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Volume 12, Issue 5
1 March 2006
Issue Cover
All Issues
ISSN 1078-0432
EISSN 1557-3265

The Biology Behind

Does Prostate-Specific Antigen Contribute to Bone Metastases?
John M. Chirgwin; Theresa A. Guise
View articletitled, Does Prostate-Specific Antigen Contribute to Bone Metastases?
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Molecular Pathways

Treatment for Advanced Tumors: Src Reclaims Center Stage
Justin M. Summy; Gary E. Gallick
View articletitled, Treatment for Advanced Tumors: Src Reclaims Center Stage
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Human Cancer Biology

Oncogenic Property of Acrogranin in Human Uterine Leiomyosarcoma: Direct Evidence of Genetic Contribution in In vivo Tumorigenesis
Noriomi Matsumura; Masaki Mandai; Masanori Miyanishi; Ken Fukuhara; Tsukasa Baba; Toshihiro Higuchi; Masatoshi Kariya; Kenji Takakura; Shingo Fujii
View articletitled, Oncogenic Property of Acrogranin in Human Uterine Leiomyosarcoma: Direct Evidence of Genetic Contribution in <em>In vivo</em> Tumorigenesis
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Aberrant Methylation and Deacetylation of Deleted in Liver Cancer-1 Gene in Prostate Cancer: Potential Clinical Applications
Ming Guan; Xiaoling Zhou; Nikolaos Soulitzis; Demetrios A. Spandidos; Nicholas C. Popescu
View articletitled, Aberrant Methylation and Deacetylation of <em>Deleted in Liver Cancer-1</em> Gene in Prostate Cancer: Potential Clinical Applications
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Prostate-Specific Antigen Modulates Genes Involved in Bone Remodeling and Induces Osteoblast Differentiation of Human Osteosarcoma Cell Line SaOS-2
Nagalakshmi Nadiminty; Wei Lou; Soo Ok Lee; Farideh Mehraein-Ghomi; Jason S. Kirk; Jeffrey M. Conroy; Haitao Zhang; Allen C. Gao
View articletitled, Prostate-Specific Antigen Modulates Genes Involved in Bone Remodeling and Induces Osteoblast Differentiation of Human Osteosarcoma Cell Line SaOS-2
Supplementary data
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Kinetics of Metastatic Breast Cancer Cell Trafficking in Bone
Pushkar A. Phadke; Robyn R. Mercer; John F. Harms; Yujiang Jia; Andra R. Frost; Jennifer L. Jewell; Karen M. Bussard; Shakira Nelson; Cynthia Moore; John C. Kappes; Carol V. Gay; Andrea M. Mastro; Danny R. Welch
View articletitled, Kinetics of Metastatic Breast Cancer Cell Trafficking in Bone
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PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma
Wanglong Qiu; Frank Schönleben; Xiaojun Li; Daniel J. Ho; Lanny G. Close; Spiros Manolidis; Boyce P. Bennett; Gloria H. Su
View articletitled, <em>PIK3CA</em> Mutations in Head and Neck Squamous Cell Carcinoma
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Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli
Cecilia Garofalo; Mariusz Koda; Sandra Cascio; Mariola Sulkowska; Luiza Kanczuga-Koda; Jolanta Golaszewska; Antonio Russo; Stanislaw Sulkowski; Eva Surmacz
View articletitled, Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli
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Refinement of the 22q12-q13 Breast Cancer–Associated Region: Evidence of TMPRSS6 as a Candidate Gene in an Eastern Finnish Population
Jaana M. Hartikainen; Hanna Tuhkanen; Vesa Kataja; Matti Eskelinen; Matti Uusitupa; Veli-Matti Kosma; Arto Mannermaa
View articletitled, Refinement of the 22q12-q13 Breast Cancer–Associated Region: Evidence of <em>TMPRSS6</em> as a Candidate Gene in an Eastern Finnish Population
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The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model
Charbel Bouez; Caroline Reynaud; Emmanuelle Noblesse; Amélie Thépot; Claudine Gleyzal; Jean Kanitakis; Eric Perrier; Odile Damour; Pascal Sommer
View articletitled, The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model
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The Cytoskeleton Regulatory Protein hMena (ENAH) Is Overexpressed in Human Benign Breast Lesions with High Risk of Transformation and Human Epidermal Growth Factor Receptor-2–Positive/Hormonal Receptor–Negative Tumors
Francesca Di Modugno; Marcella Mottolese; Anna Di Benedetto; Andrea Conidi; Flavia Novelli; Letizia Perracchio; Irene Venturo; Claudio Botti; Elke Jager; Angela Santoni; Pier Giorgio Natali; Paola Nisticò
View articletitled, The Cytoskeleton Regulatory Protein hMena (ENAH) Is Overexpressed in Human Benign Breast Lesions with High Risk of Transformation and Human Epidermal Growth Factor Receptor-2–Positive/Hormonal Receptor–Negative Tumors
Supplementary data
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Metastasis Tumor Antigen Family Proteins during Breast Cancer Progression and Metastasis in a Reliable Mouse Model for Human Breast Cancer
Hao Zhang; L. Clifton Stephens; Rakesh Kumar
View articletitled, Metastasis Tumor Antigen Family Proteins during Breast Cancer Progression and Metastasis in a Reliable Mouse Model for Human Breast Cancer
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Imaging, Diagnosis, Prognosis

Human Kallikrein 8 Protein Is a Favorable Prognostic Marker in Ovarian Cancer
Carla A. Borgoño; Tadaaki Kishi; Andreas Scorilas; Nadia Harbeck; Julia Dorn; Barbara Schmalfeldt; Manfred Schmitt; Eleftherios P. Diamandis
View articletitled, Human Kallikrein 8 Protein Is a Favorable Prognostic Marker in Ovarian Cancer
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Expression of DNA Double-Strand Break Repair Proteins ATM and BRCA1 Predicts Survival in Colorectal Cancer
Heike Grabsch; Mit Dattani; Lisa Barker; Nicola Maughan; Karen Maude; Olaf Hansen; Helmut E. Gabbert; Phil Quirke; Wolfram Mueller
View articletitled, Expression of DNA Double-Strand Break Repair Proteins ATM and BRCA1 Predicts Survival in Colorectal Cancer
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Changes of Topoisomerase IIα Expression in Breast Tumors after Neoadjuvant Chemotherapy Predicts Relapse-Free Survival
Nicola Tinari; Rossano Lattanzio; Clara Natoli; Ettore Cianchetti; Domenico Angelucci; Enrico Ricevuto; Corrado Ficorella; Paolo Marchetti; Saverio Alberti; Mauro Piantelli; Stefano Iacobelli; on behalf of the Consorzio Interuniversitario Nazionale per la Bioncologia
View articletitled, Changes of Topoisomerase IIα Expression in Breast Tumors after Neoadjuvant Chemotherapy Predicts Relapse-Free Survival
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An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non–Small Cell Lung Cancers
Quynh-Thu Le; Eunice Chen; Ali Salim; Hongbin Cao; Christina S. Kong; Richard Whyte; Jessica Donington; Walter Cannon; Heather Wakelee; Robert Tibshirani; John D. Mitchell; Donna Richardson; Ken J. O'Byrne; Albert C. Koong; Amato J. Giaccia
View articletitled, An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non–Small Cell Lung Cancers
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Defective Antitumor Function of Monocyte-Derived Macrophages from Epithelial Ovarian Cancer Patients
Ilyssa O. Gordon; Ralph S. Freedman
View articletitled, Defective Antitumor Function of Monocyte-Derived Macrophages from Epithelial Ovarian Cancer Patients
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Inhibition of Vascular Endothelial Growth Factor (VEGF)-A Causes a Paradoxical Increase in Tumor Blood Flow and Up-Regulation of VEGF-D
Bradford A. Moffat; Mark Chen; Muhammed S.T. Kariaapper; Daniel A. Hamstra; Daniel E. Hall; Jadranka Stojanovska; Timothy D. Johnson; Mila Blaivas; Mahesh Kumar; Thomas L. Chenevert; Alnawaz Rehemtulla; Brian D. Ross
View articletitled, Inhibition of Vascular Endothelial Growth Factor (VEGF)-A Causes a Paradoxical Increase in Tumor Blood Flow and Up-Regulation of VEGF-D
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Prognostic Significance of Basal-Like Phenotype and Fascin Expression in Node-Negative Invasive Breast Carcinomas
Socorro María Rodríguez-Pinilla; David Sarrió; Emiliano Honrado; David Hardisson; Francisco Calero; Javier Benitez; José Palacios
View articletitled, Prognostic Significance of Basal-Like Phenotype and Fascin Expression in Node-Negative Invasive Breast Carcinomas
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Cancer Therapy: Clinical

Phase I Trial of Intrathecal Spartaject Busulfan in Children with Neoplastic Meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004)
Sridharan Gururangan; William P. Petros; Tina Young Poussaint; Michael L. Hancock; Peter C. Phillips; Henry S. Friedman; Lisa Bomgaars; Susan M. Blaney; Larry E. Kun; James M. Boyett
View articletitled, Phase I Trial of Intrathecal Spartaject Busulfan in Children with Neoplastic Meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004)
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Increased MDR1 Expression in Normal and Malignant Peripheral Blood Mononuclear Cells Obtained from Patients Receiving Depsipeptide (FR901228, FK228, NSC630176)
Robert W. Robey; Zhirong Zhan; Richard L. Piekarz; Ganesh L. Kayastha; Tito Fojo; Susan E. Bates
View articletitled, Increased <em>MDR1</em> Expression in Normal and Malignant Peripheral Blood Mononuclear Cells Obtained from Patients Receiving Depsipeptide (FR901228, FK228, NSC630176)
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A Randomized Phase II Trial of the Matrix Metalloproteinase Inhibitor BMS-275291 in Hormone-Refractory Prostate Cancer Patients with Bone Metastases
Primo N. Lara, Jr.; Walter M. Stadler; Jeff Longmate; David I. Quinn; Jason Wexler; Marta Van Loan; Przemyslaw Twardowski; Paul H. Gumerlock; Nicholas J. Vogelzang; Everett E. Vokes; Heinz Josef Lenz; James H. Doroshow; David R. Gandara
View articletitled, A Randomized Phase II Trial of the Matrix Metalloproteinase Inhibitor BMS-275291 in Hormone-Refractory Prostate Cancer Patients with Bone Metastases
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Decreased Mitochondrial DNA Content in Posttreatment Salivary Rinses from Head and Neck Cancer Patients
Wei-Wen Jiang; Eli Rosenbaum; Elizabeth Mambo; Marianna Zahurak; Brett Masayesva; Andre Lopes Carvalho; Shaoyu Zhou; William H. Westra; Anthony J. Alberg; David Sidransky; Wayne Koch; Joseph A. Califano
View articletitled, Decreased Mitochondrial DNA Content in Posttreatment Salivary Rinses from Head and Neck Cancer Patients
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Neoadjuvant Concurrent Paclitaxel and Radiation in Stage II/III Breast Cancer
A. Bapsi Chakravarthy; Mark C. Kelley; Bernadette McLaren; Cristina I. Truica; Dean Billheimer; Ingrid A. Mayer; Ana M. Grau; David H. Johnson; Jean F. Simpson; R. Daniel Beauchamp; Catherine Jones; Jennifer A. Pietenpol
View articletitled, Neoadjuvant Concurrent Paclitaxel and Radiation in Stage II/III Breast Cancer
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Lomeguatrib, a Potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors
Malcolm Ranson; Mark R. Middleton; John Bridgewater; Siow Ming Lee; Martin Dawson; Debra Jowle; Gavin Halbert; Sue Waller; Helen McGrath; Lindsey Gumbrell; R. Stanley McElhinney; Dorothy Donnelly; T. Brian H. McMurry; Geoffrey P. Margison
View articletitled, Lomeguatrib, a Potent Inhibitor of <em>O</em><sup>6</sup>-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors
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Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor
Susannah J. Stanway; Atul Purohit; L.W. Lawrence Woo; Saulat Sufi; David Vigushin; Rebecca Ward; Richard H. Wilson; Frank Z. Stanczyk; Nicola Dobbs; Elena Kulinskaya; Moira Elliott; Barry V.L. Potter; Michael J. Reed; R. Charles Coombes
View articletitled, Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor
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Cancer Therapy: Preclinical

Recombinant Human Mullerian Inhibiting Substance Inhibits Long-term Growth of MIS Type II Receptor–Directed Transgenic Mouse Ovarian Cancers In vivo
Rafael Pieretti-Vanmarcke; Patricia K. Donahoe; Paul Szotek; Thomas Manganaro; Mary K. Lorenzen; James Lorenzen; Denise C. Connolly; Elkan F. Halpern; David T. MacLaughlin
View articletitled, Recombinant Human Mullerian Inhibiting Substance Inhibits Long-term Growth of MIS Type II Receptor–Directed Transgenic Mouse Ovarian Cancers <em>In vivo</em>
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Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers
Gregory P. Adams; Mei-Sheng Tai; John E. McCartney; James D. Marks; Walter F. Stafford, III; L.L. Houston; James S. Huston; Louis M. Weiner
View articletitled, Avidity-Mediated Enhancement of <em>In vivo</em> Tumor Targeting by Single-Chain Fv Dimers
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Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models
Thomas Schluep; Jungyeong Hwang; Jianjun Cheng; Jeremy D. Heidel; Derek W. Bartlett; Beth Hollister; Mark E. Davis
View articletitled, Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models
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Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts
Stefan R. Vink; Saskia Lagerwerf; Elly Mesman; Jan H.M. Schellens; Adrian C. Begg; Wim J. van Blitterswijk; Marcel Verheij
View articletitled, Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts
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BRAF Is a Therapeutic Target in Aggressive Thyroid Carcinoma
Giuliana Salvatore; Valentina De Falco; Paolo Salerno; Tito Claudio Nappi; Stefano Pepe; Giancarlo Troncone; Francesca Carlomagno; Rosa Marina Melillo; Scott M. Wilhelm; Massimo Santoro
View articletitled, BRAF Is a Therapeutic Target in Aggressive Thyroid Carcinoma
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YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors
Nobuaki Amino; Yukitaka Ideyama; Mayumi Yamano; Sadao Kuromitsu; Katsuinori Tajinda; Kiyohiro Samizu; Hiroyuki Hisamichi; Akira Matsuhisa; Kenna Shirasuna; Masafumi Kudoh; Masayuki Shibasaki
View articletitled, YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors
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Stomatin-like Protein 2 Is Overexpressed in Cancer and Involved in Regulating Cell Growth and Cell Adhesion in Human Esophageal Squamous Cell Carcinoma
Liyong Zhang; Fang Ding; Wenfeng Cao; Zhongmin Liu; Wei Liu; Zaicheng Yu; Yu Wu; Wendong Li; Yanda Li; Zhihua Liu
View articletitled, Stomatin-like Protein 2 Is Overexpressed in Cancer and Involved in Regulating Cell Growth and Cell Adhesion in Human Esophageal Squamous Cell Carcinoma
Supplementary data
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Cancer Prevention

Distinct Epidermal Growth Factor Receptor and KRAS Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features
Issan Yee San Tam; Lap Ping Chung; Wai Sing Suen; Elaine Wang; May C.M. Wong; Kok Keung Ho; Wah Kit Lam; Shui Wah Chiu; Luc Girard; John D. Minna; Adi F. Gazdar; Maria P. Wong
View articletitled, Distinct Epidermal Growth Factor Receptor and <em>KRAS</em> Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features
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Letters to the Editor

SMAD4 Levels and Allelic Imbalance in 18q21 in Colorectal Cancer
Toshiaki Watanabe; Takamitsu Kanazawa; Yoshihiro Kazama; Junichiro Tanaka; Toshiaki Tanaka; Soichiro Ishihara; Hirokazu Nagawa
View articletitled, SMAD4 Levels and Allelic Imbalance in 18q21 in Colorectal Cancer
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Reply to the Letter to the Editor by Watanabe et al.
Diego Arango; Pia Alhopuro; Lauri A. Aaltonen
View articletitled, Reply to the Letter to the Editor by Watanabe et al.
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Correction

Article on Synovial Sarcoma X Antigens in Epithelial Ovarian Cancer
View articletitled, Article on Synovial Sarcoma X Antigens in Epithelial Ovarian Cancer
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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