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Volume 12, Issue 4

15 February 2006

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Cover Image
Table of Contents

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

The Biology Behind
Molecular Pathways
Human Cancer Biology
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Cancer Therapy: Preclinical
Cancer Prevention

The Biology Behind

Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression.

Colin Goding; Frank L Meyskens, Jr

View articletitled, Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression.

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Molecular Pathways

Notch signaling.

Lucio Miele

View articletitled, Notch signaling.

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Human Cancer Biology

Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

Terhi Jokilehto; Krista Rantanen; Marjaana Luukkaa; Pekka Heikkinen; Reidar Grenman; Heikki Minn; Pauliina Kronqvist; Panu M Jaakkola

Abstract

View articletitled, Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

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The role of interleukin 1 in growth and metastasis of human cancer xenografts.

Dina M Elaraj; David M Weinreich; Sheelu Varghese; Markus Puhlmann; Stephen M Hewitt; Nancy M Carroll; Elizabeth D Feldman; Ewa M Turner; H Richard Alexander

Abstract

View articletitled, The role of interleukin 1 in growth and metastasis of human cancer xenografts.

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Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma.

Shiou-Hwei Yeh; Dai-Chen Wu; Ching-Yi Tsai; Ti-Jung Kuo; Wei-Che Yu; Yuan-Shau Chang; Chi-Ling Chen; Ching-Fang Chang; Ding-Shinn Chen; Pei-Jer Chen

Abstract

View articletitled, Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma.

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Gene expression profiles of head and neck carcinomas from Sudanese and Norwegian patients reveal common biological pathways regardless of race and lifestyle.

Bjarte Dysvik; Endre N Vasstrand; Roger L√∏vlie; Osman A-Aziz Elgindi; Kenneth W Kross; Hans J Aarstad; Anne Chr Johannessen; Inge Jonassen; Salah O Ibrahim

Abstract

View articletitled, Gene expression profiles of head and neck carcinomas from Sudanese and Norwegian patients reveal common biological pathways regardless of race and lifestyle.

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Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer.

Ying Ma; Dongmei Lin; Wenyue Sun; Ting Xiao; Jinsong Yuan; Naijun Han; Suping Guo; Xiaoli Feng; Kai Su; Yousheng Mao; Shujun Cheng; Yanning Gao

Abstract

View articletitled, Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer.

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Imaging, Diagnosis, Prognosis

PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer.

Donkena Krishna Vanaja; Karla V Ballman; Bruce W Morlan; John C Cheville; Roxann M Neumann; Michael M Lieber; Donald J Tindall; Charles Y F Young

Abstract

View articletitled, PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer.

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Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients.

Kazuo Koyanagi; Steven J O'Day; Rene Gonzalez; Karl Lewis; William A Robinson; Thomas T Amatruda; Christine Kuo; He-Jing Wang; Robert Milford; Donald L Morton; Dave S B Hoon

Abstract

View articletitled, Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients.

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Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

Gerald Brandacher; Alexander Perathoner; Ruth Ladurner; Stefan Schneeberger; Peter Obrist; Christiana Winkler; Ernst R Werner; Gabriele Werner-Felmayer; Helmut G Weiss; Georg G√∂bel; Raimund Margreiter; Alfred K√∂nigsrainer; Dietmar Fuchs; Albert Amberger

Abstract

View articletitled, Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

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Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin.

Ching-Hung Lin; Kuan-Ting Kuo; Shih-Sung Chuang; Sung-Hsin Kuo; Julia Hueimei Chang; Kung-Chao Chang; Hui-Chen Hsu; Hwei-Fang Tien; Ann-Lii Cheng

Abstract

View articletitled, Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin.

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

Magali Olivier; Anita Langer√∏d; Patrizia Carrieri; Jonas Bergh; Sigrid Klaar; Jorunn Eyfjord; Charles Theillet; Carmen Rodriguez; Rosette Lidereau; Ivan Bi√®che; Jennifer Varley; Yves Bignon; Nancy Uhrhammer; Robert Winqvist; Arja Jukkola-Vuorinen; Dieter Niederacher; Shunsuke Kato; Chikashi Ishioka; Pierre Hainaut; Anne-Lise B√∏rresen-Dale

Abstract

View articletitled, The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

Supplementary data

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Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer.

Karin Collett; Geir E Eide; Jarle Arnes; Ingunn M Stefansson; Johan Eide; Audun Braaten; Turid Aas; Ariel P Otte; Lars A Akslen

Abstract

View articletitled, Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer.

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A multimarker model to predict outcome in tamoxifen-treated breast cancer patients.

Steven P Linke; Troy M Bremer; Christopher D Herold; Guido Sauter; Cornelius Diamond

Abstract

View articletitled, A multimarker model to predict outcome in tamoxifen-treated breast cancer patients.

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Profiling markers of prognosis in colorectal cancer.

Matthew S Lyall; Sinclair R Dundas; Stephanie Curran; Graeme I Murray

Abstract

View articletitled, Profiling markers of prognosis in colorectal cancer.

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Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer.

Suzete de Silva Rudland; Lee Martin; Chandeene Roshanlall; John Winstanley; Samuel Leinster; Angela Platt-Higgins; Joe Carroll; Christopher West; Roger Barraclough; Philip Rudland

Abstract

View articletitled, Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer.

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Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis.

Yasushi Nakamura; Hironao Yasuoka; Masahiko Tsujimoto; Katsuhide Yoshidome; Masaaki Nakahara; Kazuyasu Nakao; Misa Nakamura; Kennichi Kakudo

Abstract

View articletitled, Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis.

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The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer.

Lingeng Lu; Dionyssios Katsaros; Andrew Wiley; Irene A Rigault de la Longrais; Harvey A Risch; Manuela Puopolo; Herbert Yu

Abstract

View articletitled, The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer.

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Significance of skp2 expression in primary breast cancer.

Hideto Sonoda; Hiroshi Inoue; Kazuhiko Ogawa; Tohru Utsunomiya; Taka-aki Masuda; Masaki Mori

Abstract

View articletitled, Significance of skp2 expression in primary breast cancer.

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Cancer Therapy: Clinical

A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer.

Jean-Jacques Body; Thierry Facon; Robert E Coleman; Allan Lipton; Filip Geurs; Michelle Fan; Donna Holloway; Mark C Peterson; Pirow J Bekker

Abstract

View articletitled, A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer.

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Adoptive transfer of allogeneic cytotoxic T lymphocytes equipped with a HLA-A2 restricted MART-1 T-cell receptor: a phase I trial in metastatic melanoma.

Lone Duval; Henrik Schmidt; Keld Kaltoft; Kirsten Fode; Jens Jorgen Jensen; Steen Mellerup Sorensen; Michael I Nishimura; Hans von der Maase

Abstract

View articletitled, Adoptive transfer of allogeneic cytotoxic T lymphocytes equipped with a HLA-A2 restricted MART-1 T-cell receptor: a phase I trial in metastatic melanoma.

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A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors.

Marwan G Fakih; Lakshmi Pendyala; Patrick F Smith; Patrick J Creaven; Mary E Reid; Vladimir Badmaev; Rami G Azrak; Joshua D Prey; David Lawrence; Youcef M Rustum

Abstract

View articletitled, A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors.

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Anastrozole versus tamoxifen treatment in postmenopausal women with endocrine-responsive breast cancer and tamoxifen-induced endometrial pathology.

Bernd Gerber; Annette Krause; Toralf Reimer; Ionas Mylonas; Josef Makovitzky; G√ºnther Kundt; Wolfgang Janni

Abstract

View articletitled, Anastrozole versus tamoxifen treatment in postmenopausal women with endocrine-responsive breast cancer and tamoxifen-induced endometrial pathology.

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Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.

Anatoly Dritschilo; Chao H Huang; Charles M Rudin; John Marshall; Brian Collins; Jeanne L Dul; Chuanbo Zhang; Deepak Kumar; Prafulla C Gokhale; Ateeq Ahmad; Imran Ahmad; Jeffrey W Sherman; Usha N Kasid

Abstract

View articletitled, Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.

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A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.

Philip M Arlen; James L Gulley; Catherine Parker; Lisa Skarupa; Mary Pazdur; Dennis Panicali; Patricia Beetham; Kwong Y Tsang; Douglas W Grosenbach; Jarett Feldman; Seth M Steinberg; Elizabeth Jones; Clara Chen; Jennifer Marte; Jeffrey Schlom; William Dahut

Abstract

View articletitled, A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.

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Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors.

Wells A Messersmith; Sharyn D Baker; Lance Lassiter; Rana A Sullivan; Kimberly Dinh; Virna I Almuete; John J Wright; Ross C Donehower; Michael A Carducci; Deborah K Armstrong

Abstract

View articletitled, Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors.

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Cancer Therapy: Preclinical

Botulinum toxin potentiates cancer radiotherapy and chemotherapy.

R√©ginald Ansiaux; Christine Baudelet; Greg O Cron; J√©r√¥me Segers; Chantal Dessy; Philippe Martinive; Julie De Wever; Julien Verrax; Val√©rie Wauthier; Nelson Beghein; Vincent Gr√©goire; Pedro Buc Calderon; Olivier Feron; Bernard Gallez

Abstract

View articletitled, Botulinum toxin potentiates cancer radiotherapy and chemotherapy.

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Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors.

Donna E Hogge; Leman Yalcintepe; Siaw-Hui Wong; Brigitte Gerhard; Arthur E Frankel

Abstract

View articletitled, Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors.

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Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts.

K Jin Kim; Lihong Wang; Yi-Chi Su; G Yancey Gillespie; Amandeep Salhotra; Bachchu Lal; John Laterra

Abstract

View articletitled, Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts.

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Intestinal microflora and digestive toxicity of irinotecan in mice.

Giovanni Brandi; Jean Dabard; Pierre Raibaud; Monica Di Battista; Chantal Bridonneau; Anna Maria Pisi; Antonio Maria Morselli Labate; Maria Abbondanza Pantaleo; Antonello De Vivo; Guido Biasco

Abstract

View articletitled, Intestinal microflora and digestive toxicity of irinotecan in mice.

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An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo.

Tetsuo Ito; Yosuke Hashimoto; Eiji Tanaka; Takatsugu Kan; Shigeru Tsunoda; Fumiaki Sato; Motoshige Higashiyama; Tomoyuki Okumura; Yutaka Shimada

Abstract

View articletitled, An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo.

Supplementary data

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Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.

Neil Desai; Vuong Trieu; Zhiwen Yao; Leslie Louie; Sherry Ci; Andrew Yang; Chunlin Tao; Tapas De; Bridget Beals; Donald Dykes; Patricia Noker; Rosie Yao; Elizabeth Labao; Michael Hawkins; Patrick Soon-Shiong

Abstract

View articletitled, Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.

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Antitumor effects of systemic and local immunization with a CTL-directed peptide in combination with a local injection of OK-432.

Takeharu Ono; Mamoru Harada; Akira Yamada; Masahiro Tanaka; Yukari Takao; Yasuaki Tanaka; Takashi Mine; Kikuo Sakamoto; Tadashi Nakashima; Kyogo Itoh

Abstract

View articletitled, Antitumor effects of systemic and local immunization with a CTL-directed peptide in combination with a local injection of OK-432.

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Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy.

Fiona Errington; Andrew Bateman; Tim Kottke; Jill Thompson; Kevin Harrington; Alison Merrick; Paul Hatfield; Peter Selby; Richard Vile; Alan Melcher

Abstract

View articletitled, Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy.

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Effective cancer therapy with the alpha-particle emitter [211At]astatine in a mouse model of genetically modified sodium/iodide symporter-expressing tumors.

Thorsten Petrich; Leticia Quintanilla-Martinez; Zekiye Korkmaz; Elenore Samson; Hans J√ºrgen Helmeke; Geerd J√ºrgen Meyer; Wolfram H Knapp; Eyck P√∂tter

Abstract

View articletitled, Effective cancer therapy with the alpha-particle emitter [211At]astatine in a mouse model of genetically modified sodium/iodide symporter-expressing tumors.

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Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus.

Hidenobu Ochiai; Stephanie A Campbell; Gary E Archer; Tracy A Chewning; Eugenia Dragunsky; Alexander Ivanov; Matthias Gromeier; John H Sampson

Abstract

View articletitled, Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus.

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Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin.

Xu Dong Zhang; Jing Jing Wu; Susan Gillespie; Jodie Borrow; Peter Hersey

Abstract

View articletitled, Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin.

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Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.

Boris Kubuschok; Frank Neumann; Rainer Breit; Martina Sester; Claudia Schormann; Claudia Wagner; Urban Sester; Frank Hartmann; Mathias Wagner; Klaus Remberger; Martin Schilling; Michael Pfreundschuh

Abstract

View articletitled, Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.

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CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.

Kam Fai Tse; Michael Jeffers; Vincent A Pollack; Denise A McCabe; Melanie L Shadish; Nikolai V Khramtsov; Craig S Hackett; Suresh G Shenoy; Bing Kuang; Ferenc L Boldog; John R MacDougall; Luca Rastelli; John Herrmann; Michael Gallo; Gadi Gazit-Bornstein; Peter D Senter; Damon L Meyer; Henri S Lichenstein; William J LaRochelle

Abstract

View articletitled, CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.

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The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.

Ada Girnita; Charlotta All-Ericsson; Mario A Economou; Kristina Astr√∂m; Magnus Axelson; Stefan Seregard; Olle Larsson; Leonard Girnita

Abstract

View articletitled, The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.

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Cancer Prevention

The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk.

Uwe Langsenlehner; Babak Yazdani-Biuki; Tanja Eder; Wilfried Renner; Thomas C Wascher; Bernhard Paulweber; Werner Weitzer; Hellmut Samonigg; Peter Krippl

Abstract

View articletitled, The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk.

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