen Zhu; Raffaele Ciampi; Samir Hanash; Arul Chinnaiyan; Roderick J. Clifton-Bligh; Bruce G. Robinson; Yuri E. Nikiforov; Ronald J. Koenig
Altered Nuclear Receptor Corepressor Expression Attenuates Vitamin D Receptor Signaling in Breast Cancer Cells
Claire M. Banwell; Donia P. MacCartney; Michelle Guy; Alice E. Miles; Milan R. Uskokovic; Janine Mansi; Paul M. Stewart; Laura P. O'Neill; Bryan M. Turner; Kay W. Colston; Moray J. Campbell
Inhibition of Phosphotyrosine Phosphatase 1B Causes Resistance in BCR-ABL-Positive Leukemia Cells to the ABL Kinase Inhibitor STI571
Noriko Koyama; Steffen Koschmieder; Sandhya Tyagi; Ignacio Portero-Robles; Jörg Chromic; Silke Myloch; Heike Nürnberger; Tanja Rossmanith; Wolf-Karsten Hofmann; Dieter Hoelzer; Oliver Gerhard Ottmann
Celecoxib Up-Regulates the Expression of the ζ Chain of T Cell Receptor Complex in Tumor-Infiltrating Lymphocytes in Human Cervical Cancer
Gabriella Ferrandina; Franco Oreste Ranelletti; Francesco Legge; Vanda Salutari; Enrica Martinelli; Andrea Fattorossi; Domenica Lorusso; Gianfranco Zannoni; Valerio Vellone; Amelia Paglia; Giovanni Scambia
Imaging, Diagnosis, Prognosis
A Two-Gene Expression Ratio of Homeobox 13 and Interleukin-17B Receptor for Prediction of Recurrence and Survival in Women Receiving Adjuvant Tamoxifen
Matthew P. Goetz; Vera J. Suman; James N. Ingle; Andrea M. Nibbe; Dan W. Visscher; Carol A. Reynolds; Wilma L. Lingle; Mark Erlander; Xiao-Jun Ma; Dennis C. Sgroi; Edith A. Perez; Fergus J. Couch
Polymorphisms in Genes of Nucleotide and Base Excision Repair: Risk and Prognosis of Colorectal Cancer
Victor Moreno; Federica Gemignani; Stefano Landi; Lydie Gioia-Patricola; Amélie Chabrier; Ignacio Blanco; Sara González; Elisabet Guino; Gabriel Capellà; Federico Canzian; Bellvitge Colorectal Cancer Study Group
Combination Analysis of Hypermethylated Wnt-Antagonist Family Genes as a Novel Epigenetic Biomarker Panel for Bladder Cancer Detection
Shinji Urakami; Hiroaki Shiina; Hideki Enokida; Toshifumi Kawakami; Ken Kawamoto; Hiroshi Hirata; Yuichiro Tanaka; Nobuyuki Kikuno; Masayuki Nakagawa; Mikio Igawa; Rajvir Dahiya
Performance of Immuno–Positron Emission Tomography with Zirconium-89-Labeled Chimeric Monoclonal Antibody U36 in the Detection of Lymph Node Metastases in Head and Neck Cancer Patients
Pontus K.E. Börjesson; Yvonne W.S. Jauw; Ronald Boellaard; Remco de Bree; Emile F.I. Comans; Jan C. Roos; Jonas A. Castelijns; Maria J.W.D. Vosjan; J. Alain Kummer; C. René Leemans; Adriaan A. Lammertsma; Guus A.M.S. van Dongen
Cancer Therapy: Clinical
Selenium Accumulation in Prostate Tissue During a Randomized, Controlled Short-term Trial of l-Selenomethionine: a Southwest Oncology Group Study
Anita L. Sabichi; J. Jack Lee; Robert J. Taylor; Ian M. Thompson; Brian J. Miles; Catherine M. Tangen; Lori M. Minasian; Louis L. Pisters; John R. Caton; Joseph W. Basler; Seth P. Lerner; David G. Menter; James R. Marshall; E. David Crawford; Scott M. Lippman
Cancer Therapy: Preclinical
Low and High Tenascin-Expressing Tumors Are Efficiently Targeted by ST2146 Monoclonal Antibody
Rita De Santis; Claudio Albertoni; Fiorella Petronzelli; Silvia Campo; Valeria D'Alessio; Antonio Rosi; Anna Maria Anastasi; Ragnar Lindstedt; Nadia Caroni; Brunilde Arseni; Pierino Chiodi; Antonio Verdoliva; Giovanni Cassani; Marco Chinol; Giovanni Paganelli; Paolo Carminati
Allogeneic MHC Gene Transfer Enhances Antitumor Activity of Allogeneic Hematopoietic Stem Cell Transplantation without Exacerbating Graft-versus-Host Disease
Masaki Ohashi; Akihiko Kobayashi; Hidehiko Hara; Yoshiaki Miura; Kimiko Yoshida; Miwa Kushida; Yoshinori Ikarashi; Masaki Mandai; Masaki Kitajima; Teruhiko Yoshida; Kazunori Aoki
Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response
Jann N. Sarkaria; Brett L. Carlson; Mark A. Schroeder; Patrick Grogan; Paul D. Brown; Caterina Giannini; Karla V. Ballman; Gaspar J. Kitange; Abjahit Guha; Ajay Pandita; C. David James
Cancer Prevention
Analysis of c-ErbB1/Epidermal Growth Factor Receptor and c-ErbB2/HER-2 Expression in Bronchial Dysplasia: Evaluation of Potential Targets for Chemoprevention of Lung Cancer
Daniel T. Merrick; John Kittelson; Ralph Winterhalder; Georgia Kotantoulas; Steen Ingeberg; Robert L. Keith; Timothy C. Kennedy; York E. Miller; Wilbur A. Franklin; Fred R. Hirsch
Letter to the Editor
Innovations and Challenges in Melanoma
Innovations and Challenges in Melanoma: Summary Statement from the First Cambridge Conference
Michael B. Atkins; David E. Elder; Richard Essner; Keith T. Flaherty; Thomas F. Gajewski; Frank G. Haluska; Patrick Hwu; Ulrich Keilholz; John M. Kirkwood; James W. Mier; Merrick I. Ross; Craig L. Slingluff; Vernon K. Sondak; Jeffrey A. Sosman; Martin A. Weinstock; Laura King
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