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1 December 2006
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Using DNA microarray analysis and RT-PCR, several genes encoding tight junction proteins and vesicular transport-related proteins were shown to be differentially expressed between chromophobe renal cell carcinoma and oncocytoma, including MAL2, a gene that encodes a protein important in basolateral-to-apical transcytosis. As shown here, MAL2 is highly expressed in the apical cytoplasm of distal nephron cells. This expression, while retained in chromophobe renal cell carcinoma, is lost in oncocytoma. For further details, please see Rohan et al. on page 6937 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Molecular Pathways
Reviews
Human Cancer Biology
Regulation of Angiogenesis by Id-1 through Hypoxia-Inducible Factor-1α–Mediated Vascular Endothelial Growth Factor Up-regulation in Hepatocellular Carcinoma
Terence K. Lee; Ronnie T.P. Poon; Anthony P. Yuen; Ming Tat Ling; Xiang Hong Wang; Yong Chuan Wong; Xin Yuan Guan; Kwan Man; Zao You Tang; Sheung Tat Fan
Molecular and Biochemical Analyses of Platelet-Derived Growth Factor Receptor (PDGFR) B, PDGFRA, and KIT Receptors in Chordomas
Elena Tamborini; Francesca Miselli; Tiziana Negri; M. Stefania Lagonigro; Samantha Staurengo; Gian Paolo Dagrada; Silvia Stacchiotti; Elisa Pastore; Alessandro Gronchi; Federica Perrone; Antonino Carbone; Marco A. Pierotti; Paolo G. Casali; Silvana Pilotti
Implication of Polycomb Members Bmi-1, Mel-18, and Hpc-2 in the Regulation of p16INK4a, p14ARF, h-TERT, and c-Myc Expression in Primary Breast Carcinomas
Javier Silva; José M. García; Cristina Peña; Vanesa García; Gemma Domínguez; Dolores Suárez; Francisca I. Camacho; Ruth Espinosa; Mariano Provencio; Pilar España; Félix Bonilla
Gene Expression Profiling Separates Chromophobe Renal Cell Carcinoma from Oncocytoma and Identifies Vesicular Transport and Cell Junction Proteins as Differentially Expressed Genes
Stephen Rohan; Jiangling J. Tu; Jean Kao; Piali Mukherjee; Fabien Campagne; Xi K. Zhou; Elizabeth Hyjek; Miguel A. Alonso; Yao-Tseng Chen
Dysregulated Expression of Stem Cell Factor Bmi1 in Precancerous Lesions of the Gastrointestinal Tract
Keisuke Tateishi; Miki Ohta; Fumihiko Kanai; Bayasi Guleng; Yasuo Tanaka; Yoshinari Asaoka; Motohisa Tada; Motoko Seto; Amarsanaa Jazag; Lin Lianjie; Makoto Okamoto; Hiroyuki Isayama; Minoru Tada; Haruhiko Yoshida; Takao Kawabe; Masao Omata
Imaging, Diagnosis, Prognosis
Wnt Antagonist Family Genes as Biomarkers for Diagnosis, Staging, and Prognosis of Renal Cell Carcinoma Using Tumor and Serum DNA
Shinji Urakami; Hiroaki Shiina; Hideki Enokida; Hiroshi Hirata; Ken Kawamoto; Toshifumi Kawakami; Nobuyuki Kikuno; Yuichiro Tanaka; Shahana Majid; Masayuki Nakagawa; Mikio Igawa; Rajvir Dahiya
Cancer Therapy: Clinical
Late Toxicity Is Not Increased in BRCA1/BRCA2 Mutation Carriers Undergoing Breast Radiotherapy in the United Kingdom
Susan Shanley; Kate McReynolds; Audrey Ardern-Jones; Roger Ahern; Indrajit Fernando; John Yarnold; Gareth Evans; Diana Eccles; Shirley Hodgson; Sue Ashley; Linda Ashcroft; Andrew Tutt; Elizabeth Bancroft; Susan Short; Gerald Gui; The Breast Unit of the Royal Marsden NHS Foundation Trust; Lester Barr; Andrew Baildam; Anthony Howell; Gavin Royle; Lori Pierce; Douglas Easton; Rosalind Eeles
Acute Chemotherapy–Related Toxicity Is Not Increased in BRCA1 and BRCA2 Mutation Carriers Treated for Breast Cancer in the United Kingdom
Susan Shanley; Kate McReynolds; Audrey Ardern-Jones; Roger Ahern; Indrajit Fernando; John Yarnold; Gareth Evans; Diana Eccles; Shirley Hodgson; Sue Ashley; Linda Ashcroft; Andrew Tutt; Elizabeth Bancroft; Susan Short; Ian Smith; Gerald Gui; The Breast Unit of the Royal Marsden NHS Foundation Trust; Lester Barr; Andrew Baildam; Anthony Howell; Gavin Royle; Lori Pierce; Douglas Easton; Rosalind Eeles
A Study to Determine the Effects of Food and Multiple Dosing on the Pharmacokinetics of Vorinostat Given Orally to Patients with Advanced Cancer
Eric H. Rubin; Nancy G.B. Agrawal; Evan J. Friedman; Pamela Scott; Kathryn E. Mazina; Linda Sun; Lihong Du; Justin L. Ricker; Stanley R. Frankel; Keith M. Gottesdiener; John A. Wagner; Marian Iwamoto
A Phase 2 Study of Rituximab in Combination with Recombinant Interleukin-2 for Rituximab-Refractory Indolent Non-Hodgkin's Lymphoma
Khuda D. Khan; Christos Emmanouilides; Don M. Benson, Jr.; Deborah Hurst; Pablo Garcia; Glenn Michelson; Sandra Milan; Amy K. Ferketich; Lawrence Piro; John P. Leonard; Pierluigi Porcu; Charles F. Eisenbeis; Amy L. Banks; Lei Chen; John C. Byrd; Michael A. Caligiuri
Primary Tumor Levels of Tissue Inhibitor of Metalloproteinases-1 Are Predictive of Resistance to Chemotherapy in Patients with Metastatic Breast Cancer
Anne-Sofie Schrohl; Marion E. Meijer-van Gelder; Mads N. Holten-Andersen; Ib Jarle Christensen; Maxime P. Look; Henning T. Mouridsen; Nils Brünner; John A. Foekens
Polymorphisms in Genes Related to Oxidative Stress (CAT, MnSOD, MPO, and eNOS) and Acute Toxicities from Radiation Therapy following Lumpectomy for Breast Cancer
Jiyoung Ahn; Christine B. Ambrosone; Peter A. Kanetsky; Chunqiao Tian; Teresa A. Lehman; Silke Kropp; Irmgard Helmbold; Dietrich von Fournier; Wulf Haase; Marie Luise Sautter-Bihl; Frederik Wenz; Jenny Chang-Claude
Modulation of Cell Cycle Progression in Human Tumors: A Pharmacokinetic and Tumor Molecular Pharmacodynamic Study of Cisplatin Plus the Chk1 Inhibitor UCN-01 (NSC 638850)
Raymond P. Perez; Lionel D. Lewis; Andrew P. Beelen; Anthony J. Olszanski; Nicholas Johnston; C. Harker Rhodes; Bernard Beaulieu; Marc S. Ernstoff; Alan Eastman
Cancer Therapy: Preclinical
Synergistic Antitumor Activity of ZD6474, An Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, with Gemcitabine and Ionizing Radiation against Pancreatic Cancer
Cataldo Bianco; Elisa Giovannetti; Fortunato Ciardiello; Valentina Mey; Sara Nannizzi; Giampaolo Tortora; Teresa Troiani; Francesco Pasqualetti; Gail Eckhardt; Mario de Liguoro; Simona Ricciardi; Mario Del Tacca; David Raben; Luca Cionini; Romano Danesi
Antitumor Activity of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Gefitinib (ZD1839, Iressa) in Non–Small Cell Lung Cancer Cell Lines Correlates with Gene Copy Number and EGFR Mutations but not EGFR Protein Levels
Barbara A. Helfrich; David Raben; Marileila Varella-Garcia; Dan Gustafson; Daniel C. Chan; Lynne Bemis; Chris Coldren; Anna Barón; Chan Zeng; Wilbur A. Franklin; Fred R. Hirsch; Adi Gazdar; John Minna; Paul A. Bunn, Jr.
In vivo Loss of Expression of Argininosuccinate Synthetase in Malignant Pleural Mesothelioma Is a Biomarker for Susceptibility to Arginine Depletion
Peter W. Szlosarek; Astero Klabatsa; Arben Pallaska; Michael Sheaff; Paul Smith; Tim Crook; Matthew J. Grimshaw; Jeremy P. Steele; Robin M. Rudd; Frances R. Balkwill; Dean A. Fennell
ABCC2 (MRP2, cMOAT) Can Be Localized in the Nuclear Membrane of Ovarian Carcinomas and Correlates with Resistance to Cisplatin and Clinical Outcome
Pawel Surowiak; Verena Materna; Irina Kaplenko; Marek Spaczynski; Barbara Dolinska-Krajewska; Elzbieta Gebarowska; Manfred Dietel; Maciej Zabel; Hermann Lage
Antiestrogenic Glyceollins Suppress Human Breast and Ovarian Carcinoma Tumorigenesis
Virgilo A. Salvo; Stephen M. Boué; Juan P. Fonseca; Steven Elliott; Cynthia Corbitt; Bridgette M. Collins-Burow; Tyler J. Curiel; Sudesh K. Srivastav; Betty Y. Shih; Carol Carter-Wientjes; Charles E. Wood; Paul W. Erhardt; Barbara S. Beckman; John A. McLachlan; Thomas E. Cleveland; Matthew E. Burow
Dasatinib (BMS-354825) Pharmacokinetics and Pharmacodynamic Biomarkers in Animal Models Predict Optimal Clinical Exposure
Feng R. Luo; Zheng Yang; Amy Camuso; Richard Smykla; Kelly McGlinchey; Krista Fager; Christine Flefleh; Stephen Castaneda; Ivan Inigo; David Kan; Mei-Li Wen; Robert Kramer; Anne Blackwood-Chirchir; Francis Y. Lee
Cancer Susceptibility and Prevention
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