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Volume 12, Issue 21
1 November 2006
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    issue cover
    Array-based CGH identifies multiple genomic alterations in MSI-H and MSS colorectal tumors. A small, previously uncharacterized deletion at 16p13.2 was found in 35% of MSI-H and 21% of MSS tumors. Figure shows homozygous deletion of this region by dual-color FISH. Nuclei (blue) show two signals for 16 centromere (green) and the absence of signals for a BAC at 16p13.2 (labeled in red). FISH to an adjacent BAC control showed two red signals. For further details, please see Trautmann et al. on page 6379 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265

Editorial

Circulating Tumor Cells in Breast Cancer: Blood Will Tell
George W. Sledge, Jr.
View articletitled, Circulating Tumor Cells in Breast Cancer: Blood Will Tell
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The Biology Behind

Is the Type I Insulin-Like Growth Factor Receptor a Therapeutic Target in Endometrial Cancer?
Hua Zhang; Douglas Yee
View articletitled, Is the Type I Insulin-Like Growth Factor Receptor a Therapeutic Target in Endometrial Cancer?
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Molecular Pathways

Advances in Targeting Human Epidermal Growth Factor Receptor-2 Signaling for Cancer Therapy
Funda Meric-Bernstam; Mien-Chie Hung
View articletitled, Advances in Targeting Human Epidermal Growth Factor Receptor-2 Signaling for Cancer Therapy
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Human Cancer Biology

Attractin Is Elevated in the Cerebrospinal Fluid of Patients with Malignant Astrocytoma and Mediates Glioma Cell Migration
Fatima W. Khwaja; Jonathan S. Duke-Cohan; Daniel J. Brat; Erwin G. Van Meir
View articletitled, Attractin Is Elevated in the Cerebrospinal Fluid of Patients with Malignant Astrocytoma and Mediates Glioma Cell Migration
Supplementary data
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Metastasis-Suppressing Potential of Ribonucleotide Reductase Small Subunit p53R2 in Human Cancer Cells
Xiyong Liu; Bingsen Zhou; Lijun Xue; Jennifer Shih; Karen Tye; Wesley Lin; Christina Qi; Peiguo Chu; Frank Un; Wei Wen; Yun Yen
View articletitled, Metastasis-Suppressing Potential of Ribonucleotide Reductase Small Subunit p53R2 in Human Cancer Cells
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Acceleration of Telomere Loss by Chemotherapy Is Greater in Older Patients with Locally Advanced Head and Neck Cancer
Brad M. Unryn; Desiree Hao; Stefan Glück; Karl T. Riabowol
View articletitled, Acceleration of Telomere Loss by Chemotherapy Is Greater in Older Patients with Locally Advanced Head and Neck Cancer
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Activation of Hypoxia-Inducible Factor-1α Is Necessary for Lysophosphatidic Acid–Induced Vascular Endothelial Growth Factor Expression
Jangsoon Lee; Soon Young Park; Eun Kyung Lee; Chang Gyo Park; Hyun Cheol Chung; Sun Young Rha; Yong Kee Kim; Gyu-Un Bae; Bum Kyeong Kim; Jeung-Whan Han; Hoi Young Lee
View articletitled, Activation of Hypoxia-Inducible Factor-1α Is Necessary for Lysophosphatidic Acid–Induced Vascular Endothelial Growth Factor Expression
Supplementary data
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Distribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression
Edward J. Filardo; Carl T. Graeber; Jeffrey A. Quinn; Murray B. Resnick; Dilip Giri; Ronald A. DeLellis; Margaret M. Steinhoff; Edmond Sabo
View articletitled, Distribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression
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Identification of the Decay-Accelerating Factor CD55 as a Peanut Agglutinin–Binding Protein and Its Alteration in Non–Small Cell Lung Cancers
Mitsunori Higuchi; Yuichi Endo; Hiroyuki Suzuki; Fumihiko Osuka; Yutaka Shio; Koichi Fujiu; Ryuzo Kanno; Akio Oishi; Teizo Fujita; Mitsukazu Gotoh
View articletitled, Identification of the Decay-Accelerating Factor CD55 as a Peanut Agglutinin–Binding Protein and Its Alteration in Non–Small Cell Lung Cancers
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Overexpression of the Insulin-Like Growth Factor I Receptor and Activation of the AKT Pathway in Hyperplastic Endometrium
Adrienne S. McCampbell; Russell R. Broaddus; David S. Loose; Peter J.A. Davies
View articletitled, Overexpression of the Insulin-Like Growth Factor I Receptor and Activation of the AKT Pathway in Hyperplastic Endometrium
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Chromosomal Instability in Microsatellite-Unstable and Stable Colon Cancer
Karolin Trautmann; Jonathan P. Terdiman; Amy J. French; Ritu Roydasgupta; Nancy Sein; Sanjay Kakar; Jane Fridlyand; Antoine M. Snijders; Donna G. Albertson; Stephen N. Thibodeau; Frederic M. Waldman
View articletitled, Chromosomal Instability in Microsatellite-Unstable and Stable Colon Cancer
Supplementary data
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RUNX3 Inhibits the Expression of Vascular Endothelial Growth Factor and Reduces the Angiogenesis, Growth, and Metastasis of Human Gastric Cancer
Zhihai Peng; Daoyan Wei; Liwei Wang; Huamei Tang; Jun Zhang; Xiangdong Le; Zhiliang Jia; Qiang Li; Keping Xie
View articletitled, RUNX3 Inhibits the Expression of Vascular Endothelial Growth Factor and Reduces the Angiogenesis, Growth, and Metastasis of Human Gastric Cancer
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Loss of Krüppel-Like Factor 4 Expression Contributes to Sp1 Overexpression and Human Gastric Cancer Development and Progression
Masashi Kanai; Daoyan Wei; Qiang Li; Zhiliang Jia; Jaffer Ajani; Xiangdong Le; James Yao; Keping Xie
View articletitled, Loss of Krüppel-Like Factor 4 Expression Contributes to Sp1 Overexpression and Human Gastric Cancer Development and Progression
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Imaging, Diagnosis, Prognosis

Circulating Tumor Cells versus Imaging—Predicting Overall Survival in Metastatic Breast Cancer
G. Thomas Budd; Massimo Cristofanilli; Mathew J. Ellis; Allison Stopeck; Ernest Borden; M. Craig Miller; Jeri Matera; Madeline Repollet; Gerald V. Doyle; Leon W.M.M. Terstappen; Daniel F. Hayes
View articletitled, Circulating Tumor Cells versus Imaging—Predicting Overall Survival in Metastatic Breast Cancer
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Reduced Expression of the Breast Cancer Metastasis Suppressor 1 mRNA Is Correlated with Poor Progress in Breast Cancer
Zhenhuan Zhang; Hiroko Yamashita; Tatsuya Toyama; Yutaka Yamamoto; Teru Kawasoe; Hirotaka Iwase
View articletitled, Reduced Expression of the <em>Breast Cancer Metastasis Suppressor 1</em> mRNA Is Correlated with Poor Progress in Breast Cancer
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Proteomics-Based Approach Identifying Autoantibody against Peroxiredoxin VI as a Novel Serum Marker in Esophageal Squamous Cell Carcinoma
Yoshihisa Fujita; Toyofumi Nakanishi; Masako Hiramatsu; Hideaki Mabuchi; Yoshiharu Miyamoto; Akiko Miyamoto; Akira Shimizu; Nobuhiko Tanigawa
View articletitled, Proteomics-Based Approach Identifying Autoantibody against Peroxiredoxin VI as a Novel Serum Marker in Esophageal Squamous Cell Carcinoma
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CA IX is an Independent Prognostic Marker in Premenopausal Breast Cancer Patients with One to Three Positive Lymph Nodes and a Putative Marker of Radiation Resistance
Donal J. Brennan; Karin Jirstrom; Åsa Kronblad; Robert C. Millikan; Goran Landberg; Michael J. Duffy; Lisa Rydén; William M. Gallagher; Sallyann L. O'Brien
View articletitled, CA IX is an Independent Prognostic Marker in Premenopausal Breast Cancer Patients with One to Three Positive Lymph Nodes and a Putative Marker of Radiation Resistance
Supplementary data
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Prognostic Value of Apoptosis in Rectal Cancer Patients of the Dutch Total Mesorectal Excision Trial: Radiotherapy Is Redundant in Intrinsically High-Apoptotic Tumors
Elza C. de Bruin; Cornelis J.H. van de Velde; Simone van de Pas; Iris D. Nagtegaal; J. Han J.M. van Krieken; Marleen J.E.M. Gosens; Lucy T.C. Peltenburg; Jan Paul Medema; Corrie A.M. Marijnen
View articletitled, Prognostic Value of Apoptosis in Rectal Cancer Patients of the Dutch Total Mesorectal Excision Trial: Radiotherapy Is Redundant in Intrinsically High-Apoptotic Tumors
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Sequential Positron Emission Tomography Using [18F]Fluorodeoxyglucose for Monitoring Response to Chemotherapy in Metastatic Breast Cancer
Olivier Couturier; Guy Jerusalem; Jean-Michel N'Guyen; Roland Hustinx
View articletitled, Sequential Positron Emission Tomography Using [<sup>18</sup>F]Fluorodeoxyglucose for Monitoring Response to Chemotherapy in Metastatic Breast Cancer
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Peroxisome Proliferator-Activated Receptor γ Is Highly Expressed in Pancreatic Cancer and Is Associated With Shorter Overall Survival Times
Glen Kristiansen; Juliane Jacob; Ann-Christin Buckendahl; Robert Grützmann; Ingo Alldinger; Bence Sipos; Günter Klöppel; Marcus Bahra; Jan M. Langrehr; Peter Neuhaus; Manfred Dietel; Christian Pilarsky
View articletitled, Peroxisome Proliferator-Activated Receptor γ Is Highly Expressed in Pancreatic Cancer and Is Associated With Shorter Overall Survival Times
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Variants of the hK2 Protein Gene (KLK2) Are Associated with Serum hK2 Levels and Predict the Presence of Prostate Cancer at Biopsy
Robert K. Nam; William W. Zhang; Laurence H. Klotz; John Trachtenberg; Michael A.S. Jewett; Joan Sweet; Ants Toi; Seamus Teahan; Vasundara Venkateswaran; Linda Sugar; Andrew Loblaw; Kathy Siminovitch; Steven A. Narod
View articletitled, Variants of the hK2 Protein Gene (<em>KLK2</em>) Are Associated with Serum hK2 Levels and Predict the Presence of Prostate Cancer at Biopsy
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Classification of Breast Cancer Using Genetic Algorithms and Tissue Microarrays
Marisa Dolled-Filhart; Lisa Rydén; Melissa Cregger; Karin Jirström; Malini Harigopal; Robert L. Camp; David L. Rimm
View articletitled, Classification of Breast Cancer Using Genetic Algorithms and Tissue Microarrays
Supplementary data
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Gastric and Intestinal Phenotypic Marker Expression in Early Differentiated-Type Tumors of the Stomach: Clinicopathologic Significance and Genetic Background
Yusuke Tajima; Kimiyasu Yamazaki; Reiko Makino; Nobukazu Nishino; Shigeo Aoki; Masanori Kato; Koji Morohara; Tsutomu Kaetsu; Mitsuo Kusano
View articletitled, Gastric and Intestinal Phenotypic Marker Expression in Early Differentiated-Type Tumors of the Stomach: Clinicopathologic Significance and Genetic Background
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Cancer Therapy: Clinical

Effect of Chemotherapy on Skeletal Health in Male Survivors from Testicular Cancer and Lymphoma
Janet E. Brown; Sue P. Ellis; Paul Silcocks; Aubrey Blumsohn; Sandra A. Gutcher; Clare Radstone; Barry W. Hancock; Matthew Q. Hatton; Robert E. Coleman
View articletitled, Effect of Chemotherapy on Skeletal Health in Male Survivors from Testicular Cancer and Lymphoma
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Long-term Events in Adult Patients with Clinical Stage IA-IIA Nonbulky Hodgkin's Lymphoma Treated with Four Cycles of Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine and Adjuvant Radiotherapy: A Single-Institution 15-Year Follow-up
Ercole Brusamolino; Ambrogia Baio; Ester Orlandi; Luca Arcaini; Francesco Passamonti; Vassiliki Griva; William Casagrande; Cristiana Pascutto; Pietro Franchini; Mario Lazzarino
View articletitled, Long-term Events in Adult Patients with Clinical Stage IA-IIA Nonbulky Hodgkin's Lymphoma Treated with Four Cycles of Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine and Adjuvant Radiotherapy: A Single-Institution 15-Year Follow-up
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Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors
Marissa N. Balak; Yixuan Gong; Gregory J. Riely; Romel Somwar; Allan R. Li; Maureen F. Zakowski; Anne Chiang; Guangli Yang; Ouathek Ouerfelli; Mark G. Kris; Marc Ladanyi; Vincent A. Miller; William Pao
View articletitled, Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors
Supplementary data
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Flat Dosing of Carboplatin Is Justified in Adult Patients with Normal Renal Function
Corine Ekhart; Milly E. de Jonge; Alwin D.R. Huitema; Jan H.M. Schellens; Sjoerd Rodenhuis; Jos H. Beijnen
View articletitled, Flat Dosing of Carboplatin Is Justified in Adult Patients with Normal Renal Function
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A Phase I Study of Single Administration of Antibody-Directed Enzyme Prodrug Therapy with the Recombinant Anti–Carcinoembryonic Antigen Antibody-Enzyme Fusion Protein MFECP1 and a Bis-Iodo Phenol Mustard Prodrug
Astrid Mayer; Roslyn J. Francis; Surinder K. Sharma; Berend Tolner; Caroline J. Springer; Jan Martin; Geoff M. Boxer; James Bell; Alan J. Green; John A. Hartley; Clare Cruickshank; Julie Wren; Kerry A. Chester; Richard H.J. Begent
View articletitled, A Phase I Study of Single Administration of Antibody-Directed Enzyme Prodrug Therapy with the Recombinant Anti–Carcinoembryonic Antigen Antibody-Enzyme Fusion Protein MFECP1 and a Bis-Iodo Phenol Mustard Prodrug
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Pharmacokinetics of Cetuximab After Administration of Escalating Single Dosing and Weekly Fixed Dosing in Patients with Solid Tumors
Antoinette R. Tan; Dirk F. Moore; Manuel Hidalgo; James H. Doroshow; Elizabeth A. Poplin; Susan Goodin; David Mauro; Eric H. Rubin
View articletitled, Pharmacokinetics of Cetuximab After Administration of Escalating Single Dosing and Weekly Fixed Dosing in Patients with Solid Tumors
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Cancer Therapy: Preclinical

Increased Safety with Preserved Antitumoral Efficacy on Hepatocellular Carcinoma with Dual-Regulated Oncolytic Adenovirus
Qi Zhang; Guihua Chen; Linhui Peng; Xinghua Wang; Yang Yang; Chen Liu; Wenfang Shi; Changqing Su; Hongping Wu; Xinyuan Liu; Mengchao Wu; Qijun Qian
View articletitled, Increased Safety with Preserved Antitumoral Efficacy on Hepatocellular Carcinoma with Dual-Regulated Oncolytic Adenovirus
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2-Methoxyestradiol, an Endogenous Mammalian Metabolite, Radiosensitizes Colon Carcinoma Cells through c-Jun NH2-Terminal Kinase Activation
HuiChao Zou; Masaaki Adachi; Kohzoh Imai; Masato Hareyama; Katsuji Yoshioka; Shiguang Zhao; Yasuhisa Shinomura
View articletitled, 2-Methoxyestradiol, an Endogenous Mammalian Metabolite, Radiosensitizes Colon Carcinoma Cells through c-Jun NH<sub>2</sub>-Terminal Kinase Activation
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Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-β Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib
Paul La Rosée; Taiping Jia; Shadmer Demehri; Nicolai Härtel; Peter de Vries; Lynn Bonham; David Hollenback; Jack W. Singer; Junia V. Melo; Brian J. Druker; Michael W. Deininger
View articletitled, Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-β Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib
Supplementary data
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Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines
Ana I. Robles; Mollie H. Wright; Bheru Gandhi; Steven S. Feis; Christin L. Hanigan; Adrian Wiestner; Lyuba Varticovski
View articletitled, Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines
Supplementary data
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Synthetic MicroRNA Designed to Target Glioma-Associated Antigen 1 Transcription Factor Inhibits Division and Induces Late Apoptosis in Pancreatic Tumor Cells
Naotake Tsuda; Satoshi Ishiyama; Yufeng Li; Constantin G. Ioannides; James L. Abbruzzese; David Z. Chang
View articletitled, Synthetic MicroRNA Designed to Target Glioma-Associated Antigen 1 Transcription Factor Inhibits Division and Induces Late Apoptosis in Pancreatic Tumor Cells
Supplementary data
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Hedgehog: an Attribute to Tumor Regrowth after Chemoradiotherapy and a Target to Improve Radiation Response
Jennifer Sims-Mourtada; Julie G. Izzo; Smith Apisarnthanarax; Tsung-Teh Wu; Usha Malhotra; Rajyalashmi Luthra; Zhongxing Liao; Ritsuko Komaki; Albert van der Kogel; Jaffer Ajani; K.S. Clifford Chao
View articletitled, Hedgehog: an Attribute to Tumor Regrowth after Chemoradiotherapy and a Target to Improve Radiation Response
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Anti-Vascular Endothelial Growth Factor Receptor-1 Antagonist Antibody as a Therapeutic Agent for Cancer
Yan Wu; Zhaojing Zhong; James Huber; Rajiv Bassi; Bridget Finnerty; Erik Corcoran; Huiling Li; Elizabeth Navarro; Paul Balderes; Xenia Jimenez; Henry Koo; Venkata R.M. Mangalampalli; Dale L. Ludwig; James R. Tonra; Daniel J. Hicklin
View articletitled, Anti-Vascular Endothelial Growth Factor Receptor-1 Antagonist Antibody as a Therapeutic Agent for Cancer
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Cancer Susceptibility and Prevention

Genetic Variants of UGT1A6 Influence Risk of Colorectal Adenoma Recurrence
Richard A. Hubner; Kenneth R. Muir; Jo-Fen Liu; Richard F.A. Logan; Matthew Grainge; Nicholas Armitage; Vic Shepherd; Sanjay Popat; Richard S. Houlston; the United Kingdom Colorectal Adenoma Prevention Consortium
View articletitled, Genetic Variants of <em>UGT1A6</em> Influence Risk of Colorectal Adenoma Recurrence
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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