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15 September 2006
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Cover Image
Antitumor immune response changes drastically during the development and progression of cancers. We demonstrated that the prevalence of FOXP3+ regulatory T cells is increased in pancreatic ductal adenocarcinoma and is an independent prognostic factor. Furthermore, infiltration of FOXP3+ regulatory T cells is closely correlated to the progression of premalignant lesions of pancreatic cancer, suggesting that FOXP3+ regulatory T cells play a role in controlling the immune response in pancreatic multistep carcinogenesis. The photograph shows newly established monoclonal antibody detecting FOXP3 (green) in CD4+CD25+ regulatory T cells and few CD8+ T cells (red) of lymph node in formalin-fixed paraffin-embedded section. For further details, please see Hiraoka et al. on page 5423 in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Editor’s Note
Editorial
The Biology Behind
Molecular Pathways
CCR Focus
Report from the FDA
Approval Summary: Nelarabine for the Treatment of T-Cell Lymphoblastic Leukemia/Lymphoma
Martin H. Cohen; John R. Johnson; Tristan Massie; Rajeshwari Sridhara; W. David McGuinn, Jr.; Sophia Abraham; Brian P. Booth; M. Anwar Goheer; David Morse; Xiao H. Chen; Nallaperumal Chidambaram; Leslie Kenna; Jogarao V. Gobburu; Robert Justice; Richard Pazdur
Review
Human Cancer Biology
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
In vitro Drug Sensitivity Predicts Response and Survival after Individualized Sensitivity-Directed Chemotherapy in Metastatic Melanoma: A Multicenter Phase II Trial of the Dermatologic Cooperative Oncology Group
Selma Ugurel; Dirk Schadendorf; Claudia Pföhler; Karsten Neuber; Adina Thoelke; Jens Ulrich; Axel Hauschild; Konstanze Spieth; Martin Kaatz; Werner Rittgen; Stefan Delorme; Wolfgang Tilgen; Uwe Reinhold
A Phase I Biological and Pharmacologic Study of the Heparanase Inhibitor PI-88 in Patients with Advanced Solid Tumors
Michele Basche; Daniel L. Gustafson; Scott N. Holden; Cindy L. O'Bryant; Lia Gore; Samir Witta; Mary Kay Schultz; Mark Morrow; Adrah Levin; Brian R. Creese; Michael Kangas; Kaye Roberts; Thu Nguyen; Kat Davis; Russell S. Addison; Jane C. Moore; S. Gail Eckhardt
Pharmacogenetics of Capecitabine in Advanced Breast Cancer Patients
Rémy Largillier; Marie-Christine Etienne-Grimaldi; Jean-Louis Formento; Joseph Ciccolini; Jean-François Nebbia; Aurélie Ginot; Mireille Francoual; Nicole Renée; Jean-Marc Ferrero; Cyril Foa; Moïse Namer; Bruno Lacarelle; Gérard Milano
Phase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Paul Sabbatini; Jakob Dupont; Carol Aghajanian; Felicia Derosa; Elizabeth Poynor; Sybil Anderson; Martee Hensley; Phillip Livingston; Alexia Iasonos; David Spriggs; William McGuire; Silke Reinartz; Sally Schneider; Cathy Grande; Shashikant Lele; Kerry Rodabaugh; James Kepner; Soldano Ferrone; Kunle Odunsi
Cancer Therapy: Preclinical
Human Regulatory T Cells Control Xenogeneic Graft-versus-Host Disease Induced by Autologous T Cells in RAG2−/−γc−/− Immunodeficient Mice
Tuna Mutis; Rozemarijn S. van Rijn; Elles R. Simonetti; Tineke Aarts-Riemens; Maarten E. Emmelot; Louis van Bloois; Anton Martens; Leo F. Verdonck; Saskia B. Ebeling
The Thalidomide Analogue, CC-4047, Induces Apoptosis Signaling and Growth Arrest in Childhood Acute Lymphoblastic Leukemia Cells In vitro and In vivo
Shabnam Shalapour; Andrea Zelmer; Madlen Pfau; Eva Moderegger; Cristiane Costa-Blechschmidt; Frank K.H. van Landeghem; Tillmann Taube; Iduna Fichtner; Christoph Bührer; Günter Henze; Karl Seeger; Sven Wellmann
Interleukin 6, a Nuclear Factor-κB Target, Predicts Resistance to Docetaxel in Hormone-Independent Prostate Cancer and Nuclear Factor-κB Inhibition by PS-1145 Enhances Docetaxel Antitumor Activity
Josep Domingo-Domenech; Cristina Oliva; Ana Rovira; Jordi Codony-Servat; Marta Bosch; Xavier Filella; Clara Montagut; Marian Tapia; Clara Campás; Lenny Dang; Mark Rolfe; Jeffrey S. Ross; Pere Gascon; Joan Albanell; Begoña Mellado
Bispecific Antibody Pretargeting of Tumor Neovasculature for Improved Systemic Radiotherapy of Solid Tumors
Dieter Moosmayer; Dietmar Berndorff; Chien-Hsing Chang; Robert M. Sharkey; Axel Rother; Sandra Borkowski; Edmund A. Rossi; William J. McBride; Thomas M. Cardillo; David M. Goldenberg; Ludger M. Dinkelborg
Cancer Susceptibility and Prevention
Letters to the Editor
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