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Volume 12, Issue 22
15 November 2006
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    issue cover
    FISH analysis of 9p21 locus in HPV16-positive oropharyngeal squamous cell carcinoma. The cytogenetic analysis was performed using a CEP9/9p21 probe to interphasic nuclei. The nuclei showed a normal disomic hybridization pattern of 9p21 represented by two centromere 9 signals (green spots) coupled with two 9p21 signals (red spots). For further details, please see Perrone et al. on page 6643 in this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Editorial

Epigenetic Biomarkers and Breast Cancer: Cause for Optimism
Kala Visvanathan; Saraswati Sukumar; Nancy E. Davidson
View articletitled, Epigenetic Biomarkers and Breast Cancer: Cause for Optimism
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The Biology Behind

Fluorescence Visualization in Oral Neoplasia: Shedding Light on an Old Problem
William H. Westra; David Sidransky
View articletitled, Fluorescence Visualization in Oral Neoplasia: Shedding Light on an Old Problem
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Molecular Pathways

Of Spiders and Crabs: The Emergence of Lysophospholipids and Their Metabolic Pathways as Targets for Therapy in Cancer
Mandi Murph; Tamotsu Tanaka; Shuying Liu; Gordon B. Mills
View articletitled, Of Spiders and Crabs: The Emergence of Lysophospholipids and Their Metabolic Pathways as Targets for Therapy in Cancer
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Review

Synopsis of a Roundtable on Validating Novel Therapeutics for Multiple Myeloma
William Dalton; Kenneth C. Anderson
View articletitled, Synopsis of a Roundtable on Validating Novel Therapeutics for Multiple Myeloma
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Human Cancer Biology

Enhanced RASGEF1A Expression Is Involved in the Growth and Migration of Intrahepatic Cholangiocarcinoma
Katsuaki Ura; Kazutaka Obama; Seiji Satoh; Yoshiharu Sakai; Yusuke Nakamura; Yoichi Furukawa
View articletitled, Enhanced <em>RASGEF1A</em> Expression Is Involved in the Growth and Migration of Intrahepatic Cholangiocarcinoma
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Identification of Carboxypeptidase of Glutamate Like-B as a Candidate Suppressor in Cell Growth and Metastasis in Human Hepatocellular Carcinoma
Pingping Zhang; David Wai Chan; YiYi Zhu; Jin Jun Li; Irene Oi-Lin Ng; Dafang Wan; Jianren Gu
View articletitled, Identification of <em>Carboxypeptidase of Glutamate Like-B</em> as a Candidate Suppressor in Cell Growth and Metastasis in Human Hepatocellular Carcinoma
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Mapping Geographic Zones of Cancer Risk with Epigenetic Biomarkers in Normal Breast Tissue
Pearlly S. Yan; Chinnambally Venkataramu; Ashraf Ibrahim; Joseph C. Liu; Rulong Z. Shen; Nils M. Diaz; Barbara Centeno; Frank Weber; Yu-Wei Leu; Charles L. Shapiro; Charis Eng; Timothy J. Yeatman; Tim H.-M. Huang
View articletitled, Mapping Geographic Zones of Cancer Risk with Epigenetic Biomarkers in Normal Breast Tissue
Supplementary data
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Reprimo Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression
James P. Hamilton; Fumiaki Sato; Zhe Jin; Bruce D. Greenwald; Tetsuo Ito; Yuriko Mori; Bogdan C. Paun; Takatsugu Kan; Yulan Cheng; Suna Wang; Jian Yang; John M. Abraham; Stephen J. Meltzer
View articletitled, <em>Reprimo</em> Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression
Supplementary data
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Molecular and Cytogenetic Subgroups of Oropharyngeal Squamous Cell Carcinoma
Federica Perrone; Simona Suardi; Elisa Pastore; Paola Casieri; Marta Orsenigo; Stefano Caramuta; Gianpaolo Dagrada; Marco Losa; Lisa Licitra; Paolo Bossi; Samantha Staurengo; Maria Oggionni; Laura Locati; Giulio Cantu; Massimo Squadrelli; Antonino Carbone; Marco A. Pierotti; Silvana Pilotti
View articletitled, Molecular and Cytogenetic Subgroups of Oropharyngeal Squamous Cell Carcinoma
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FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas
Jorge Sergio Reis-Filho; Pete T. Simpson; Nicholas C. Turner; Maryou Ballo Lambros; Chris Jones; Alan Mackay; Anita Grigoriadis; David Sarrio; Kay Savage; Tim Dexter; Marjan Iravani; Kerry Fenwick; Barbara Weber; David Hardisson; Fernando Carlos Schmitt; Jose Palacios; Sunil R. Lakhani; Alan Ashworth
View articletitled, <em>FGFR1</em> Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas
Supplementary data
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Imaging, Diagnosis, Prognosis

Nomograms Provide Improved Accuracy for Predicting Survival after Radical Cystectomy
Shahrokh F. Shariat; Pierre I. Karakiewicz; Ganesh S. Palapattu; Gilad E. Amiel; Yair Lotan; Craig G. Rogers; Amnon Vazina; Patrick J. Bastian; Amit Gupta; Arthur I. Sagalowsky; Mark Schoenberg; Seth P. Lerner
View articletitled, Nomograms Provide Improved Accuracy for Predicting Survival after Radical Cystectomy
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Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors
G. Ramachandra Reddy; Mahaveer S. Bhojani; Patrick McConville; Jonathan Moody; Bradford A. Moffat; Daniel E. Hall; Gwangseong Kim; Yong-Eun L. Koo; Michael J. Woolliscroft; James V. Sugai; Timothy D. Johnson; Martin A. Philbert; Raoul Kopelman; Alnawaz Rehemtulla; Brian D. Ross
View articletitled, Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors
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Frequent Epigenetic Inactivation of Spleen Tyrosine Kinase Gene in Human Hepatocellular Carcinoma
Yunfei Yuan; Jianping Wang; Jinqing Li; Li Wang; Meixiang Li; Zuli Yang; Changqing Zhang; Jia Le Dai
View articletitled, Frequent Epigenetic Inactivation of <em>Spleen Tyrosine Kinase</em> Gene in Human Hepatocellular Carcinoma
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Axillary Lymph Node Nanometastases Are Prognostic Factors for Disease-Free Survival and Metastatic Relapse in Breast Cancer Patients
Patrizia Querzoli; Massimo Pedriali; Rosa Rinaldi; Anna Rita Lombardi; Elia Biganzoli; Patrizia Boracchi; Stefano Ferretti; Claudia Frasson; Caterina Zanella; Sara Ghisellini; Federico Ambrogi; Laura Antolini; Mauro Piantelli; Stefano Iacobelli; Ettore Marubini; Saverio Alberti; Italo Nenci
View articletitled, Axillary Lymph Node Nanometastases Are Prognostic Factors for Disease-Free Survival and Metastatic Relapse in Breast Cancer Patients
Supplementary data
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Loss of Breast Cancer Metastasis Suppressor 1 Protein Expression Predicts Reduced Disease-Free Survival in Subsets of Breast Cancer Patients
David G. Hicks; Brian J. Yoder; Sarah Short; Shannon Tarr; Nichole Prescott; Joseph P. Crowe; Andrea E. Dawson; G. Thomas Budd; Steven Sizemore; Muzaffer Cicek; Toni K. Choueiri; Raymond R. Tubbs; Daniel Gaile; Norma Nowak; Mary Ann Accavitti-Loper; Andra R. Frost; Danny R. Welch; Graham Casey
View articletitled, Loss of Breast Cancer Metastasis Suppressor 1 Protein Expression Predicts Reduced Disease-Free Survival in Subsets of Breast Cancer Patients
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Galectin-3 Expression Is Associated with Tumor Progression and Pattern of Sun Exposure in Melanoma
Victor G. Prieto; Alexandra A. Mourad-Zeidan; Vladislava Melnikova; Marcella M. Johnson; Adriana Lopez; A. Hafeez Diwan; Alexander J.F. Lazar; Steven S. Shen; Peter S. Zhang; Jon A. Reed; Jeffrey E. Gershenwald; Avraham Raz; Menashe Bar-Eli
View articletitled, Galectin-3 Expression Is Associated with Tumor Progression and Pattern of Sun Exposure in Melanoma
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Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients
Catherine F. Poh; Lewei Zhang; Don W. Anderson; J. Scott Durham; P. Michele Williams; Robert W. Priddy; Ken W. Berean; Samson Ng; Olivia L. Tseng; Calum MacAulay; Miriam P. Rosin
View articletitled, Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients
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Fragile Histidine Triad Expression in Oral Squamous Cell Carcinoma and Precursor Lesions
Omar Kujan; Richard Oliver; Luca Roz; Gabriella Sozzi; Noel Ribeiro; Robert Woodwards; Nalin Thakker; Philip Sloan
View articletitled, Fragile Histidine Triad Expression in Oral Squamous Cell Carcinoma and Precursor Lesions
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Computed Tomography–Diagnosed Emphysema, Not Airway Obstruction, Is Associated with the Prognostic Outcome of Early-Stage Lung Cancer
Kazuhiro Ueda; Mitsutaka Jinbo; Tao-Sheng Li; Takaharu Yagi; Kazuyoshi Suga; Kimikazu Hamano
View articletitled, Computed Tomography–Diagnosed Emphysema, Not Airway Obstruction, Is Associated with the Prognostic Outcome of Early-Stage Lung Cancer
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Cancer Therapy: Clinical

A Phase I Study of OncoVEXGM-CSF, a Second-Generation Oncolytic Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating Factor
Jennifer C.C. Hu; Robert S. Coffin; Ceri J. Davis; Nicola J. Graham; Natasha Groves; Peter J. Guest; Kevin J. Harrington; Nicholas D. James; Colin A. Love; Iain McNeish; Louise C. Medley; Agnieszka Michael; Christopher M. Nutting; Hardev S. Pandha; Claire A. Shorrock; Julie Simpson; Jan Steiner; Neil M. Steven; Dennis Wright; R. Charles Coombes
View articletitled, A Phase I Study of OncoVEX<sup>GM-CSF</sup>, a Second-Generation Oncolytic Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating Factor
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Nitroglycerin Treatment May Enhance Chemosensitivity to Docetaxel and Carboplatin in Patients with Lung Adenocarcinoma
Hiroyasu Yasuda; Katsutoshi Nakayama; Mika Watanabe; Satoshi Suzuki; Hiromi Fuji; Shoji Okinaga; Akio Kanda; Kiyoshi Zayasu; Takahiko Sasaki; Masanori Asada; Tomoko Suzuki; Motoki Yoshida; Shinsuke Yamanda; Daisuke Inoue; Tomohiro Kaneta; Takashi Kondo; Yoshihiro Takai; Hidetada Sasaki; Kazuhiro Yanagihara; Mutsuo Yamaya
View articletitled, Nitroglycerin Treatment May Enhance Chemosensitivity to Docetaxel and Carboplatin in Patients with Lung Adenocarcinoma
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Cancer Therapy: Preclinical

NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model
James C. Cusack, Jr.; Rong Liu; Lijun Xia; Ta-Hsiang Chao; Christine Pien; Wei Niu; Vito J. Palombella; Saskia T.C. Neuteboom; Michael A. Palladino
View articletitled, NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model
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CXCR4 Inhibition Synergizes with Cytotoxic Chemotherapy in Gliomas
Navid Redjal; Jennifer A. Chan; Rosalind A. Segal; Andrew L. Kung
View articletitled, CXCR4 Inhibition Synergizes with Cytotoxic Chemotherapy in Gliomas
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Down-Regulation of Insulin-Like Growth Factor I Receptor Activity by NVP-AEW541 Has an Antitumor Effect on Neuroblastoma Cells In vitro and In vivo
Barbara Tanno; Camillo Mancini; Roberta Vitali; Mariateresa Mancuso; Heather P. McDowell; Carlo Dominici; Giuseppe Raschellà
View articletitled, Down-Regulation of Insulin-Like Growth Factor I Receptor Activity by NVP-AEW541 Has an Antitumor Effect on Neuroblastoma Cells <em>In vitro</em> and <em>In vivo</em>
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Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma
Silvia Mateo-Lozano; Prafulla C. Gokhale; Viatcheslav A. Soldatenkov; Anatoly Dritschilo; Oscar M. Tirado; Vicente Notario
View articletitled, Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma
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Dominant-Negative Fibroblast Growth Factor Receptor Expression Enhances Antitumoral Potency of Oncolytic Herpes Simplex Virus in Neural Tumors
Ta-Chiang Liu; Tingguo Zhang; Hiroshi Fukuhara; Toshihiko Kuroda; Tomoki Todo; Xavier Canron; Andreas Bikfalvi; Robert L. Martuza; Andreas Kurtz; Samuel D. Rabkin
View articletitled, Dominant-Negative Fibroblast Growth Factor Receptor Expression Enhances Antitumoral Potency of Oncolytic Herpes Simplex Virus in Neural Tumors
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A Tracer Dose of Technetium-99m–Labeled Liposomes Can Estimate the Effect of Hyperthermia on Intratumoral Doxil Extravasation
Miriam M. Kleiter; Daohai Yu; Lenore A. Mohammadian; Nelsen Niehaus; Ivan Spasojevic; Linda Sanders; Benjamin L. Viglianti; Pavel S. Yarmolenko; Marlene Hauck; Neil A. Petry; Terence Z. Wong; Mark W. Dewhirst; Donald E. Thrall
View articletitled, A Tracer Dose of Technetium-99m–Labeled Liposomes Can Estimate the Effect of Hyperthermia on Intratumoral Doxil Extravasation
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Vascular Endothelial Growth Factor Blockade Reduces Intratumoral Regulatory T Cells and Enhances the Efficacy of a GM-CSF–Secreting Cancer Immunotherapy
Betty Li; Alshad S. Lalani; Thomas C. Harding; Bo Luan; Kathryn Koprivnikar; Guang Huan Tu; Rodney Prell; Melinda J. VanRoey; Andrew D. Simmons; Karin Jooss
View articletitled, Vascular Endothelial Growth Factor Blockade Reduces Intratumoral Regulatory T Cells and Enhances the Efficacy of a GM-CSF–Secreting Cancer Immunotherapy
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Arsenic Trioxide Affects Signal Transducer and Activator of Transcription Proteins through Alteration of Protein Tyrosine Kinase Phosphorylation
Meir Wetzler; Michael T. Brady; Erin Tracy; Zhang-Rong Li; Kathleen A. Donohue; Kieran L. O'Loughlin; Yijun Cheng; Amir Mortazavi; Amy A. McDonald; Padmaja Kunapuli; Paul K. Wallace; Maria R. Baer; John K. Cowell; Heinz Baumann
View articletitled, Arsenic Trioxide Affects Signal Transducer and Activator of Transcription Proteins through Alteration of Protein Tyrosine Kinase Phosphorylation
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Combination Mammalian Target of Rapamycin Inhibitor Rapamycin and HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin Has Synergistic Activity in Multiple Myeloma
Lanie K. Francis; Yazan Alsayed; Xavier Leleu; Xiaoying Jia; Ujjal K. Singha; Judith Anderson; Michael Timm; Hai Ngo; Ganwei Lu; Alissa Huston; Lori A. Ehrlich; Elizabeth Dimmock; Suzanne Lentzsch; Teru Hideshima; G. David Roodman; Kenneth C. Anderson; Irene M. Ghobrial
View articletitled, Combination Mammalian Target of Rapamycin Inhibitor Rapamycin and HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin Has Synergistic Activity in Multiple Myeloma
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Diallyl Trisulfide Suppresses Growth of PC-3 Human Prostate Cancer Xenograft In vivo in Association with Bax and Bak Induction
Dong Xiao; Karen L. Lew; Young-Ae Kim; Yan Zeng; Eun-Ryeong Hahm; Rajiv Dhir; Shivendra V. Singh
View articletitled, Diallyl Trisulfide Suppresses Growth of PC-3 Human Prostate Cancer Xenograft <em>In vivo</em> in Association with Bax and Bak Induction
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SD-1029 Inhibits Signal Transducer and Activator of Transcription 3 Nuclear Translocation
Zhenfeng Duan; James E. Bradner; Edward Greenberg; Ross Levine; Rosemary Foster; Jennifer Mahoney; Michael V. Seiden
View articletitled, SD-1029 Inhibits Signal Transducer and Activator of Transcription 3 Nuclear Translocation
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A Novel HSV-1 Virus, JS1/34.5−/47−, Purges Contaminating Breast Cancer Cells From Bone Marrow
Jennifer C. Hu; Matthew J. Booth; Gopichand Tripuraneni; Derek Davies; Syed A.A. Zaidi; Manuela Tamburo de Bella; Martin J. Slade; Stephen B. Marley; Myrtle Y.A. Gordon; Robert S. Coffin; R. Charles Coombes; Tahereh Kamalati
View articletitled, A Novel HSV-1 Virus, JS1/34.5<sup>−</sup>/47<sup>−</sup>, Purges Contaminating Breast Cancer Cells From Bone Marrow
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Letters to the Editor

Unexpected Immunohistochemical Localization of Deoxycytidine Kinase
Lorelei Johnson; Raymond Lai; Cheryl Santos; Laith Dabbagh; John Mackey
View articletitled, Unexpected Immunohistochemical Localization of Deoxycytidine Kinase
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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